Download Current Projects - McMaster University`s Faculty of Health Sciences

Examples of Research Happening
in the Department of Surgery
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CADENCE Research Group – Our Mission
 Founded and directed by Dr. Andre Lamy in 2000
 Our mission is as its name stated: Cardiac Diseases:
Economic Analysis and Clinical Evaluation
 We have participated in many clinical trials, conducted and
published economic analysis such as HOPE, CURE,
MEDENOX, Canadian Off-pump CABG Registry.
 CORNARY trial (CABG Off or On Pump Revascularization
Study), funded by the CHIR, is the the largest, multi-nation,
randomized clinical trial in surgical patient populations.
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CADENCE Research Group – Our People
From left to right: Dr. Andre Lamy (Director); Parvaz Khatib (Study
coordinator), Helen Shing (Research nurse), Sherry Wang (Health Economist),
Rosanne Kent (former manager), Patti Schneider (Secretary), Lisa Trombetta
(Database), Toni Rizzo (Research nurse), Kamil Malikov (Project Manager).
Not in picture: Cathy Ther (DataFax), Kristina Novosel (Research Nurse).
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MacHANd
McMaster University
Hand, Arm, Nerve
What is MacHANd?
MacHANd is a new initiative promoting excellence in education, clinical service,
and research for hand and upper limb injuries, diseases, and disorders.
Core Members
Dr. J. Bain (Plastic Surgery)
Dr. F. Farrokhyar (Surgery)
Dr. N. Hynes (Plastic Surgery)
Dr. C. Levis (Plastic Surgery)
Dr. J. MacDermid (Rehabilitation Science)
Dr. J. Moro (Orthopaedic Surgery)
Dr. K. Rajaratnam (Orthopaedic Surgery)
Dr. A. Thoma (Plastic Surgery)
Current Projects:
 The Impact of Waiting for Carpal Tunnel Surgery
 Health-Related Quality of Life (HRQoL) in Patients
with Dupuytren's Disease: A Prospective Cohort Study
(NCT00468949)
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MacHANd
McMaster University
Hand, Arm, Nerve
Research Themes
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hand
wrist
elbow
shoulder
nerve
occupational disorders
articles/resources for EBP
systematic reviews
economic analyses
utilities
randomized controlled trials
outcome measures
For More Information:
Margaret Lomotan,
Research Assistant
E-mail: [email protected]
Phone: 905-525-9140 Ext. 27328
Website: http://www.machand.ca
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Dr. Sheila Singh’s Laboratory
Wednesday July 16, 2008
Research Overview
Lab overview
• Operating since August 2007
• Located at the Stem Cell &
Cancer Research Institute at
McMaster Main Campus
• Personnel includes: one post
doctoral
fellow,
one
undergraduate student & a
research technician
• Dr. Singh is a pediatric neurosurgeon
and scientist
• This is a basic science laboratory with a
strong clinical focus
• The overall research goal is to further
elucidate the cancer stem cell hypothesis
in brain tumours and to characterize the
Brain Tumour Initiating Cell (BTIC)
• Our work includes
tissue culture work,
molecular lab work
and in vivo
animal work
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Cancer Stem Cell Hypothesis & the BTIC
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Nature. 2004;432(7015):281-2
Neural stem cells (found in brain) are tightly
regulated & differentiate into normal cells of
brain tissue
Cancer neural stem cells, by virtue of
mutations, are dysregulated, & self renew &
differentiate aberrantly, generating the
abnormal cells that make up the brain cancer
The BTIC was identified by its cell surface
protein expression of CD133
In 2004, Singh et. al identified an abnormal
stem cell (termed the BTIC) that drove the
formation of brain tumours (Nature,
2004;432(7015):396-401)
BTIC’s represent a small fraction of the
whole tumour, but these cells alone may be
entirely responsible for the continued growth
of the tumour
Clinical implications: therapies that focus on
killing the bulk of the tumour may miss the
rare stem cell fraction, allowing the tumour to
continue to grow & potentially metastasize to
form secondary tumours
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Tumor spheres of Anaplastic medulloblastoma in vitro
100x
200x
0.05mm
400x
0.05mm
0.05mm
Tumor spheres of Metastatic Melanoma in vitro
200x
100x
0.05mm
200x
0.05mm
0.05mm
Not recruiting residents for 2008-09 Core program
Please contact us for more info:
Monika Lenkiewicz [email protected] Sheila Singh
[email protected]
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Dr. Peter J. Lovrics
Clinical Associate Professor, McMaster University
General Surgeon, specializing in breast oncology
