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Thursday
May 9, 2013
LIFE-CHANGING RESEARCH
MAY 5 – 9 | SEATTLE
342
530 Gene Therapy and Delivery
[PH] #5963-5969
532 Corneal Wound Repair and
Healing [CO] #5974-5980
533 Disruptions to Visual
Development: Detection,
Treatment and Consequences
[EY] #5981-5987
531 Beyond Large Print:
Advances in Accessibility and
Technology for the Visually
Impaired — Minisymposium [LV]
#5970-5973
TCC 303
TCC 305
TCC LL 4/5
528 Photoreceptor Degeneration
and Death [RC] #5949-5955
611-614
618-620
527 Cataract II [LE] #5942-5948
609
529 Refractive Error and Visual
Function: What Affects How We
See [CL] #5956-5962
526 Anatomy Challenges for the
Future [AP] #5935-5941
608
615-617
525 Clinical and Translational
Studies in Ocular Inflammation
[IM] #5928-5934
524 Imaging: Diagnostic and
Function [RE] #5921-5927
502 ER Stress and the Unfolded
Protein Response in Ocular
Health and Disease [BI, RE, RC,
PH, LE, GL, CO] #5362-5367
6C
606-607
523 Structure/Function [GL]
#5914-5920
501 Restoration of Vision [BI, VI,
RE, RC, PH, NT, LE, GL, GEN,
CO, CL] #5355-5361
8:30–10:30am
Symposium
10:30am–12:15pm
6B
Room
Thursday, May 9
548 ARVO/Alcon Keynote Series
2–3:15pm
Orlando Welcomes ARVO
2014 Kickoff Reception
East Lobby, 6th Floor
3:15–4pm
Networking Happy Hour,
Exhibit Halls, 12:30–2pm
Exhibit Halls, 10am–2pm
343
Posterior Segment Inflammation II [IM, BI]
Anterior Eye: Physiology and Pharmacology [PH, AP]
Ocular Surface in Health and Disease [CO]
Contact Lens II [CO, VI]
Image Processing and Segmentation Algorithms [MOI]
Improving Imaging and Ophthalmic Instrumentation [VI]
Diabetic Retinopathy and Vascular Biology II [RC]
Glia in Health and Disease [RC]
Intraocular Pressure [GL]
Pediatric Epidemiology [CL]
Myopia, CL [CL]
Vision Impairment [CL]
Chemical Composition and Physical Properties [LE]
Trauma [RE]
Laser/Intravitreal Treatment [RE]
Vitreoretinal Surgery III [RE]
Retina-RPE Transplantation [RE]
Imaging II, RE [RE]
Ocular and Orbital Tumors [AP]
Thyroid Eye Disease [EY]
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
Session
Title
8:30–10:15am
503
Session
Number
Thursday, May 10 n Posters
#5900-5913
#5874-5899
#5819-5873
#5811-5818
#5764-5810
#5760-5763
#5754-5759
#5730-5753
#5719-5729
#5693-5718
#5664-5692
#5615-5663
#5582-5614
#5555-5580
#5543-5554
#5491-5542
#5453-5490
#5418-5452
#5399-5417
#5368-5398
(D0263-D0276)
(D0237-D0262)
(D0130-D0184)
(D0071-D0078)
(D0011-D0057)
(D0007-D0010)
(D0001-D0006)
(C0201-C0224)
(C0190-C0200)
(C0164-C0189)
(C0135-C0163)
(C0001-C0049)
(B0105-B0137)
(B0078-B0103)
(B0053-B0064)
(B0001-B0052)
(A0152-A0189)
(A0117-A0151)
(A0043-A0061)
(A0001-A0031)
ProgramBoard
Number
Number
Dry Eye and Lacrimal Gland V [CO, VI]
Inner Retina and Blood Vessels [VI]
Cell Biology of the Retina and RPE II [RC, VN]
Apoptosis and Cell Stress [BI]
Advancing Functional Assessment of the
Visual System [VN, VI]
Bipolar and Horizontal Cells [VN]
Genetic Risk Factors for Common Eye Disorders
with Complex Inheritance [GEN, VN]
Genetics II [GL]
Proliferative Vitreoretinopathy [RE]
AMD IV, RE [RE]
Retina: Physiology and Pharmacology [PH, BI, VN]
Oculoplastics: Eyelids [EY]
536
537
538
539
540
541
542
543
544
545
546
#6366-6382
#6314-6365
#6263-6313
#6250-6262
#6216-6249
#6165-6215
#6145-6164
#6119-6144
#6109-6118
#6067-6108
#6054-6066
#5999-6053
#5988-5998
(D0277-D0293)
(D0185-D0236)
(D0079-D0129)
(D0058-D0070)
(C0101-C0134)
(C0050-C0100)
(B0216-B0235)
(B0190-B0215)
(B0180-B0189)
(B0138-B0179)
(B0065-B0077)
(A0062-A0116)
(A0032-A0042)
ProgramBoard
Number
Number
12:30–1:30pm: All Posters — authors will be present at poster boards
12:30–2pm: Networking Happy Hour in Exhibit/Poster Halls.
Poster board numbers indicate location:
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall
Corneal Infection/Inflammation II [IM, CO]
535
Session
Title
534
Session
Number
10:30am–12:15pm
NOTES
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344
266
Thursday – Symposium – 5355 – 5367
6B
6C
Thursday, May 09, 2013 8:30 AM-10:30 AM
Thursday, May 09, 2013 8:30 AM-10:30 AM
Biochemistry/Molecular Biology / Clinical/
Epidemiologic Research / Cornea / Genetics /
Glaucoma / Lens / Nanotechnology and
Regenerative Medicine / Physiology/
Pharmacology / Retinal Cell Biology / Retina /
Visual Psychophysics / Physiological Optics
Biochemistry/Molecular Biology / Cornea /
Glaucoma / Lens / Physiology/Pharmacology /
Retinal Cell Biology / Retina
501 Restoration of Vision
The greatest contributions to life-changing research
may be the ability to restore vision. A number
of advancements in ophthalmic research have
already achieved this with corneal transplants,
retinal prosthetics, and gene therapy. In addition,
rapidly developing therapies using stem cells and
optogenetics are poised to offer new therapeutic
options for eye disease. An important element of
this work is the higher order processing that must
occur to incorporate the newly restored visual
input from the retina. This symposium provides
an overview of each of these areas by a dynamic
leader in the field. Each speaker will examine the
recent developments in their area and the exciting
advancements that will continue to provide new
opportunities for sight to individuals with blinding
eye disease.
Moderators: Machelle Pardue and David Berson
5355 — 8:30 Corneal Transplants. Donald T.
Tan. Singapore National Eye Center, Singapore,
Singapore *CR
5356 — 8:46 Stem Cell Transplantation.
Kang Zhang. Attn: Zhang Lab-Osler Ln, Univ Of
California, San Diego, La Jolla, CA *CR
5357 — 9:02 Stem Cell Therapy. Thomas A.
Reh. Dept of Biological Structure, University of
Washington, Seattle, WA
5358 — 9:18 Retinal Prosthetics. Eberhart
Zrenner. Institute for Ophthalmic Research, Centre
for Ophthalmology, Tuebingen, Germany *CR
5360 — 9:50 Optogenetics. Botond Roska.
Friedrich Mieshcer Institute for Biomedical
Research, Basel, Switzerland *CR
5361 — 10:06 Learning to See Late in Life.
Pawan Sinha. Brain and Cognitive Sciences, MIT,
Cambridge, MA
Endoplasmic reticulum (ER) stress and the unfolded
protein response (UPR) have been implicated in a
variety of biological and pathological processes,
the latter including atherosclerosis, Alzheimer’s
disease, Parkinson’s disease, and diabetes, to name
but a few. In the eye, ER stress and the UPR have
been associated with several clinically significant
diseases, including glaucoma, age-related macular
degeneration, corneal dystrophy, and cataracts. In
addition, ER stress also is a normal process that
occurs during ocular development, such as in the
formation of the lens. This symposium will present
a succinct overview of the key features of ER stress
and UPR mechanisms, as well as the evidence
pointing to their involvement in ocular diseases and
the development of novel therapeutic approaches to
intervene in or prevent such diseases.
Moderators: Steven J. Fliesler and
Melinda K. Duncan
— 8:30 Introduction
5362 — 8:35 Protein Folding in the
Endoplasmic Reticulum and the Unfolded
Protein Response. Randal J. Kaufman.
Neuroscience & Stem Cell Research, SanfordBurnham Medical Research Institute, La Jolla, CA
5363 — 8:55 ER Stress and the Unfolded
Protein Response in Diabetic Retinopathy. Sarah
X. Zhang. Ophthalmology, SUNY-Buffalo, Buffalo,
NY
5364 — 9:14 Targeting ER Stress and the
Unfolded Protein Response in Treatment of
Primary Open Angle Glaucoma. Gulab S. Zode.
Univ of Iowa, Howard Hughes Medical Institute,
Iowa City, IA *CR
5365 — 9:33 The Unfolded Protein Response
in the Control of Normal Lens Development and
Cataract. Melinda K. Duncan. Biological Sciences,
University of Delaware, Newark, DE
5366 — 9:52 7-Ketocholesterol-mediated ER
Stress is an Age-Related Risk Factor in the
Pathogenesis of AMD. Ignacio R. Rodriguez.
LRCMB-MRDS, National Eye Institute, Bethesda,
MD
5367 — 10:11 Fuchs Endothelial Corneal
Dystrophy: Role of the Unfolded Protein
Response in Cellular Pathogenesis. Albert S. Jun.
Ophthal-Smith 5011, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
345
Thursday Symposium
8:30 am – 10:30 am
5359 — 9:34 Range of retinal targets amenable
to AAV mediated gene therapy. William W.
Hauswirth. Dept. of Ophthalmology, University of
Florida College of Medicine, Gainesville, FL *CR
502 ER Stress and the Unfolded Protein
Response in Ocular Health and Disease
5368 – 5386 – Thursday – Posters
Exhibit Hall A0001-A0031
Thursday, May 09, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Biochemistry/
Molecular Biology
503 Posterior Segment Inflammation II
Moderator: Manfred Zierhut
5368 — A0001 Pivotal roles of EBI3 for the
initiation and maintenance of experimental
autoimmune uveitis. Atsunobu Takeda1, T.
Yoshimura1, E. Hasegawa1, S. Hirakawa1,
T. Hisatomi1, K. Sonoda2, T. Ishibashi1.
1
Ophthalmology, Graduate School of Medical
Sciences, Kyushu University, Fukuoka, Japan;
2
Ophthalmology, Graduate School of Medicine,
Yamaguchi University, Ube, Japan
5369 — A0002 The effect of light on retinal
structure and the development of EAU in
the transgenic spontaneous model of uveitis.
Clare L. Corbett, E. Muckersie, J. V. Forrester.
Ophthalmology, University of Aberdeen, Aberdeen,
United Kingdom
5370 — A0003 Comparison of Pharmacokinetic
profiles of Sirolimus following Subconjunctival
or Intravitreal Administrations in Rabbits
and Humans. Masaaki Kageyama1, J. Naor2, H.
Takanaga1, L. J. Wilson2, N. Ihekoromadu2, A. A.
Khwaja2, S. Mudumba1. 1Research & Development,
Santen Inc, Emeryville, CA; 2Global Clinical
Development & Medical Affairs, Santen Inc,
Emeryville, CA *CR, f
5371 — A0004 Regulatory Effect of Interleukin
37 in Behcet’s disease. Zi Ye1, C. Wang1, A.
Kijlstra2, P. Yang1. 1The First Affiliated Hospital
of Chongqing Medical University, Chongqing
Key Lab of Ophthalmology, Chongqing Eye
Institute, Chongqing, China; 2University Eye Clinic
Maastricht, Maastricht, Netherlands
Thursday Posters
8:30 am – 10:15 am
5372 — A0005 Efficacy of Rebamipide in
an Endotoxin-Induced Uveitis Model. Akira
Takamiya, H. Yokota, A. Shimouchi, A. Yoshida.
Ophthalmology, Asahikawa Medical Unversity,
Asahiawa, Japan *CR
5373 — A0006 Evidence-Based Analysis for the
Medical Treatment of Behçet’s Disease. Philip
I. Murray, M. Mubin, H. Knott, B. Markandey, N.
Joji, R. Malhotra, A. K. Denniston. Academic Unit
of Ophthalmology, University of Birmingham,
Birmingham, United Kingdom
5374 — A0007 Activation of the aryl
hydrocarbon receptor(AhR) inhibits Th1 and
Th17 cell immune response in Behcet’s disease.
Peizeng Yang1, C. Wang1, Z. Ye1, A. Kijlstra2.
1
Ophthal, The 1st Hosp, Chongqing Medical
University, Chongqing, China; 2University Eye
Clinic Maastricht, Maastricht, Netherlands
5375 — A0008 Comparison of the Spectral
Domain Optical Coherence Tomography
Characteristics in Patients with Multifocal
Choroiditis and Punctate Inner Choroidopathy.
Roomasa Channa1, J. Wang2, M. A. Ibrahim1, J.
Lee1, D. Ferraz1, Y. J. Sepah1, M. G. Bittencourt1,
R. Sophie1, E. Hatef Naimi1, Q. Nguyen1. 1Retinal
Imaging Research and Reading Center, Johns
Hopkins University, Wilmer Eye Institute,
Baltimore, MD; 2Dana Center, Johns Hopkins
University, Wilmer Eye Institute, Baltimore, MD
*CR
5382 — A0015 Choroidal Bulging in Patients
with Vogt-Koyanagi-Harada and Long-standing
Disease. Viviane M. Sakata1, F. G. da Silva1,
C. Hirata1, E. Olivalves1, W. Y. Takahashi1, R.
A. Costa2, 3, J. H. Yamamoto1. 1Ophthalmology,
Hospital das Clínicas da Faculdade de Medicina
da Universidade São Paulo, São Paulo, Brazil;
2
Division of Macula: Imaging & Treatment, Centro
Brasileiro de Ciências Visuais, Belo Horizonte,
Brazil; 3Ophthalmology, Faculdade de Medicina
da Universidade de Ribeirão Preto, Ribeirão Preto,
Brazil *CR
5376 — A0009 Fundus autofluorescence and
birdshot chorioretinopathy: a study of 162
patients. Astrid Queant, D. Monnet, A. P. Brezin.
Cochin Hospital, Paris, France
5383 — A0016 Sympathetic ophathalmia:
Histopathological and Immunohistochemical
Characteristics. Hassan Aziz, H. W. Flynn, R. C.
Young, J. L. Davis, S. R. Dubovy. Bascom Palmer
Eye Institute, Miami, FL
5377 — A0010 Treatment Paradigms in
Retinal Vasculitis. Jacqueline R. Busingye1,
S. Schwartzman2, 3, J. M. Ackert1, T. Flynn1.
1
Ophthalmology, Mount Sinai School of Medicine,
New York, NY; 2Rheumatology, Hospital for
Special Surgery, New York, NY; 3Rheumatology,
Weill Medical College of Cornell University, New
York, NY *CR
5378 — A0011 Punctate Inner Choroidopathy
characterization by Enhanced Depth ImagingOptical Coherence Tomography: Quantitative
analysis of Retinal and Choroidal layers by
manual segmentation. Noa Fernandez Ledo, J.
Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A.
Egan, P. J. Patel, M. C. Westcott, R. W. Lee, A.
Tufail, C. E. Pavesio. Medical Retina, Moorfields
Eye Hospital, London, United Kingdom *CR
5379 — A0012 Clinical course of a cohort of
patients with Punctate Inner Choroidopathy
managed with different modalities of treatment
in North Scotland. Shiao Wei Wong1, 2, P. Tyagi2,
K. Khan1, S. Hewick2, L. Kuffova1. 1Aberdeen
Royal Infirmary, NHS, Aberdeen, United Kingdom;
2
Raigmore Hospital, NHS, Inverness, United
Kingdom
5380 — A0013 Clinical Characteristics of
Vogt-Koyanagi-Harada Disease with Choroidal
Folds. Kouhei Hashizume1, Y. Imamura2, T.
Fujiwara1, S. Machida1, M. Ishida2, D. Kurosaka1.
1
Ophthalmology, Iwate Medical University,
Morioka, Japan; 2Ophthalmology, Teikyo University
School of Medicine, Mizonokuchi Hospital,
Kawasaki, Japan
5381 — A0014 Clinical Outcomes of VogtKoyanagi-Harada Disease at a Tertiary Center in
194 Patients: The KKESH Uveitis Survey Study
Group. Abdulaziz A. Alrushood1, 4, J. Arevalo1, 2,
H. A. Al Dhibi1, Y. A. Al-Zahrani1, V. Gupta1, S.
M. Alsulaiman1, A. F. Lasave3, H. N. Al-Shamsi1.
1
Retina and Vitreous, KKESH, Riyadh, Saudi
Arabia; 2Retina and Vitreous, Wilmer Eye Institute,
Baltimore, MD; 3Retina and Vitreous, Clínica de
Oftalmologia de Cali and Hospital Universitario del
Valle, cali, Cambodia; 4Ophthalmology, Dammam
universty, dammam, Saudi Arabia *CR
5384 — A0017 Natural history of Multiple
Evanescent White Dot Syndrome: a
multimodality imaging study. Mafalda Macedo1, 2,
S. Vaz-Pereira1, 3, G. De Salvo1, B. Pal1. 1Medical
Retina Department, Moorfields Eye Hospital,
London, United Kingdom; 2Department of
Ophthalmology, Hospital de Santo Antonio-CHP,
Porto, Portugal; 3Department of Ophthalmology,
Hospital de Santa Maria, Lisbon, Portugal
5385 — A0018 A retrospective analysis of the
natural history and management of serpiginous
choroidopathy (SC) in Australia and New
Zealand. Anthony J. Hall1, 2, J. Toniolo1, 2, J.
Sims4, S. Fraser-Bell5, J. Khan6, C. Younan7,
B. Kent-Smith8, S. Young9, E. Paul2, L. Lim3.
1
Ophthalmology, Alfred Hospital, Melbourne,
Prahran, VIC, Australia; 2Faculty of Medicine,
Nursing and Health Science, Monash University,
Melbourne, VIC, Australia; 3Centre for Eye
Research Australia, University of Melbourne,
Melbourne, VIC, Australia; 4Auckland Eye,
Auckland, New Zealand; 5Sydney Eye Hospital,
Sydney, NSW, Australia; 6Ophthalmology,
Royal Perth Hospital, Perth, WA, Australia;
7
Ophthalmology, Westmead Hospital, Sydney,
NSW, Australia; 8Ophthalmology, Whangarei
Area Hospital, Whangarei, New Zealand;
9
Ophthalmology, Repatriation General Hospital,
Sydney, NSW, Australia
5386 — A0019 MicroRNA-146a and Ets1 gene polymorphisms in ocular Behcet’s
disease and Vogt-Koyanagi-Harada syndrome.
Qingyun Zhou1, A. Kijlstra2. 1Ophthalmology, The
First Affiliated Hospital of Chongqing Medical
University, Chongqing, China; 2Eye Research
Institute Maastricht, Maastricht, Netherlands
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
346
Thursday – Posters – 5387 – 5408
5387 — A0020 Characteristics, Complications,
and Surgical Outcomes of Panuveitis in 400
patients (727 eyes) over 25 Years: The KKESH
Uveitis Survey Study Group. J Fernando
Arevalo1, 2, A. F. Lasave3, H. N. Al-Shamsi2, S. M.
Al Sulaiman2, A. A. Alrushood2, Y. A. Alzahrani2,
V. Gupta2, A. M. Al-Mahmood4, H. A. Al Dhibi2.
1
Retina Division, Wilmer Eye Institute, Johns
Hopkins University School of Medicine, Baltimore,
MD; 2Vitreoretinal Division, King Khaled Eye
Specialist Hosp, Riyadh, Saudi Arabia; 3Clínica de
Oftalmologia de Cali and Hospital Universitario
del Valle, Cali, Colombia; 4Anterior Segment and
Uveitis Division, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia *CR
5388 — A0021 Comparison of the effect
of Dexamethasone drug delivery system in
macular edema in patients with uveitis or retinal
vein occlusion. Thomas Ness, D. Boehringer, A.
Pielen, S. Heinzelmann. University Eye Hospital,
University of Freiburg, Freiburg, Germany *CR
5389 — A0022 Involvement of Vitreous in
Castleman’s Disease. Sunju Park, M. S. Katz, D.
C. Gritz. Ophthalmology and VIsual Sciences,
AECOM/Montefiore Medical Center, Bronx, NY
5390 — A0023 The use of Bromfenac for the
Treatment of Macular Edema Secondary to NonInfectious Uveitis. Joanna Saade, M. Abdulaal, R.
N. Hamam. American University of Beiirut, Beirut,
Lebanon
5391 — A0024 Assessment of Changes in
Quality of Life Among Patients in the SAVE
Study - Sirolimus As Therapeutic Approach
To UVEItis: A Randomized Study To Assess
The Safety And Bioactivity Of Intravitreal And
Subconjunctival Injections Of Sirolimus In
Patients With Non-infectious Uveitis. Erin Vigil,
Y. J. Sepah, O. O. Agbedia, A. L. Watters, M. A.
Sadiq, M. Ansari, M. G. Bittencourt, M. A. Ibrahim,
Q. Nguyen. The Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR, f
5392 — A0025 Mycophenolate Mofetil in
Refractory Non-infectious Uveitis. Manoel
Gusmao Isidro, V. M. Sakata, D. C. Cavalcanti, J.
Zaghetto, E. Olivalves, C. Hirata, J. H. Yamamoto.
Hospital das Clinicas da Faculdade de Medicina da
Universidade São Paulo, São Paulo, Brazil
5394 — A0027 Decline in Ocular Toxoplasmosis
in the Midwestern United States. Asim Farooq1, J.
H. Hou1, S. Patel1, 2, H. Tessler1, D. A. Goldstein1, 3.
1
Ophthalmology, Illinois Eye & Ear Infirmary,
Chicago, IL; 2Ophthalmology, Weill Cornell
Medical College, New York, NY; 3Ophthalmology,
Feinberg School of Medicine, Northwestern
University, Chicago, IL *CR
5396 — A0029 The serum angiotensin
converting enzyme and lysozyme levels in
patients with ocular involvement of ankylosing
spondylitis, behcet disease, sarcoidosis and latent
tuberculosis. Ozlem Gurses1, E. Karaismailoglu1, 2.
1
Ophthalmology, Middle East Technical University,
Oran ankara, Turkey; 2Statistics, Hacettepe
University Medical Faculty, Ankara, Turkey f
5397 — A0030 Inflammatory activity and
visual outcomes in patients treated with
cryotherapy for pars planitis. Benjamin C. Chaon,
J. C. Folk, E. H. Sohn. Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA
5398 — A0031 Predictive factors for postoperative complications in diagnostic vitrectomy.
Michael Karampelas1, R. Moya1, D. A. Sim1, 2, J.
Zarranz-Ventura1, D. G. Charteris1, R. W. Lee1, 3,
C. E. Pavesio1, 2. 1NIHR Biomedical Research
Centre for Ophthalmology, Moorfields Eye
Hospital NHS Foundation Trust, London, United
Kingdom; 2University College London, Institute
of Ophthalmology, London, United Kingdom;
3
Department of Clinical Sciences, University of
Bristol, Bristol, United Kingdom *CR
Exhibit Hall A0043-A0061
Thursday, May 09, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology / Anatomy/Pathology
504 Anterior Eye: Physiology and
Pharmacology
5401 — A0045 The effect of sulindac
liposome on inflammation induced corneal
neovascularization. Jun-Sub Choi, C. Joo.
Ophthalmology & Visual Science, Catholic Univ
Korea Coll of Med, Seoul, Republic of Korea
5402 — A0046 Application of
phosphoproteomic analysis in myopic chick
retina. Fengjuan Yu1, K. Li1, T. Lam1, C. To1, 2.
1
Laboratory of Experimental Optometry, School of
Optometry, the HongKong Polytechnic University,
Kowloon, Hong Kong; 2State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Centre,
SunYat-sen University, Guangzhou, China
5403 — A0047 Gender, Ethnicity, and Time
After Awakening Affect Tear Film Cytokine
Concentrations. Meng C. Lin1, 2, J. O. Niimi1, N.
A. McNamara2, 3, Y. Zhou1, J. Shumaker1, H. M.
French1, T. Leung1, S. L. Wang1, K. Siemasko4,
M. E. Stern4. 1School of Optometry, Clinical
Research Center, University of California, Berkeley,
Berkeley, CA; 2School of Optometry, University
of California, Berkeley, Berkeley, CA; 3Francis
I. Proctor Foundation, University of California,
San Francisco, San Francisco, CA; 4Allergan, Inc,
Irvine, CA *CR
5404 — A0048 Cross-Species and Cross-Age
Comparison of Esterase Mediated Metabolism
in Vitreous Humor: Human versus Rabbit, Dog
and Monkey. Mayssa Attar, J. Shen, M. S. Kim, Q.
Radojicic. Drug Safety Evaluation, Allergan, Irvine,
CA *CR
5405 — A0049 Bicarbonate sensitive soluble
adenylyl cyclase (sAC) generates the cAMP
in aqueous humor (AH). Yong Lee1, Y. Lee1, L.
Ramos-Espiritu3, L. Y. Marmorstein1, J. Buck3, L.
Levin3, A. D. Marmorstein1, 2. 1Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
Physiology, University of Arizona, Tucson, AZ;
3
Pharmacology, Weill Cornell College of Medicine,
New York, NY *CR
Moderator: Caterina Gagliano
5406 — A0050 Beneficial Assessment of A
Combined Tropicamide and Various Oxime
Treatments Against Miosis and Visual
Dysfunction Following Ocular Exposure to the
Nerve Agent Sarin.
5399 — A0043 Induction of MAPK
Phosphatase-1 by the Novel Selective
Glucocorticoid Receptor Agonist Mapracorat
Suppresses Inflammatory Signaling Pathways in
Human Corneal Epithelial Cells. Megan E. Cavet,
K. L. Harrington, T. R. Vollmer, M. Richardson,
J. Zhang. Pharmaceutical R&D, Bausch & Lomb,
Rochester, NY *CR
5407 — A0051 Dexamethasone Modifies
Viability of Mitomycin C-Treated Tenon’s
Fibroblasts. Shu-Wen Chang1, 2, W. Ho1, T. Chen1, S.
Chou3. 1Department of Ophthalmology, Far Eastern
Memorial Hospital, New Taipei City, Taiwan;
2
Department of Ophthalmology, National Taiwan
University Hospital, Taipei, Taiwan; 3Department of
Medical Research, Far Eastern Memorial Hospital,
New Taipei City, Taiwan
5400 — A0044 Pirfenidone nanoparticles
improve healing and prevent corneal scarring
following alkali burn. Sarbani Hazra1, S.
Chowdhury2, R. Guha2, T. Ruchit3, U. B. Kompella3,
A. Konar2. 1Veterinary Surgery & Radiology,
WBUAFS, Kolkata, India; 2Animal Facilities,
Indian Institute of Chemical Biology, Kolkata,
India; 3Department of Pharmaceutical Sciences,
University of Colorado Anschutz Medical Campus,
Aurora, CO *CR
5408 — A0052 TRPV1 and corneal Pain. Eric
Senning, S. E. Gordon. Physiology and Biophysics,
University of Washington, Seattle, WA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
347
Thursday Posters
8:30 am – 10:15 am
5393 — A0026 Study of the Prevalence of
Ophthalmology Uveitis Tertiary Hospital in
Teresina-Pi. Leonardo Pinheiro Teixeira1, L.
