Download 12-IT LLC-0309 Planplex2

TECHNICAL DATA
Panplex 2-Phase
Background
Numerous factors are capable of affecting the function of the gastrointestinal system.
Recent research has demonstrated that the healthy production of hydrochloric acid and
gastric enzymes are uniquely vulnerable to the effects of stress, occasional
sleeplessness, and the aging process.1,2
Panplex 2-Phase Supplement Facts
Serving Size 2 tablets
Amount per 2 tablets
Calcium
Nutritional supplements are available that support healthy hydrochloric acid and
digestive enzyme production.* Betaine hydrochloride has been used for over 100 years
to safely support gastric acidity.*3 Supplements containing digestive enzymes have
been in use since the 1930s when Dr Edward Howell, an Illinois physician and scientist,
began his study of food enzymes and human health.*4 Since that time researchers,
nutritionists, and other healthcare practitioners have steadily increased both their
understanding and use of enzyme supplements.
PHASE I
Betaine Hydrochloride
Pepsin (1:3000 Concentrate)
L-Glutamic Acid Hydrochloride
How It Works
Phase I
Pancreatin USP (6X Concentrate)
Amylase (25,200 USP units)
Protease (25,200 USP units)
Lipase (2,016 USP units)
Ox Bile Extract
*Daily Value (DV) not established.
Following the gastric phase of digestion, partially digested food components enter the
second phase, or intestinal digestive phase. This triggers the release of digestive
enzymes from the pancreas. Enzymes are organic compounds, frequently proteins, able
to accelerate, or produce by catalytic action, change in substrates for which they are
specific.1 Their chief function is to metabolize nutrients from food for digestion,
absorption, and utilization. Nutritional supplements containing a broad range of
pancreatic digestive enzymes act on proteins, fats and carbohydrates and have been
shown to support healthy digestion.*
Phase II Ingredients:
Pancreatin: Supplemental enzymes, particularly pancreatic digestive enzymes, have a
long history of traditional use.19 In addition to digestive support, pancreatic enzymes
have been recommended for immune system support, to support urinary tract health,
lung health, and for the relief of occasional pain and inflammation associated with
exercise.*20 Panplex 2-Phase contains high potency (6X) pancreatin for maximum
digestive support.* “6X” refers to the strength of the pancreatic enzyme complex; it is 6
times more potent than the minimum activity specified by the United States
Pharmacopeia (USP), a standard for nutritional supplements and pharmaceuticals.
Amylase: Saliva contains amylase, which initiates the digestions of dietary starches.*
Pancreatic secretions also contain amylase as well. Amylase breaks down starch into
several smaller molecules, including maltose, a disaccharide, and dextrins.*20
Protease: These enzymes primarily work in the neutral to alkaline environment of the
intestine; however they can function in the stomach as well. Proteins are ultimately
broken down into amino acids.*20
Lipase: Fat digestion begins in the second portion of the small intestine with the action
of the pancreatic lipases. These enzymes break down fat into fatty acids.* The lipase
enzymes, along with bile salts, are responsible for the absorption of the fat-soluble
vitamins: A, D, E, and K.*20
Ox Bile Extract: Bile salts form micelles that transport triglycerides containing mediumand long-chain fatty acids to the surface of intestinal villi, where they are absorbed.20
Supplementation has been shown to increase the output of bile and help promote a
mild laxative effect.*12
**
**
**
168 mg
**
130 mg
**
Other ingredients: Calcium phosphate, stearic acid, hydroxypropyl cellulose,
cottonseed oil, microcrystalline cellulose, calcium carbonate, magnesium
stearate, and silicon dioxide.
Recommendations: Take 1 or 2 tablets three times daily with meals or as
directed by your healthcare practitioner. Do not chew. Not recommended for
use if peptic ulcer, gastritis or heartburn is present.
Label Precautions: If you are pregnant, nursing, or taking prescription drugs,
consult your healthcare practitioner prior to use.
Storage Recommendations: Store at room temperature, 59° to 86°F (15°- 30°C).
Contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial
coloring, artificial flavoring, preservatives. This product contains natural
ingredients; color variations are normal.
