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Download Cancer Immunology Course Code: Credit Units: 4
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Annexure ‘CD – 01(VIII)’ FORMAT FOR COURSE CURRICULUM Course Title: Cancer Immunology Credit Units: 4 Course Code: L T P/S SW/F W 3 - 2 - TOTAL CREDIT UNITS 4 Course Objectives: Cancers are a unique disease recognized to elicit a distinctive response from the immune system giving rise to a branch of immunology dedicated to its study. This course aims to bring the students abreast with the intricacies of this branch and its latest trends. Prerequisites: Basic immunology and Understanding of Cell Biology Student Learning Outcomes: At the end of this course, the students will be able to: Define and analyze the key features of cancers and classify various types of cancers Describe the mechanisms of cellular transformation. Illustrate the cellular and molecular process of immune evasion by cancer cells. Analyse mechanisms of immune modulation of cancer and develop knowledge on therapeutic strategies for cancer control. Course Contents/Syllabus: Module I Weightage (%) 25 Descriptors/Topics Introduction to different classes of tumor. Tumour antigens Tumour specific antigens, tumour associated antigens Oncospermatogonal antigens (“Cancer-Testis” antigens), Differentiation antigens Oncofetal and carcinoembryonic antigens, Clonal antigens, Tumour antigens encoded by virus genes. Module II Descriptors/Topics Immune response to tumours Concept of immune surveillanceEffector mechanisms in cancer immunity: Innate and adaptive immune response, Assays to study the importance of effector mechanisms. Role of antibodies and B cells, T lymphocytes, Natural killer cells and Lymphokine activated killer cells, Macrophages and neutrophils, Cytokines in cancer immune response, Cancer stem cells and their properties. Module III Descriptors/Topics . Evasion of immune response by tumours Role of immune system in promoting tumours Evasion mechanisms Major histocompatibility complex, haplotype Tolerance versus ignoranceTumor microenvironment: Tumor stroma and other local factors Changes in expression of Class I major histocompatibility complex antigens Selection of antigen loss or epitope loss variants Antigenic modulation Module IV Immunotherapy of tumours, BCG, T cell therapy, Antibody-based therapy, Animal models in cancer research, tumour vaccines, biomarkers in cancer 25 25 25 Module V Descriptors/Topics Pedagogy for Course Delivery: interactive classroom teaching from text books, published reviews and articles Lab/ Practicals details, if applicable: List of Experiments: Growth characteristics of normal and transformed cell line Viability assessment of cell lines Effect of cytotoxic agents on cancer cells Assessment/ Examination Scheme: Theory L/T (%) Lab/Practical/Studio (%) Total 75 25 100 Theory Assessment (L&T): Continuous Assessment/Internal Assessment Components Weightage (%) End Term Examination Class Test Attendance Assignment 15 5 10 70 Lab/ Practical/ Studio Assessment: Continuous Assessment/Internal Assessment Components (Drop down Weightage (%) Class test (practical based) 15 Practical record Viva 5 10 End Term Examination Practical performance 40 Practical record 10 Viva 20 Text Cancer Immunology, RA Robins, RC Rees, RA Robin, 2001, Springer. References: Tumor Immunology: Molecularly Defined Antigens and Clinical Applications, Giorgio Parmiani & Michael T. Lotze, 2002, CRC Press.