Rosa Ribeiro Cunha1, C. Dar’k Amorim Teles1, V.
Cortizo2. 1Faculdade de Saúde Ciencias Humanas e
Tecnológicas do Piauí - NOVAFAPI, Teresina- PI,
Brazil; 2Universidade Federal do Piauí - UFPI,
Teresina- PI, Brazil
5395 — A0028 Treatments and visual
outcomes in patients with ocular sarcoidosis.
Hisae Nakahara1, 2, T. Kaburaki1, M. Takamoto1,
A. Yoshida3, K. Okinaga1, J. Numaga1, K.
Ando1, Y. Fujino1, 4, H. Kawashima3, S. Amano1.
1
Ophthalmology, Univ of Tokyo School of Med,
Bunkyo-ku, Japan; 2Ophthalmology, Senpo
Tokyo Takanawa Hospital, Minato-ku, Japan;
3
Ophthalmology, Jichi Medical University,
Shimotsuke-shi, Japan; 4Ophthalmology, Tokyo
Kosei Nenkin Hospital, Shinjuku-ku, Japan *CR
5409 – 5430 – Thursday – Posters
5409 — A0053 Different Roles of Carbonic
Anhydrase in Human vs. Bovine Corneal
Endothelial Transport. Thomas M. Malikowski1,
M. E. Duffey2, S. P. Patel3, 4. 1School of Medicine
& Biomedical Sciences, University at Buffalo,
Buffalo, NY; 2Physiology & Biophysics, University
at Buffalo, Buffalo, NY; 3Ophthalmology, SUNY
Eye Institute, University at Buffalo, Buffalo, NY;
4
Research Service, VAWNYHS, Buffalo, NY *CR
5410 — A0054 ROCK Inhibitor Y-27632
Enhances the Mucin Secretion from Goblet
Cells Derived from Limbal Stem Cells. Won
Seok Choi1, E. Chung2, T. Chung2, J. Hyon3, 4, W.
Wee3, Y. Shin1. 1Ophthalmology, Hallym University
College of Medicine, Seoul, Republic of Korea;
2
Ophthalmology, Sungkyunkwan University
School of Medicine, Seoul, Republic of Korea;
3
Ophthalmology, Seoul National University
College of Medicine, Seoul, Republic of Korea;
4
Ophthalmology, Seoul National University
Bundang Hospital, Seoul, Republic of Korea
5411 — A0055 Impact of Acute Exposure to
High Altitude on Anterior Chamber Geometry.
M Dominik Fischer1, 2, G. Willmann1, A. Schatz1,
K. Schommer3, A. Zhour1, E. Zrenner1, K. BartzSchmidt1, F. Gekeler1. 1Centre for Ophthalmology,
University Hospital Tuebingen, Tuebingen,
Germany; 2Nuffield Laboratory of Ophthalmology,
University of Oxford, Oxford, United Kingdom;
3
Department of Sports Medicine, Medical Clinic,
University Hospital Heidelberg, Heildelberg,
Germany *CR
5412 — A0056 Evaluation of Feature Detectors
and Descriptors on the Iris. Sandro I. De Zanet1, 2,
M. Rueegsegger1, 2, T. Rudolph1, 2, S. Wolf2, J. H.
Kowal1, 2. 1Ophthalmic Technologies ARTORG
Center, University of Bern, Bern, Switzerland;
2
Department of Ophthalmology, University of Bern,
Bern, Switzerland *CR
Thursday Posters
8:30 am – 10:15 am
5413 — A0057 Tear Film and Lid Margins
in Over-Blink. Heiko Pult2, 1, B. H. Riede-Pult2, 1,
C. A. Blackie3, 4, P. J. Murphy5, D. R. Korb3, 4.
1
School of Optometry and Vision Sciences, Cardiff
University, Cardiff, United Kingdom; 2Dr. Heiko
Pult - Optometry and Vision Research, Weinheim,
Germany; 3TearScience Inc., MA, USA, Boston,
MA; 4Korb Associates, Boston, MA; 5School of
Optometry and Vision Sciences, University of
Waterloo, Waterloo, ON, Canada *CR
5414 — A0058 The role of reactive oxygen
species on cytotoxicity of moxifloxacin and
benzalkonium chloride on human corneal
epithelial cells. Ta-Ching Chen, F. Hu. National
Taiwan University Hospital, Taipei, Taiwan
5415 — A0059 Growth factor secretion
in human keratocyte cultures following
photodynamic inactivation (PDI). Tanja
Stachon1, J. Wang1, 2, A. Langenbucher3, B. Seitz1,
N. Szentmáry1. 1Department of Ophthalmology,
Saarland University Hospital, Homburg/Saar,
Germany; 2Department of Ophthalmology, Renmin
Hospital of Wuhan University, Wuhan, China;
3
Experimental Ophthalmology, Saarland University,
Homburg/Saar, Germany
5416 — A0060 Efficacy of a novel synthetic
topical tetrapeptide on eliciting analgesia
subsequent to experimentally induced chemical
corneal injury. Bruce I. Gaynes, M. Russo, D.
Goldmeier. Ophthalmology, Loyola University
Chicago, Maywood, IL *CR
5417 — A0061 Enantiomeric Separation,
Ophthalmic Formulations and Mydriatic
Activity Oo Cyclopentolate Hydrochloride.
Danilo Aleo1, S. Mangiafico1, M. G. Saita1, B.
Melilli1, M. G. Cro1, S. Mangiafico1, N. D’Antona2,
G. Nicolosi2. 1R&D, Medivis, Catania, Italy;
2
Istituto Chimico Biomolecolare, CNR, Catania,
Italy *CR
Exhibit Hall A0117-A0151
Thursday, May 09, 2013 8:30 AM-10:15 AM
Cornea
505 Ocular Surface in Health
and Disease
Moderator: Mary Ann Stepp
5418 — A0117 A Modified Delphi Technique
to Obtain Consensus on the Scoring of Ocular
Surface Disease Damage and Activity Indices.
Priscilla Mathewson, G. P. Williams, P. J. Tomlins,
S. Kolli, P. I. Murray, S. Rauz. Academic Unit of
Ophthalmology, University of Birmingham, West
Midlands, United Kingdom
5419 — A0118 Indications and Outcomes of
the Needle Dissection Technique for the Full
Gundersen Conjunctival Flap in 76 eyes. Heidrun
Gollogly, L. Maguire. Ophthalmology, Mayo Clinic,
Rochester, MN
5420 — A0119 Characterization of patients
with ocular chronic graft-versus-host disease
and evaluation of a new grading scale. Christiane
Blecha1, D. Wolff2, D. A. Maerker1, H. Helbig1, T.
Dietrich-Ntoukas1. 1Ophthalmology, University
Hospital Regensburg, Regensburg, Germany;
2
Hematology and Oncology, University Hospital
Regensburg, Regensburg, Germany
5421 — A0120 Proliferative Gain of Function
of Stromal Fibroblasts via SDF-1 in Pathogenesis
of Pterygia. Kyoung Woo Kim, S. Park, J. Kim.
Department of Ophthalmology, Chung-Ang
University Hospital, Seoul, Republic of Korea
5422 — A0121 Behaviour of Conjunctival
Goblet Cells after allogenic Hematopoietic
Stem Cell Transplantation. Alexandra B. Knoll1,
E. Jakob1, K. Brandauer1, B. C. Dobner1, U.
Hegenbart3, P. Dreger3, G. Auffarth2, F. Mackensen1.
1
Interdisciplinary Uveitis Center, University
Hospital Heidelberg, Heidelberg, Germany;
2
Ophthalmology, University Hospital Heidelberg,
Heidelberg, Germany; 3Heamatology, University
Hospital Heidelberg, Heidelberg, Germany *CR
5423 — A0122 Differences among signs and
symptoms of dry eye among patients with
Sjogren’s syndrome, blepharitis, or no ocular
surface disease. Bridgette E. McCabe1, M.
Massaro-Giordano1, N. M. Fuerst1, M. Pistilli1,
G. Ying1, I. Macchi2, 1, R. Salvo1, V. Y. Bunya1.
1
Scheie Eye Institute- Ophthalmology, University
of Pennsylvania, Philadelphia, PA; 2Campus
Biomedico Rome, Rome, Italy *CR
5424 — A0123 Evaluation of a protocol
for isolation and expansion of murine and
rat lacrimal gland mesenchymal stem cells.
Mathias Roth, A. Kunze, G. Geerling, S. Schrader.
Ophthalmology, University of Düsseldorf,
Düsseldorf, Germany *CR
5425 — A0124 Long-Term Outcomes of
Patients with Ocular Surface Stem Cell
Transplant: 20 years follow-up. Kunal Suri,
S. C. Kaufman. Ophthalmology and Visual
Neurosciences, University of Minnesota,
Minneapolis, MN *CR
5426 — A0125 Mild-moderate dry eye patients
exhibit ocular surface temperature lower than
normal subjects. Giuseppe Giannaccare, P.
Versura, M. Grillini, E. C. Campos. Ophthalmology
Unit, DIMES Department, Alma Mater Studiorum
University of Bologna and S.Orsola-Malpighi
Teaching Hospital, Bologna, Italy
5427 — A0126 Ocular Surface Changes in
Glaucomatous Patients Treated with and without
Preservatives beta-Blockers. Serena Telani1, M. M.
Iester1, P. Frezzotti2, M. Figus3, P. Fogagnolo4, A.
Perdicchi5, A. Ferreras6, C. Traverso1. 1University
Eye Clinic, Genova, Italy; 2University Eye Clinic,
Siena, Italy; 3University Eye Clinic, Pisa, Italy;
4
University Eye Clinic, Milano, Italy; 5University
Eye Clinic, La Sapienza, Rome, Italy; 6Univerisity
Eye Clinic, Zaragoza, Spain *CR
5428 — A0127 Ocular surface findings
associated to clinical signs of hyperandrogenism
assessed by an innovative videodermoscopic
method. Ilaria Macchi1, L. Guccione2, F.
Mantelli1, A. Micera3, C. G. Moretti2, S. Bonini1.
1
Ophthalmology, Campus Biomedico Unversity,
Rome, Italy; 2Endocrinology, San Giovanni Calibita
Fatebenefratelli Hospital, Rome, Italy; 3IRCCS GB
Bietti, Rome, Italy *CR, f
5429 — A0128 PROSE treatment for Ocular
Surface Disease in patients with history of
Stevens-Johnson Syndrome/Toxic Epidermal
Necrolysis. Thanos D. Papakostas1, H. Le2, J.
Chodosh1, D. S. Jacobs2, 1. 1Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA;
2
Boston Foundation for Sight, Needham, MA *CR
5430 — A0129 Assessment of the EyePRIM
Device for Conjunctival Impression for Flow
Cytometry. Paul J. Tomlins1, P. Roy2, J. Curnow1,
S. Rauz1. 1Centre for Translational Inflammation
Research, University of Birmingham, Birmingham,
United Kingdom; 2Opia Technologie, Paris, France
*CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
348
Thursday – Posters – 5431 – 5455
5431 — A0130 Relationships of meibomian
gland dysfunction and cardiovascular disease
risk factors in a middle-aged population. HungChi Chen1, 2, C. Chen2, H. Chen3, Y. Hwang1, 2, H.
Lin1, D. H. Ma1. 1Ophthalmology, Chang Gung
Memorial Hospital, Taoyuan County, Taiwan;
2
Medicine, Chang Gung University College of
Medicine, Taoyuan, Taiwan; 3Internal Medicine,
Taipei City Hospital-Heping Branch, Taipei, Taiwan
5440 — A0139 Extended Soft Bandage Contact
Lenses Therapy for Ocular Graft-VersusHost Disease. Yichen Sun1, 4, Y. Inamoto3, J. P.
Sheehan1, P. Li2, R. K. Wang1, 2, S. Lee3, T. T. Shen1, 2.
1
Ophthalmology, University of Washington, Seattle,
WA; 2Bioengineering, University of Washington,
Seattle, WA; 3Fred Hutchinson Cancer Research
Center, Seattle, WA; 4Graduate Institute of Clinical
Medicine, National Taiwan University, Taipei,
Taiwan *CR, f
5449 — A0148 A Plaque Method for Direct
and Sensitive Enumeration of Surviving
Acanthamoeba During Biocidal Efficacy and
Regimen Testing of Contact Lens Disinfection
Solutions. Shawn C. Lynch, J. G. Carr, C. Kovacs,
M. A. Dehmler, T. Bassage, W. Haas, T. W. Morris.
Bausch & Lomb, Rochester, NY *CR
5441 — A0140 Three-dimensional volumetric
reconstruction of the mouse diabetic cornea.
Danielle M. Robertson1, M. Petroll1, M. Zhu1,
V. Koppaka1, 2. 1Ophthalmology, Univ Texas
Southwestern Med Ctr, Dallas, TX; 2Pharmacy,
University of Colorado Denver, Denver, CO
5450 — A0149 Atypical Pathogens Observed
in Recent Clinical Studies of Bacterial
Conjunctivitis. Lynne S. Gearinger1, C. M.
Sanfilippo1, L. Zhang2, W. Haas1, T. L. Comstock3,
T. W. Morris1. 1Microbiology and Sterilization
Sciences, Bausch & Lomb, Inc, Rochester, NY;
2
Global Clinical Operations, Bausch & Lomb, Inc,
Rochester, NY; 3Global Medical Affairs, Bausch &
Lomb, Inc, Rochester, NY *CR, f
5442 — A0141 Rat Exorbital Lacrimal Gland
Ducts Have Gastrin Receptors. Mortimer
Lorber1, E. C. Permaul2, S. Sen2, D. Berry2.
1
Pharmacology & Physiology, Georgetown Univ
School of Medicine, Washington, DC; 2Lombardi
Comprehensive Cancer Center, Georgetown Univ
School of Medicine, Washington, DC
5451 — A0150 A Parallel-Group Study
Evaluating the Safety and Efficacy of
BrimonidineTartrate 0.025% Ophthalmic
Solution in a Population of Adult and Geriatric
Subjects. Gerald Horn1, M. J. Chapin2, P. J.
Gomes2. 1Eye Therapeutics, Schaumburg, IL; 2Ora,
Inc, Andover, MA *CR, f
5434 — A0133 Prevention, Prophylaxis,
and Treatment of Ocular Surface Disease in a
Tertiary Care Inpatient Setting: Identifying
Patients at Risk. Jesse T. McCann, I. Belinsky, L.
Park. NYU Medical Center, New York, NY
5443 — A0142 Changes in corneal innervations
after herpes simplex virus type 1 (HSV-1)
latency established with different reactivation
phenotypes. Jiucheng He1, 2, R. Cosby1, 2, J.
M. Hill1, 2, H. E. Bazan1, 2. 1Ophthalmology &
Neuroscience Ctr, LSU Health Sciences Center,
New Orleans, LA; 2LSU Eye Center, LSU Health
Sciences Center, New Orleans, LA
5435 — A0134 Risk Factors of Severe
Acanthamoeba Keratitis. Machiko ShimmuraTomita, H. Takano, N. Kinoshita, F. Toyoda, A.
Ota, A. Kakehashi. Ophthalmology, Jichi Medical
University Saitama Medical Center, Saitama, Japan
5444 — A0143 Assessment of the Eyeprim®
Device for Conjunctival Impression and
PCR. Pierre Roy1, H. Groux2, F. Cottrez2, L.
Protat1. 1OPIA Technologies SAS, Paris, France;
2
IMMUNOSEARCH, Grasse, France *CR
5452 — A0151 Evolution in post transplant
patients with Herpetic Keratitis in Hospital
Fundacion Nuestra Señora de la Luz. cristina C.
fernandez1, C. Pacheco-Del-Valle2, A. Babayan3,
O. Baca4, R. Velasco5. 1cornea, Hospital Fundacion
Nuestra Señora de la Luz, Distrito Federal, Mexico;
2
cornea, Hospital Fundacion Nuestra Señora de la
Luz, Distrito Federal, Mexico; 3cornea, Hospital
Fundacion Nuestra Señora de la Luz, Distrito
Federal, Mexico; 4cornea, Hospital Fundacion
Nuestra Señora de la Luz, Distrito Federal, Mexico;
5
cornea, Hospital Fundacion Nuestra Señora de la
Luz, Distrito Federal, Mexico
5436 — A0135 Evaluation of different
applicator-systems for autologous serum eyedrops. Alexander Kunze, K. Spaniol, G. Geerling.
Ophthalmology, University Hospital Duesseldorf,
Duesseldorf, Germany *CR
5445 — A0144 Classification of the ocular
surface manifestations in patients with StevensJohnson Syndrome. Tais H. Wakamatsu, M. S.
Santos, T. P. Barreiro, C. C. Farias, F. E. Hirai, J.
A. Gomes. Ophthalmology, Federal University of
São Paulo, Sao Paulo, Brazil *CR
5432 — A0131 Antibacterial Activity of
Lysozyme in Hyperosomolar Conditions.
Poonam Mudgil, J. Whitehall. School of Medicine,
University of Western Sydney, Penrith, NSW,
Australia
5433 — A0132 Treatment of Ocular
Surface Failure Due to Limbal Stem Cell
Deficiency by Cultivated Limbal Epithelial
Cell Transplantation (CLET). Beatriz Eugenia
E. Ramirez Villagran1, M. F. Pastor3, J. M.
Herreras1, 2, I. Pérez1, J. García-Sancho3, A.
Sanchez3, M. Calonge1, 2. 1Ocular Surface Group,
IOBA-University of Valladolid, Valladolid, Spain;
2
CIBER-BBN (Biomedical Research Networking
Center in Bioengineering, Biomaterials and
Nanomedicine), Spain, Spain; 3IBGM-University of
Valladolid, Valladolid, Spain *CR
5438 — A0137 Cytokine tear film expression in
patients with primary and recurrent pterygium.
Victor M. Bautista, N. Rangel-Acosta, N. LópezEspinosa, A. Nava-Castañeda. Microbiology and
Ocular Proteomics, Inst de Ophthal Conde de
Valenciana, Mexico, Mexico
5439 — A0138 Effectiveness and safety of
intralesional injection of 0.01 mg Mitomycin
C one month prior to bare sclera excision for
pterygium treatment. Brian Tieu, M. Kapur.
UTMB, Galveston, TX
5446 — A0145 Ocular surface in Sjögren’s
syndrome. Hayette Rebika1, S. Lazreg2. 1CHU
Clermont Ferrand, Clermont Ferrand, France;
2
Cabinet Dr Lazreg, Blida, Algeria
Thursday, May 09, 2013 8:30 AM-10:15 AM
Cornea / Visual Psychophysics /
Physiological Optics
506 Contact Lens II
Moderators: J. Martin Heur and Vasile Diaconu
5447 — A0146 Treatment of Ocular cGVHD
with PRP: a confocal microscopy study. Marco
Marenco1, E. Gerace1, A. Plateroti1, C. Colica1,
G. Ferrazza2, L. De Felice2, E. M. Vingolo1, M.
Gharbiya1, R. Plateroti1. 1Ophthalmology, Sapienza
University of Roma, Rome, Italy; 2Hematology,
Sapienza University of Roma, Rome, Italy
5453 — A0152 Corneal confocal and
topographical changes with use of rigid contact
lens in keratoconus patients following collagen
cross linking. Sri Vatsa Sehra, J. S. Titiyal, R.
Tandon, N. Sharma, R. Sinha. Dr Rajendra Prasad
Centre for Ophthalmic Sciences, All India Institute
of Medical Sciences, New Delhi, India
5448 — A0147 Angiogenin is a Requirement for
Active Stromal tissue Formation and Recurrence
of Pterygium. Jae Chan Kim, K. Kim, S. Park,
Y. Chun, S. Wee. Department of Ophthalmology,
Chung-Ang University Hospital, Seoul, Republic
of Korea
5454 — A0153 Is the Use of an Integrating
Sphere Really Desirable When Measuring
Contact Lens Transmittance? Claude J.
Giasson1, 2, C. Deschênes1, V. Diaconu1. 1School of
Optometry, University of Montreal, Montreal, QC,
Canada; 2LOEX, CHA, Quebec, QC, Canada
5455 — A0154 Peripheral Defocus with
Spherical and Bifocal Soft Contact Lenses. David
A. Berntsen, C. E. Kramer. College of Optometry,
University of Houston, Houston, TX *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
349
Thursday Posters
8:30 am – 10:15 am
5437 — A0136 Standardized Quantification
of Inflammatory Biomarker HLA-DR for
Multicenter Clinical Trials of Ocular Surface
Disease. Penny A. Asbell1, S. P. Epstein1, N.
Gadaria-Rathod1, Y. Wei1, M. G. Maguire2.
1
Ophthalmology, Mount Sinai School of Medicine,
New York, NY; 2Ophthalmology, University of
Pennsylvania, Philadelphia, PA *CR
Exhibit Hall A0152-A0189
5456 – 5478 – Thursday – Posters
5456 — A0155 Functional and visual
improvement with Prosthetic Replacement of
the Ocular Surface Ecosystem (PROSE) scleral
lenses for irregular corneas. Jennifer C. Lee, G.
B. Chiu, D. Bach, S. R. Bababeygy, J. A. Irvine, J.
M. Heur. Ophthalmology, Doheny Eye Institute
at Keck School of Medicine of the University of
Southern California, Los Angeles, CA
5463 — A0162 Optical Path Length
Quantification of Soft Contact Lens Parameter
Changes During Dehydration. Pete S. Kollbaum1,
D. Iskander2, R. McGiffen1, M. E. Jansen1.
1
Optometry, Indiana University, Bloomington,
IN; 2Institute of Biomedical Engineering
and Instrumentation, Wroclaw University of
Technology, Wroclaw, Poland *CR
5473 — A0172 Ocular Signs and Symptoms
in Contact Lens Wearers in a Controlled Low
Humidity Environmental Exposure Chamber
(LH-EEC), A Natural Provocation Research
Model. Piyush Patel1, F. Soong1, J. P. Varikooty2,
N. J. Keir2, L. W. Jones2. 1Inflamax Research,
Mississauga, ON, Canada; 2CCLR, University of
Waterloo, Waterloo, ON, Canada *CR
5457 — A0156 Migrating versus Stationary
Pressure Experiments in Lubricity
Measurements of Hydrogels. Alison C. Dunn1,
J. M. Uruena1, J. Pruitt2, T. E. Angelini1,
W. G. Sawyer1. 1Mechanical and Aerospace
Engineering, University of Florida, Gainesville,
FL; 2Biocompatibility Projects, Alcon Vision Care
Research, Johns Creek, FL *CR
5464 — A0163 A Novel Approach for Data
Collection Evaluating Doctor and Patient
Preferences for Wearing a Daily Disposable
Contact Lens for Astigmatism. W L. Ball. PDMA,
Johnson & Johnson, Jacksonville, FL *CR
5474 — A0173 Correction of infant aphakia
after cataract surgery with rigid gas-permeable
contact lenses. Anja K. Gruenert1, M. Klueppel3,
J. Hausser4, T. Reinhard2, R. Sundmacher1,
T. Guthoff1, T. A. Fuchsluger1, G. Geerling1.
1
Department of Ophthalmology, Heinrich-HeineUniversity, Duesseldorf, Germany; 2Department of
Ophthalmology, University of Freiburg Hospital,
Freiburg, Germany; 3Practice, Moers, Germany;
4
Practice, Duesseldorf, Germany *CR
5458 — A0157 Struggle with Soft Contact
Lens Wear Addressed by Refitting with Daily
Disposable Lenses. Robin L. Chalmers, S. B.
Hickson-Curran, L. J. Keay, W. Gleason, R.
Albright. Clinical Trial Consultant, Atlanta, GA
*CR, f
5459 — A0158 In vivo confocal microstructural
analysis of corneal epithelial cell changes
related to daily wear use of silicone hydrogel
contact lenses. Jessica Lee1, X. Zhang1, C.
Marchetti1, Y. Jiang2, Y. Sun1, S. M. Debanne2, J.
Lemp3, B. Benetz1, P. Eric1, L. B. Szczotka-Flynn1.
1
Ophthalmology, University Hospitals Case
Medical Center, Cleveland, OH; 2Epidemiology &
Biostatistics, University Hospitals Case Medical
Center, Cleveland, OH; 3Alcon Laboratories, Fort
Worth, TX *CR, f
Thursday Posters
8:30 am – 10:15 am
5460 — A0159 The relationship between clinical
grading and objective image analysis of Lid Wiper
Epitheliopathy. Jalaiah P. Varikooty1, B. J. Lay3,
N. J. Keir1, H. Burdin3, L. W. Jones1, T. L. Simpson2,
J. Lemp4. 1CCLR, School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 2School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada;
3
ADCIS, Baltimore, MD; 4Global Medical Affairs,
R&D, Alcon, Fort Worth, TX *CR, f
5461 — A0160 Corneal Stroma and Endothelial
Cell Changes in Contact Lens Wearers
Visualized with Confocal Microscopy. Christine
Marchetti1, J. Lee1, X. Zhang1, Y. Sun1, S. M.
Debanne1, Y. Jiang1, J. R. Kern2, B. Benetz1, E.
Pearlman1, L. B. Szczotka-Flynn1. 1Ophthalmology,
University Hospitals Case Western Reserve,
Cleveland, OH; 2Alcon Laboratories, Fort Worth,
TX *CR, f
5462 — A0161 The effect of recovery periods
on end of day comfort. Ulrike Stahl1, N. J. Keir1,
J. P. Varikooty1, K. Nandakumar1, A. J. Keech1, A.
Landers2, L. W. Jones1. 1School of Optometry and
Vision Science, Centre for Contact Lens Research,
Waterloo, ON, Canada; 2Alcon Vision Care, Duluth,
GA *CR, f
5465 — A0164 Visual Correction for Irregular
Corneas with Scleral Lenses. Muriel Schornack,
C. B. Nau, J. Pyle, S. V. Patel. Ophthalmology,
Mayo Clinic, Rochester, MN
5466 — A0165 Visual Performance and
Residual Aberration in Keratoconus Subjects
Wearing Custom Scleral Contact Lenses. Jason
D. Marsack, C. Nguyen, D. E. Koenig, A. Ticak, J.
D. Elswick, R. A. Applegate. Optometry, University
of Houston, Houston, TX *CR
5467 — A0166 Direct comparison between in
situ versus extraction techniques for measuring
adsorbed proteins: application to lysozyme
deposited onto hydrogel contact lenses. Brad
Hall, C. Phan, L. N. Subbaraman, L. W. Jones, J.
A. Forrest. University of Waterloo, Waterloo, ON,
Canada *CR
5468 — A0167 PRG4 as a Natural Boundary
Lubricant for Commercial Silicone Hydrogel
Contact Lenses. Michael L. Samsom1, A. Chan1, L.
W. Jones2, T. A. Schmidt1. 1Biomedical Engineering,
University of Calgary, Calgary, AB, Canada;
2
School of Optometry, University of Waterloo,
Waterloo, ON, Canada *CR
5469 — A0168 Decreased Clearance between
Scleral Contact Lens and Cornea after 2 Hours
of Lens Wear. Cherie B. Nau, M. Schornack.
