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UVa BME LABS GUIDE for Undergraduate Students. Last Updated 10/10/2012. Director Acton, Scott [email protected] Student Contact Projects (434) 982-2003 Emmanuel Denloye-Ito [email protected] Biomedical image analysis, image processing. Website: http://viva.ee.virginia.edu. Director Berr, Stuart [email protected] Projects Students/Yr 2 per year Academic Year: 5-10 hours/week. Hours/Wk How to find out about current needs Talk to Dr. Acton. Paid, Volunteer, or For Credit? Paid (sometimes), volunteer or for credit. Tracking cells, classifying MR images, analyzing imagery. Recommended that students take ECE 323/324 or equivalent. Research Student Contact Lab VIVA: Virginia Image and Video Analysis Thornton E-309 434 924-5096 Landon Locke [email protected] Lab Small Animal MRI Lab MR4, Room 1192 Students/Yr 2 per year 10 hours/week. Hours/Wk How to find out about current needs Talk to Dr. Berr. Paid, Volunteer, or For Credit? Mostly volunteer or for credit. Occasional paid position. Develop high resolution MR imaging techniques for phenotyping mice. Research Cardiovascular and cancer research in mice. In vivo magnetic resonance, bioluminescence, and flourescence imaging. Director Blemker, Silvia [email protected] Student Contact Projects 434-924-6291 Handsfield, Geoffrey [email protected] Lab 'M3: Multiscale Muscle Mechanics Lab' MR5 2313 Students/Yr 1-3 10 hours/week Hours/Wk How to find out about current needs Contact Dr. Blemker. Paid, Volunteer, or For Credit? Volunteer or for credit. 'Image processing of MRI images for creating 3D datasets of in vivo muscle, mechanical modeling, MRI image acquisition' Research We characterize the relationships between muscle structure, mechanical properties, biology, and function. We are applying these findings to understanding and improving the treatments for musculoskeletal impairments associated with movement disorders, such as cerebral palsy. We are integrating a variety of computational and experimental approaches, including computational models, MRI techniques, and anatomical measurements and tissue testing. Website: http://www.mae.virginia.edu/muscle/ Director Crandall, Jeff & Kent, Rich [email protected] Student Contact Projects Research Director Sabrina Lau, [email protected] Projects Research Lab Automobile Safety Lab North of the airport! Students/Yr 2-3 per year How to find out about current needs Contact Rich Kent or Jeff Crandall. Paid, Volunteer, or For Credit? Paid, volunteer, and for credit. Hours/Wk Development of constitutive models for biological materials, development of injury criteria/thresholds, assessment of crash test dummies, design of test apparatus/methods. Note: Lab is offgrounds, north of the airport! Biomechanics, Injury Biomechanics, Trauma Prevention, Automobile Safety. http://auto-safety.mech.virginia.edu Website: http://www.centerforappliedbiomechanics.org/ Epstein, Fred H. [email protected] Student Contact 434 296-7288 434 982-0563 Naresh, Nivedita [email protected] Lab Epstein Lab MR5 1223 Students/Yr 1 per year How to find out about current needs Contact Dr. Epstein. Paid, Volunteer, or For Credit? Usually volunteer or for credit. Develop Matlab software for image analysis. Use of MRI to image myocardial function and perfusion. Website: http://www.medicine.virginia.edu/clinical/departments/radiology/research/home.html Hours/Wk Director French, Brent A. [email protected] Student Contact 434 924-5728 Bryan Piras [email protected] Lab Molecular Bioengineering Laboratory MR5, Room 1219 Students/Yr 1 per year 10 hours/week. Hours/Wk How to find out about current needs Contact by email: [email protected]. Paid, Volunteer, or For Credit? Mostly volunteer or for credit. Research Depends largely on student's aptitude, experience, and inclination. Projects range from studying gene expression at the mRNA and protein levels to studying cardiac function with magnetic resonance imaging. Roles of oxidative stress and inflammation in myocardial infarction and left ventricular remodeling. Director Gillies, George T. Projects [email protected] 434 924-7634 Student Contact Lab Bio/Thermal Fluids Lab MEC 105D Students/Yr 3 