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Dr. Lovrics - Research Projects
• A randomized, multisite, controlled trial of
radioguided seed localization versus standard
needle localization in early stage breast
carcinomas – funded by CBCF
• Practice patterns and perceptions of breast
conserving surgery in early stage breast cancer:
Survey of Canadian General Surgeons and
Radiation Oncologists – funded by CBCRA
• A prospective cohort study to evaluate the impact
of preoperative breast magnetic resonance
imaging (MRI) on surgical decision-making in
young patients with breast cancer – funded by
JCC Foundation
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Dr. Lovrics – Research Projects
• Long term quality of life assessment of patients
with early stage breast cancer using the Health
Utilities Index
• Systematic review of radioguided breast surgery
for nonpalpable lesions
• Technical and surgical factors affecting surgical
margin status in breast conserving surgery (BCS)
– funded by JCC Foundation
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Dr. Marko Simunovic
Associate Professor, Department of Surgery
Surgical Oncologist, Juravinski Cancer Centre
Research Coordinator: Angela Coates Email: [email protected]
Research office: 905-527-4322 x42472
Clinical research area is colorectal cancer surgery
Primary research focus - health services research
Specific research interests:
• Quality improvement - addressing quality gaps in surgery,
CQI, surgeon-directed quality initiatives
• Knowledge translation
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Dr. Simunovic - Current projects
Quality Initiative in Rectal Cancer (QIRC) Trial
Protocol: Simunovic et al. BMC Surg. 2008 Feb 15;8:4.
• Cluster randomized trial to test if a KT strategy can improve patient
outcomes - permanent colostomy & local recurrence
• 16 Ontario hospitals, 105 surgeons, 1015 patients
• Experimental arm surgeons – received KT strategy - workshop, audit &
feedback, operative demonstrations, post-op questionnaires
• Patient data - diagnostic tests, surgery (procedure type, audit of OR note),
pathology, pre & post radiation/chemo
Secondary analyses:
• Pathology reporting – radial margin distance
• Participation of experimental arm surgeons in the KT components
• Operative demonstrations – surgeon satisfaction and perceived changes in
surgical practice
** Project ideas: Assess a quality marker, use of diagnostic tests, chemo/rads 13
Dr. Simunovic - Current projects
Evaluating a knowledge translation strategy for pancreatic surgery in
Ontario (in progress)
• To determine if care was transferred to high-volume providers and if rates
of operative mortality improved after release of recommendations (1999)
• Chart review data on 800+ patients to assess surgeon, hospital and
treatment measures
** Project idea: Use chart review data to assess a process of care measure
Other projects:
• Assessing the uptake and effectiveness of laparoscopic surgery for
colorectal cancer in Ontario - begins Fall 2008
• Improving the quality of colorectal and breast cancer surgery in LHIN 4
(Audit & Feedback,Tailoring) – colorectal is in progress; breast to begin
Fall 2008
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CLARITY Orthopaedic Research
Group
• Dr. Mohit Bhandari MD, MSc, FRCSC
Canadian Research Chair in
Musculoskeletal Trauma
• Department of Surgery
• Department of Clinical Epidemiology and
Biostatistics
McMaster University
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Current Trials
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FLOW: Fluid Lavage of Open Wounds: A Multi-Center,
Blinded, Factorial Trial Comparing Alternative Irrigating
Solutions and Pressures in Patients with Open Fractures
TRUST: Trial to Evaluate Ultrasound in the Treatment of
Tibial Fractures
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Current Trials
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FAITH: Fixation using Alternative Implants for Treatment of
Hip Fractures: A Multi-Centre Randomized Trial Comparing
Sliding Hip Screw and Cancellous Screws on Revision
Surgery Rates and Quality of Life in the Treatment of
Femoral Neck Fractures.
HEALTH: Hip Fracture Evaluation with Alternatives of
Total Hip Arthroplasty versus Hemi-Arthroplasty: A MultiCentre Randomized Trial Comparing Total Hip Arthroplasty
and Hemi-Arthroplasty on Revision Surgery and Quality of
life in Patients with Displaced Femoral Neck Fractures
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If you have any questions, some of the
research assistants in the department
are here today or
feel free to contact them at any time.
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