Download Clofarabine

Drug – Clofarabine
Office for Human Research Studies
DANA-FARBER / HARVARD CANCER CENTER
Clofarabine
FDA Approved
Risks Associated with Clofarabine
Frequent (Between a 10-50% chance that this will happen)
 Condition in which the number of white blood cells called neutrophils is
abnormally low. This increases the risk of infection, which may be serious or life
threatening.
 Low number of platelets, which may cause bleeding and bruising. Bleeding may
be serious or life threatening and may required a blood transfusion.
 Low number of red blood cells that can causes tiredness and shortness of
breath. May require a blood transfusion.
 Loss of appetite and weight loss
 Any change from the normal heartbeat (abnormal heartbeat)
 Skin irritation, rash
 Diarrhea, which is frequent, loose watery stools, which can cause dehydration
and may require hospitalization and treatment with intravenous fluids. Severe
and prolonged diarrhea can be life-threatening.
 Bloody nose
 Feeling tired, tiredness, weakness.
 Headache
 High body temperature, a fever.
 High blood pressure
 Low blood pressure, which may cause dizziness, lightheadedness or fainting.
 Liver damage which can cause fatigue, and jaundice (yellowing of the skin and
eyes). Although this is usually mild and reversible, this can be serious or life
threatening and may require hospitalization and surgery.
 Feeling sick to the stomach, vomiting
 Worry
Occasional (Between a 1-10% chance that this will happen)
 Stroke
 Sudden reddening of the face and/or neck
 A serious condition that occurs in response to an infection that causes
widespread inflammation, resulting in poor blood supply to vital organs (Sepsis).
CF Builder Generated Version: 05.27.2016
DFCI IRB Approved Version: 05.20.2016
Drug – Clofarabine
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Symptoms may include a fast heart rate, fever, confusion and rapid breathing.
Sepsis can rapidly lead to a life threatening clinical deterioration.
Kidney damage which may cause swelling, may require dialysis
Severe skin rash with blisters and can involve the inside of the mouth and other
parts of the body
Fluid in the organs which may cause low blood pressure, shortness of breath,
and swelling of ankles
Rare (Less than a 1% chance that this will happen)
 Damage to the bone marrow (irreversible) which may cause infection, bleeding,
and may require blood transfusions
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