Ophthalmology, Mayo Clinic, Rochester, MN
5470 — A0169 Multivariate Statistical Analysis
Examining and Modeling Drug Release from
Contact Lens Materials. Frances Lasowski, G.
Guidi, H. Sheardown. Chemical Engineering,
McMaster University, Hamilton, ON, Canada *CR
5471 — A0170 A study of the feasibility
of fitting custom designed contact lenses to
guinea pigs, guided by AS-OCT imaging and
corneal topography. Yue Liu1, Z. Chen2, C. F.
Wildsoet1. 1VIsion Science, Univ of CA, Berkeley
Sch of Optometry, Berkeley, CA; 2Department of
Ophthalmology & Vision Science, Eye & ENT
hospital,Fudan University, Shanghai, China *CR
5475 — A0174 The evaluation of Lid Wiper
Epitheliopathy in contact lens wearers in a
Controlled Low Humidity Environmental
Exposure Chamber. Lyndon W. Jones1, J. P.
Varikooty1, N. J. Keir1, F. Soong2, P. Patel2. 1CCLRSchool of Optometry, University of Waterloo,
Waterloo, ON, Canada; 2Inflamax Research,
Mississauga, ON, Canada *CR
5476 — A0175 Determination of Oxygen
Permeability of Soft Contact Lenses Using
Polarographic Lens Stacking and Single-Lens
with Various Powers. X Michael Liu, G. L. Oltean.
Global R&D, Bausch & Lomb, Rochester, NY *CR
5477 — A0176 The Large-Scale
Epidemiological Study on the Prescription
of Contact Lenses in Japan -The Result from
Analyzing approximately 330,000 Eyes of
Japanese Subjects-. Eiichi Okada1, N. Mizuki2,
T. Kawagoe2, M. Nagasaki1, N. Matsunaga3, M.
Yoshida3. 1Okada Eye Clinic, Yokohama, Japan;
2
Department of Ophthalmology, Yokohama City
University, School of Medicine, Yokohama, Japan;
3
Department of Public Health, Kyorin University,
School of Medicine, Mitaka, Japan
5478 — A0177 Comparative study of refractive
change between glasses and contact lenses users
-5 years prospective study against approximately
273 thousand Japanese eyes-. Masao Yoshida1,
N. Mizuki2, T. Kawagoe2, M. Nagasaki3, N.
Matsunaga1, E. Okada3. 1Department of Public
Health, Kyorin University School of Medicine,
Mitaka, Japan; 2Department of Ophthalmology,
Yokohama City University School of Medicine,
Yokohama, Japan; 3Okada Eye Clinic, Yokohama,
Japan
5472 — A0171 Investigation of Latanoprost
Release from Contact Lens Materials Using
in vitro Cell Models. Saman Mohammadi1,
L. W. Jones2, 3, M. Gorbet1, 3. 1Systems Design
Engineering, University of Waterloo, Waterloo,
ON, Canada; 2School of Optometry, University
of Waterloo, Waterloo, ON, Canada; 3Centre for
Contact Lens Research, University of Waterloo,
Waterloo, ON, Canada *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
350
Thursday – Posters – 5479 – 5498
5479 — A0178 Risk Factors for microbial
bioburden during daily wear of silicone
hydrogel contact lenses. Ying Jiang1, M. Jacobs2,
S. Bajaksouzian2, A. Foster2, S. M. Debanne1, R.
Bielefeld3, M. Garvey3, S. Raghupathy Bsoptom4,
J. R. Kern5, L. B. Szczotka-Flynn4. 1Department
of Epidemiology & Biostatistics, Case Western
Reserve Rniversity, Cleveland, OH; 2Department
of Pathology, Case Western Reserve University,
Cleveland, OH; 3Division of Information
Technology Services, Case Western Reserve
University, Cleveland, OH; 4Department of
Ophthalmology & Visual Sciences and University
Hospitals Eye Institute, University Hospitals
Case Medical Center, Cleveland, OH; 5Alcon
Laboratories, Fort Worth, TX *CR, f
5480 — A0179 An Examination of the Effects
of Evaporation on Antimicrobial Efficacy of
Contact Lens Care Solutions. Nancy Brady, M.
Milenkovic, A. Lam. Corneal Microbiology, Abbott
Medical Optics, Santa Ana, CA *CR
5481 — A0180 Evaluation of an auto-refractor
for over-refraction with multifocal contact lenses
patients. Anna Giner2, M. Aldaba2, M. Arjona1, J.
Pujol1. 1CD6 - Optica i optometria, Polithechnical
University of Catalonia, Terrassa, Spain; 2CD6,
Polithechnical University of Catalonia, Terrassa,
Spain *CR
5482 — A0181 Evaluation of the effect of
soft contact lens edge shape on conjunctival
epithelium. Dorota H. Szczesna-Iskander1, D.
Iskander2. 1Institute of Physics, Wroclaw University
of Technology, Wroclaw, Poland; 2Institute of
Biomedical Engineering And Instrumentation,
Wroclaw University of Technology, Wroclaw,
Poland *CR
5486 — A0185 Effect of Static and NonStatic in-vitro Techniques on Lipid Penetration
Into SiHy Contact Lenses. Jean T. Jacob1, 2, R.
Frederick1, 2, C. Tucker1, 3, L. Love1, 4. 1Department
of Ophthalmology, LSU Health Sciences Center,
New Orleans, LA; 2Biomedical Engineering, Tulane
University, New Orleans, LA; 3University of New
Orleans, New Orleans, LA; 4Xavier University,
New Orleans, LA *CR
5487 — A0186 Visual Performance and Optical
Quality with New Silicone-hydrogel Soft Contact
Lenses for Keratoconus. Asaki Suzaki1, N. Maeda2,
M. Fuchihata2, S. Koh2, K. Nishida2, T. Fujikado1.
1
Applied Visual Science, Osaka University Graduate
School of Medicine, Suita, Japan; 2Ophthalmology,
Osaka University Graduate School of Medicine,
Suita, Japan *CR
5488 — A0187 In-Vitro Spoilation of SiHy Soft
Contact Lenses using LAESI-MS and FCSLM.
Trust T. Razunguzwa1, H. Goodman1, C. Peng2,
N. Fajardo2, C. J. Radke2. 1Protea Biosciences
Group Inc., Morgantown, WV; 2Chemical and
Biomolecular Engineering, University of California,
Berkeley, CA *CR
5489 — A0188 Tear Film Proteins StronglyAdherent to a Non-Ionic Silicone Hydrogel
Contact Lens Across the Wear Cycle. Michael S.
Foster, A. Landers, M. M. Gabriel, J. D. Lane, W. L.
Nash. Vision Care, Alcon, Duluth, GA *CR
5490 — A0189 Objective Visual Performance of
Low-add Multifocal Contact Lenses. Balamurali
Vasudevan, S. N. Gaib. Optometry, Midwestern
University, Glendale, AZ *CR
Exhibit Hall B0001-B0052
5483 — A0182 The Cause of Midday Visual
Fogging in Scleral Gas Permeable Lens Wearers.
Anna McKinney1, W. L. Miller1, N. E. Leach1, C.
Polizzi1, E. van der Worp2, J. P. Bergmanson1.
1
University of Houston College of Optometry,
Houston, TX; 2Maastricht University, Maastricht,
Netherlands *CR
Thursday, May 09, 2013 8:30 AM-10:15 AM
5484 — A0183 Designing Multifocal Contact
Lenses using a Novel Through-Focus Image
Quality Metric Highly Correlated with Clinical
Visual Acuity. Nishant Mohan, A. C. Kingston, I.
G. Cox. Bausch and Lomb, Rochester, NY *CR
Moderator: Delia DeBuc
507 Image Processing and
Segmentation Algorithms
5491 — B0001 Using Asymmetry Analysis to
Reduce Normal Variability of Spectral Domain
Optical Coherence Tomography (SD-OCT)
Macular Thickness. Muhammed S. Alluwimi, W.
H. Swanson, V. Malinovsky. School of Optometry,
Indiana University Bloomington, Bloomington, IN
5492 — B0002 Comparison and normalization
of retinal reflectivity profiles between spectraldomain optical coherence tomography devices.
Zhihong Hu, M. Nittala, S. Sadda. Retina, Doheny
Eye Institute, Arcadia, CA *CR
5494 — B0004 An automated system for the
detection of AMD-related drusen in retinal
fundus images. Damon Wong1, J. Liu1, F. Yin1, J.
Zhang2, N. Tan1, M. Bhargava3, G. C. Cheung3,
T. Y. Wong3. 1Insittute for Infocomm Research,
Singapore, Singapore; 2Nanyang Technological
University, Singapore, Singapore; 3Singapore Eye
Research Insttute, Singapore, Singapore *CR
5495 — B0005 Automated quantification of
drusen and choroid using clinical SD-OCT. Li
Zhang1, G. H. Buitendijk3, 4, K. Lee1, A. Wahle1,
M. Sonka1, 2, C. C. Klaver3, 4, M. D. Abramoff2, 5.
1
Electrical And Computer Engineering, University
of Iowa, Iowa City, IA; 2Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
3
Department of Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 4Department of
Epidemiology, Erasmus Medical Center, Rotterdam,
Netherlands; 5Veterans Affairs, Iowa City VA
Medical Center, Iowa City, IA *CR
5496 — B0006 Automatic Drusen
Quantification and Risk Assessment of Agerelated Macular Degeneration on Color
Fundus Images. Mark J J P van Grinsven1, Y. T.
Lechanteur2, J. P. van de Ven2, B. van Ginneken1, C.
B. Hoyng2, T. Theelen2, C. I. Sanchez1. 1Radiology,
Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands; 2Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands *CR
5497 — B0007 Tissue, microscopy, and
computational techniques for mapping human
retinal pigment epithelium cell number and
autofluorescence. Thomas Ach1, J. D. Messinger1,
M. J. Bentley2, F. C. Delori3, K. R. Sloan2, C. A.
Curcio1. 1Dept of Ophthalmology, University
of Alabama at Birmingham, Birmingham, AL;
2
Computer and Information Science, University
of Alabama at Birmingham, Birmingham, AL;
3
Ophthalmology, Schepens Eye Research Institute,
Boston, MA
5498 — B0008 A Multimodal MachineLearning-Based Approach for Segmenting
the Optic Disc and Cup in Fundus and SDOCT Images. Mohammad Saleh Miri1, 2, M. D.
Abramoff2 3, K. Lee1, M. Niemeijer1, A. Wahle1, Y. H.
Kwon3, M. K. Garvin2, 1. 1Electrical and Computer
Engineering, The University of Iowa, Iowa City, IA;
2
Center for the Prevention and Treatment of Visual
Loss, Iowa City VA Health Care System, Iowa City,
IA; 3The Department of Ophthalmology and Visual
Sciences, The University of Iowa, Iowa City, IA
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
351
Thursday Posters
8:30 am – 10:15 am
5485 — A0184 Prosthetic Replacement of the
Ocular Surface Ecosystem (PROSE) Treatment:
A Partner Clinic Experience. Kira L. Segal1,
M. N. Lee2, K. O. Chapman2, M. Rosenblatt2, K.
C. Sippel2, C. E. Starr2, J. Ciralsky2. 1Medicine,
Memorial Sloan Kettering Cancer Center, New
York, NY; 2Ophthalmology, NewYork-Presbyterian,
New York, NY
Multidisciplinary Ophthalmic Imaging
5493 — B0003 Retinal Central Reflex
Quantification: A New Approach for Central
Reflex Grading and Severity Measurement.
Alauddin Bhuiyan1, E. L. Lamoureux2, J. Wang3, C.
Y. Cheung2, K. Yogesan1, T. Y. Wong2. 1Australian
E-Health Research Centre, Commonwealth
Scientific &Industrial Research Organization,
Floreat, WA, Australia; 2Singapore Eye Research
Institute, Singapore, Singapore; 3University of
Sydney, Sydney, NSW, Australia *CR
5499 – 5517 – Thursday – Posters
5499 — B0009 Automated segmentation of
the in-vivo lamina cribrosa (LC) imaged using
3D optical coherence tomography (OCT). Bo
Wang1, 2, Z. Nadler1, J. E. Nevins1, R. A. Bilonick1, 3,
H. Ishikawa1, 4, L. Kagemann1, 4, I. Grulkowski5, J.
J. Liu5, J. G. Fujimoto5, J. S. Schuman1, 4. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh,
Pittsburgh, PA; 2Medical Scientist Training
Program, University of Pittsburgh, Pittsburgh, PA;
3
Department of Biostatistics, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh,
PA; 4Department of Bioengineering, University
of Pittsburgh, Pittsburgh, PA; 5Department of
Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, Cambridge,
MA *CR
5500 — B0010 Automated Choroidal
Segmentation in 1µm Swept Source Deep
Range Imaging OCT. Qi Yang1, C. A. Reisman1,
R. Ramachandran2, A. S. Raza2, D. C. Hood2, 3,
K. Chan1. 1Topcon Adv Biomed Imaging
Lab, Topcon Medical Systems, Oakland, NJ;
2
Psychology, Columbia University, New York, NY;
3
Ophthalmology, Columbia University, New York,
NY *CR
5501 — B0011 SD OCT Analysis of Retinal
Zones Identified as Abnormal with UltraWidefield Autofluorescence. Jerome Sherman1, 2,
D. Epshtein1, S. Nath3, 4, S. Slotnick1, 2. 1Clinical
Sciences, SUNY College of Optometry, New York,
NY; 2SUNY Eye Institute, State University of New
York, NY, NY; 3Eye Institute and Laser Center, New
York, NY; 4NY Eye and Ear Infirmary, New York,
NY *CR
Thursday Posters
8:30 am – 10:15 am
5502 — B0012 Validation of the Precision of
a Novel Representation of Images Obtained by
the Optos P200Tx Ultra Wide-Field Imaging
System. Natasha Maqsood1, R. Sophie1, J. van
Hemert2, D. Swan2, M. Verhoek2, M. G. Bittencourt1,
D. A. Ferraz1, H. Jang1, Y. J. Sepah1, Q. Nguyen1.
1
Retinal Imaging Research and Reading Centre,
Johns Hopkins University, Baltimore, MD; 2Optos,
Dunfermline, United Kingdom *CR
5503 — B0013 Total Retinal Thickness Using
Iowa Reference Algorithm: Measurement
Reproducibility in 5 SD-OCT Scanners. Adnan
Rashid1, U. Schmidt-Erfurth4, 5, B. S. Gerendas5,
S. M. Waldstein6, H. Bogunovic1, A. Wahle1, C.
Simader6, K. Lee1, M. Sonka1, 2, M. D. Abramoff2, 3.
1
Electrical and Computer Engineering, The
University of Iowa, Iowa City, IA; 2Ophthalmology
and Visual Sciences, The university of Iowa,
Iowa City, IA; 3Veterans Affairs, Medical Center,
Iowa City, IA; 4Department of Ophthalmology,
Medical University of Vienna, Vienna, Austria;
5
Ophthalmology & Optometry, Med Univ Vienna,
Vienna Gen Hosp, Vienna, Austria; 6Vienna Reading
Center, Department of Ophthalmology, University
of Vienna, Vienna, Austria *CR
5504 — B0014 Fully Automatic Risk
Assessment Of Diabetic Retinopathy In Digital
Fundus Images. E Simon Barriga1, 2, C. Agurto1,
H. Yu1, V. Joshi1, C. Carranza2, J. Wigdahl1, S. C.
Nemeth1, G. Zamora1, W. C. Bauman3, P. Soliz1, 4.
1
VisionQuest Biomedical LLC, Albuquerque, NM;
2
Electrical and Computer Engineering, University of
New Mexico, Albuquerque, NM; 3Retina Institute
of South Texas, San Antonio, TX; 4Ophthalmology
and Visual Sciences, University of Iowa, Iowa City,
IA *CR
5510 — B0020 Automated choroidal
neovascularization associated abnormality
detection and quantitative analysis from clinical
SD-OCT. Xiayu Xu1, L. Zhang1, K. Lee1, A.
Wahle1, X. Chen3, X. Wu1, M. D. Abramoff1, 2, M.
Sonka1. 1Department of Electrical and Computer
Engineering, University of Iowa, Iowa City, IA;
2
Ophthalmology & Visual Sciences, University of
Iowa, Iowa City, IA; 3School of Electronics and
Information Engineering, Soochow University,
Soochow, China *CR
5505 — B0015 Correlation between Fluorescein
Leakage Maps Generated by Automated
Leakage Quantification of Fluorescein
Angiogram and Retinal Thickness Maps Created
by OCT in Eyes with Neovascular AMD.
Mostafa Hanout1, E. Magdy2, O. O. Agbedia1, M.
A. Ibrahim1, M. G. Bittencourt1, M. A. sadiq1, D.
Ferraz1, A. Moradi1, A. S. Fahmy2, 3, Q. Nguyen1.
1
Retinal Imaging Research and Reading Center,
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD; 2Center for Informatics Science,
Nile University, Cairo, Egypt; 3Systems of
Biomedical Engineering Department, Cairo
University, Cairo, Egypt *CR
5511 — B0021 A new computer-assisted
image processing technique for quantitative
analysis of the impact of pterygia on refractive
indices and ocular higher-order aberrations.
Koray Gumus1, A. Guven2, M. Guler2, M. Gerdan1.
1
Department of Ophthalmology, Erciyes University
School of Medicine, Kayseri, Turkey; 2Biomedical
Engineering Faculty, Erciyes University, Kayseri,
Turkey
5506 — B0016 Semi-automated Contour
Analysis of SD-OCT images after Epiretinal
Membrane Peeling using either air tamponade
or balanced salt solution. Focke Ziemssen, M.
Leitritz, D. Zobor, M. Voelker, K. Bartz-Schmidt,
F. Gelisken. Center of Ophthalmology, University
Tuebingen, Tuebingen, Germany *CR
5507 — B0017 A Fully Automatic Framework
for Segmentation and Localization of Retinal
Structures in Fundus Images. Attila Budai1, 2,
K. Mogalle1, K. Laurik4, J. M. Hornegger1, 2, G.
Michelson3. 1Pattern Recognition Lab, University
of Erlangen-Nuremberg, Erlangen, Germany;
2
Erlangen Graduate School in Advanced
Optical Technologies, Erlangen, Germany;
3
Interdisciplinary Center of Ophthalmic Preventive
Medicine and Imaging (IZPI), Erlangen, Germany;
4
Department of Ophthalmology, Semmelweis
University, Budapest, Hungary *CR
5508 — B0018 Reliability of automatic
measurements for thickness profiles of intraretinal layers using ultra-high resolution optical
coherence tomography. Xinting Liu, M. Shen, S.
Huang, D. Zhu, L. Leng, F. Lu. Wenzhou Medical
College, Wen Zhou, China
5509 — B0019 Automatic Segmentation of
OCT Datasets Using Superpixels-Classification.
Pascal A. Dufour1, 2, H. Abdillahi3, 2, L. Ceklic3, 2, U.
E. Wolf-Schnurrbusch3, 2, S. Wolf2, J. H. Kowal1, 2.
1
Ophthalmic Technologies ARTORG Center,
University of Bern, Bern, Switzerland; 2Department
of Ophthalmology, University Hospital Bern, Bern,
Switzerland; 3Bern Photographic Reading Center,
University Hospital Bern, Bern, Switzerland *CR
5512 — B0022 Choroidal Thickness in AgeRelated Macular Degeneration as measured by
Semi-Automated Segmentation of the Choroid
in Enhanced-Depth Imaging Optical Coherence
Tomography. Glenn Yiu1, S. Fekrat1, N. Sarin1,
S. J. Chiu2, S. Stinnett1, S. Farsiu1, 2, C. A. Toth1, 2.
1
Ophthalmology, Duke University Medical Center,
Durham, NC; 2Biomedical Engineering, Duke
University, Durham, NC *CR
5513 — B0023 Clinical Utility of Thresholding
Segmentation in Ultra-Widefield (Optos®)
Fundus Autofluorescence Images. Sarah
MacIver1, J. Sherman2, 3, N. Hutchings1. 1Univ of
Waterloo Sch of Optom, Waterloo, ON, Canada;
2
Clinical Sciences, SUNY State College of
Optometry, New York, NY; 3SUNY Eye Institute,
State University of New York, New York, NY *CR
5514 — B0024 Reliability of Automated
Leakage Quantification of Fluorescein
Angiography in Eyes with Diabetic Macular
Edema. Owhofasa O. Agbedia1, E. Magdy2,
M. A. Ibrahim1, Y. J. Sepah1, R. Sophie1, M. G.
Bittencourt1, M. Hanout1, D. V. Do1, A. Fahmy2, Q.
Nguyen1. 1Retinal Imaging Research and Reading
Center, Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD; 2Center for Informatics
Science, Nile University, Giza, Egypt *CR
5515 — B0025 Evaluation of a New
Registration Algorithm Using iVue SD-OCT. Jing
Cui, B. K. Jang. Optovue, Inc, Fremont, CA *CR
5516 — B0026 Digital Image Grading Tool
for Uveitis Clinical Trials. Brian Madow.
Ophthalmology, University of South Florida,
Tampa, FL
5517 — B0027 Automated correction of 3D
acquisitions using a high frequency rotative
ultrasound probe. Charly Maindron1, 2, M. Le
Loir4 1, B. Cochener4, 1, M. Lamard3, 1. 1LaTIM
- UMR 1101, Brest, France; 2Quantel Medical,
Cournon d’Auvergne, France; 3Université de
Bretagne Occidentale, Brest, France; 4CHU Brest,
Service d’ophtalmologie, Brest, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
352
Thursday – Posters – 5518 – 5538
5518 — B0028 3D Motion Correction and
Signal Improvement in High speed Polarization
Sensitive Optical Coherence Tomography. Martin
F. Kraus1, 2, A. Dhalla2, J. J. Liu2, K. J. Mohler2, C.
D. Lu2, B. Potsaid2, J. M. Hornegger1, D. Huang3,
J. G. Fujimoto2. 1Pattern Recognition Lab and
SAOT, University Erlangen Nuremberg, Erlangen,
Germany; 2Dept. of Electrical Engineering and
Computer Science and Research Laboratory of
Electronics, Massachusetts Institute of Technology,
Cambridge, MA; 3Casey Eye Institute, Oregon
Health & Science University, Portland, OR *CR
5519 — B0029 Retinal layer segmentation
in a pediatric normal group. Stefan Pelz, H.
Wildberger, C. Gerth-Kahlert. Ophthalmology,
University of Zurich, Zurich, Switzerland
5520 — B0030 Detection of Neovascularization
in Digital Fundus Images Using a Multiscale
Analysis Approach. Carla Agurto Rios1, H.
Yu1, J. Wigdahl1, V. Murray2, E. Barriga1, W. C.
Bauman3, P. Soliz1, 4. 1Research & Development,
VisionQuest Biomedical LLC, Albuquerque, NM;
2
Universidad de Ingenieria & Tecnologia, Lima,
Peru; 3Retina Institute of South Texas, San Antonio,
TX; 4Department of Ophthalmology and Visual
Sciences, University of Iowa, Iowa city, IA *CR
5526 — B0036 Spectral Domain OCT
individual retinal layering of diabetics with and
without retinopathy. Silvia Bini1, S. Vujosevic1,
M. Berton1, E. Pilotto1, E. Midena1, 2. 1Department
of Ophthalmology, University of Padova, Padova,
Italy; 2G.B. Bietti Foundation, IRCCS, Roma, Italy
5527 — B0037 Large Retinal Hemorrhage
Detector for Automated Diabetic Retinopathy
Screening System. Li Tang1, 2, M. Niemeijer3, M. D.
Abramoff1, 2. 1Ophthal & Visual Sciences, University
of Iowa, Iowa City, IA; 2Department of Veterans
Affairs, Center of Excellence for Prevention of
Visual Loss and Blindness, Iowa City, IA; 3IDx
LLC, Iowa City, IA *CR
5528 — B0038 Image Registration for Motion
Artifact Removal in Retinal Vascular Imaging
Using Speckle Variance Fourier Domain Optical
Coherence Tomography. Hansford C. Hendargo1,
R. Estrada2, S. J. Chiu1, C. Tomasi2, S. Farsiu3,
1
, J. A. Izatt1, 3. 1Biomedical Engineering, Duke
University, Durham, NC; 2Computer Science, Duke
University, Durham, NC; 3Ophthalmology, Duke
University, Durham, NC *CR
5522 — B0032 Multispectral Retinal Image
Analysis (MRIA) for the Quantification of
Macular Pigment. Antonio Calcagni1, 2, I. Styles2,
A. D. Palmer2, Y. Shen2, H. Bartlett1, F. Eperjesi1,
J. M. Gibson1, E. Claridge2. 1School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom; 2School of Computer Science,
University of Birmingham, Birmingham, United
Kingdom
5530 — B0040 Automatic Segmentation of
Corneal Lamellar Graft Surfaces from LowContrast Optical Coherence Tomography
Images. Alec V. Arshavsky1, 3, F. LaRocca2, J.
A. Izatt2, 3, A. N. Kuo3, S. Farsiu2, 3. 1East Chapel
Hill High School, Chapel Hill, NC; 2Biomedical
Engineering, Duke University, Durham, NC;
3
Ophthalmology, Duke University, Durham, NC
*CR
5523 — B0033 Automatic Segmentation of
Photoreceptors in AOSLO Images Using Graph
Theory and Dynamic Programming. Stephanie J.
Chiu1, A. M. Dubis2, A. Dubra3, 4, J. Carroll3, 4, J. A.
Izatt1, 2, S. Farsiu2, 1. 1Biomedical Engineering, Duke
University, Durham, NC; 2Ophthalmology, Duke
University, Durham, NC; 3Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 4Biophysics,
Medical College of Wisconsin, Milwaukee, WI *CR
5531 — B0041 Automated Segmentation of
Sub-Retinal Layers in Age-related Macular
Degeneration. Katrina A. Mears1, L. Zhang2,
K. Lee2, X. Xu2, M. Sonka1, 2, M. D. Abramoff1, 2.
1
Department of Ophthalmnology and Visual
Sciences, University of Iowa Hospitals and
Clinids, Iowa city, IA; 2Electrical and Computer
Engineering, University Of Iowa, Iowa city, IA *CR
5524 — B0034 Texture-Based Eye Motion
Correction for 3D OCT Imaging. Omaima
M. Nomir, H. Jiang, J. Wang, D. DeBuc.
Ophthalmology, Univ of Miami School of Med,
Miami, FL *CR
5525 — B0035 Automated Detection of Hyperreflective Structures Associated with Diabetic
Retinopathy using Spectral Domain Optical
Coherence Tomography (SD-OCT). David W.
Stein1, N. K. Waheed2, M. Adhi2, S. K. Semy1, J.
