Download The Treatment Method of Salivary Gland Malignant Tumor

The Treatment Method of Salivary Gland Malignant Tumor
Xinsheng HUANG1,a , Daofeng LIU1,band Yanbin HUANG1,c
1
Shengli oilfield central hospital
No. 31, Jinan Road #1, Dongying City, Shandong Prov. 257034, China
Keyword: salivary gland, tumor, lymphatic metastasis
Abstract: Through analyzing 139 comprehensive treatment cases of salivary gland
malignant tumor, our researching team developed the method that it can prevent
recurrence, diffusion and transfer of the cancer cells through the radiotherapy,
chemotherapy and combination treatment with chemotherapy and radiotherapy. And
the method has obtained a good curative effect.
1 introduction
Salivary gland malignant tumor is a significant malignant tumor of oral maxillofacial
region with high incidence rate. There is no significant difference in sex incidence and
age incidence of salivary gland malignant tumor. The salivary gland malignant tumor
which mostly originates from salivary gland epithelial tissue may occur in large
salivary glands such as parotid gland, submaxillary gland and minor salivary glands
like palate gland and so on. These tumors have features of complicated tissue typing
and cell component. Our hospital had cured 139 cases of oral and maxillofacial
salivary gland malignant tumor with unscheduled surgery, chemotherapy, radiation
therapy and comprehensive treatment from 2001 to 2010.
2 clinical data
Our hospital had cured 139 cases of oral and maxillofacial salivary gland malignant
tumor from 2001 to 2010. And there were 69 cases of male, 57 cases of female, and
the ages are from 30 to 80 years, and the average age is 55, and the people who is
older than 50 year is 64.12%. All the patients were confirmed by pathology. And there
were 40 cases of mucoepidermoid carcinoma, 27 cases adenoid cystic carcinoma, 23
cases of adenocarcinoma, 16 cases of squamous carcinoma, 9 cases of malignant
mixed tumor, 5 cases of acinic cell carcinoma and undifferentiated carcinoma.
3 treatment
The keyword of salivary gland malignant tumor surgery is to cut tumors completely
and enough disease-free cut edge. According to intraoperative pathologic, surgery
area of the parotid gland is ensured. And other area is ensured by the quick pathology.
For the salivary gland tumors which are near the bottom mouth and pharynx, our
research team choose mandibular cut method. And this method can expose and cut the
tumors completely. And the method can keep the chin nerve and avoid the lower lip to
be numb. And the method can stay away the bone cutting area to avoid the
osteoporosis.
The research team choose radiotherapy, chemotherapy drugs according to the
pathology after the surgical incision healed. The team should be attention to the blood
picture, biochemical indicator during the treatment.
4 clinical observation
Our hospital had cured 139 cases of oral and maxillofacial salivary gland malignant
tumor through the radiotherapy, chemotherapy and combination treatment with
chemotherapy and radiotherapy. from 2001 to 2010. Through the treatment, the
survival rate of 1 year was 100%, the survival rate of 2 year was 98.6%, the survival
rate of 3 year was 94.4%, he survival rate of 4 year was 83.3%, he survival rate of 5
year was 67.4%. The survival rate of parotid gland tumors was the highest based on
the pathogenic site, and the survival rate of the sublingual gland was the lowest. The
survival rate of the mucoepidermoid carcinoma was the highest based on the
pathological type, and the survival rate of the undifferentiated carcinoma, malignant
mixed tumor and squamous carcinoma was the lowest.
5 discussions
At present, the surgery is the main means of curing the salivary gland malignant
tumor. And the correct surgical method is the key to improve the curative effect. The
statistics showed that the treatment of the salivary gland malignant tumor can’t be
palliative conservative because of the maxillofacial, but expand the resection. And we
should pay attention to prevent the tumor transferring to the lymph. For the primary
parotid tumors, the parotid gland was cut completely or not based on the
characteristics of the tumors, the position and the scope. For the high degree of the
malignant salivary gland tumors, such as undifferentiated carcinoma, malignant
mixed tumor and squamous carcinoma, the principal was the extensive local resection.
And we should cut the tissue around the tumors as far as possible without effecting
the function, such as parotid masseter, jaw, tongue skeletal muscle and abdominal
muscle. And we must be cut the tumors completely if the facial nerve adhere to the
tumors, and we can cut the near facial nerve branch if the degree of the malignant
tumors is low. For the adenoid cystic carcinoma which spread along the nerve, we
should cut completely without considering the facial nerve and the inferior alveolar
nerve. It is not unified completely that neck cleaning operation is selected for the
salivary gland carcinoma. It is generally believed that we should choose neck cleaning
for the malignant degree which is high, such as undifferentiated carcinoma, malignant
mixed tumor and squamous carcinoma, and we should choose other methods for the
malignant degree which is low.
our researching team developed the method that it can prevent recurrence, diffusion
and transfer of the cancer cells through the radiotherapy, chemotherapy and
combination treatment with chemotherapy and radiotherapy. And the amount of the
radiotherapy or chemotherapy must be sufficient, and the therapy time must be
prompt, and the site of the radiotherapy must be correct. Somebody thought that the
salivary gland malignant tumors resist to the radiation, so the radiotherapy is not the
first choice. Recently, our researching team developed the method that it can prevent
recurrence, diffusion and transfer of the cancer cells through the radiotherapy,
chemotherapy and combination treatment with chemotherapy and radiotherapy
according to the property of the tumors, and the method has obtained a good curative
effect.
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