Download PHS 398/2590 (Rev. 06/09), Biographical Sketch Format Page

BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Semple-Rowland, Susan L
Professor of Neuroscience
eRA COMMONS USER NAME (credential, e.g., agency login)
Semple-Rowland
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Gustavus Adolphus College, St. Peter, MN
University of Pittsburgh, Pittsburgh, PA
University of Florida, Gainesville, FL
University of Florida, Gainesville, FL
BA
MSc
PhD
Post Doc
1977
1979
1986
1986-1989
Biology/Psychology
Psychobiology
Neuroscience
Ophthalmology
A.
Personal Statement
My research program focuses on development of lentiviral vector-based gene therapies for the treatment of
Leber congential amaurosis – 1, an inherited retinal degeneration that is caused by null mutations in the gene
encoding guanylate cyclase 1 (GC1). We have developed several different types of vector transgenes that we
package into lentivirus and permit targeted delivery of multiple proteins to neural cells. In addition to my
research program, my laboratory also designs, constructs, and packages vectors in collaboration with
investigators interested in targeted delivery of genes to the CNS.
B. Positions and Honors
Positions and Employment
1979-1981
1990-1995
1995-1997
1998-2006
2006 – present
2000 – present
2003 –2010
Teaching Fellow, University of Pittsburgh, Pittsburgh, PA
Assistant Research Scientist, University of Florida College of Medicine, Gainesville, FL
Associate Research Professor, University of Florida College of Medicine, Gainesville, FL
Associate Professor, University of Florida College of Medicine, Gainesville, FL
Professor, University of Florida College Medicine, Dept. Neuroscience, Gainesville, FL
Director, UF McKnight Brain Institute BSL-3 facility, University of Florida College of
Medicine, Gainesville, FL
Director IDP Neuroscience Graduate Program, University of Florida College of Medicine,
Gainesville, FL
Other Experience and Professional Memberships
Grant reviewer
1998
1998-2000
2000
2001
2001
2001
2002
2003 – 2006
2004
2005
NIH/NEI VISB Study section/Special Emphasis panel
Biochemistry/Molecular Biology Programming Committee for ARVO
NIH/NEI VISB Study section/Special Emphasis panel
NEI Board of Scientific Counselors, review Laboratory of Retinal Cell and Molecular
Biology, NIH (Dec. 3-4)
Ad hoc member of NINDS Training grant and Career Development Study section
Reviewer for NSF Division of Sensory Biology and for the Division of Behavioral
Neuroscience and NSF Behavioral Neuroscience
NSF Sensory Systems and Computational Neuroscience Advisory Panel
Fight-for-Sight Grant Review Board
NEI special emphasis review panel
Reviewer Special Emphasis NIH Panel – Gene Expression and Neuronal Development
(11/9/05)
Reviewer Vision SBIR BDCN IRG R43 grant (3/2/05)
Reviewer for NSF Integrative Organismal Biology Section 3/20/06
Reviewer for Health Research Board – Ireland (12/07)
Reviewer for NSF Neural Systems Activation Program
Reviewer for Medical Research Council, London, England
2005
2006
2007
2008
2009
Editorial Boards
2001 – present
Executive Editor for Experimental Eye Research
2004 – present
Editorial Board Member – Molecular Vision
Professional Societies
1986 – present
Member Association for Research in Vision and Ophthalmology
2000 – present
Member Society for Neuroscience
Honors
1998
2000
2001
2003
2005
2006
2006-11
C.
Lecture for Distinguished Scientist Seminar Series, University of Southern Alabama.
Alcon Foundation Lecture in Ophthalmology - Emory University School of Medicine.