S. Duker2, W. Kuklinski1. 1MITRE, Bedford, MA;
2
Ophthalmology, New England Eye Center, Boston,
MA *CR
5532 — B0042 Methods for manual and
automated detection of the four outer retinal
hyper-reflective bands in optical coherence
tomography scans. Douglas Ross1, 2, M. Clark4,
P. Godara6, 3, G. McGwin3, R. F. Spaide5, K. R.
Sloan2, C. A. Curcio3. 1Mechanical Engineering,
UAB, Birmingham, AL; 2Computer and Information
Sciences, UAB, Birmingham, AL; 3Ophthalmology,
UAB, Birmingham, AL; 4UAB, Birmingham,
AL; 5Vitreous Retina Macula Consultants NY,
New York, NY; 6Ophthalmology, Eye Institute,
Birmingham, AL *CR
5534 — B0044 Novel method for registration
and statistical analysis of volumetric retinal OCT
data using surface currents. Evgeniy Lebed1,
S. Lee1, S. X. Han1, P. Mackenzie3, A. Trouve2,
M. V. Sarunic1, M. Beg1. 1Engineering Science,
Simon Fraser University, Burnaby, BC, Canada;
2
Centre de Mathématiques et Leurs Applications,
Ecole Normale Supérieure, Cachan, France;
3
Ophthalmology and Visual Sciences, University of
British Columbia, Vancouver, BC, Canada
5535 — B0045 Signal Normalization Between
Non-Averaged and Frame-Averaged Optical
Coherence Tomography (OCT) Images.
Chieh-Li Chen1, 2, H. Ishikawa1, 2, G. Wollstein1,
R. A. Bilonick1, 3, I. A. Sigal1, 2, L. Kagemann1, 2,
J. G. Fujimoto4, J. S. Schuman1, 2. 1UPMC Eye
Center, Eye and Ear Institute, Ophthalmology and
Visual Science Research Center, Department of
Ophthalmology, University of Pittsburgh School
of Medicine, Pittsburgh, PA; 2Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA;
3
Department of Biostatistics, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh,
PA; 4Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA *CR
5536 — B0046 Use of super-resolution image
reconstruction techniques in optical coherence
tomography. David Alonso-Caneiro, S. A. Read,
M. J. Collins. Contact Lens and Visual Optics Lab,
Queensland University of Technology, Brisbane,
QLD, Australia
5537 — B0047 Image Fusion System to
Combine Fluorescence Lifetime Imaging of the
Retina with Optical Coherence Tomography
Imaging. Jens H. Kowal1, 2, P. A. Dufour1, 2, T.
Rudolph1, 2, S. Wolf2. 1Ophthalmic Technologies
ARTORG Center, University of Bern, Bern,
Switzerland; 2Department of Ophthalmology,
University of Bern, Bern, Switzerland *CR
5538 — B0048 Volumes of retinal layers
measured by spectral-domain optical coherence
tomography and public domain software
ImageJ. Albert Caramoy1, K. Droge1, B. Kirchhof1,
C. B. Hoyng2, S. Fauser1. 1Department of
Ophthalmology, University of Cologne, Cologne,
Germany; 2Department of Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
353
Thursday Posters
8:30 am – 10:15 am
5521 — B0031 Triangle mesh segmentation
and reconstruction of HD 3D OCT data sets for
augmented reality simulation purposes. Carl G.
Glittenberg, S. Binder. Dept of Ophthalmology,
Rudolph Foundation Hospital, Vienna, Austria
5529 — B0039 A computer-aided manual
segmentation method for SD-OCT images yields
increased inter-grader reproducibility. Yijun
Huang1, J. W. Pak1, S. Luo1, J. White1, X. Zhang2,
R. P. Danis1. 1Ophthal & Vis Sciences-FUNDUS,
University of Wisconsin-Madison, Madison, WI;
2
Department of Psychology, Columbia University,
New York, NY *CR
5533 — B0043 Global and Regional
Intrasession Test-Retest Variability of Macular
Thickness Measurements with Spectral-domain
Optical Coherence Tomography with and
without Tracking. Elaine Thung, S. Knipping,
J. Caprioli, K. Nouri-Mahdavi. Ophthalmology,
UCLA Jules Stein Eye Institute, Los Angeles, CA
*CR
5539 – 5554 – Thursday – Posters
5539 — B0049 Fully-automated multimodal
co-registration of optical coherence tomography
to colour fundus photography and fluorescein
angiography. Pedro Guimaraes1, P. Rodrigues2,
C. F. Lobo2, P. Serranho3, 1, R. Bernardes1, 2. 1IBILI
- Faculty of Medicine, University of Coimbra,
Coimbra, Portugal; 2CNTM/AIBILI - Association
for Innovation and Biomedical Research on Light
and Image, Coimbra, Portugal; 3Mathematics
Section, Department of Science and Technology,
Open University, Lisbon, Portugal f
5540 — B0050 Automatic Segmentations
of Intra-retinal Layers and Optic Nerve
Head in UHR-OCT Images Using Dynamic
Programming. Shenghai Huang, M. Shen, X.
Liu, L. Leng, F. Lu. Wenzhou Medical College,
Wenzhou, China
5541 — B0051 Virtual Frame Averaging
- A Novel Image Enhancement Method for
Three-Dimensional (3D) Optical Coherence
Tomography (OCT) Images. Hiroshi Ishikawa1, 2,
C. Chen1, 2, G. Wollstein1, L. Kagemann1, 2, I. A.
Sigal1, 2, R. A. Bilonick1, 3, J. G. Fujimoto4, J. S.
Schuman1, 2. 1UPMC Eye Center, Eye and Ear
Institute, Ophthalmology and Visual Science
Research Center, Department of Ophthalmology,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 2Department of Bioengineering,
Swanson School of Engineering, University
of Pittsburgh, Pittsburgh, PA; 3Department
of Biostatistics, Graduate School of Public
Health, University of Pittsburgh, Pittsburgh,
PA; 4Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA *CR
Thursday Posters
8:30 am – 10:15 am
5542 — B0052 DTI Fiber tracking Analysis
of the visual input to the pallidum in humans:
preliminary results. Hachemi Nezzar1, 2, L.
J. Sakka3, 2, J. Coste3, 2, J. Gabrillargues4, 2,
F. Chiambaretta1, J. Lemaire3, 2. 1Dept of
Ophthalmology, CHU Clermont Ferrand,
Clermont-Ferrand, France; 2IGCNC EA 3295,
Université d’Auvergne, Clermont Ferrand, France;
3
Dept of Neurosurgery, CHU Clermont Ferrand,
Clermont Ferrand, France; 4Dept of Radiology,
neuroradiology, CHU Clermont Ferrand, Clermont
Ferrand, France
Exhibit Hall B0053-B0064
Thursday, May 09, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
508 Improving Imaging and
Ophthalmic Instrumentation
Moderator: Zoran Popovic
5543 — B0053 Stabilized cone imaging with
adaptive optics optical coherence tomography.
Omer P. Kocaoglu1, R. D. Ferguson2, Z. Liu1,
R. S. Jonnal1, Q. Wang1, D. X. Hammer3, D. T.
Miller1. 1School of Optometry, Indiana University,
Bloomington, IN; 2Physical Sciences Inc.,
Andover, MA; 3Office of Science and Engineering
Laboratories, Center for Devices and Radiological
Health, Food and Drug Administration, Silver
Spring, MD *CR
5544 — B0054 In vivo Imaging of the Human
Retinal Pigment Epithelium Cell Mosaic
using Short-wavelength Autofluorescence and
achromatizing lenses. Alfredo Dubra1, 2, D. H.
Scoles3, Y. N. Sulai4. 1Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 2Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
3
Biomedical Engineering, University of Rochester,
Rochester, NY; 4The Institute of Optics, University
of Rochester, Rochester, NY *CR
5545 — B0055 A novel compact optical
instrument for the clinical measurement of
intraocular light scattering. Onurcan Sahin1,
H. S. Ginis2, 1, G. M. Perez3, J. M. Bueno2, P.
Artal2. 1Institute of Vision & Optics, University of
Crete, Heraklion, Greece; 2Laboratorio de Optica,
Universidad de Murcia, Murcia, Spain; 3Voptica SL,
Murcia, Spain *CR
5546 — B0056 The Effect of AOSLO Image
Distortion on Metrics of Mosaic Geometry.
Robert F. Cooper1, Z. Harvey2, M. Dubow3, 4, Y.
N. Sulai5, A. Pinhas3, 4, D. H. Scoles6, N. Shah3, R.
B. Rosen3, A. Dubra2, 7, J. Carroll2, 8. 1Biomedical
Engineering, Marquette University, Milwaukee, WI;
2
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 3New York Eye and Ear Infirmary,
New York, NY; 4Mount Sinai School of Medicine,
Mount Sinai Hospital, New York, NY; 5The Institute
of Optics, University of Rochester, Rochester, NY;
6
Biomedical Engineering, University of Rochester,
Rochester, NY; 7Biophysics, Medical College of
Wisconsin, Milwaukee, WI; 8Cell Biology, Medical
College of Wisconsin, Milwaukee, WI *CR
5548 — B0058 Evaluation of a Dual-Conjugate
Adaptive Optics Clinical Prototype for
Retinal Imaging. Zoran Popovic1, J. Thaung1,
B. Svensson2, M. Owner-Petersen1. 1Department
of Ophthalmology, University of Gothenburg,
Mölndal, Sweden; 2Exomed AB, Sollentuna,
Sweden *CR
5549 — B0059 AO-OCT Retinal Imaging with
163-Segment Deformable Mirror. Susanna C.
Finn1, C. Greiner1, N. Doble1, R. J. Zawadzki2,
J. S. Werner2, S. S. Choi1. 1Vision Science, New
England College of Optometry, Boston, MA;
2
Ophthalmology & Vision Science, University of
California Davis, Davis, CA *CR
5550 — B0060 Use of multiple metrics to
describe the parafoveal cone mosaic. Marco
Lombardo1, S. Serrao1, P. Ducoli1, G. Lombardo2,
3 1
. Fondazione GB Bietti IRCCS, Rome, Italy;
2
CNR-IPCF Unit of Support Cosenza, Rende, Italy;
3
Vision Engineering, Rome, Italy
5551 — B0061 Improved Sensitivity of
Automated Cone Identification in Images
of Adaptive Optics Scanning Laser
Ophthalmoscope (AOSLO). Keiko Yonezawa1,
H. Sonobe1, A. Uji2, S. Ooto2, M. Hangai2, N.
Yoshimura2. 1Medical Imaging Project, Canon Inc.,
Tokyo, Japan; 2Ophthalmology, Kyoto University
Graduate School of Medicine, Kyoto, Japan *CR
5552 — B0062 Photoreceptors, Retinal Nerve
Fibers and Retinal Blood Flow Observation by
AOSLO Applied to Wide Diopter Range. Takashi
Yuasa1, F. Hirose1, K. Saito1, K. Matsumoto1,
H. Sonobe1, A. Uji2, S. Ooto2, M. Hangai2, N.
Yoshimura2. 1Medical Imaging Project, Canon Inc.,
Ohta-ku, Japan; 2Ophthalmology, Kyoto University
Graduate School of Medicine, Kyoto City, Japan
*CR
5553 — B0063 Compact multimodal adaptive
optics imager (MAOI). R. D. Ferguson, M. Mujat,
A. Patel, N. Iftimia. Biomedical Imaging Group,
Physical Sciences Inc, Andover, MA *CR
5554 — B0064 Use of variable Field Size
in AOSLO retinal imaging to improve postprocessing. Ting Luo, G. Huang, T. Y. Chui, S. A.
Burns. School of Optometry, Indiana University
Blooomington, Bloomington, IN
5547 — B0057 Photoreceptor imaging with
in-the-plane adaptive optics optical coherence
tomography using toroidal mirrors. Zhuolin Liu,
O. P. Kocaoglu, Q. Wang, D. T. Miller. School of
Optometry, Indiana University, Bloomington, IN
*CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
354
Thursday – Posters – 5555 – 5575
Exhibit Hall B0078-B0103
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
509 Diabetic Retinopathy and
Vascular Biology II
Moderators: Michael H. Elliott and
M. Elizabeth Hartnett
5555 — B0078 Pleiotropic effects of Dll1RGD in mice oxygen-induced retinopathy.
Guorui Dou1, 2, Y. Wang1, H. Han2, X. Zhao2.
1
Ophthalmology, Xijing Hospital, Xian, China;
2
Developmental Biology and Medical Genetics,
Fourth Military Medical University, Xian, China
5556 — B0079 Mice lacking Adenylyl Cyclase
(AC) 1 and 8 Mimic Supernormal Intraretinal
Ion Channel Activity in Light-adapted Diabetic
Mice But have No Impairment in Visual
Performance. Robin Roberts1, A. C. Conti3, 4, B. A.
Berkowitz1, 2. 1Anatomy & Cell Biol, Wayne State
Univ Sch of Med, Detroit, MI; 2Ophthalmology,
Wayne State University School of Medicine,
Detroit, MI, MI; 3Neurosurgery, Wayne State
University School of Medicine, Detroit, MI, MI;
4
Research Service, John D. Dingell VA Medical
Center, Detroit, MI, MI
5557 — B0080 Detection and Quantification of
VEGF, HIF-1α, HIF-2α and TEAD4 Transcripts
in the Mouse Model of Oxygen-Induced
Retinopathy. Andrew J. Stempel1, C. W. Morgans2,
T. Stout1, B. Appukuttan1. 1Ophthalmology, Casey
Eye Institute-OHSU, Portland, OR; 2Physiology
& Pharmacology, Oregon Health & Science
University, Portland, OR *CR
5558 — B0081 Müller Cell Associated
Surfactant Protein A Impairs Retinal Endothelial
Cell Function. Faizah N. Bhatti1, 2, G. S. Ball1,
R. R. Akram1, M. H. Elliott2. 1Neonatal Perinatal
Medicine, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK; 2Ophthalmology, Univ of
Oklahoma Hlth Sci Ctr, Oklahoma City, OK
5561 — B0084 Quercetin protects retinal
vascular degeneration through anti-angiogenic
mechanisms in STZ-induced diabetic rats. Binit
Kumar1, S. K. Gupta1, B. P. Srinivasan1, T. C.
Nag2, S. Srivastava1, R. Saxena3. 1Department of
Pharmacology, Ocular Pharmacology Lab, Delhi
Institute of Pharmaceutical Sciences & Research,
University of Delhi, New Delhi, India; 2Department
of Anatomy, All India Institute of Medical Sciences,
New Delhi, India; 3Dr R P Centre For Ophthalmic
Sciences, All India Institute of Medical Sciences,
New Delhi, India
5562 — B0085 Retinal pathology reminiscent
of retinopathy of prematurity in a rat model
for periventricular leucomalacia. Janina Steck1,
C. Blueml2, S. E. Kampmann2, B. Gerstner3, R. F.
Maier2, K. Stieger1, B. Lorenz1. 1Department of
Ophthalmology, Justus-Liebig-University, Giessen,
Germany; 2Department of Pediatrics, PhillipsUniversity, Marburg, Germany; 3Department of
Pediatric Cardiology, Justus-Liebig-Universtiy,
Giessen, Germany *CR
5563 — B0086 Tweak/Fn14 Pathway is
Involved in Retinal Neovascularization. Hossein
Ameri1, 2, R. Liu1, Y. Ha1, A. A. Paulucci3, M.
Motamedi1, 3, B. F. Godley1, R. G. Tilton1, 4, W.
Zhang1, 2. 1Ophthalmology & Visual Sciences,
University of Texas Medical Branch, Galveston,
TX; 2Neuroscience and Cell Biology, University
of Texas Medical Branch, Galveston, TX; 3Center
for Biomedical Engineering, University of Texas
Medical Branch, Galveston, TX; 4Division
of Endocrinology and Stark Diabetes Center,
Department of Internal Medicine, University of
Texas Medical Branch, Galveston, TX
5564 — B0087 Kelch like-ECH-associated
protein 1 (Keap1) and retinal antioxidant defense
in the development of diabetic retinopathy. Qing
Zhong, R. A. Kowluru. Ophthalmology, Wayne State
Univ/Kresge Eye Inst, Detroit, MI
5565 — B0088 Curcumin-induced MiRNAs
Decrease VEGF, VEGFR, and NF-kB Expression
in Human Retinal Endothelial Cells (hRECs)
Under Hyperglycemic Condition. Annie N.
Farrell, E. Y. Hur, J. C. Howell, R. Haque.
Department of Ophthalmology, Emory University,
Atlanta, GA
5566 — B0089 The combined effect with EPO
and VEGF in retinal angiogenesis. Zhihong Yang,
H. Wang, Y. Jiang, M. McCloskey, M. Hartnett.
Moran Eye Center, Salt Lake City, UT *CR
5567 — B0090 Role of Prorenin Receptor
(PRR) and NADPH Oxidase (NOX) in the
Regulation of VEGF in ARPE-19 Cells under
Hyperglycemic Conditions. Rashidul Haque, P.
M. Iuvone, K. S. Choi, D. J. Park, A. N. Farrell,
E. Y. Hur. Department of Ophthalmology, Emory
University School of Medicine, Atlanta, GA
5568 — B0091 Retinal Protease and Collagen
Responses to Increasing Numbers of Intermittent
Hypoxia During Hyperoxia in a Rat Model
for Oxygen-Induced Retinopathy. Kay D.
Beharry1, C. L. Cai2, P. Sharma2, G. B. Valencia2,
D. R. Lazzaro3, J. V. Aranda1. 1Pediatrics &
Ophthalmology, State Univ of New York Downstate
Med Ctr, Brooklyn, NY; 2Pediatrics/Neonatology,
State Univ of New York Downstate Med Ctr,
Brooklyn, NY; 3Ophthalmology, State Univ of New
York Downstate Med Ctr, Brooklyn, NY
5569 — B0092 Insulin and Angiogenesis:
Excessive Insulin Induces Over-Proliferation
of Tunic Vasculosa Lentis in Mice. Huiyi Chen,
D. P. Hainsworth, L. W. Reneker. Ophthalmology,
University of Missouri-Columbia, Columbia, MO
5570 — B0093 Angiogenic profile of hypoxic
vascular endothelial cells overexpressing RTEF1. Binoy Appukuttan1, A. J. Stempel1, B. Wilmot2,
T. Stout1. 1Ophthalmology, Casey Eye Institute OHSU, Portland, OR; 2OCTRI, OHSU, Portland,
OR *CR
5571 — B0094 Manipulating Pericyte
Contractility Alters Endothelial Growth and
Angiogenic Potential. Jennifer T. Durham, I. M.
Herman. Molecular Physiology and Pharmacology,
Tufts University School of Medicine, Boston, MA
*CR
5572 — B0095 Enhancing function of
endothelial progenitors by targeting the
transforming growth factor-β1/plasminogen
activator inhibitor-1 system. Sergio Caballero1,
S. Hazra1, V. Stepps3, A. D. Bhatwadekar1, M.
E. Boulton2, R. N. Mames4, S. Bartelmez3, M. B.
Grant1. 1Pharmacology/Therapeutics, University
of Florida, Gainesville, FL; 2Anatomy and Cell
Biology, University of Florida, Gainesville, FL;
3
BetaStem Therapeutics, Inc., San Franscisco, CA;
4
The Retina Center, Gainesville, FL *CR
5573 — B0096 Mechanisms of Hyperoxiainduced Retinal Endothelial Cell Death and
Senescence. Orla M. Galvin, T. A. Gardiner, D. M.
McDonald. Queen’s University Belfast, Belfast,
United Kingdom
5574 — B0097 SOCS3 inhibits pathologic
angiogenesis. Jean-Sebastien Joyal1, A. Stahl2, Y.
Sun1, Z. Shao1, Z. Fu1, A. Juan1, D. T. Pei1, C. G.
Hurst1, J. Chen1, L. E. Smith1. 1Ophthalmology,
Children’s Hospital, Harvard Med Sch, Boston,
MA; 2Ophthalmology, University Eye Hospital
Freiburg, Freiburg, Germany
5575 — B0098 The Alternative Complement
System Mediates Neovascularization in
Retinopathy. John H. Sweigard, R. Yanai, K. M.
Connor, P. Y. Gaissert, A. Thanos. Angiogenesis,
Harvard Medical School/MEEI, dorchester, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
355
Thursday Posters
8:30 am – 10:15 am
5559 — B0082 Knockout of IGFBP-3 in Mice
Produces Changes Similar to Chronic Diabetes
in the Retina. Jena J. Steinle1, 4, Y. Jiang1, Q.
Zhang1, L. Liu4, B. Peng3, J. Pintar3, T. S. Kern2.
1
Ophthalmology, Univ of Tennessee Hlth Sci Ctr,
Memphis, TN; 2Ophthalmology and Medicine,
Case Western Reserve University, Cleveland,
Oman; 3Neuroscience and Cell Biology, UMDNJRobert Wood Johnson Medical School, Piscataway,
NJ; 4Anatomy and Cell Biology, University of
Tennessee Health Science Center, Memphis, TN
*CR
5560 — B0083 A potential role for cytochrome
P450 epoxygenases and their epoxyeicosatrienoic
acid products in oxygen-induced retinopathy.
Megan E. Capozzi1, J. S. Penn1, 2. 1Department of
Molecular Physiology and Biophysics, Vanderbilt
University, Nashville, TN; 2Department of
Ophthalmology and Visual Sciences, Vanderbilt
University, Nashville, TN *CR
5576 – 5596 – Thursday – Posters
5576 — B0099 Regulation of Retinal
Angiogenesis by a Novel Lactate Receptor,
GPR81. Ankush Madaan1, 2, D. Hamel2, J. Rivera2,
S. Chemtob1, 2. 1Pharmacology and Therapeutics,
McGill University, Montreal, QC, Canada; 2CR Hospital Sainte Justine, Universite de Montreal,
Montreal, QC, Canada
5577 — B0100 TEAD4 Isoform Inhibits Vessel
Growth in an Aortic Ring Assay. Trevor J.
McFarland, B. Appukuttan, T. Stout. Retina, Casey
Eye Institute-OHSU, Portland, OR *CR
5578 — B0101 Human adipose stem cell
derived pericytes protect against retinal
vasculopathy in vivo. Thomas A. Mendel1, 2, E. B.
Clabough2, 3, D. S. Kao2, T. N. Demidova-Rice4, 5, B.
Zotter2, E. P. Rakoczy6, A. J. Katz7, 8, I. M. Herman4,
S. M. Peirce9, P. A. Yates2. 1Pathology, University
of Virginia, Charlottesville, VA; 2Ophthalmology,
University of Virginia, Charlottesville, VA;
3
Biology, Randolph-Macon College, Ashland, VA;
4
Molecular Physiology and Pharmacology, Tufts
University, Boston, MA; 5E.L. Steele Laboratory for
Tumor Biology, Harvard Medical School, Boston,
MA; 6Molecular Ophthalmology, The University of
Western Australia, Nedlands, WA, Australia; 7Plastic
Surgery, University of Virginia, Charlottesville, VA;
8
Plastic Surgery, University of Florida, Gainesville,
FL; 9Biomedical Engineering, University of
Virginia, Charlottesville, VA *CR
5579 — B0102 Regulating the Regulator:
MicroRNA-dependent Control of the Proangiogenic Activity of the Matricellular Protein
CCN1 in Ischemic Retinopathy. Lulu Yan, O.
Szereszowiec, B. Chaqour. SUNY Downstate
Medical Center, Brooklyn, NY
Thursday Posters
8:30 am – 10:15 am
5580 — B0103 Role of Nrf2 in the regulation
of retinal revascularization and pathologic
angiogenesis in oxygen-induced retinopathy.
Yanhong Wei1, J. Gong1, R. Thimmulappa2, S.
Biswal2, E. J. Duh1. 1Ophthalmology, Johns
Hopkins University, Baltimore, MD; 2Bloomberg
School of Public Health, Johns Hopkins University,
Baltimore, MD
Exhibit Hall B0105-B0137
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
510 Glia in Health and Disease
Moderators: Erica L. Fletcher and
Przemyslaw Sapieha
5582 — B0105 Gene Expression Changes
in Aging Retinal Microglia: Relationship to
Microglial Support Functions and Regulation of
Microglial Activation. Wenxin Ma1, 4, R. Cojocaru2,
4
, N. Gotoh2, 4, L. Gieser2, 4, R. Villasmil3, 4, T.
Cogliati2, 4, A. Swaroop2, 4, W. T. Wong1, 4. 1Unit
on Neuron-Glia Interactions in Retinal Disease,
NEI/NIH, Bethesda, MD; 2NeurobiologyNeurodegeneration and Repair Laboratory, NEI/
NIH, Bethesda, MD; 3Flow Cytometry Core
Facility, NEI/NIH, Bethesda, MD; 4NEI/NIH,
Bethesda, MD
5583 — B0106 Reactive microglia and the
formation of Müller glia-derived retinal
progenitors. Chris Zelinka, M. Scott, A. J. Fischer.
Neuroscience, Ohio State University, Columbus,
OH
5584 — B0107 Dicer Loss Leads to Müller
Cell Gliosis in the Mouse Retina. Vijay P.
Sarthy1, V. Dudley1, D. Dalkara2, D. V. Schaffer2,
J. G. Flannery2. 1Ophthal-Feinberg Med Sch,
Northwestern University, Chicago, IL; 2Chemical
and Biomolecular Engineering, The Helen Wills
Neuroscience Institute, University of California
Berkeley, Berkeley, CA
5585 — B0108 A Novel Glial Cell in the
Human Retina. Ellen Miller1, C. Zelinka2, A. J.
Fischer2, C. M. Cebulla1. 1Ophthalmology, Havener
Eye Institute, The Ohio State University Wexner
Medical Center, Columbus, OH; 2Neuroscience, The
Ohio State University, Columbus, OH
5586 — B0109 The Time Course of Gene
Expression during Reactive Gliosis in the Optic
Nerve. Juan Qu, T. C. Jakobs. Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA
5587 — B0110 Retinal Astrocytes in the
Mouse Model of Oxygen-Induced Retinopathy.
Felicitas Bucher, A. Stahl, G. Martin, H. T. Agostini.
University Eye Hospital Freiburg, Freiburg,
Germany
5588 — B0111 Glia alterations in the retina of
a multiple sclerosis animal model. Heiko Schmid1,
L. Horstmann1, F. Kurschus2, A. Waisman2, B. H.
Dick1, S. C. Joachim1. 1Experimental Eye Research
Institute, Knappschaftskrankenhaus Bochum,
Bochum, Germany; 2Institute for Molecular
Medicine, University Medical Center of the
Johannes Guntenberg University, Mainz, Germany
*CR
5589 — B0112 Powerful Beneficial Effects
of Macrophage Colony-stimulating Factor on
Retinal Microglia Proliferation and Vascular
Repair in the Mouse Model of Oxygen-Induced
Retinopathy. Xiaoshuang Jiang, Y. Ni, G. Xu.
Ophthalmology Department, Eye and ENT Hosp of
Fudan University, Shanghai, China
5590 — B0113 Role of Translocator Protein
(TSPO) in the Regulation of Microglial Function
in the Mouse Retina. Minhua Wang1, L. Zhao1, W.
Ma1, R. Fariss2, W. T. Wong1. 1Unit on Neuron-Glia
Interations in Retinal Disease, National Institutes
of Health, National Eye Institute, Bethesda, MD;
2
Biological Imaging Core, National Institutes of
Health, National Eye Institute, Bethesda, MD
5591 — B0114 Microglial response to
nanosecond laser application to the retinal
pigment epithelium. Erica L. Fletcher1, S.