per year Minimum of 4-6 hours/week. Hours/Wk How to find out about current needs See Dr. Gillies. Paid, Volunteer, or For Credit? Volunteer and For credit only. Projects Research Research interests include medical device development and precision measurement technology. More specifically, they include magnetic guidance systems for medical implants, design of catheters for positive pressure infusion systems, novel methods for delivering therapies into brain tumors, design of instrumentation systems for epicardial electrophysiology, and the development and testing of neurosurgical instrumentation. Director Guilford, William H. [email protected] Student Contact Projects 434 243-2740 Amy Clobes [email protected] Lab Molecular Biomechanics Laboratory MR5, Room 1213 Students/Yr 2 per year 2 afternoons/week minimum. Hours/Wk How to find out about current needs Projects are continually evolving. Contact Dr. Guilford. Paid, Volunteer, or For Credit? Volunteer or for credit. Possible to be paid, but only Projects range from the molecular basis of heart and neural diseases, to the development of computer algorithms for tracking images of single molecules. Research The molecular basis of muscle contraction and cell adhesion, and its relationship to cardiovascular disease. Website: http://faculty.virginia.edu/guilford/ Director Helmke, Brian P. [email protected] Student Contact 434 924-1726 Rachel Evans [email protected] Lab Cellular Mechanotransduction MR5, Room 1207 Students/Yr 1-2 per year 10 hours/week. Hours/Wk How to find out about current needs Contact Dr. Helmke. Paid, Volunteer, or For Credit? Depends: mostly volunteer or for credit. Research Recent undergraduate projects include imaging nitric oxide production inside endothelial cells, imaging structural deformation inside cells during "tickling" with a micropipette, creating micropatterned surfaces to control cell adhesion, and investigating how white blood cell migration across the endothelium depends on cell structure. Our lab is investigating how cells sense mechanical forces. In particular, we're interested in how endothelial cells lining the blood vessels sense changes in frictional shear stress due to blood flow. This has important clinical implications since endothelial dysfunction plays a crucial role in the development of arterial diseases such as atherosclerosis. We are developing innovative tools to investigate cell mechanics and control cell behavior, including high-resolution microscopy, 4-D image analysis, and nanotechnology. Director Holmes, Jeffrey Projects [email protected] Student Contact Projects Research 434 243-6321 Tracy Burcin, Lab Manager [email protected] Lab Cardiac Biomechanics Group MR5, Room 2334 Students/Yr 2 How to find out about current needs Contact Dr. Holmes. Paid, Volunteer, or For Credit? Focuses on the interactions between mechanics, function, and growth and remodeling in the heart. See faculty web page on BME website for current projects. Lab website: http://bme.virginia.edu/holmes/ UVa BME Labs Guide for Undergraduate Students. Updated 10/10/2012. Page 2 of 6. Hours/Wk Director Horwitz, Rick [email protected] 434-243-6812 Student Contact Projects Research Director Students/Yr 1-2 per year 10 hours/week Hours/Wk How to find out about current needs Contact post doc Alexia Bachir, [email protected] Paid, Volunteer, or For Credit? Paid, volunteer or for credit Digital image analysis, adhesion turnover assays, implementation of computational image analysis tools. Depending on applicant possibility of live cell imaging, tissue culture, and transfection protocols. The lab studies cell migration and is interested in the mechanisms that control cell movement via cell-substrate adhesion formation, turnover and disassembly. The project will apply imaging techniques to further understand the spatial and temporal distribution, dynamics and regulation of these processes during cell migration. Hossack, John [email protected] Student Contact Lab Cell Adhesion and Migration Jordan Hall, Room 3226 434 243-5866 Ali Dhanaliwala [email protected] Lab Biomedical Ultrasound Laboratory MR5, Room 2219 Students/Yr 1-2 per year 10 hours/week. Hours/Wk How to find