Invited speaker Glaucoma Foundation 8th Annual Think Tank meeting on Gene Therapy
University of Florida College of Medicine Exemplary Teacher Award
UF College of Medicine Award for Outstanding Doctoral Dissertation Mentor Award
Distinguished Alumni Citation in the field of Neuroscience –Gustavus Adolphus College,
St. Peter, MN
University of Florida College of Medicine Exemplary Teacher Award
Selected Peer-reviewed Publications (Selected from 47 peer-reviewed publications)
Most relevant to the current application
Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL,
Raizada MK (2003) Efficient large-scale production and concentration of HIV-1-based lentiviral vectors
for use in vivo. Physiol. Genomics, 12, 221-228.
Coleman JE, Wu K, Fulle HJ, Semple-Rowland SL (2004) The 5’ flanking sequence of the
human retinal guanylyl cyclase 1 gene acquires a photoreceptor cell-restricted activity pattern over the
course of retinal development. Mol Vision Oct 10:720-727 <http://www.molvis.org/molvis/v10/a87/>.
Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, and
Semple-Rowland SL (2006) Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) in retina
restores vision in an avian model of childhood blindness. PLoS Medicine 3(6):e201.
[http://medicine.plosjournals.org/perlserv?request=get-document&doi=10.1371/journal.pmed.0030201]
Semple-Rowland SL, Eccles KS, Humberstone EJ (2007) Targeted expression of two proteins in neural
retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters.
Mol Vision 13, 2001-2011.
Foster, T.C., Rani, A., Kumar, A., Cui, L. and Semple-Rowland, S.L. (2008) Viral vector mediated delivery of
estrogen receptor-alpha to the hippocampus improves spatial learning in adult estrogen receptor-alpha
knockout mice. Mol Ther 16, 1587-1593.
Semple-Rowland SL, Coggin WE, Geesey M, Eccles K, Abraham L, Pachigar K, Ludlow R, Khani SC, Smith
WC (2010) Expression characteristics of dual-promoter lentiviral vectors targeting retinal
photoreceptors and Müller cells. Mol Vision 16, 916-934.
Verrier, J.D., Semple-Rowland, S., Madorsky, I., Papin, J.E., Notterpek, L. (2010) Reduction of Dicer impairs
Schwann cell differentiation and myelination. J Neuroscience Res. 88, 2558-2568.
Jackson TC, Verrier JD, Semple-Rowland S, Kumar A, Foster TC. (2010) PHLPP1 splice variants
differentially regulate AKT and PKCalpha signaling in hippocampal neurons: Characterization of PHLPP
proteins in the adult hippocampus. J Neurochem. 115, 941-955.
D.
Research Support
Ongoing Research Support
2R01 EY011388-11A2 (Susan Semple-Rowland – PI)
12/1/08 - 11/30/2012
NEI/NIH
“Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy”
The goals of this project are: (1) Develop dual-promoter, self-inactivating, insulated lentiviral vectors capable
of delivering multiple therapeutic transgenes to specific retinal cell types and (2) To test the hypothesis that
degeneration of photoreceptors that have been treated with targeted corrective gene therapy can be
prevented by combining corrective gene therapy with either targeted anti-apoptotic or targeted neurotrophic
therapies.
Role: PI
9R56 AG037984-11 (Thomas C. Foster – PI)
9/15/2010 - 8/31/2011
“Estrogen and Cognition Over the Lifespan”
Examines the hypothesis that estrogen exerts its effects on memory function and delays brain aging by
regulating gene transcription through activation of the alpha-estrogen receptor.
Role: Co-investigator
Completed Research Support
2R01 MH059891 (Thomas C. Foster – PI)
NIMH/NIH
3/05/05 - 8/31/2010
“Estrogen and Cognition Over the Lifespan”
Examines the hypothesis that estrogen exerts its effects on memory function and delays brain aging by
regulating gene transcription through activation of the alpha-estrogen receptor.
Role: Co-investigator
5R01 AG014979-11 (Thomas C. Foster -PI)
6/01/07 - 5/31/2012
NIA/NIH
“Mechanisms of altered synaptic function during aging”
The goals of this project are to understand the basic mechanisms by which synaptic function diminishes with
aging and how such changes impact the functions of memory circuits.
Role: Co-investigator