A. Mills1, U. Greferath1, R. H. Guymer2, M.
J. Plunkett3, A. I. Jobling1. 1Dept Anatomy/
Neuroscience, University of Melbourne, Parkville,
VIC, Australia; 2Centre for Eye Research Australia,
The University of Melbourne, Parkville, VIC,
Australia; 3Ellex Pty Ltd, Adelaide, SA, Australia
*CR
5592 — B0115 BMP7 Can Act as a Trigger of
Reactive Gliosis in Muller Glia. Subramanian
Dharmarajan1, N. Sheibani2, T. L. Belecky-Adams1.
1
Dept of Biology, IUPUI, Indianapolis, IN;
2
Ophthalmology and Visual Sciences, University of
Wisconsin, Madison, WI
5593 — B0116 Modulation of Müller
glial-neuronal cell interactions attenuates
photoreceptor damage in a novel transgenic
model of conditional Müller cell ablation.
Weiyong Shen, L. Zhu, S. Lee, S. H. Chung, M. C.
Gillies. Clin Ophthal & Eye Health, University of
Sydney, Sydney, NSW, Australia *CR
5594 — B0117 The change of retinal ganglion
cells and expression of vascular endothelial
growth factor in diabetic rat model. Chankee
Park, J. Kim, H. L. Park. Catholic University of
Korea, Seoul St. Mary’s hospital, Seoul, Republic
of Korea
5595 — B0118 Functional Analysis of Cultured
Astrocytes from the Murine Optic Nerve Head.
Rumi Kawashima, K. Matsushita, S. Usui, K.
Nishida. Osaka University Medical School, Suita,
Japan *CR
5596 — B0119 Retinal glial changes in
Alzheimer’s disease. Malia M. Edwards1, D. S.
McLeod1, R. Gutierrez-Lanza2, J. J. Rodriguez
Arellano2, 3, G. A. Lutty1. 1Wilmer Eye Institute,
Baltimore, MD; 2Department of Neusosciences,
University of the Basque Country UPV/EHU,
Leioa, Spain; 3Department of Neuroscience,
Ikerbasque, Bizkaia, Spain
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
356
Thursday – Posters – 5997 – 5616
5597 — B0120 Quantitative Profiling of RMG
Cell Surface Proteome Changes in Response
to LPS Treatment. Stefanie M. Hauck1, C. von
Toerne1, M. Blindert1, J. Behler1, C. A. Deeg2,
M. Ueffing3, 1. 1Department of Protein Science,
Helmholtz Center Munich, Neuherberg, Germany;
2
Institute of Animal Physiology, Department
for Veterinary Sciences, Faculty of Veterinary
Medicine, LMU Munich, Munich, Germany;
3
Centre of Ophthalmology, University Medical
Centre, Tübingen, Germany
5598 — B0121 Anti-VEGF therapy inhibits
microglial activation and migration in the retina.
Aude Couturier1, 2, E. Bousquet2, M. Zhao2, B.
Goldenberg2, Y. De Kozak2, F. F. Behar-Cohen2, 3.
1
ophthalmology, Hopital Lariboisière, Université
Paris Diderot-Sorbonne Paris Cité, APHP, Paris,
France; 2UMRS 872 Physiopathology of Ocular
Diseases: Therapeutic Innovations, INSERM,
Paris, France; 3Ophthalmology, Hopital Hotel Dieu,
Université Paris Descartes, APHP, Paris, France
*CR
5599 — B0122 The Role of Endoglin in
Retinal Neovascularization. Sandra Suarez2,
J. M. Barnett3, J. S. Penn1, 2. 1Ophthalmology
and Visual Sciences, Vanderbilt Univ Medical
Center, Nashville, TN; 2Cell and Developmental
Biology, Vanderbilt University, Nashville, TN;
3
Pharmacology, Vanderbilt University, Nashville,
TN *CR
5600 — B0123 Investigation of Iba1+/NG2+
cells In the Adult Mouse Retina after IschemiaReperfusion Injury with or without Lycium
barbarum polysaccharide treatment. Qian Feng1,
S. Chung1, K. So1, 2. 1Department of Anatomy, The
University of Hong Kong, Hong Kong, Hong Kong;
2
Laboratory of Neurodegenerative Diseases, The
University of Hong Kong, Hong Kong, Hong Kong
5601 — B0124 Vitreous Levels of Soluble
Vascular Adhesion Protein-1 and Prorenin
in Proliferative Diabetic Retinopathy. Saori
Takashina1, 2, K. Noda1, 2, S. Namba1, 2, R. Ando1, 2,
M. Murata1, 2, C. Yoshizawa2, W. Saito2, A. Kanda1, 2,
S. Ishida1, 2. 1Laboratory of Ocular Cell Biology
and Visual Science, Hokkaido University Graduate
School of Medicine, Sapporo, Japan; 2Department
of Ophthalmology, Hokkaido University Graduate
School of Medicine, Sapporo, Japan
5603 — B0126 The involvement of
apolipoprotein E on intraocular angiogenesis.
Yuhei Hashimoto, S. Nakamura, H. Takizawa,
K. Tsuruma, M. Shimazawa, H. Hara. Gifu
Pharmaceutical University, Gifu, Japan
5606 — B0129 Knocking Down p75NTR
Expression Prevents Retinal Acellular Capillary
Formation In ProNGF-Overexpression Model.
Ahmed Shanab1, 2, B. A. Mysona1, 2, S. Matragoon1, 3,
A. B. El-Remessy1, 2. 1Clinical and Experimental
Therapeutic, University of Georgia, Augusta, GA;
2
Vision Discovery Institute, Georgia Health Science
University, Augusta, GA; 3VA Medical Center,
Charlie Norwood Veterans Affairs Medical Center,
Augusta, GA
5607 — B0130 Angiogenic potency of
endogenous calcitonin gene-related peptide
(CGRP) in mouse model of oxygen-induced
retinopathy. Yuichi Toriyama1, 2, Y. Iesato1, 2,
T. Sakurai2, A. Kamiyoshi2, Y. IchikawaShindo1, 2, T. Shindo2, T. Murata1. 1Department
of Ophthalmology, Shinshu University Graduate
School of Medicine, Matsumoto,Nagano, Japan;
2
Department of Cardiovascular Research,
Shinshu University Graduate School of Medicine,
Matsumoto,Nagano, Japan
5608 — B0131 Involvement of netrin-4 in
oxygen induced neovascularisation. Sabrina
V. Klein1, A. B. Maier1, Y. Liang2, N. Kociok1, M.
Koch3, W. J. Brunken4, O. Strauss1, A. M. Joussen1.
1
Ophthalmology, Charite Universitätsmedizin
Berlin, Berlin, Germany; 2Ophthalmology,
Peking University, Beijing, China; 3Institute for
Biochemistry II, University of Cologne, Cologne,
Germany; 4Department of Ophthalmology and Cell
Biology, SUNY Downstate Medical Center, New
York, NY
5609 — B0132 Annexin V inhibits pathological
retinal angiogenesis but not physiological
retinal vascular development. Satoshi Morooka1,
T. Murakami1, M. Nukada1, 2, N. Yoshimura1.
1
Ophthalmology and Visual Sciences, Kyoto
University, Kyoto, Japan; 2Shiga Medical Center for
Adults, Shiga, Japan *CR
5610 — B0133 Loss of Caveolin-1 Results in
Blood-Retinal Barrier Permeability, Venous
Enlargement and Mural Cell Alteration. Xiaowu
Gu1, 2, S. J. Fliesler3, 4, M. H. Elliott1, 2. 1Oklahoma
Center for Neuroscience, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
2
Department of Ophthalmology, University of
Oklahoma Health Sciences Center, Oklahoma
City, OK; 3Departments of Ophthalmology
and Biochemistry, SUNY/Buffalo & SUNY
Eye Institute, Buffalo, NY; 4Research Service,
VAWNYHS, Buffalo, NY
5611 — B0134 Systemic Inflammatory
Stress Provokes Abnormal Retinal Vascular
Development. Sophie Tremblay1, S. Favret1, F.
Binet1, S. Chaychi2, A. Polosa2, P. Lachapelle2,
S. Chemtob3, P. Sapieha1. 1Vision Health,
HMR Research Center, Montreal, QC, Canada;
2
Ophtalmology Department, McGill UniversityChildren’s Hospital, Montreal, QC, Canada; 3FoetoMaternal Pathologies, CHU Ste-Justine Research
Center, Montreal, QC, Canada
5612 — B0135 Elucidating molecular
mechanisms of blood retina barrier permeability.
Daniel L. Chao1, E. Salero1, Y. Wang1, C. Volmar2, J.
L. Goldberg1. 1Ophthalmology, Bascom Palmer Eye
Inst, Univ of Miami, Coral Gables, FL; 2Psychiatry,
University of Miami, Miami, FL
5613 — B0136 EphA2 Stimulation of
Angiogenesis is Dependent on VEGFR2. Luciana
Ferrara, A. De Erkenez, E. Fassbender, S. Shen,
A. Woolfenden, Y. Qiu, S. H. Poor, K. Anderson, B.
D. Jaffee. Ophthalmology, Novartis Institutes for
Biomedical Research, Cambridge, MA *CR
5614 — B0137 Blockade of transient receptor
potential (TRP) channels inhibits retinal
neovascularization via inhibition of calcium
ion dependent signaling pathway. Hyun Beom
Song1, 2, H. Jun1, J. Kim1, I. Jo3, J. Kim2, 4. 1Fight
against Angiogenesis-Related Blindness (FARB)
Laboratory, Clinical Research Institute, Seoul
National University Hospital, Seoul, Republic of
Korea; 2Department of Biomedical Sciences, Seoul
National University College of Medicine, Seoul,
Republic of Korea; 3Department of Molecular
Medicine and Ewha Medical Research Institute,
Ewha Womans University Medical School, Seoul,
Republic of Korea; 4Department of Ophthalmology,
Seoul National University College of Medicine,
Seoul, Republic of Korea
Exhibit Hall C0001-C0049
Thursday, May 09, 2013 8:30 AM-10:15 AM
Glaucoma
511 Intraocular Pressure
Moderator: Arthur J. Sit
5615 — C0001 Postural change in intraocular
pressure between sitting and lying body positions
- a direct comparison of its measurement with an
unmodified Goldmann applanation tonometer,
Tonopen XL, pneumatonometer, and HA-2
hand-held applanation tonometer. Yaniv Barkana.
1
Ophthalmology, Assaf Harofe Medical Center,
Beer Yaakov, Israel; 2Ophthalmology, Tel Aviv
University, Tel Aviv, Israel *CR
5616 — C0002 A new Tonometer-the Corvis
ST Tonometer Clinical Comparison with
Non-contact, and Goldmann Applanation
Tonometers. Jiaxu Hong, J. Xu, A. Wei, S. X. Deng,
X. Sun. Ophthalmology, Eye & Ear, Nose, Throat
Hospital, Shanghai, China
5604 — B0127 Increased expression of
Adenosine A2B receptor in endothelial precursor
cells contributes to diabetes-induced dysfunction.
Rehae C. Miller, M. B. Grant. Pharmacology and
Therapeutics, University of Florida, Gainesville, FL
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
357
Thursday Posters
8:30 am – 10:15 am
5602 — B0125 Are hypoxia and succinate
mediators of renin-angiotensin system related
vascular injury in the retina? Roksana Armani,
A. Agrotis, J. L. Wilkinson-Berka. Immunology,
Monash University, Melbroune, VIC, Australia *CR
5605 — B0128 Role of Sp1 transcription factor
in the pathogenesis of diabetic retinopathy.
Kelly Donovan, O. Alekseev, J. Azizkhan-Clifford.
Biochemistry and Molecular Biology, Drexel
University College of Medicine, Philadelphia, PA
5617 – 5640 – Thursday – Posters
5617 — C0003 Intraocular pressure
characteristics of subjects with either exfoliation
syndrome or exfoliative glaucoma as determined
with the Water Drinking Test: preliminary
findings. Mehmet C. Mocan1, B. Kasım1, E. Muz1,
M. Orhan1, M. T. Irkec1, D. G. Mikropoulos2,
A. P. Konstas2. 1Department of Ophthalmology,
Hacettepe Univ School of Medicine, Ankara,
Turkey; 21st Department of Ophthalmology, AHEPA
Hospital, Thessaloniki, Greece *CR
5618 — C0004 Investigation of the Effect
of Gonioscopy on Intraocular Pressure.
Ardalan Aminlari, C. Callahan, I. U. Scott, G. C.
Papachristou, J. Olson. Ophthalmology, Penn State
Hershey Eye Center, Hershey, PA
5619 — C0005 Diurnal Non-Clinic-Measured
Intraocular Pressure Profile in Primary AngleClosure Glaucoma Patients. Shaoying Tan, N.
B. Baig, C. C. Tham. Ophthalmology and Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, Hong Kong *CR
5620 — C0006 The Effect of Child Delivery
Process on the Intraocular Pressure in Healthy
Women. Amit Meshi1, S. Armarnik1, H. Kaneti2, F.
Segev1, E. I. Assia1, 3, N. Geffen1. 1Ophthalmology,
Meir Medical Center, Kfar-Saba, Israel; 2Obstetrics
and Gynecology, Meir Medical Center, Kfar-Saba,
Israel; 3Ein-Tal, Tel Aviv, Israel *CR, f
5621 — C0007 Association of Epidural
Steroid Injections(s) with Intraocular Pressure
Elevation. Deepti Saini1, I. U. Scott1, C. Callahan1,
J. Malayil2, J. Gillon1, J. Eckert2. 1Ophthalmology,
Penn State Milton S. Hershey Medical Center,
Hershey, PA; 2Pain Management, Penn State Milton
S. Hershey Medical Center, Hershey, PA
5622 — C0008 Relationship between Central
Corneal Thickness and Intraocular Pressure in
Indigenous Africans in Nigeria. Nwamalubia N.
Nzelu- Egwuonwu. 1Ophthalmology, Mass Medical
Mission, Lagos, Nigeria; 2Ophthalmology, Mass
Medical Mission, Lagos, Nigeria
Thursday Posters
8:30 am – 10:15 am
5623 — C0009 Refined IOP measurement with
rebound tonometry in the rabbit. Hong Zhang1, 2,
D. Yang1, 3, C. Ross1, J. P. Wigg1, S. S. Pandav1.
1
Ophthalmology, Ctr for Eye Resrch Australia,
East Melbourne, VIC, Australia; 2Royal Victorian
Eye and Ear Hospital, Melbourne, VIC, Australia;
3
Harbin Medical University, Harbin, China
5624 — C0010 IOP measurement with I-CARE
Rebound Tonometer, Pneumotonometer and
Tonopen in Sedated Children with Glaucoma
and Controls. Fatemah T. Al-Shamlan1, J. Song1, 2,
D. P. Edward1, 2, I. Al Jadaan1, S. A. Al Shahwan1, J.
Morales1, A. O. Khan1, S. Al-Mesfer1, A. H. Awad1,
S. Al Turkmani1. 1King Khalid Eye Specialist
Hospital, Riyadh, Saudi Arabia; 2Ophthalmology,
Wilmer Eye Institute/Johns Hopkns University,
Baltimore, MD f
5626 — C0012 24-Hour Intraocular Pressure
Rhythm in Young Healthy Subjects Evaluated
With Continuous Monitoring Using Contact
Lens Sensor. Christophe Chiquet1, 2, B. Mottet1, 2,
F. Aptel1, 2, R. Hubanova1, J. Pépin2, J. Romanet1.
1
Department of Ophthalmology, University
Hospital, CHU Grenoble, Grenoble, France; 2Lab
Hypoxia and Physiopathology, INSERM U1042,
Joseph Fourier University, Grenoble, France *CR
5627 — C0013 Randomized Clinical
Investigation to Assess the Efficacy of
SENSIMED Triggerfish® Continuous IOP
Monitoring. Milko E. Iliev1, J. Thygesen2, E.
Vandewalle3, J. Garcia-Feijoo4, S. GarciaDelpech5. 1Ophthalmology, University of Bern,
Bern, Switzerland; 2Ophthalmology, Copenhagen
University Hospital, Glostrup, Denmark;
3
Ophthalmology, University Hospitals Leuven,
Leuven, Belgium; 4Ophthalmology, Instituto
de Investigación Sanitaria HCSC, Universidad
Complutense, Madrid, Spain; 5Ophthalmology,
Hospital Universitario y Politécnico la Fe, Valencia,
Spain *CR, f
5628 — C0014 Single versus Multiple
Measurements for Comparing Group
Intraocular Pressure. Brian Chon1, 2, G. Smits3,
S. C. Lin2, S. Ianchulev2, 3. 1School of Medicine,
Duke University, Durham, NC; 2Department of
Ophthalmology, University of California San
Francisco, San Francisco, CA; 3Transcend Medical,
Menlo Park, CA *CR, f
5629 — C0015 Ocular Hypertension Profile
after Pterygium Excision. Maria Husain, A.
Nguyen, K. Nagi. Ophthalmology, University of
Texas Health Science Center, San Antonio, TX
5630 — C0016 IOP lowing effect of prostanoid
FP and EP3 receptor dual agonist on mouse
eyes. Reiko Yamagishi1, K. Nagai3, S. Yamane3, M.
Aihara2, 1. 1Dept of Ophthalmology Sch of Med,
University of Tokyo, Bunkyo-ku, Japan; 2Shirato
eye clinic, Tokyo, Japan; 3Ono Pharmaceutical Co.,
LTD., Osaka, Japan *CR
5631 — C0017 Sub-chronic IOP lowering
effect of AMA0076 and Y-39983 in Dutch Belted
rabbits. Sarah Van de Velde1, T. Van Bergen1,
D. Sijnave1, K. P. Hollanders1, E. Vandewalle1,
L. K. Moons2, D. Leysen3, I. Stalmans1. 1Lab of
Ophthalmology, KULeuven, Leuven, Belgium;
2
Biology, Zoölogical Institute, KULeuven, Leuven,
Belgium; 3Amakem Therapeutics, Diepenbeek,
Belgium *CR
5632 — C0018 Altered expression of TGFβ1
and MMP-9 results in elevated intraocular
pressure in mice. Anuja Siwakoti1, J. Robertson2,
J. A. West-Mays2. 1Medical Sciences, Mcmaster
University, Hamilton, ON, Canada; 2Pathology
and Molecular Medicine, McMaster University,
Hamilton, ON, Canada
5633 — C0019 Sustained Delivery of
Travoprost from a Biodegradable Hydrogel
Punctum Plug for the Treatment of Glaucoma.
Abbe Miller, C. D. Blizzard, A. S. Sawhney, M.
Bassett, P. Jarrett, A. Driscoll, M. O’Connor,
D. Molla, S. Takach. Ocular Therapeutix, Inc.,
Bedford, MA *CR
5634 — C0020 Assessment of Intervisit IOP
Control in Eyes with Advanced Glaucoma. Priya
Patel, N. Pritz, R. D. Fechtner, A. S. Khouri. New
Jersey Medical School, Newark, NJ
5635 — C0021 Short duration intraocular
pressure patterns detected by a contact lens
sensor for 24-hour recording. Kaweh Mansouri1, 2,
R. N. Weinreb2, R. Goedkoop3, M. Moshtaghi2, S.
Dorairaj4, 2, A. Tafreshi2, J. H. Liu2. 1Glaucoma
sector, Division of Ophthalmology, University
of Geneva, Geneva, Switzerland; 2Department
of Ophthalmology, Hamilton Glaucoma Center,
University of California, San Diego, La Jolla, CA;
3
Sensimed AG, Lausanne, Switzerland; 4Department
of Ophthalmology, Mayo clinic, Jacksonville, FL
*CR, f
5636 — C0022 Intraocular pressure after
phacoemulsification in glaucoma patients.
Karine D. Bojikian1, 2, M. A. Slabaugh1, P. P. Chen1.
1
Ophthalmology, University of Washington, Seattle,
WA; 2Ophthalmology, Universidade Federal de Sao
Paulo, Sao Paulo, Brazil *CR
5637 — C0023 24-hour intraocular pressure
(IOP) fluctuation profile before and after laser
peripheral iridotomy in newly diagnosed subjects
with primary angle closure. Baskaran Mani1, 2,
T. Aung1, 2. 1Singapore Eye Research Institute,
Singapore, Singapore; 2Ophthalmology, Yong Loo
Lin School of Medicine, National University of
Singapore, Singapore, Singapore *CR
5638 — C0024 Effects of Different Sleeping
Postures on Intraocular Pressure and Ocular
Perfusion Pressure in Healthy Young Subjects.
Chungkwon Yoo, T. Lee, Y. Y. Kim. Department
of Ophthalmology, Korea University College of
Medicine, Seoul, Republic of Korea
5639 — C0025 Intraocular pressure and
central corneal thickness in 91,000 patients.
Shilpa Desai1, J. Schallhorn1, S. C. Schallhorn2, Y.
Ou1. 1Ophthalmology, USCF, San Francisco, CA;
2
Optical Express, San Diego, CA *CR
5640 — C0026 Spectral analysis of intraocular
pressure pulse wave for early prediction of
glaucoma. Magdalena Widlicka1, D. Iskander2,
P. Krzyzanowska-Berkowska3, M. A. Kowalska1.
1
Institute of Physics, Wroclaw University of
Technology, Wroclaw, Poland; 2Institute of
Biomedical Engineering and Instrumentation,
Wroclaw University of Technology, Wroclaw,
Poland; 3Department of Ophthalmology, Wroclaw
Medical University, Wroclaw, Poland *CR
5625 — C0011 Twenty-Four-Hour Habitual
Intraocular Pressure in Young, Myopic,
Untreated Open- Angle Glaucoma Patients.
Jeong D. Dawoon, K. S. Michael, L. Kyong Sub,
L. Jong Rak. Ophthalmolgy, Asan Medical Center,
Seoul, Republic of Korea
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
358
Thursday – Posters – 5641 – 5662
5641 — C0027 Intraocular pressure
measured by tonometry and a contact lens
sensor in patients with open angle glaucoma.
Katrin Lorenz1, R. Goedkoop2, M. M. Keilani1,
N. Berssenbruegge1, C. A. Korb1, J. WasielicaPoslednik1, N. Pfeiffer1. 1Department of
Ophthalmology, University Medical Center Mainz,
Mainz, Germany; 2Sensimed AG, Lausanne,
Switzerland *CR, f
5642 — C0028 Characterization of Vav2/3deficient mice with spontaneous IOP elevation.
Keiko Fujikawa1, K. Inoue1, T. Koshiyama2, R.
Yamagishi3, M. Aihara3, 4. 1Hokkaido University
Graduate School of Health Science, Sapporo, Japan;
2
Hokkaido University Graduate School of Medicine,
Sapporo, Japan; 3University of Tokyo Graduate
School of Medicine, Tokyo, Japan; 4Shirato Eye
Clinic, Tokyo, Japan *CR
5649 — C0035 Establishment of the ocular
hypertension model using the common
marmoset. Masamitsu Shimazawa1, S. Nakamura1,
M. Miwa2, K. Tsuruma1, M. Aihara3, K. Nakamura2,
H. Hara1. 1Molecular Pharmacology, Department
of Biofunctional Evaluation, Gifu Pharmaceutical
University, Gifu, Japan; 2Department of Behavioral
and Brain Sciences, Primate Research Institute,
Kyoto University, Inuyama, Japan; 3Department
of Ophthalmology, University of Tokyo School of
Medicine, Tokyo, Japan *CR
5650 — C0036 Intraocular pressure in chronic
users of low-dose oral corticosteroids for
connective tissue disease. Beatriz Gomes1, 2, M.
R. Santhiago1, H. Moraes1. 1Federal University of
Rio de Janeiro, Rio de Janeiro, Brazil; 2Bonsucesso
Federal Hospital, Rio de Janeiro, Brazil
5643 — C0029 First implantation of a
telemetric, intraocular pressure sensor in patients
with glaucoma. Niklas Plange, A. Koutsonas, P.
Walter. Dept of Ophthalmology, RWTH Aachen
University, Aachen, Germany *CR, f
5651 — C0037 Changes in intraocular pressure
measurements and corneal biomechanical
properties in eyes with glaucoma using
prostaglandin analogues. Maria Jose Montero, O.
D. Albis-Donado, J. Jimenez-Roman. Glaucoma,
APEC, mexico city, Mexico
5644 — C0030 Comparison of Rebound
Tonometer Icare-Pro and Goldmann Handheld
Applanation Tonometer in Congenital
Glaucoma. Laura Morales-Fernandez, L. Borrego,
J. M. Martinez de la Casa, F. Saenz-Frances,
J. Garcia-Feijoo. Glaucoma, Hospital Clinico,
Madrid, Spain *CR
5652 — C0038 Effect on intraocular pressure
after intravitreal injection of anti-vascular
endothelial growth factor agents in eyes with
neovascular age related macular degeneration.
Junglim Kim1, J. Lee2. 1busan paik hospital, Busan,
Republic of Korea; 2Yonseiplus eye center, seoul,
Republic of Korea
5645 — C0031 The Effect of the Automated
Visual Field Examination on Intraocular
Pressure (IOP) in Patients with Glaucoma. Sonya
Makhni1, D. Dave1, M. Karl2, J. B. Serle1. 1Mount
Sinai School of Medicine, New York, NY; 2SUNY
Downstate College of Medicine, Brooklyn, NY *CR
5653 — C0039 Intraocular Pressure Changes
by Continous Recording Through Triggerfish
Contact Lens Application in Patients Undergoing
Water Drinking Test: Correlation with
Goldmann Readings in Controlateral Eye. Nicola
Ungaro1, G. Scazzi1, M. Giacosa1, M. Tardini2, G.
Bacchi1, S. A. Gandolfi2. 1Azienda Ospedaliera
Universitaria di Parma, Parma, Italy; 2Università
degli studi di Parma, Parma, Italy *CR
5646 — C0032 Ocular Indications of Partial
Penetrance in Mice Heterozygous for NBCe1
(Slc4a4). Michael F. Romero1, 2, H. L. Holmes1,
U. Roy Chowdhury3, C. R. Hann3, M. Chang1, M.
P. Fautsch3, A. Chen1. 1Physiology & Biomedical
Engineering, Mayo Clinic College of Medicine,
Rochester, MN; 2Nephrology & Hypertension,
Mayo Clinic College of Medicine, Rochester, MN;
3
Ophthalmology, Mayo Clinic College of Medicine,
Rochester, MN
5648 — C0034 The Role Of Ageing In
Experimental Glaucoma. T. H. Khanh Vu1, 2, K.
Cho1, M. M. Jager2, D. F. Chen1. 1Ophthalmology,
Schepens Eye Research Institute, Boston, MA;
2
Ophthalmology, Leiden University Medical Center,
Leiden, Netherlands *CR
5655 — C0041 Are thinner corneas associated
with reduced hystersis? Trupti Patil, R. Sasikumar,
S. A. Devi. Glaucoma, Narayana Nethralaya,
Banglore, India
5656 — C0042 Continuous intraocular
pressure monitoring with a wireless contact lens
and ocular telemetry sensor in patients with
open angle glaucoma: pilot study. Claudia Cortes
Alcocer1, 2, J. Jimenez-Roman1, F. Gil Carrasco1, F.
Del Real2. 1Glaucoma, APEC, Mexico City, Mexico;
2
Universidad La Salle, Mexico City, Mexico
5658 — C0044 24-hour IOP monitoring with
the SENSIMED Triggerfish contact lens: effect
of sleep position and assessment of upward drift.