out about current needs www.faculty.virginia.edu/hossack/ & then contact Dr. Hossack Paid, Volunteer, or For Credit? Paid, volunteer, or for credit. Research Involve supporting some component of one of the active research projects listed below. Projects are best suited to those interested in imaging/mathematical modeling. Some projects are available that involve assisting in the collection of clinical imaging data and analyzing it. There are openings in mouse heart imaging. Various projects: quantitative 3D ultrasound imaging of mouse heart chambers, quantification of perfusion in mouse heart after myocardial infarction, breast and prostate cancer detection using ultrasound-based measurements of elasticity, transducer modeling and design. Simulating the image formation process, finite element simulation of transducers (emphasis on high signal bandwidth transducers). Collaborations with mouse researchers, Radiology and CV Division. Website: http://bme.virginia.edu/hossack/ Director Janes, Kevin Projects [email protected] Student Contact Projects 434 243-2126 Sameer Bajikar [email protected] Lab Cell-Signaling Bioanalysis Laboratory MR5 2nd floor lab Hallway, Room 2014 Students/Yr 1-2 10 hours/week Hours/Wk How to find out about current needs Email contact preferred. See Note below. Paid, Volunteer, or For Credit? Molecular cloning, image analysis Note: I am exclusively looking for long-term commitments (ideally, 2+ years). Research Our lab is interested in understanding how cells interpret their environment and respond accordingly. We design biochemical and cell-biological tools for tracking the molecular events that underlie cell-signal processing. Website: http://bme.virginia.edu/janes/index.html Director Kelly, Kimberly [email protected] Student Contact 434-243-9352 Soo Shin [email protected] Lab Targeted Molecular Imaging MR5, Room 1129 Students/Yr How to find out about current needs Attend Lab Meeting & Contact Dr. Kelly Paid, Volunteer, or For Credit? Hours/Wk Projects Research I am interested in applying powerful combinatorial approaches to the development and design of targeted, multimodal, and amplifiable imaging agents. Using this method of attack, I have generated imaging agents capable of the early detection in vivo of colon, pancreatic, lung, and prostate cancers as well as specific targets in atherosclerosis and inflammation. Director Lawrence, Michael B. [email protected] Student Contact Projects Research Caroline Whitaker [email protected] 434 982-4269 Lab Adhesion Mechanics/Membrane Immunobiolgy MR5, Room 2111 Students/Yr 2 per year 5 hours/week (one good afternoon). Hours/Wk How to find out about current needs Contact Dr. Lawrence. Paid, Volunteer, or For Credit? Paid (summer only), volunteer or for credit. Students choose a project based on their interests and current lab needs. Examples of previous undergraduate projects include the design of microbubbles and peptide-presenting hydrogels with possible applications to targeted drug delivery. There are additional opportunities in modeling cell and microbead rolling and investigating the relationship between molecular structure Role of shear stress in inflammation. Cell recruitment to sites of tissue injury. Targeted drug delivery. Progenitor cell homing. Website: http://bme.virginia.edu/lawrence/ UVa BME Labs Guide for Undergraduate Students. Updated 10/10/2012. Page 3 of 6. Director Meyer, Craig H. [email protected] Student Contact Projects Research Director Student Contact Projects 434 243-9495 Sam Fielden [email protected] Lab Cardiac Imaging Lab MR5, Room 2228 Students/Yr 1-2 per year 5-10 hours/week. Hours/Wk How to find out about current needs Contact Dr. Meyer. Paid, Volunteer, or For Credit? Mostly volunteer or for credit. One technique we are studying is real-time interactive imaging, which allows images of the beating heart to be acquired, displayed and controlled in real-time. Non invasive coronary angiography and coronary vessel wall imaging. Developing novel rapid MRI techniques. [email protected] Papin, Jason Lab Computational Systems Biology Lab MR5 2041 Students/Yr 2-4 More than 4 Hours/Wk Matthew Biggs [email protected] How to find out about