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Joann B. Powell PhD
Affiliation:
Clark Atlanta University
Biological Sciences
"Cancer","Other"
Title: Assistant Professor
Rank: Dr.
Address:
223 James P. Brawley Drive
Atlanta , GA 30314
Contact:
Email: [email protected]
Telephone: 404-880-6794
Narrative
Our lab aims to understand the molecular mechanisms by which cancer cells progress into advanced
and malignant phenotypes. In particular, we focus on the role of the aryl hydrocarbon receptor (AhR)
in prostate cancer progression. AhR is widely known for its role in mediating the harmful effects of a
number of environmental toxins. However, evidence suggests that it may also play a key role in the
progression of prostate cancer from castration dependent to castration independent. Specific goals
of our lab are to:
1. Determine the role of AhR in the development of castration independent prostate cancer via
interaction with the androgen signaling pathway.
2. Investigate the effects of environmental toxins (AhR agonist) on prostate cancer progression.
3 Establish AhR as a potential therapeutic target in the treatment of castration independent prostate
cancer.
Reviews/Chapters/Editorials
1. Ghotbaddini M, Powell JB. Biochem Pharmacol. Cancer-promoting and Inhibiting Effects of
Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR). 2014; 131(3).
2. Powell J.B., Goode G. and Eltom S. E. . Journal of Cancer Therapy. The Aryl Hydrocarbon
Receptor: A Target for Breast Cancer Therapy. 2013; 4:1177-1186.
Publications
1. Richmond O, Ghotbaddini M, Allen C, Walker A, Zahir S, Powell JB. The aryl PubMed
hydrocarbon receptor is constitutively active in advanced prostate cancer cells. PLoS
One. 2014; 9(4):e95058.
2. Tran C, Richmond O, Aaron L, Powell JB. Inhibition of constitutive aryl hydrocarbon PubMed
receptor (AhR) signaling attenuates androgen independent signaling and growth in
(C4-2) prostate cancer cells. Biochem Pharmacol. 2013 Mar 15; 85(6):753-62.
3. Brooks J, Eltom SE. Malignant transformation of mammary epithelial cells by ectopic PubMed
overexpression of the aryl hydrocarbon receptor. Curr Cancer Drug Targets. 2011 Jun;
11(5):654-69.
4. Liang Z, Brooks J, Willard M, Liang K, Yoon Y, Kang S, Shim H. CXCR4/CXCL12 axis PubMed
promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway.
Biochem Biophys Res Commun. 2007 Aug 3; 359(3):716-22.
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