Laura Beltran-Agullo1, J. Cheng1, Y. M. Buys1, 2,
F. Jahan3, J. G. Flanagan1, 2, C. M. Shapiro3,
1
, N. Hossain3, S. Simon-Zoula4, G. E. Trope1, 2.
1
Ophthalmology, Toronto Western Hospital,
Toronto, ON, Canada; 2University of Toronto,
Toronto, ON, Canada; 3Sleep Research Unit,
Toronto Western Hopsital, Toronto, ON, Canada;
4
Sensimed AG, Lausanne, Switzerland *CR, f
5659 — C0045 The Effect of Intravitreal
Kenolog on Intraocular Pressure in Patients
with Glaucoma. Melanie McQueen, J. Tannir, R.
Momi, B. A. Hughes, A. Goyal, M. S. Juzych, C.
Kim, A. M. Eby, F. Fatima, M. H. Peracha. Kresge
Eye Institute, Wayne State University School of
Medicine, Detroit, MI
5660 — C0046 Comparative Agreement
Among Three Methods of Tonometry: Goldmann
Applanation, Transpalpebral, and Dynamic
Contour. Luis A. Zarate1, M. García-Huerta1,
R. Castañeda1, M. Turati1, F. Gil Carrasco1,
J. Jimenez-Roman1, J. A. Paczka2. 1Glaucoma,
Asociacion Para Evitar la Ceguera en Mexico,
Mexico, Mexico; 2Glaucoma, 3. Asistencia e
Investigacion en Glaucoma, A.C, Guadalajara,
Mexico
5661 — C0047 Hemofiltration impact on
intraocular pressure in patients with end stage
renal disease without any evidence of glaucoma.
Ruth Georgina Navarrete Ortega1, R. Navarrete
Ortega1, H. Perez Grovas1, 2. 1Glaucoma, Hospital
Nuestra Señora De La Luz, México, City, Mexico;
2
Nefrology, Instituto Nacional De Cardiologia
“Ignacio Chavez”, México, City, Mexico f
5662 — C0048 Central Corneal Thickness and
IOP Response to Topical Ocular Hypotensive
Medication in the Low-pressure Glaucoma
Treatment Study. Christopher C. Teng1, 2, G. De
Moraes1, 2, J. M. Liebmann2, D. S. Greenfield3, R.
Ritch1, 4, T. Krupin5, 6. 1Ophthalmology, Einhorn
Clinical Research Center, New York Eye & Ear
Infirmary, New York, NY; 2Ophthalmology,
NYU School of Medicine, New York, NY;
3
Ophthalmology, Bascom Palmer Eye Institute,
Palm Beach Gardens, FL; 4Ophthalmology,
New York Medical College, Valhalla, NY;
5
Ophthalmology, Feinberg School of Medicine,
Northwestern University, Chicago, IL; 6The
Chicago Center for Vision Research, Chicago, IL
*CR, f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
359
Thursday Posters
8:30 am – 10:15 am
5647 — C0033 Microbead Occlusion Model
of Glaucoma in Non-Human Primates. Wendi S.
Lambert, B. J. Carlson, D. J. Calkins. Vanderbilt
Eye Institute, Vanderbilt University Med Center,
Nashville, TN *CR
5654 — C0040 Comparison of the Cellular
Response to Overnight Contact Lens Wear on
the Sclera and Cornea. John G. Flanagan1, 2, A. D.
Stavropoulos1, 5, D. Luensmann2, 3, C. K. Postnikoff4,
M. Gorbet4, 3. 1Dept of Ophthal & Vision Sci, Univ
of Toronto,Toronto Western Hosp, Toronto, ON,
Canada; 2School of Optometry and Vision Science,
Univeristy of Waterloo, Waterloo, ON, Canada;
3
Centre for Contact Lens Research, Univeristy of
Waterloo, Waterloo, ON, Canada; 4Systems Design
Engineering, Univeristy of Waterloo, Waterloo, ON,
Canada; 5Institute of Medical Sciences, Univeristy
of Toronto, Toronto, ON, Canada *CR
5657 — C0043 Development of an implantable
system for measuring intraocular pressure
in rats. Christopher L. Passaglia1, S. Bello2,
R. T. Tzekov3, 4, S. S. Malavade3. 1Chemical and
Biomedical Engineering, University of South
Florida, Tampa, FL; 2Electrical Engineering,
University of South Florida, Tampa, FL;
3
Ophthalmology, University of South Florida,
Tampa, FL; 4Roskamp Institute, Sarasota, FL *CR
5663 – 5685 – Thursday – Posters
5663 — C0049 Comparison of Intraocular
Pressure Measurements Using a Tono-Pen with
Ocufilm + Cover Versus Examination Glove
Fingertip Cover. Daniel Apple, B. Markowitz.
Ophthalmology, University of South Carolina
School of Medicine, Columbia, SC
5670 — C0141 Inter-ocular Difference of Axial
Lengths in Children with Unilateral Congenital
and Developmental Cataracts. Kathryn M. Haider,
J. Wang, D. C. Mitchell, H. A. Smith, H. A. Smith,
G. Roberts, D. Sprunger, D. E. Neely, D. Plager.
Ophthalmology, Indiana University, Indianapolis,
IN *CR
5677 — C0148 A comparison of non-cycloplegic
and cycloplegic autorefraction using Spot™
(PediaVision LLC, Pompano Beach, FL) to
manual cycloplegic retinoscopy in a pediatric
population. Adil Bhatti, R. Abo-Shasha, R. Munger,
M. O’Connor. Ophthalmology, University of
Ottawa, Ottawa, ON, Canada
Exhibit Hall C0135-C0163
5671 — C0142 Ophthalmic abnormalities
in children with Developmental Coordination
Disorder: Data from the Avon Longitudinal
Study of Parents and Children. Alex Creavin1, 2, R.
Lingam1, K. Northstone1, C. Williams1. 1School of
social and community medicine, Bristol University,
Bristol, United Kingdom; 2Ophthalmology,
Cheltenham general hospital, Cheltenham, United
Kingdom
5678 — C0149 Statistical evaluation in
pediatric patients of Lang I stereo-test for the
diagnosis of microesotropia in daily practice.
Davide Allegrini1, M. Spera2, L. M. Rossetti1, L.
Ottobelli1, A. C. Piantanida2. 1Eye Clinic, San Paolo
Hospital, Milano, Italy; 2Eye Center, C.O.L. Centro
Oculistico Lariano, Cernobbio (Como), Italy
Thursday, May 09, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
512 Pediatric Epidemiology
Moderators: Marjean T. Kulp and
Mark A. Bullimore
5664 — C0135 The Prevalence of Infantile
Esotropia in Children of Chinese Descent.
Maria del Pilar Gonzalez Diaz, A. M. Wong.
Ophthalmology and Visual Sciences, University of
Toronto - The Hospital for Sick Children, Toronto,
ON, ON, Canada
5665 — C0136 Chronic anterior uveitis in
paediatric patients. Cristobal A. Couto, M. Frick,
B. A. Schlaen, E. Hurtado Jallaza, M. Lopez.
Ophthalmology, University of Buenos Aires,
Buenos Aires, Argentina
Thursday Posters
8:30 am – 10:15 am
5666 — C0137 Pediatric Idiopathic Orbital
Inflammation. Jordan Spindle1, M. Pellegrini2, T.
R. Shepler3, B. Esmaeli4, E. Wladis5, E. Piozzi6, C.
L. Shields2, R. Shinder1, 4. 1Ophthalmology, SUNY
Downstate Ophthalmology, Brooklyn, NY; 2Ocular
Oncology, Wills Eye Institute, Philadelphia, PA;
3
Texas Oculoplastic Consultants, Austin, TX;
4
University of Texas MD Anderson Cancer Center,
Houston, TX; 5Opthalmology, Albany Medical
College, Albany, NY; 6A. O. Ospedale Niguarda Ca’
Granda, Milan, Italy
5667 — C0138 Risk Factors for Amblyopia in
the Vision in Preschoolers (VIP) Study. Maisie R.
Pascual1, J. Huang2, M. G. Maguire2, M. T. Kulp3,
G. E. Quinn4, E. Ciner5, L. A. Cyert6, D. A. OrelBixler7, B. Moore8, G. Ying2. 1Drexel University
College of Medicine, Philadelphia, PA; 2University
of Pennsylvania, Philadelphia, PA; 3Ohio State
University, Columbus, OH; 4Children’s Hospital of
Philadelphia, Philadelphia, PA; 5Salus University,
Elkins Park, PA; 6Northeastern State University,
Tahlequah, OK; 7University of California, Berkeley,
Berkeley, CA; 8New England College of Optometry,
Boston, MA *CR
5668 — C0139 Refractive error and amblyopia
in a school-children population of Central Italy.
Paolo Trabucco1, M. Salomone1, I. Domanico1,
E. gerace2, C. Carnevale2, E. M. Vingolo1.
1
Ophthalmology, Univ of Rome La Sapienza Osp “S
M Goretti” LT, Latina, Italy; 2Ophthalmology, Univ
of Rome La Sapienza, Rome, Italy
5669 — C0140 Efficacy and Safety of Ahmed
Glaucoma Valve Implantation for Pediatric
Glaucoma. Maria E. Lim, D. E. Neely, K. M.
Haider, D. Plager. Indiana University School of
Medicine, Indianapolis, IN
5672 — C0143 IOLunder2 study: outcomes
following surgery with and without primary
intraocular lens implantation in children <2years
old. Lola A. Solebo1, 2, I. Russell-Eggitt2, 3, J. S.
Rahi2, 4. 1MRC Centre Epidemiology (Child Health),
Institute Child Health, UCL, London, United
Kingdom; 2Ulverscroft Vision Research Group,
London, United Kingdom; 3Clinical and Academic
Department of Ophthalmology, Great Ormond
Street Hospital, London, United Kingdom; 4Institute
of Ophthalmology, UCL, London, United Kingdom
5673 — C0144 Clinical testing of a new
objective binocular refraction device. Lei Shi1,
Y. Chen1, J. W. Lewis2, M. X. Wang3. 1Center for
Laser Applications, University of Tennessee Space
Inst, Tullahoma, TN; 2E-Vision Technologies,
Tullahoma, TN; 3Wang Vision Institute, Nashville,
TN *CR
5674 — C0145 Ophthalmological long-term
follow-up in children and young adults with
Kearns-Sayre Syndrome. Marita A. Gronlund1,
A. K. Seyedi Honarvar1, N. Darin2, M. Tulinius2,
S. Andersson1. 1Pediatric Ophthalmology, Inst
Neurosci & Phys/Ophthal, Goteborg, Sweden;
2
Dept of Peadiatrics, The Queen Silvia Children’s
Hospital, The Sahlgrenska Academy at the
University of Gothenburg, Gothenburg, Sweden
5675 — C0146 How should we assess reliability
of visual field assessment in children? Dipesh
Patel1, 3, P. Cumberland1, 2, I. Russell-Eggitt4, 2,
B. Walters4, 2, J. S. Rahi1, 5. 1MRC Centre of
Epidemiology for Child Health, UCL Institute
of Child Health, London, United Kingdom;
2
Ulverscroft Vision Research Group, London,
United Kingdom; 3Moorfields Eye Hospital,
London, United Kingdom; 4Great Ormond Street
Hospital, London, United Kingdom; 5UCL Institute
of Ophthalmology, London, United Kingdom
5676 — C0147 Intraocular Pressure and
Traumatic Hyphema in Children. Jeffrey
SooHoo1, E. A. McCourt1, 2. 1Ophthalmology,
University of Colorado Denver, Aurora, CO;
2
Ophthalmology, Children’s Hospital Colorado,
Aurora, CO
5679 — C0150 Demographic Trends in
Pediatric Cataract Surgery at a Tertiary
Referral Center. Monica L. Bratton1, A. Lam2, D.
Weakley1, S. Wang1. 1Department of Ophthalmology,
University of Texas Southwestern, Dallas, TX;
2
University of Texas Southwestern Medical School,
Dallas, TX
5680 — C0151 Relation between grade and
gender and reasons for spectacle non-compliance
among school aged children. Mabel Crescioni1,
J. D. Twelker1, 2, J. M. Miller1, 2, T. K. Green1, I.
Campus1, E. M. Harvey1, 2. 1Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
Public Health, University of Arizona, Tucson, AZ
5681 — C0152 Pilot testing of a multifunctional device for pediatric vision screening
application. Ying-Ling Chen1, L. Shi1, J. W. Lewis2,
M. X. Wang3. 1Center for Laser Applications, Univ
of Tennessee Space Inst, Tullahoma, TN; 2E-Vision
Technologies, Inc, Tullahoma, TN; 3Wang Vision
Institute, Nashville, TN *CR
5682 — C0153 Ophthalmologic correlates of
disease severity in Wolfram Syndrome. Smith
Ann Chisholm1, 2, J. Hoekel2, T. Hershey3, 4, L.
Tychsen1, 2. 1Ophthalmology, Washington University
in St. Louis, Saint Louis, MO; 2Ophthalmology,
Saint Louis Children’s Hospital, Saint Louis,
MO; 3Neurology, Washington University in St.
Louis, Saint Louis, MO; 4Radiology, Washington
University in St. Louis, Saint Louis, MO
5683 — C0154 Detecting Tumor Progression
in Optic Pathway Glioma. John P. Kelly, A. H.
Weiss. Ophthalmology W-4743, Seattle Children’s
Hospital, Seattle, WA
5684 — C0155 Down Syndrome and
Accommodation: The Added Advantage of
Bifocals. Brinda Muthusamy, R. Adyanthaya, S.
Isenor, K. Irsch, K. Klein, D. L. Guyton. Pediatric
Ophthalmology & Adult Strabismus, The Wilmer
Eye Institute, Johns Hopkins Hospital, Baltimore,
MD *CR
5685 — C0156 Retrospective Review of
Refractive Error in Two Age Groups of Hispanic
and African American Children Seen in a
Chicago Vision Clinic. Sandra S. Block, M. A.
Suckow, K. O’Leary, V. Conrad. School-Based
Vision Clinic, Illinois College of Optometry,
Chicago, IL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
360
Thursday – Posters – 5686 – 5705
5686 — C0157 Development and validation of
a novel functional vision instrument for children
and young people with visual impairment. Val
Tadic1, A. Cooper2, G. Lewando Hundt3, J. S.
Rahi1, 4. 1MRC Centre of Epidemiology for Child
Health, UCL Institute of Child Health, London,
United Kingdom; 2Psychology Department,
Goldsmiths, University of London, London, United
Kingdom; 3School of Health and Social Studies,
University of Warwick, London, United Kingdom;
4
UCL Institute of Ophthalmology, London, United
Kingdom
5687 — C0158 A novel measure of visual
function and vision related quality of life for
childhood uveitis. Sheila Angeles-Han1, 2, S. Yeh1, 3,
C. McCracken1, L. Vogler1, 2, K. Rouster-Stevens1, 2,
C. Kennedy2, S. R. Lambert1, 3, K. Jenkins2, S.
Prahalad1, 2, C. Drews-Botsch4. 1Pediatrics, Emory
University, Atlanta, GA; 2Children’s Healthcare
of Atlanta, Atlanta, GA; 3Ophthalmology, Emory
University, Atlanta, GA; 4Rollins School of Public
Health, Emory University, Atlanta, GA *CR
5688 — C0159 Effects of Lighting on Test
Performance on the Odom-Robin Visual
Efficiency Near Vision Chart in a School
Aged Population. Robin B. Mumford1, S. Silva2,
E. Stoddard2, J. V. Odom3. 1Mumford Institute,
Highlands, NJ; 2After-School All- Stars of NY
CampUs, New York, NY; 3WVU Eye Institute,
Morgantown, WV *CR
5689 — C0160 Prevalence of Anisocoria and
Association Between Age and Pupil Size in
Children. Jillian Silbert1, N. S. Matta1, J. Tian2,
E. Singman2, D. I. Silbert1. 1Vision Research
Department, Family Eye Group, Lancaster, PA;
2
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD *CR
5690 — C0161 Mutation analysis in patients
suspected to have PAX6-related ocular
malformations. Daniel Gratie, E. M. Stone, J.
East, R. F. Mullins, A. V. Drack. Ophthalmology,
University of Iowa, Iowa City, IA *CR
5692 — C0163 Quality Improvement in
the Ophthalmic Care of Patients with Down
Syndrome through a Comprehensive, CenterBased Model. Daniel Hammer, S. M. Culican.
Washington University in Saint Louis, Saint Louis,
MO
Thursday, May 09, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
513 Myopia, CL
Moderators: Jane E. Gwiazda and
Donald O. Mutti
5693 — C0164 Predicting the onset of myopia:
a retrospective study. Bjorn Drobe1, R. de SaintAndré2, 3. 1R&D Singapore, Essilor International,
Singapore, Singapore; 2Sarl Roger de Saint-André,
Gaillac, France; 3Centre d’Optométrie, Université
Paris-Sud (Paris 11), Faculté des Sciences d’Orsay,
Les Ulis, France *CR
5694 — C0165 A genome-wide association
study for simple myopia and hyperopia in Twin
Eye Study population. Li Deng. Vision Science,
New England College of Optometry, Boston, MA
5695 — C0166 Heritability of Myopia and
Ocular Biometrics in Koreans: The Healthy
Twin Study. Tae-Young Chung, D. Lim, M. Kim,
M. Lee, E. Chung. Samsung Medical Center, Seoul,
Republic of Korea
5696 — C0167 Larger refractive group
differences in visual activities are found in
children than in young adults. Kara E. Gerger,
J. E. Gwiazda. The New England Coll of Optom,
Boston, MA
5697 — C0168 Refractive Errors and Ocular
Biometry in Singapore Adults: The Singapore
Epidemiology of Eye Disease (SEED) Study. Gus
Gazzard1, 2, C. Pan3, Y. Zheng4, 5, A. R. Anuar4, P.
Mitchell6, T. Aung5, 4, C. Cheng4, 3, T. Y. Wong4, 3, S.
Saw3, 4. 1Institute of Ophthalmology, UCL, London,
United Kingdom; 2NIHR Biomedical Research
Centre, London, United Kingdom; 3Saw Swee Hock
School of Public Health, Singapore, Singapore;
4
SERI, Singapore Eye Research Institute,
Singapore, Singapore; 5SNEC, Singapore National
Eye Centre, Singapore, Singapore; 6University of
Sydney, Sydney, NSW, Australia *CR
5698 — C0169 Outdoor activity exhibit
protective effect for myopia in children having
a moderate near workload. Yuanbo Liang1, 2, Z.
Lin3, 2, B. Vasudevan4, V. Jhanji2, T. Gao5, N. Wang3,
K. J. Ciuffreda6. 1Clinical Research Center, The
Joint Shantou International Eye Center (JSIEC)
of Shantou, Shantou, China; 2Department of
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China;
3
Beijing Tongren Eye Center, Beijing Tongren
Hospital, Beijing, China; 4College of Optometry,
Mid Western University, Glendale, AZ; 5Handan
Eye Hospital, Handan, China; 6Department of
Biological and Vision Sciences, SUNY College of
Optometry, New York, NY
5699 — C0170 The effect of light intensity
and accommodation on short-term axial length
changes in myopes and emmetropes. Emma
Chu, J. E. Gwiazda. Vision Science, New England
College of Optometry, Boston, MA
5700 — C0171 International educational
performance and myopia - a role for cram
schools? Ian G. Morgan1, K. A. Rose2. 1Research
School of Biology, Australian National University,
Canberra, ACT, Australia; 2Discipline of Orthoptics,
University of Sydney, Sydney, NSW, Australia
5701 — C0172 Age of Spectacle Wear as a
proxy for myopia severity in genetic studies.
Katie M. Williams1, P. G. Hysi1, A. Nag1, E. Yonova1,
C. Venturini1, 2, C. J. Hammond1. 1Departments of
Ophthalmology and Twin Research, King’s College
London, London, United Kingdom; 2Institute
of Ophthalmology, University College London,
London, United Kingdom
5702 — C0173 Prevalence of myopia at age 6
in a Dutch Birth Cohort Study: The Generation
R Study. Jan Roelof Polling1, 2, R. Gaillard3,
A. Hofman4, V. Jaddoe3, J. R. Vingerling1, 4, C.
C. Klaver1, 4. 1Ophthalmology, Erasmus MC,
Rotterdam, Netherlands; 2Orthoptics & Optomery,
University of Applied Sciences, Utrecht,
Netherlands; 3Generation R Study Group, Erasmus
MC, Rotterdam, Netherlands; 4Epidemiology,
Erasmus MC, Rotterdam, Netherlands *CR
5703 — C0174 Peripheral Refraction in a
Population of Schoolage Children in Central
China: the Anyang Childhood Eye Study. ShiMing Li1, S. Li1, N. Wang1, P. Mitchell2. 1Beijing
Tongren Eye Center, Beijing Tongren Hospital,
Beijing, China; 2Centre for Vision Research,
Department of Ophthalmology and Westmead
Millennium Institute, University of Sydney, Sydney,
ACT, Australia *CR
5704 — C0175 Scleral Encircling Acceleration
or Deceleration of Myopic Progression in Myopic
Eyes. Changho Kim, S. Kim. Ophthalmology,
Severance hospital, Yonsei Univ College of
Medicine, Seoul, Republic of Korea
5705 — C0176 Curry consumption and high
myopia in adults: A possible protective effect.
Ainur R. Anuar2, 1, Y. Zheng1, 3, L. Huang1, B.
Mani1, C. Y. Cheung1, C. Cheng1, M. Chew1, J. S.
Mehta1, 5, T. Y. Wong1, 4, T. Aung1, 4. 1Epidemiology,
Singapore Eye Research Institute, Singapore,
Singapore; 2Ophthalmology, Faculty of Medicine,
University of Malaya, Kuala Lumpur, Malaysia;
3
State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Guangzhou,
China; 4Department of Ophthalmology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Yong Loo Lin School
of Medicine, National University of Singapore,
Singapore, Singapore; 5Duke-NUS Graduate
Medical School of Medicine, National University of
Singapore, Singapore, Singapore *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
361
Thursday Posters
8:30 am – 10:15 am
5691 — C0162 Risk Factors of Astigmatism
in the Vision in Preschoolers (VIP) Study.
Jiayan Huang1, G. Ying1, M. G. Maguire1, G.
E. Quinn2, M. T. Kulp3, E. Ciner4, L. A. Cyert5,
D. A. Orel-Bixler6, B. Moore7. 1University of
Pennsylvania, Philadelphia, PA; 2Children’s
Hospital of Philadelphia, Philadelphia, PA; 3Ohio
State University, Columbus, OH; 4Salus University,
Elkins Park, PA; 5Northeastern State University,
Tahlequah, OK; 6University of California, Berkeley,
CA; 7New England College of Optometry, Boston,
MA *CR
Exhibit Hall C0164-C0189
5706 – 5727 – Thursday – Posters
5706 — C0177 Comparison of Cycloplegic
refraction between Retinoscopy, Closed field
and Open field autorefraction in Pseudomyopia.
Jameel Rizwana Hussaindeen, K. Ramani. Elite
School of Optometry, Sankara Nethralaya, Unit of
Medical Research Foundation, Chennai, India
5707 — C0178 Eye shape and peripheral
refraction as predictors of myopia progression in
a population of Chinese children. David Troilo1,
L. Jiang2, A. Benavente-Perez1, X. Zhou2, F. Lu2, J.
Qu2. 1SUNY College of Optometry, New York, NY;
2
Wenzhou Medical College, Wenzhou, China
5708 — C0179 Three-Dimensional Modeling
of Highly Myopic Human Eyes Using Optical
Coherence Tomography Imaging. Yumiko AkagiKurashige, K. Yamashiro, M. Miyake, A. Oishi, A.
Tsujikawa, M. Hangai, N. Yoshimura. Department
of Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto,
Japan *CR
5709 — C0180 Biometric characteristics
of the Marfan eye: From the Marfan Eye
Consortium of Chicago. Sarah Wehrli2, 1, M.
Mets1, 2, I. S. Kassem3, 1, A. A. Fawzi2, 1, N. F. Azar3, 1,
I. H. Maumenee3, 1. 1Lurie Children’s Hospital of
Chicago, Chicago, IL; 2Northwestern, Chicago, IL;
3
UIC, Chicago, IL
5710 — C0181 Implementation of atropine
treatment for progressive myopia in children.
Ruben Kok1, J. Polling1, 2, C. C. Klaver1, 3.
1
Ophthalmology, Erasmus MC Rotterdam, the
Netherlands, Rotterdam, Netherlands; 2Optometry
& Orthoptics, University of Applied Sciences,
Utrecht, Netherlands; 3Epidemiology, Erasmus
Medical Center, Rotterdam, Netherlands *CR
Thursday Posters
8:30 am – 10:15 am
5711 — C0182 The Economic Cost of
Myopia in Singapore. Seang-Mei Saw1, 2, Y.
Zheng2, J. Chay3, C. Pan1, E. L. Lamoureux2, 3,
E. A. Finkelstein3, 1, T. Y. Wong2, 4. 1Saw Swee
Hock School of Public Health, National Univ
of Singapore, Singapore, Singapore; 2Singapore
Eye Research Institute, Singapore Eye Research
Institute, Singapore, Singapore; 3HSSR, DukeNUS Graduate Medical School, Singapore,
Singapore; 4Ophthalmology, National University
Health System, National University of Singapore,
Singapore, Singapore *CR
5712 — C0183 Correlation in Myopia
Progression between right and left eyes in
Chinese children with Myopia. Padmaja
Sankaridurg1, 2, B. A. Holden1, 3, X. Chen4, 2, A. Ho1, 3,
L. Li4, 2, L. Donovan1, 2, J. Ge4. 1Optometry, Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
Research, Vision Cooperative Research Centre,
Sydney, NSW, Australia; 3School of Optometry and
Vision Science, University of New South Wales,
Sydney, NSW, Australia; 4State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Centre,
Guangzhou, China *CR, f
5713 — C0184 Prevalence of myopia in
Chinese urban and rural children. Mingzhi
Zhang. Ophthalmology, Joint Shantou International
Eye Center, Shantou, China
5714 — C0185 Refractive Errors and AgeRelated Macular Degeneration: A Systematic
Review and Meta-Analysis. Chen Wei Pan1,
M. K. Ikram2, 3, C. Y. Cheung2, 3, G. C. Cheung2,
3
, J. B. Jonas4, T. Y. Wong2, 3, S. Saw1, 2. 1Saw
Swee Hock School of Public Health, National
University of Singapore, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3Ophthalmology, National University of
Singapore, Singapore, Singapore; 4Ophthalmology,
Medical Faculty Mannheim of the Ruprecht-KarlsUniversity Heidelberg, Mannheim, Germany *CR
5721 — C0192 The global burden of visual
difficulty. Fawzia Djafari1, 2, S. Haddad3, M.
Aubin1, 2, M. Roy-Gagnon1, C. Vela1, E. E.
Freeman1, 2. 1Maisonneuve-Rosemont hospital,
Montréal, QC, Canada; 2Ophthalmology, Université
de Montréal, Montreal, QC, Canada; 3Centre de
Recherche, Centre Hospitalier de l’Université de
Montréal, Montreal, QC, Canada
5715 — C0186 Longitudinal anterior globe
width growth depends on refractive error.