current needs Email interests and resume/CV. Paid, Volunteer, or For Credit? Paid, volunteer, or for credit. Model-building; high throughput data analysis; microbial growth cultures. Research Computational analysis of biochemical networks in cancer and infectious disease. Website: http://bme.virginia.edu/csbl/index.php Director Peirce-Cottler, Shayn M. [email protected] Student Contact 434 243-5795 Peirce Lab shadowing is coordinated by Kitter Kitter Bishop - [email protected] Lab Peirce-Cottler Lab MR5 2228 Students/Yr 2 during year; 2 during summer 5-20 hours/week, depending on project. Hours/Wk How to find out about current needs Call, email, or visit www.bme.virginia.edu/peirce Paid, Volunteer, or For Credit? Paid volunteer, or for-credit Research Tissue engineering, cell culture, and assisting with small animal surgeries. Immunohistochemistry benchtop work (staining tissues with antibodies). Image analysis and data acquisition on tissues. Computational modeling of tissue patterning events. Lab technician work. Tissue Patterning, Stem Cells in Microvascular Growth, Computational Modeling of Complex Biological Systems. Advice from Dr. Peirce: Don't wait to get started. I recommend looking Director Price, Richard Projects for a project (or lab experience) in your first or second year, but it's never too late to start! Pick a lab that you are really interested in...do your research to figure out what scientific projects (or questions) are really interesting to you. If you commit to working in a lab, make sure that you have the time to spend there and do your best work! [email protected] Student Contact 434 924-0020 Josh Meisner [email protected] Lab Microvascular Remodeling & Ultrasound-Mediated Therapies MR5, Room 2216 Students/Yr 1-3 per year/per grad student 5-30 hours/week. Hours/Wk How to find out about current needs Contact Dr. Price by email. Paid, Volunteer, or For Credit? Paid, volunteer or for credit. Research Often, projects involve assisting with small animal surgery, immunofluorescence, and microscopy for analyzing microvascular networks and applied ultrasound techniques. Additional areas include developing image analysis tools, data processing, cell culture, and molecular biology techniques. Our research spans multiple disciplines with one focus on determining the mechanisms of microvascular network growth and remodeling during both sprouting of new capillaries (angiogenesis) and remodeling of existing arteries (arteriogenesis). Our second focus is the application of therapeutic ultrasound for targeted drug delivery, gene transfection, and ablation therapy. Director Saucerman, Jeffrey Projects [email protected] Student Contact Projects Research Karen Ryall [email protected] 434 924-5095 Lab Cardiac Systems Biology Lab MR5 1123 Students/Yr 2 10 hours/week Hours/Wk How to find out about current needs Email Dr. Saucerman Paid, Volunteer, or For Credit? Isolation and culture of muscle cells from rat hearts. Microscopy to image heart muscle cell contractions and remodeling. Computational modeling of biochemical pathways that lead to heart disease. Our lab combines experimental studies and computational modeling to understand how biochemical networks make decisions impacting the development of heart disease. This basic research is helping us identify new therapeutic targets to prevent or reverse disease. Website: http://bme.virginia.edu/saucerman/ UVa BME Labs Guide for Undergraduate Students. Updated 10/10/2012. Page 4 of 6. Director Williams, Mark B. [email protected] Student Contact Projects Research Judy, Patty [email protected] 434 982-4422 Lab Detector Lab MR4 Room 1174 Students/Yr 3 - 5 per year 10 hours/week. Hours/Wk How to find out about current needs Contact Dr. Williams. Paid, Volunteer, or For Credit? Paid, volunteer or for credit Detector development and characterization, data acquisition and image analysis, software development, design and implementation of studies using both phantoms and patient volunteers. Development of x-ray and gamma ray based medical imaging systems. Website: http://www.faculty.virginia.edu/mbwlabwebsite/ UVa BME Labs Guide for Undergraduate Students. Updated 10/10/2012. Page 5 of 6.