Phase I Ingredients:
Betaine Hydrochloride and L-Glutamic Acid Hydrochloride: Normal and expected
changes occur in the gastrointestinal tract’s production of HCl with advancing age.5,6
Researchers have demonstrated this begins in the second decade (ages 11 to 20).7 HCl
production can also be influenced by hormonal changes, occasional over consumption
of food, liver health, intestinal tract integrity, and overall health.8-11 Supplementation
with betaine hydrochloride and L-Glutamic Acid Hydrochloride promotes healthy
stomach acidity and aids in the digestion of protein.*8-12
Phase II
320 mg
220 mg
200 mg
PHASE II
The first phase of digestion occurs in the stomach where ingestion of food leads to the
distension of the stomach and alterations in pH. In response, the body releases gastric
juices. Hydrochloric acid (HCl) is an inorganic compound produced by the parietal cells
of the stomach. Highly acidic with a pH of 1.6, hydrochloric acid breaks down proteins,
activates important enzymes and hormones, and maintains a sterile environment in the
stomach.1 Adequate amounts of HCl are needed for the absorption of vitamins,
increasing the bioavailability of minerals, and converting inactive phytonutrients into
biologically active compounds. Hydrochloric acid is also needed to convert pepsinogen
into pepsin, a proteolytic (protein-breaking) enzyme that converts protein molecules
into smaller, usable subcomponents.2 Betaine hydrochloride (betaine HCl) and
L-glutamic acid hydrochloride are two supplemental nutrients that support healthy acid
levels within the gastrointestinal tract.*
Pepsin: While human gastric secretions contain many protein-digesting enzymes, the
pepsins represent approximately 70 percent of these enzymes.13 Pepsin is a powerful
enzyme that breaks down proteins from food into usable amino acids.*14 Research has
shown that HCl levels, liver health, commensal bacteria balance, and healthy stomach
mucosal integrity support healthy pepsin production.15-18 Supplementation with pepsin
aids in the digestion of protein and the absorption of minerals.*12
Servings per container 30
Amt/Serving
%DV**
14C mg
14%
References:
1.
Guyton AC, Hall JE. Gastrointestinal physiology. In: Textbook of Medical Physiology.11th Ed. Philadelphia, Pa: W.B.
Saunders Company; 2005: 718-723.
2.
Porth CM. Secretory function of the gastrointestinal tract. In: Pathophysiology: Concepts of Altered Health States. 7th ed.
Philadelphia, Pa: Lippincott; 2004: 824-827
3.
Murray MJ, Stein N. A gastric factor promoting iron absorption. Lancet 1968;1:614.
4.
Russell RM, Krasinski SD, Samloff IM, et al. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in
subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
5.
Xiao ZQ, Li J, Majumdar AP. Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa. Am J Physiol
Gastrointest Liver Physiol. 2003;285:G396-403.
6.
Trey G, Marks IN, Louw JA, Jaskiewicz K, Sipponen P, Novis BH, Bank S, Tigler-Wybrandi NA. Changes in acid secretion over
the years. A 30-year longitudinal study. J Clin Gastroenterol. 1997;25:499-502.
7.
Majumdar AP, Fligiel SE, Jaszewski R. Gastric mucosal injury and repair: effect of aging. Histol Histopathol. 1997
Apr;12(2):491-501.
8.
Sica DA, Wood M, Hess M. Gender and its effect in cardiovascular pharmacotherapeutics: recent considerations. Congest
Heart Fail. 2005;11:163-6.
9.
Nakamura K, Ogoshi K, Makuuchi H. Influence of aging, gastric mucosal atrophy and dietary habits on gastric secretion.
Hepatogastroenterology. 2006 Jul-Aug;53(70):624-8.
10. Varis KS. Peptic cells. Prog Clin Biol Res. 1985;173:177-84.
11. McCloy RF, Arnold R, Bardhan KD, et al. Pathophysiological effects of long-term acid suppression in man. Dig Dis Sci. 1995
Feb;40(2 Suppl):96S-120S.
12. Murray M, and Pizzorno J. Encyclopedia of Natural Medicine. Revised 2nd Edition. Rocklin, CA: Prima Publishing, 1998:
127-128.
13. Cichocke AJ. What are enzymes? In: Enzymes and Enzyme Therapy. New Caanan, Conn: Keats Publishing;1994: 5-11.
14. Howell E. Food Enzymes for Health and Longevity. Twin Lakes, WI: Lotus Press, 1994.
15. Schumann KM, Massarrat S. Changes in total pepsin activity and pepsinogen I in human sera under stimulation and inhibition
of gastric acid secretion. Hepatogastroenterology. 1991;1:33-6
16. Roberts NB, Sheers R, Taylor WH. Secretion of total pepsin and pepsin 1 in healthy volunteers in response to pentagastrin.
Scand J Gastroenterol. 2007;42:555-61.
17. Roberts NB. Review article: human pepsins - their multiplicity, function and role. Aliment Pharmacol
Ther. 2006 Sep;24 Suppl 2:2-9.
18. Walker V, Taylor WH. Pepsin 1 secretion. Gut. 1980;21:766-71.
19. Cichoke AJ. Pancreatic enzymes. In: Textbook of Natural Medicine. Pizzorno JE, Murray MT, eds. Edinburgh: Churchill
Livingstone; 1993:857.
20. Porth C. Digestion and Absorption. In: Pathophysiology: Concepts of Altered Health States. 5th ed. New York,
NYott;1998:715 – 718.
12-IT LLC 0309 Rev.5/12 #64554