Melissa D. Bailey, N. G. Satiani, L. T. Sinnott.
Optometry, Ohio State University, Columbus, OH
5722 — C0193 Improving Visual Prognosis
of Glaucoma Patients during 30 Years based
on the Data of the Finnish Register of Visual
Impairment. Hannu M. Uusitalo1, 2, A. Siitonen1,
M. Ojamo2. 1Department of Ophthalmology, SILK,
University of Tampere, Tampere, Finland; 2Finnish
Register of Visual Impairment, THL, Helsinki,
Finland
5716 — C0187 Macular Thickness in Myopic
and Mon-myopic Young Adults. Leslie Hyman1,
J. E. Gwiazda2, E. Harb2, W. L. Marsh-Tootle3.
1
Preventive Medicine, Stony Brook Medicine,
Stony Brook, NY; 2New England College of
Optometry, Boston, MA; 3UAB College of
Optometry, University of Alabama at Birmingham,
Birmingham, AL
5723 — C0194 A New Computerized
Autoacuity Test for Assessment of the Visual
Acuity of Pre-school Children. Mingxing
Wu1, Y. Qin1, L. Liu1, S. Ye1, M. Fu3, Z. Liu1, Y.
Tsau2. 1Cataract, Zhongshan Ophthalmic Center,
Guangzhou, China; 2Dimetek Digital Medical
Technologies, Limited, Shenzhen, China; 3Shenzhen
Children and Women Hospital, Shenzhen, China
5717 — C0188 Vitamin D receptor gene
polymorphisms and the risk of myopia. Jeremy
A. Guggenheim1, K. Northstone2, G. McMahon2,
B. St Pourcain2, C. Williams2. 1Centre for Myopia
Research, Hong Kong Polytechnic University,
Kowloon, Hong Kong; 2School of Social and
Community Medicine, University of Bristol,
Bristol, United Kingdom
5724 — C0195 Longitudinal Relationships
between Visual Acuity and Depressive
Symptoms: the Salisbury Eye Evaluation Study.
Dandan D. Zheng1, S. L. Christ2, S. K. West3, B. E.
Munoz3, B. K. Swenor3, B. L. Lam4, D. J. Lee1, 4.
1
Epidemiology & Public Health, University of
Miami, Miami, FL; 2Human Development and
Family Studies, Purdue University, West Lafayette,
FL; 3Dana Center for Preventive Ophthalmology,
Wilmer Eye Institute, The Johns Hopkins University
School of Medicine, Baltimore, FL; 4Bascom
Palmer Eye Institute, University of Miami, Miami,
FL
5718 — C0189 What is the ‘real’ baseline
for the rate of progress of myopia for a
child?The rate of progress of myopia with and
without spectacle vision correction. Li Li2, 1, P.
Sankaridurg1, T. J. Naduvilath1, X. Chen2, Z. Lin2, B.
A. Holden1. 1Brien Holden Vision Institute, Sydney,
NSW, Australia; 2Zhongshan Ophthalmic Center,
Guangzhou, China *CR, f
Exhibit Hall C0190-C0200
Thursday, May 09, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
514 Vision Impairment
Moderators: Priya M. Mathews and Tunde Peto
5719 — C0190 The utility of routine testing
for tuberculosis in a county-hospital uveitis
population. An analysis of predictive values.
Bryan K. Hong, S. R. Bababeygy, H. Nazari
Khanamiri, N. A. Rao. Ophthalmology, Doheny Eye
Institute, LAC & USC, Los Angeles, CA
5720 — C0191 Correlation of Ophthalmic
Screening Tests in an American Indian/Alaskan
Native Cohort. Laura J. Kopplin1, D. Choi3, S. L.
Mansberger2. 1Casey Eye Institute, Portland, OR;
2
Devers Eye Institute, Portland, OR; 3Public Health
& Preventive Medicine, Oregon Health and Science
University, Portland, OR *CR
5725 — C0196 The Vision In Stroke (VIS)
study: Profile of visual impairment following
stroke. Fiona J. Rowe. Orthoptics and Vision
Science, University of Liverpool - Sydney Jones
Library, Liverpool, United Kingdom
5726 — C0197 Vision Impairment and Eye
Care Utilization Among Older Adults Residing
in Assisted Living. Amanda Elliott1, G. McGwin2, 3,
C. Owsley2. 1Nursing, University of South Florida,
Tampa, FL; 2Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL; 3Epidemiology,
University of Alabama at Birmingham,
Birmingham, AL *CR
5727 — C0198 Refractive Error And Cause Of
Vision Impairment Among Children In A Low
Vision Service. Dawn K. DeCarlo1, G. McGwin1, 2,
E. L. Forte1, L. Gao1, C. Owsley1. 1Ophthalmology,
Univ of Alabama at Birmingham, Birmingham,
AL; 2Epidemiology, University of Alabama at
Birmingham, Birmingham, AL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
362
Thursday – Posters – 5728 – 5749
5728 — C0199 Estimation of design effect,
sample size and number of clusters needed for
trachoma prevalence surveys. Beatriz E. Munoz1,
J. King2, J. M. Ngondi3, P. Emerson2, S. K. West1.
1
Ophthalmology, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD; 2Carter Center, Atlanta, GA;
3
Public Health and Primary Care, Institute of Public
Health, University of Cambridge, Cambrige, United
Kingdom
5729 — C0200 Visual Acuity and Associated
Risk Factors in indigenous and non-indigenous
Mexican population. Jesus Arrieta-Camacho,
E. O. Graue-Hernández, A. J. Ramirez-Miranda,
A. Jimenez-Corona. Anterior Segment, Inst de
Oftalmologia CONVAL, Mexico City, Mexico *CR
Exhibit Hall C0201-C0224
Thursday, May 09, 2013 8:30 AM-10:15 AM
Lens
515 Chemical Composition and
Physical Properties
Moderator: Ales Cvekl
5730 — C0201 The viscosity of the lens. Mai T.
Thao1, D. S. Perez1, J. P. Dillon1, E. R. Gaillard1, 2.
1
Chemistry and Biochemistry, Northern Illinois
University, Dekalb, IL; 2Biology, Northern Illinois
University, Dekalb, IL
5731 — C0202 Resting Potential of Rat
Crystalline Lens. Sebastiao Cronemberger1, V. V.
Oliveira2, R. Fleming2, N. S. Calixto1, A. Dantas2.
1
Ophthalmology, Federal University of Minas
Gerais, Belo Horizonte, Brazil; 2Ophthalmology,
Federal University of Rio de Janeiro, Rio de
Janeiro, Brazil
5732 — C0203 Conformational characteristics
of proteins and lipids in transparent human
lenses and lenses with cortical opacities - A
Raman spectroscopic study. Ralph Michael1,
C. Otto2, A. Lenferink2, G. A. Montenegro1, R. I.
Barraquer1, G. Vrensen3. 1Institut Universitari
Barraquer, Barcelona, Spain; 2Medical Cell
Bio Physics, University of Twente, Enschede,
Netherlands; 3Leiden University Medical Center,
University of Leiden, Leiden, Netherlands
5735 — C0206 The Spectrin-Actin Network
and Beaded Filaments Cooperate to Assemble
Large Gap Junction Plaques, Facilitating
Normal Ion Homeostasis in Mouse Lens
Fiber Cells. Velia M. Fowler1, R. B. Nowak1, J.
Gao2, R. T. Mathias2, S. K. Biswas3, W. Lo3. 1Cell
Biology, Scripps Research Institute, La Jolla, CA;
2
Physiology and Biophysics, State University
of New York at Stonybrook, Stony Brook, NY;
3
Neurobiology, Morehouse School of Medicine,
Atlanta, GA
5736 — C0207 Filensin and CP49 expression
are not restricted to lens fiber cells. Paul G.
FitzGerald1, R. A. Quinlan2. 1Cell Biol & Human
Anatomy, Univ of California, Davis, Davis, CA;
2
Biophysical Sciences Institute, Durham University,
Durham, United Kingdom
5737 — C0208 A Putative glutathione
transporter identified in mouse lens with
glutathione de novo synthesis deficiency
(LEGSKO) is also elevated in aged human lens.
Xingjun Fan. Pathology, Case Western Reserve
Univ, Cleveland, OH
5738 — C0209 Metabolite and lipid mapping
in normal and functionally perturbed ocular lens
by MALDI imaging mass spectrometry. Angus
C. Grey1, M. G. Nye-Wood1, J. M. Spraggins3, R.
M. Caprioli4, 3, K. L. Schey4, 3, P. J. Donaldson2.
1
Optometry and Vision Science, University of
Auckland, Auckland, New Zealand; 2School
of Medical Sciences, University of Auckland,
Auckland, New Zealand; 3Mass Spectrometry
Research Center, Vanderbilt University, Nashville,
TN; 4Biochemistry, Vanderbilt University,
Nashville, TN
5739 — C0210 Discovery of key proteins
involved in Parkinson’s disease and Alzheimer’s
disease in human eyes. Chunmei He1, J. Zhang2, 1,
T. T. Shen1. 1Ophthalmology, University of
Washington, Seattle, WA; 2Pathology, University of
Washington, Seattle, WA
5740 — C0211 Danio rerio αB1-crystallin
encodes for an activated chaperone. Hanane A.
Koteiche, S. Mishra, H. S. Mchaourab. Molecular
Physiology and Biophysics, Vanderbilt University,
Nashville, TN
5741 — C0212 Assessing the zebrafish as
an efficient model for analyzing mammalian
α-crystallin transcriptional regulation. Mason
Posner, Z. Haley, A. Drossman. Biology, Ashland
University, Ashland, OH
5742 — C0213 Kinetics of Diabetes Related
Modifications in Heat Shock Proteins.
Devi Kalyan Karumanchi1, E. R. Gaillard1, 2,
J. P. Dillon1. 1Department of Chemistry and
Biochemistry, Northern Illinois University, Dekalb,
IL; 2Department of Biology, Northern Illinois
University, Dekalb, IL
5743 — C0214 UVA light through sensitization
of kynurenines oxidizes ascorbate and promotes
lens protein modification: Implications for lens
aging and cataract formation. Cibin T. Raghavan1,
M. D. Linetsky2, R. H. Nagaraj1. 1Ophthalmology,
Case Western Reserve University, Cleveland, OH;
2
Chemistry, Case Western Reserve University,
Cleveland, OH
5744 — C0215 Stimulation of Glycolysis in the
Lens by Pyruvate. Implications in Protection
against Oxidative Stress. Kavita R. Hegde1,
S. D. Varma2. 1Natural Sciences, Coppin State
University, Baltimore, MD; 2Ophthalmology and
Visual Sciences, University of Maryland School of
Medicine, Baltimore, MD
5745 — C0216 Patterns of Cellular
Expression and Self Assembly of Human
Amyloid Proteins in vivo. Owen Lawrence1, J.
L. Dodge1, J. M. Clark1, J. I. Clark1, 2. 1Biological
Structure, University of Washington, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA
5746 — C0217 Domain Structure of
Reconstituted Cortical and Nuclear Human Lens
Lipid Membranes. Laxman Mainali1, M. Raguz1, 3,
W. J. O’Brien2, W. K. Subczynski1. 1Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
2
Ophthalmology and Microbiology/Molecular
Genetics, Medical College of Wisconsin,
Milwaukee, WI; 3Medical Physics and Biophysics,
University of Split, Split, Croatia
5747 — C0218 Mice Expressing CRYAAN101D
Show Altered Membrane Structure and
Increased Membrane-Association of Deamidated
αA Compared to CRYAA Wild-Type (WT) Mice.
Kiran Srivastava, R. Joseph, S. M. Hegde, O. P.
Srivastava. Vision Sciences, University of Alabama
at Birmingham, Birmingham, AL
5748 — C0219 Probing structure of human
β-crystallins by protein cross-linking. Kirsten
J. Lampi1, L. L. David2. 1Integrative Biosciences,
Oregon Health and Science University, Portland,
OR; 2Biochemistry and Molecular Biology, Oregon
Health and Science University, Portland, OR
5749 — C0220 Oxygen Metabolism in Primary
Human Lens Epithelial Cells. Miyuki Kubota1, 2,
C. J. Siegfried1, Y. Shui1, F. Bai1, A. J. Huang1, D.
C. Beebe1, 3. 1Ophthalmology & Visual Sciences,
Washington University School of Medicine, St
Louis, MO; 2Ophthalmology, Keio University
School of Medicine, Tokyo, Japan; 3Cell Biology
and Physiology, Washington University School of
Medicine, St. Louis, MO *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
363
Thursday Posters
8:30 am – 10:15 am
5733 — C0204 Fiber Cell Compaction in Adult
Human Lenses Begins Near the Remodeling
Zone in the Outer Cortex. M J. Costello1,
A. Mohamed2, K. Gilliland1, W. C. Fowler3, S.
Johnsen4. 1Cell Biology & Physiology, University
of North Carolina, Chapel Hill, NC; 2Prof. Brien
Holden Eye Research Centre, L V Prasad Eye
Institute, Hyderabad, India; 3Ophthalmology,
University of North Carolina, Chapel Hill, NC;
4
Biology, Duke University, Durham, NC
5734 — C0205 The Tropomodulin1-Actin
Network and CP49 Beaded Filaments Regulate
Formation of Undulating Aquaporin Junctions
in Mouse Lens Fiber Cells. Sondip K. Biswas1, R.
B. Nowak2, V. M. Fowler2, W. Lo1. 1Neurobiology,
Morehouse School of Medicine, Atlanta, GA; 2Cell
Biology, The Scripps Research Institute, La Jolla,
CA
5750 – 5768 – Thursday – Posters
5750 — C0221 Gap junctional conductance
produced by Cx50, but not Cx46, is regulated by
the PI3K signaling pathway in the lens. Jennifer
M. Martinez1, H. Wang1, P. V. Mhaske1, C. Sellitto1,
M. Srinivas2, R. Z. Lin1, T. W. White1. 1Physiology,
Stony Brook University, Patchogue, NY; 2Biological
Sciences, State University of New York- College of
Optometry, New York, NY
5756 — D0003 A prospective study on Terson’s
syndrome and intraocular infections in critically
ill patients. Daniel Barthelmes1, 2, M. Haenggi2,
T. M. Merz2, J. Takala2, M. Lensch2, S. M. Jakob2.
1
Ophthalmology and Eye health, The University
of Sydney, Sydney, NSW, Australia; 2Intensive
Care Medicine, University Hospital Bern, Bern,
Switzerland
5751 — C0222 Cell transduction of
αA-crystallin is negatively impacted by
phosphorylation mimics. Niklaus H. Mueller,
K. L. Christopher, D. A. Ammar, J. M. Petrash.
Ophthalmology, Univ of Colorado School of
Medicine, Aurora, CO *CR
5757 — D0004 Torsion-Induced Traumatic
Optic Neuropathy (TON). Matthew A. Reilly1,
R. E. Sponsel1, 2, R. D. Glickman3. 1Biomedical
Engineering, University of Texas at San Antonio,
San Antonio, TX; 2WESMDPA, San Antonio,
TX; 3Ophthalmology, University of Texas Health
Science Center San Antonio, San Antonio, TX *CR
5752 — C0223 αB-Crystallin secretion from
astrocytes and its implications for Alzheimer’s
Disease. Juliet A. Moncaster1, 2, J. Ghosh1, T.
Ikezu2, J. C. Voss3, R. K. Gangalum4, S. Sarangi1,
C. R. Abraham2, S. P. Bhat4, P. K. Stanton5, L. E.
Goldstein1, 2. 1Psychiatry, School of Medicine,
Boston University, Boston, MA; 2BU Alzheimer’s
Disease Center, School of Medicine, Boston
University, Boston, MA; 3Biochemistry and
Molecular Medicine, UC Davies, Sacramento, CA;
4
Ophthalmology, Jules Stein Eye Institute, Los
Angeles, CA; 5Cell Biology and Anatomy, New
York Medical College, Valhalla, NY *CR
5753 — C0224 Chaperone peptides of
α-crystallin inhibit cataract formation in rats.
Rooban B. Nahomi1, B. Wang2, C. T. Raghavan1,
O. Voss3, A. Doseff3, P. Santhoshkumar4, R. H.
Nagaraj1. 1Ophthalmology, Case Western Reserve
University, Cleveland, OH; 2Center for Proteomics
and Bioinformatics, Case Western Reserve
University, Cleveland, OH; 3Davis Heart and Lung
Research Institute, The Ohio State University,
Columbus, OH; 4Ophthalmology, University of
Missouri, Columbia, MO
Exhibit Hall D0001-D0006
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
516 Trauma
Thursday Posters
8:30 am – 10:15 am
Moderator: Hugo Quiroz-Mercado
5754 — D0001 High-Power Blue Laser PointerInduced Maculopathy. sulaiman M. Alsulaiman1,
A. A. Alrushood1, J. Almasaud1, S. Alzaaidi1, Y.
A. Alzahrani1, J. Arevalo1, 2, N. G. Ghazi1, E. B.
Abboud1, S. Alreshaid1. 1King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 2Wilmer Eye
Institute, Baltimore, MD
5755 — D0002 The effects of repeated exposure
to low level blast overpressure on rat ocular
tissues. Jae Hyek Choi1, 2, W. A. Greene1, 2, M.
Chavko3, A. J. Johnson2, J. M. Cleland2, H. H.
Wang2. 1National Research Council, Washington,
DC; 2Ocular Trauma Department, U.S. Army
Institute of Surgical Research, Fort Sam Houston,
TX; 3NeuroTrauma Department, Naval Medical
Research Center, Silver Spring, MD
5758 — D0005 Pars Plana Vitrectomy with
medium-term Perfluoro-N-Octane for severe
ocular trauma and hemorrhage with or without
retinal detachment. Ramanath Bhandari1,
S. Schwartz2, C. Gonzalez2, R. Victoria2, N.
Mandava1, H. Quiroz-Mercado2. 1Ophthalmology,
Rocky Mountain Lions Eye Institute, University
of Colorado School of Medicine, Aurora, CO;
2
Ophthalmology, Denver Health Medical Center,
Denver, CO *CR
5762 — D0009 Rescue Laser Photo Stimulation
for Diabetic Macular Edema Unresponsive to
Anti-VEGF Therapy. Jose A. Cardillo1, 2, A. J.
Dare4, R. Peroni3, 4, R. Jorge2. 1Retina Department,
Universidade Federal de São Paulo, São Paulo,
Brazil; 2Retina Department, Universidade de São
Paulo, Ribeirão Preto, Brazil; 3Retina Department,
Hospital de Olhos de Araraquara, Araraquara,
Brazil; 4Retina Department, Centro Brasileiro de
Especialidades Oftalmológicas, Araraquara, Brazil
5763 — D0010 A Simple Artificial Eye
Model for Practicing Anterior and Posterior
Segment Lasers. Malav Joshi, T. W. Altenbernd.
Ophthalmology and Vision Science, University of
Arizona, Tucson, AZ
Exhibit Hall D0011-D0057
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
518 Vitreoretinal Surgery III
Moderator: Elliott H. Sohn
5759 — D0006 Outcome of Retinal Surgery
in Eyes with Ruptured Globes. Khoa V. Lam1,
D. Xing2, E. K. Chin2, S. S. Park2. 1UC Davis
School of Medicine, Davis, CA; 2Department
of Ophthalmology & Vision Science, Univ of
California Davis Eye Ctr, Sacramento, CA
5764 — D0011 The Effect of Internal Limiting
Membrane Peeling in Epiretinal Membrane
Including Pseudolamellar Macular Hole. Jung
Min Park1, S. Oh1, S. Lee2. 1Ophthalmology,
Maryknoll Hospital, Busan, Republic of Korea;
2
Ophthalmology, Haeundae paek hospital, Busan,
Republic of Korea
Exhibit Hall D0007-D0010
5765 — D0012 Clinical Findings at Initial
Pan Retinal Photocoagulation for Proliferative
Diabetic Retinopathy Predict Future Need for
Pars Plana Vitrectomy. Ravi Parikh1, 4, J. Van
Houten3, E. F. Cherney2. 1School of Medicine,
Vanderbilt University, Nashville, TN; 2Vanderbilt
Eye Institute, Vanderbilt University Medical Center,
Nashville, TN; 3Biomedical Informatics, Vanderbilt
University Medical Center, Nashville, TN; 4Health
Policy and Management HSPH, Harvard University,
Boston, MA
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
517 Laser/Intravitreal Treatment
Moderator: Robert L. Avery
5760 — D0007 A comparison of anti-VGEF
therapy and laser in preserving visual function in
patients with proliferative diabetic retinopathy.
Marisol Estudillo, V. H. Gonzalez. OpthalmologyRetina, Valley Retina Institute,PA, McAllen, TX
*CR, f
5761 — D0008 Intravitreal Ranibizumab
Combined with Panretinal Photocoagulation
in Patients with Treatment-Naive Proliferative
Diabetic Retinopathy. Daniel A. Ferraz1, 2, R.
Sophie2, M. G. Bittencourt2, R. C. Preti1, L. M.
Vazquez1, A. A. Motta1, M. Hanout2, Y. J. Sepah2,
Q. Nguyen2, W. Y. Takahashi1. 1Ophthalmology,
University of São Paulo, São Paulo, Brazil; 2Retinal
Imaging Research and Reading Center, Wilmer Eye
Institute, Johns Hopkins University, Baltimore, MD
*CR
5766 — D0013 Retinal ganglion cell layer
thickness reduces after internal limiting
membrane peeling during macular hole
surgery. Adil Darugar, V. Caillaux, A. Erginay,
B. M. Dupas, V. Krivosic, J. Perol, S. Bruneau, A.
Gaudric, P. Massin, R. Tadayoni. Department of
Ophthalmology, Hôpital Lariboisière, Université
Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris,
France, Paris, France *CR
5767 — D0014 Trends in choice of surgical
technique and reimbursement for retinal
detachment repair. Baseer Ahmad, G. K. Shah, K.
J. Blinder. The Retina Institute / Retina Consultants
of St. Louis, St. Louis, MO *CR
5768 — D0015 Retained Lens Fragments
After Cataract Surgery: Outcomes of Same-Day
Versus Delayed Pars Plana Vitrectomy. Yasha
S. Modi, A. E. Epstein, W. E. Smiddy, W. J. Feuer,
H. W. Flynn. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
364
Thursday – Posters – 5769 – 5790
5769 — D0016 Anatomical outcomes of
epiretinal membrane surgery with or without
internal limiting membrane peeling. Sheyman,
J. S. Myung, T. Lyu, K. Wald. Department of
Ophthalmology, Mount Sinai School of Medicine,
New york, NY
5778 — D0025 Retinal Vascular Remodeling
Following Macular Hole Surgery. Gene Chen1,
R. Iezzi1, J. W. McLaren1, R. C. Gentile2, A. J.
Barkmeier1. 1Ophthalmology, Retina, Mayo Clinic,
Rochester, MN; 2Ophthalmology, Retina, New York
Eye and Ear Infirmary, New York City, NY
5770 — D0017 One-year anatomical and
functional outcomes after macular hole surgery:
a prospective controlled study. Sumeer Thinda, R.
J. Shah, S. J. Kim. Ophthalmology, Vanderbilt Univ
Medical Center, Nashville, TN f
5779 — D0026 One-year results of the
Prospective Retinal and Optic nerve Vitrectomy
Evaluation (PROVE) Study: A controlled clinical
trial. Rohan J. Shah, M. Lalezary, S. J. Kim, R.
Reddy, J. Kammer, R. W. Kuchtey, K. M. Joos, F.
Recchia, E. F. Cherney, J. C. Law. Department of
Ophthalmology, Vanderbilt University, Nashville,
TN *CR, f
5771 — D0018 Retrospective analysis of laser
therapy versus observation for symptomatic
retinal artery macroaneurysms. Jacob C. Meyer,
G. K. Shah. The Retina Institute, St. Louis, MO
*CR
5772 — D0019 Ultrastructural changes of the
vitreoretinal interface during longterm followup after the removal of the internal limiting
membrane. Toshio Hisatomi1, 2, H. Enaida1, S.
Notomi1, Y. Sassa1, A. Takeda1, T. Ishibashi1.
1
Ophthalmology, Kyushu Univ., Fukuoka, Japan;
2
Clinical Research Institute, Kyushu Medical
Center, Fukuoka, Japan *CR
5773 — D0020 Evaluation of Brilliant Blue
Green (BBG) Toxicity on Retinal Ganglion Cells
Exposed to Varying levels of Illumination with
Surgical Metal Halide Endoilluminator. K V
Chalam, W. Li, S. Balaiya. Ophthalmology, Univ of
Florida-Jacksonville, Jacksonville, FL
5774 — D0021 Outcomes of Transpupillary
Posterior Chamber Intraocular Lens Removal
with Pars Plana Vitrectomy and Placement of
Anterior Chamber Intraocular Lens. Pavlina
Kemp, A. T. Johnson, J. C. Folk, S. R. Russell, V.
B. Mahajan, H. Boldt, T. A. Oetting, E. H. Sohn.
Department of Ophthalmology, University of Iowa,
Iowa City, IA *CR
5775 — D0022 Microfiltration of Brilliant Blue
G Dye. Sri Krishna Mukkamala. 1Ophthalmology,
Columbia University, New York, NY; 2Vitreous
Retina Macula Consultants, New York, NY
5776 — D0023 Traumatic Optic Neuropathy
after Vitrectomy Surgery: A controlled
prospective trial. Sivashakthi Kanagalingam, M.
Lalezary, S. J. Kim. Ophthalmology, Vanderbilt
University Medical Center, Nashville, TN f
5781 — D0028 Quantitative assessment of
Differences in Macular Visibility through a
Variety of Intraocular Lenses during Vitrectomy:
an Eye Model Experimental Study. Hirokazu
Sakaguchi1, J. Hidaka2, Y. Oshima1, N. Maeda1,
K. Nishida1. 1Ophthalmology, Osaka University
Graduate School of Medicine, Suita, Japan; 2HOYA
Corporation Medical Division, Itabashi, Japan *CR
5782 — D0029 Risk factors for development of
full thickness macular holes following pars plana
vitrectomy for myopic foveoschisis. Yasushi Ikuno,
X. Gao, S. Fujimoto, K. Nishida. Department of
Ophthalmology, Osaka Univ Medical School, Suita,
Japan *CR
5783 — D0030 Clinical Efficacy and Safety
of Dexamethasone/Netilmicin Gel in the
Management of Ocular Inflammation After
Vitreoretinal Surgery. Vincenzo Papa1, D. Rasà1,
C. Iannacone3, C. Cannatella1, A. Rapisarda2.
1
Medical Affairs, SIFI SPA, Catania, Italy;
2
Ophthalmology Unit, Garibaldi Hospital, Catania,
Italy; 3Department of Statistics, Sparc Consulting
Srl, Milano, Italy *CR, f
5784 — D0031 Cone implicit time as a
predictor for visual outcome in Macular Hole
Surgery. Sten Andreasson, S. Kjellstrom, H. Barth,
F. K. Ghosh. Ophthalmology, University Hospital of
Lund, Lund, Sweden
5786 — D0033 Diluted Preserved
Triamcinolone Acetonide for Internal Limiting
Membrane Staining: Staining Morphology
and Cytotoxicity Evaluations. Jerry Huang1, L.
