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Transcript
Antimicrobial stewardship
Mike Richards
Kirsty Buising
IT IS NOT ACCEPTABLE:




200,000 healthcare-associated infections
(HAIs) in Australia annually
2 x 106 HAIs in USA annually
30 to 50% hospitalised patients receive
antibiotics
Up to half antimicrobial use is
inappropriate
International attention on increasing
antimicrobial resistance
White paper
IDSA
advocacy
2004
10x20
campaign –
incentives for
drug
development
Recognition as a public health issue
“Antimicrobial resistance is a Public Health problem”
WHO Global Patient Safety Challenge
2010
Tremendous variety in antibiotic consumption
and antibiotic resistance in Europe
Antibiotic consumption correlates with
antibiotic resistance on national levels
2008 First antibiotic awareness day –
30 countries
In our region….
Factors encouraging spread of Antimicrobial resistance


In hospitals
 prolonged broad spectrum antibiotics use
 cross transmission of pathogens
Belief that new, expensive drug are more efficacious
than older

Prescribers driven by patient expectations

Poor patient compliance

Self medication in some countries – choice, duration

Veterinary use
Tackling antimicrobial resistance

Rational drug use

Infection prevention

Surveillance

Research

Animal husbandry
What is antimicrobial stewardship?
Optimal selection of drug
Optimal dosage
Optimal duration
Best clinical outcome
Minimal toxicity
Minimal impact on resistance
Antimicrobial stewardship

Educate



Restrict



Guidelines – empiric and directed
Access to information – micro sensitivities,
dosing advice
Formularies
Approval systems
 pre and post prescription
Audit and feedback
Principles of antibiotic prescribing
Antimicrobial stewardship
Strategies:
Phone approval
Paper based approval forms
Stewardship teams
RMH Guidance team
Investigating role of computerised decision
support
Software only one element- need antimicrobial
committee, team, audit, feedback, education
Local efforts: AAS

RMH 2001 - addressed ceftriaxone use
Reduced ceftriaxone consumption
Local efforts – iMicro in ICU

Access to information on sensitivies,
prescribing advice


More likely to cover the pathogen
Less antibiotic consumption
Reduced MDR gram negatives in ICU
Yong JAC 2010
Guidance DS
Guidance DS
Less antibiotic
consumption –
several classes
broad spectrum
drugs
Buising JAC
2008
Roll out to other hospitals…..
Eastern Health
St Vincents Health
Guidance MS
www.guidancems.org.au