Yeung1, N. Wang2, Y. Chen2, Y. Hwang2, K. Chen2,
W. Wu2, T. Chen2, C. Lai2. 1Chang-Gung Memorial
Hospital, Keelung, Taiwan, Keelung City, Taiwan;
2
Chang-Gung Memorial Hospital, Taoyuan, Taiwan,
Guishan Township, Taoyuan County, Taiwan
5787 — D0034 A computational study
of the pressure burden on localized retina
during vitrectomy. Yong Joon Kim1, K. Choi1,
S. Jo2, Y. Joo2. 1Department of Ophthalmology,
Soonchunhyang University, College of Medicine,
Seoul, Republic of Korea; 2Department of
Mechanical Engineering, Soonchunhyang
University, Asan, Republic of Korea
5788 — D0035 Iatrogenic retinal breaks in
25-gauge air vitrectomy compared with the
standard 25-gauge system for macular diseases.
Cesare Mariotti1, F. Viti1, T. Avitabile2, M. D.
Toro2, A. Saitta1, A. Giovannini1, A. Longo2, V.
De Grande2, S. Stella2, M. Reibaldi2. 1Clinica
Oculistica, Universita Politecnica delle Marche,
Ancona, Italy; 2Ophthalmology, University of
Catania, Catania, Italy
5789 — D0036 Dynamic Contour Tonometry
versus Goldmann Applanation Tonometry
after vitrectomy. Nikolaos Mamas, M. Fuest,
G. Roessler, B. A. Mazinani, N. Plange.
Ophthalmology, RWTH Aachen University, Aachen,
Germany *CR
5790 — D0037 Macular hole repair closure
rates in phakic and non-phakic patients with
nonsupine positioning and sulfur hexafluoride
endotamponade. Jaafar El Annan1, J. Heffez3, J.
D. Udoetuk1, M. M. Sanghvi2, P. E. Carvnounis1.
1
Ophthalmology, Baylor College of Medicine,
Houston, TX; 2George Washington University
School of Medicine and Health Sciences,
Washington, DC; 3Retina Consultants P.C.,
Washington, DC *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
365
Thursday Posters
8:30 am – 10:15 am
5777 — D0024 Macular hole surgery: Does
C3F8 provide better anatomical and functional
outcomes than SF6 and C2F6? Javier ZarranzVentura1, 2, A. Sallam1, P. A. Keane2, D. A. Sim2, N.
Kirkpatrick1, R. Johnston1. 1Vitreo-Retinal Service,
Cheltenham General Hospital, Cheltenham, United
Kingdom; 2Medical Retina Service, National
Institute for Health Research (NIHR) Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom *CR
5780 — D0027 Association of M2 macrophages
in the development of fibrovascular membranes
in diabetic retinopathy. Yoshiyuki Kobayashi1, S.
Yoshida1, S. Nakao1, T. Tachibana1, T. Nakama1,
K. Ishikawa1, Y. Sassa1, 2, H. Enaida1, Y. Oshima1,
T. Ishibashi1. 1Ophthalmology, Kyushu University,
Fukuoka, Japan; 2Ophthalmology, Fukuoka
University Chikushi Hospital, Fukuoka, Japan
5785 — D0032 One Year Clinical Outcomes
Of A Randomized Clinical Trial Investigating
Pre-operative Adjunctive Bevacizumab For
Tractional Retinal Detachment (TRD) Due
To Proliferative Diabetic Retinopathy (PDR).
Elizabeth O. Tegins1, M. Javaheri2, D. Eliott4, 2,
L. A. Kim2, 4, H. Salehi-Had2, 5, D. R. Hinton2, 3, E.
H. Sohn1, 2. 1Department of Ophthalmology and
Visual Sciences, University of Iowa, Iowa City,
IA; 2Doheny Eye Institute, University of Southern
California and Los Angeles County Hospitals,
Los Angeles, CA; 3Departments of Pathology
and Ophthalmology, Keck School of Medicine,
University of Southern California, Los Angeles,
CA; 4Massachusetts Eye and Ear Infirmary, Boston,
MA; 5Atlantis Retina Institute, Huntington Beach,
CA *CR, f
5791 – 5817 – Thursday – Posters
5791 — D0038 Efficacy of pneumatic
displacement of sub macular haemorrhage
(SMH) secondary to wet age related macular
degeneration (ARMD). Indu Kumar, T.
Papathomas, A. Kamal. Ophthalmology, Aintree
University Hospital, Liverpool, United Kingdom
5792 — D0039 Movement of fovea toward
optic disc after macular hole surgery with
internal limiting membrane peeling. Kenichi
Kawano1, Y. Ito1, M. Kondo1, 2, H. Terasaki1.
1
Opthalmology, Nagoya University, Nagoya, Japan;
2
Opthalmology, Mie University, Tsu, Japan
5793 — D0040 Course of Intra-Ocular
Pressure After Vitreoretinal Surgery With
Silicone Oil Injection: A Follow-Up of 5 Years.
Elyse Jabbour1, G. Azar1, 2, J. Antoun1, A. Jalkh1, 2.
1
Ophthalmology, Eye & Ear University Hospital,
Beirut, Lebanon; 2Department of Medicine,
Université Saint Esprit Kaslik (USEK), Beirut,
Lebanon
5794 — D0041 27-gauge sutureless
microincision vitrectomy surgery for various
retinal pathologies. Stanislao Rizzo, F. GenovesiEbert, F. Barca, E. Di Bartolo. UO Chirurgia
Oftalmica, Azienda Ospedaliero-Univ Pisana, Pisa,
Italy
5795 — D0042 Anatomic and functional followup of patients with an idiopathic epiretinal
membrane and a preserved visual acuity. Arnaud
Bonnabel, R. Isaico, A. M. Bron, C. CreuzotGarcher. Ophthalmology, General Hospital, Dijon,
France *CR
5796 — D0043 To develop a new surgical
strategy for removing emulsified droplets in
the eye to reduce the complications associated
the use of silicone oil (SO). Yau Kei J. Chan1, H.
Shum2, S. Wong1. 1Department of Ophthalmology,
University of Hong Kong, Pokfulam, Hong Kong;
2
Department of Mechanical Engineering, University
of Hong Kong, Hong Kong, Hong Kong
Thursday Posters
8:30 am – 10:15 am
5797 — D0044 Blood flow changes of the
retina and choroid after vitrectomy for
epiretinal membrane measured by laser speckle
flowgraphy. Eiko Tsuiki, K. Suzuma, Y. Maekawa,
T. Kitaoka. Department of Ophthalmology and
Visual Sciences, Graduate School of Biomedical
Sciences, Nagasaki University, Nagasaki, Japan
5798 — D0045 Vitreous oxygenation bioimplant for central retina artery occlusion.
Raul Velez-Montoya, J. Olson. Ophthalmology,
University of Colorado, Aurora, CO *CR
5799 — D0046 Epiretinal Membrane Peeling
Following Uncomplicated Primary Retinal
Detachment Repair. Kyle Godfrey1, T. Banker2,
E. Weichel3, 2. 1Georgetown University School
of Medicine, Washington, DC; 2Ophthalmology,
Georgetown University Hospital, Washington, DC;
3
Retina Group of Washington, Washington, DC
5800 — D0047 Vitreous levels of MCP-1
and CD163 in vitreoretinal diseases. Takashi
Tachibana, S. Yoshida, Y. Kobayashi, T. Nakama, K.
Ishikawa, S. Nakao, Y. Sassa, H. Enaida, Y. Oshima,
T. Ishibashi. Kyushu University, Fukuoka, Japan
5801 — D0048 Vitrectomy for macular hole
secondary to blunt ocular trauma. Satomi Ohta,
T. Baba, S. Yamamoto. Chiba University, Chiba,
Japan
5802 — D0049 Rate of Elevated Intraocular
Pressure Post Primary Vitrectomy Surgery.
Milad Hakimbashi1, 2, K. A. Rezaei2, 1.
1
Ophthalmology, Rush University, Chicago,
IL; 2Ophthalmology, Illinois Retina Associates,
Chicago, IL *CR
5803 — D0050 An Experimental Proliferative
Vitreoretinopathy (PVR) Model in Pigmented
Rabbits for Testing of New Treatment. Lichun
Zhong. Ocular Science Department, Toxikon
Corporation, Bedford, MA
5804 — D0051 Light Microscopy Features of
Epiretinal Membranes. Laura N. Distefano2, M.
Dutra Medeiros5, A. Salas Torras2, A. R. Carvalho2,
M. Dinarès i Fernández3, F. Tresserra4, M. A.
Zapata1, 2, J. Garcia-Arumi1, 2. 1Retina and Vitreous,
Vall d’ Hebron Hospital, Barcelona, Spain; 2Vall
d’Hebron Research Institute, Barcelona, Spain;
3
Anatomical Pathology, Vall d’Hebron Hospital,
Barcelona, Spain; 4Anatomical Pathology, Instituto
Universitario USP Dexeus, Barcelona, Spain;
5
Centro Hospitalar Lisboa Central, Lisboa, Portugal
5805 — D0052 Treatment of Surgically
Induced Cystoid Macular Edema by Intravitreal
Implant of Dexamethasone. Rino Frisina.
Ophthalmology, Sant’Anna Hospital, Brescia, Italy
5806 — D0053 Anatomic and Visual Success
after Macular Hole Surgery in an Asian
population. Karen Chia, H. Wong. Ophthalmology,
National Healthcare Group Eye Institute, Tan Tock
Seng Hospital, Singapore, Singapore, Singapore
5807 — D0054 Cutter Velocities of Two
Vitrectomy Probes: Dual Pneumatic and a Single
Pneumatic Drive With Spring Return. Dina Joy
K. Abulon. Medical Affairs, Alcon Labs, Irvine, CA
*CR
5808 — D0055 Robot assistance for micrometer
precision in vitreoretinal surgery. Thijs H.
Meenink1, 2, G. Naus1, 2, M. D. de Smet3, 4, M.
Beelen1, 2, M. Steinbuch1. 1Mechanical Engineering,
Technische Universiteit Eindhoven, Eindhoven,
Netherlands; 2PRECEYES Medical Robotics,
Eindhoven, Netherlands; 3Ophthalmology, Clinique
de Montchoisi, Lausanne, Switzerland; 4Department
of Ophthalmology, University of Amsterdam,
Amsterdam, Netherlands *CR
5809 — D0056 Results of long-term silicone
oil tamponade for more than 12 months and
its complications. Yong Sok Ji, H. Jung, K. Yoon,
S. Park. Chonnam National University Hospital,
Gwangju, Republic of Korea
5810 — D0057 Temporal pattern of macular
thickness resolution and visual acuity
improvement after epiretinal membrane
peel surgeries. Ashley Campbell, D. Vavvas.
Ophthalmology, Massachusetts Eye and Ear,
Boston, MA *CR
Exhibit Hall D0071-D0078
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
519 Retina-RPE Transplantation
Moderators: Robert L. Avery and Susanne Binder
5811 — D0071 iPS-RPE implantation in the
Royal College of Surgeons Rat does not lead to
adverse events in a long term study of health and
graft stability. Stephen Bravo1, P. D. Westenskow1,
T. Kurihara1, A. Dorsey1, L. Paris1, J. H. Lin2,
M. Friedlander1. 1Department of Cell Biology,
The Scripps Research Institute, La Jolla, CA;
2
Department of Pathology, UC San Diego School of
Medicine, La Jolla, CA
5812 — D0072 Development of a Novel Device
for Subretinal Transplantation Surgery of
Human iPSC-RPE Cell-Sheet. Hiroyuki Kamao1, 2,
M. Mandai1, O. Mita3, Y. Harada3, J. Kiryu2, M.
Takahashi1. 1Laboratory for Retinal Regeneration,
Riken Center for Developmental Biology, Kobe,
Japan; 2Ophthalmology, Kawasaki Medical School,
Okayama, Japan; 3Nidek inc., Gamagori, Japan *CR
5813 — D0073 Three-dimensional imaging
of developing photoreceptors transplanted in
a mouse model of CEP290-Leber congenital
amaurosis (LCA). Yi-Sheng Chang1, 2, R. Fariss2,
C. Lin2, J. Nakamura2, W. McIntosh Ambrose2,
K. Homma2, R. A. Rachel2, A. V. Cideciyan3,
S. G. Jacobson3, A. Swaroop2. 1Department of
Ophthalmology, National Cheng Kung University,
Tainan City, Taiwan; 2National Eye Institute,
National Institutes of Health, Bethesda, MD;
3
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA
5814 — D0074 Retinal Pigment Epithelium
- Choroid Transplantation: results up to 3
years. Laura Bertazzi1, A. Peroglio Deiro1, M. G.
Cereda2, G. Pertile1. 1Ophthalmology, Ospedale
Sacro Cuore Don Calabria, Negrar, Verona, Italy;
2
Ophthalmology, Ospedale Sacco, Milano, Italy
5815 — D0075 The sodium iodate model
for transplantation of hESC-derived RPE.
Madalena Carido1, Y. Zhu1, B. Benkner2, T. Kurth1,
T. A. Münch2, E. Tanaka1, M. Ader1. 1Center for
Regenerative Therapies Dresden, DRESDEN,
Germany; 2Werner Reichardt Centre for Integrative
Neuroscience, Tubingen, Germany
5816 — D0076 Transplantation of CD73-sorted
photoreceptor precursors into the rat retina. Kai
Postel, T. Santos-Ferreira, M. Ader. DFG-Center
for Regenerative Therapies Dresden, Technische
Universität Dresden, Dresden, Germany
5817 — D0077 Cone-like photoreceptor
transplantation into the mouse retina. Tiago
Santos-Ferreira, K. Postel, M. Ader. AG Ader,
DFG-Center for Regenerative Therapies Dresden,
Technische Universität Dresden, Dresden, Germany
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
366
Thursday – Posters – 5818 – 5838
5818 — D0078 Development of an ex-vivo
retinal explant model to assess transplantation
efficiency of photoreceptor progenitor cells.
Anat Yanai, C. R. Laver, A. E. Bashar, A. Metcalfe,
K. Gregory-Evans. Ophthalmology and Visual
Sciences, University of British Columbia,
Vancouver, BC, Canada
5823 — D0134 Pigment Migration
Distribution in Eyes with Non-neovascular
Age-Related Macular Degeneration. Yanling
Ouyang1, 2, F. M. Heussen1, 2, A. C. Walsh2, A. M.
Joussen1, S. R. Sadda2. 1Ophthalmology, CharitéUniversitätsmedizin Berlin, Berlin, Germany;
2
Ophthalmology, Doheny Eye Institute, Los
Angeles, CA *CR
5831 — D0142 Long-term progression, cystoid
macular edema and secondary epiretinal
membranes in severe chloroquine retinopathy.
Simone Kellner1, 2, S. Weinitz1, 2, G. Farmand1,
U. Kellner1, 2. 1Rare Retinal Disease Center,
AugenZentrum Siegburg, MVZ ADTC Siegburg
GmbH, Siegburg, Germany; 2RetinaScience, Bonn,
Germany
Exhibit Hall D0130-D0184
5824 — D0135 Acute zonal occult outer
retinopathy: A new classification based on
multimodal imaging. Samira Khan, L. M. Jampol.
Ophthalmology, Northwestern Univeristy, Chicago,
IL *CR
5832 — D0143 Reading Center Evaluation
of Retinal Vein Occlusion Using Wide-field
Angiography. Eric Brinton1, A. Domalpally2, B. A.
Blodi1, 2. 1Ophthalmology, University of Wisconsin,
Madison, WI; 2Ophthalmology, Fundus Photograph
Reading Center, Madison, WI
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
520 Imaging II, RE
Moderators: Michael D. Abramoff and
Stephen H. Tsang
5819 — D0130 The Papillomacular Fold in
Posterior Microphthalmos: New Insights Based
on Novel Spectral-Domain Optical Coherence
Tomography Findings. Sawsan R. Nowilaty1, A.
Mousa2, N. G. Ghazi1. 1Vitreoretinal Division, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 2Department of Ophthalmology, King Saud
University, Riyadh, Saudi Arabia
5820 — D0131 The Use of PolyChromatic
Angiography for the Assessment of the Effects of
VEGF and Bevacizumab on the Rabbit Retina.
Samir R. Tari1, C. Samson2, U. B. Kompella4,
R. L. Harris3, C. Lin5, D. A. Antonetti5, G. R.
Barile6. 1PCAsso Diagnostics, North Brunswick,
NJ; 2New York Eye and Ear Infirmary, New
York, NY; 3Rutgers University, New Brunswick,
NJ; 4University of Colorado Denver, Denver,
CO; 5University of Michigan, Ann Arbor, MI;
6
Manhattan Eye Ear and Throat Hospital, New
York, NY *CR
5822 — D0133 Choroidal Thickness in
Pseudoxanthoma Elasticum Measured by
Enhanced Depth Imaging Optical Coherence
Tomography. Martin Gliem, C. K. Brinkmann,
F. G. Holz, P. Charbel Issa. Department of
Ophthalmology, University of Bonn, Bonn,
Germany *CR
5833 — D0144 Characterization of Ultrawidefield Fundus Autofluorescence Patterns
in Retinal Dystrophies. George Trichonas, E. I.
Traboulsi, J. P. Ehlers. Ophthalmology, Cleveland
Clinic, Cleveland, OH *CR
5826 — D0137 Comparison of a widefield
Polarization-sensitive OCT with standard
imaging of Geographic atrophy. Philipp K.
Roberts1, 2, S. Zotter2, B. Baumann2, M. Bolz1,
C. G. Kiss1, R. G. Sayegh1, M. Baratsits1, M.
Pircher2, C. K. Hitzenberger2, U. Schmidt-Erfurth1.
1
Ophthalmology and Optometry, Medical University
of Vienna, Vienna, Austria; 2Center for Medical
Physics And Biomedical Engineering, Medical
University of Vienna, Vienna, Austria *CR
5834 — D0145 The Characterization of Retinal
Bestrophinopaties, and Pseudovitelliform
Dystrophies using Polarisation Sensitive Optical
Coherence Tomography. Gabor Deak1, M.
Ritter1, S. Zotter2, P. K. Roberts1, B. Baumann2, M.
Pircher2, C. K. Hitzenberger2, U. Schmidt-Erfurth1.
1
Department of Ophthalmology, Medical University
of Vienna, Vienna, Austria; 2Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria *CR
5827 — D0138 Detection of Fundus
Abnormalities in Diabetic Retinopathy using
Spectal Domain OCT versus Mydriatic
Color Fundus Imaging. Qing Shao1, Y.
Ouyang1, 2, F. M. Heussen1, 2, A. C. Walsh2, A.
M. Joussen1, S. R. Sadda2. 1Ophthalmology,
Charité-Universitätsmedizin, Berlin, Germany;
2
Ophthalmology, Doheny Eye Institute - USC, Los
Angeles, CA *CR
5835 — D0146 Choroidal Thickness after
Treatment of Uveal Melanoma with Plaque
Brachytherapy. Kavitha R. Sivaraman, C. C.
Chow, W. F. Mieler. Department of Ophthalmology,
University of Illinois Eye & Ear Infirmary, Chicago,
IL *CR
5828 — D0139 Efficacy of NIR and SW-FAF
in resolved central serous chorioretinopathy:
Detecting outer retinal layer abnormality.
Seong-Woo Kim1, J. Oh1, S. Kim1, J. Oh2, C. Yun1,
K. Huh1. 1Ophthalmology, Korea University,
College of Medicine, Seoul, Republic of Korea;
2
Ophthalmology, Dongguk University, Ilsan
Hospital, Goyang, Republic of Korea
5829 — D0140 A Comparison of Heidelberg
and Zeiss OCT Imaging in Common Laboratory
Animals: Retinal Cell Layer Definition and
Correlation to Histopathology. Margaret E.
Collins1, W. S. Culp3, K. Tenneson2, S. Wise2, M.
Vezina2. 1Toxicology, Charles River, Reno, NV;
2
Ocular and Neuroscience, Charles River, Montreal,
QC, Canada; 3Technical Operations, Charles River,
Reno, NV *CR
5830 — D0141 Retinal Arteriolar Dilation
to Flicker Light is Reduced with Repeated
Stimulation. Jonathan E. Noonan1, R. Man1, T. T.
Nguyen1, J. Wang1, 2, E. L. Lamoureux1, 3. 1Centre
for Eye Research Australia, East Melbourne, VIC,
Australia; 2Centre for Vision Research, Sydney,
NSW, Australia; 3Singapore Eye Research Institute,
Singapore, Singapore
5836 — D0147 Choroidal and Retinal
Thickness in Patients Affected by Chronic
Posterior Uveitis. Luisa Pierro, M. Gagliardi, E.
Miserocchi, L. Iuliano, I. Bianchi, C. Del Turco, G.
Parrinello, G. Modorati, M. B. Parodi, F. Bandello.
Department of Ophthalmology, Vita-Salute
University, San Raffaele Scientific Institute, Milan,
Italy *CR
5837 — D0148 Loss of GCL in HIV positive
patients with low (< 100) nadir CD4 counts.
Frank D. Verbraak1, 2, N. Demirkaya1, M. D.
Abramoff3. 1Ophthalmology, Univ of Amsterdam
Acad Med Ctr, Amsterdam, Netherlands;
2
Biomedical Engineering & Physics, Academic
Medical Center, Amsterdam, Netherlands;
3
University of Iowa, Iowa City, IA *CR
5838 — D0149 Long-term follow-up of fundus
autofluorescence and multi-spectral reflectance
imaging using ultra-widefield scanning laser
ophthalmoscopy in patients with different retinal
pathologies. Viola Graham, M. Fleckenstein,
K. Zilkens, S. Schmitz-Valckenberg, F. G. Holz.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
367
Thursday Posters
8:30 am – 10:15 am
5821 — D0132 In-vivo Imaging and
Measurement of the Bursa Premacularis using
1,050nm Swept-Source Deep Range Imaging
Optical Coherence Tomography (DRI-OCT1
Atlantis®). Silvestro Caputo1, A. Sala-Puigdollers1,
H. Jaberansari2, J. Gray1, Y. D’Souza1, S. J.
Charles1, S. Biswas1, D. B. Henson1, 3, D. McLeod1,
3
, P. E. Stanga1, 3. 1Vitreoretinal Unit, Manchester
Royal Eye Hospital, Manchester, United Kingdom;
2
School of Medicine, University of Manchester,
Manchester, United Kingdom; 3Manchester
Academic Health Science Centre and Centre for
Ophthalmology and Vision Research, Institute of
Human Development, University of Manchester,
Manchester, United Kingdom *CR
5825 — D0136 Retinal Morphology Changes
After Epiretinal Membrane Peeling. Judy E.
Kim1, N. R. Mathews1, S. Tarima2. 1Department of
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 2Department of Biostatistics,
Medical College of Wisconsin, Milwaukee, WI
5839 – 5863 – Thursday – Posters
5839 — D0150 Measuring drusen over time:
OCT vs. Fundus Photography. Giovanni Gregori1,
C. A. Garcia Filho1, Z. Yehoshua1, R. Portella
Nunes1, W. J. Feuer1, S. R. Sadda2, P. J. Rosenfeld1.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Ophthalmology, Doheny Eye Institute USC, Los Angeles, FL *CR
5840 — D0151 Varicela Zoster virus and
Central serous retinopathy. Lukan P. Mishev,
A. Misheva, I. Misheva, Y. Cankova, A. Angelov.
Ophthalmology, Focus Eye Center, Sofia, Bulgaria
5841 — D0152 Comparison of foveal central
thickness in using different spectral-domain
OCT machines with manual measurements.
Makoto Shirasawa, H. Terasaki, H. Kawano, T.
Yamashita, S. Sonoda, T. Sakamoto. Ophthalmology,
Kagoshima University, Kagoshima City, Japan
5842 — D0153 Optical coherence tomography
features in uveitic macular edema. Breno R.
Lima1, S. Mahesh2, H. Sen1. 1National Eye Institute,
National Institutes of Health, Bethesda, MD; 2Wills
Eye Institute, Philadelphia, PA
5843 — D0154 Posterior Eye Wall Radius
of Curvature as a Measure of Staphyloma
Progression in Myopic Foveoschisis Patients
as Gauged by Optical Coherence Tomography.
Pamela Sherwood1, J. Leong1, S. Chang1, G.
C. Cheung2, Q. V. Hoang1. 1Ophthalmology,
Columbia University Medical Center, New York,
NY; 2Singapore National Eye Centre, Singapore,
Singapore *CR
5844 — D0155 Evaluation of the Digital Light
Projector Camera (DLP-Cam) for Low-Cost
Diabetic Retinopathy Screening. Taras V. Litvin1,
G. Y. Ozawa1, J. A. Cuadros1, M. S. Muller3, A. E.
Elsner2, 3, T. Gast3, J. Clendenon3, L. Ensman2, T.
Roy1, D. Li1. 1School of Optometry, UC Berkeley,
Berkeley, CA; 2School of Optometry, Indiana
University, Bloomington, IN; 3Aeon Imaging, LLC,
Bloomington, IN *CR
Thursday Posters
8:30 am – 10:15 am
5845 — D0156 Ultra-widefield retinal imaging
documentation and analysis of peripheral retinal
disease in Marfan syndrome: From the Marfan
Eye Consortium of Chicago. Safa Rahmani1, 2,
A. A. Fawzi1, A. T. Lyon1, 2, I. H. Maumenee3, M.
Mets2. 1Northwestern University, Chicago, IL;
2
Lurie Children’s Hospital of Chicago, Chicago, IL;
3
Univeristy of Illinois at Chicago, Chicago, IL
5846 — D0157 Intravitreal Injection of
Bevacizumab for Macula Edema Secondary to
Central Retinal Vein Occlusion: Efficacy at 1
Day after Injection. Atsushi Ishikawa, Y. Imamura,
M. Mita-Takahashi, R. Higashida, Y. Tsutsumi, Y.
Ichikawa, M. Ishida. Teikyo University, Kawasaki,
Japan
5847 — D0158 Fundus Autofluorescence of
Exudative Age-Related Macular Degeneration
with Intraretinal Cystoid Lesion. Tetsuya
Yamagishi1, H. Koizumi2, T. Yamazaki1, N. Terao1,
K. Nakayama1, S. Kinoshita1. 1Department of
Ophthalmology, Kyoto Prefectural Univ of Med,
Kyoto, Japan; 2Department of Ophthalmology,
Tokyo Women’s Medical University, Tokyo, Japan
*CR
5848 — D0159 Retinal vascular abnormalities
in the far periphery of pathologic myopic
eyes imaged by ultra wide-field fluorescein
angiography. Yuichiro Kaneko1, M. Moriyama1, N.
Shimada1, N. Nagaoka1, K. Shinohara1, Y. Tanaka1,
K. Ohno-Matsui1, T. Tokoro1, S. Hirahara2, Y.
Ogura2. 1Ophthalmology & Visual Science, Tokyo
Medical and Dental University Graduate School of
Medicine and Dental Sciences, Bunkyo-ku, Japan;
2
Ophthalmology & Visual Science, Nagoya City
University Graduate School of Medical Scinences,
Nagoya, Japan
5849 — D0160 Retinal-choroidal changes
after loading phase of ranibizumab in diabetic
macular edema. Paola Giorno, M. Parravano, A.
Cacciamani, F. Oddone, F. Scarinci, A. Boninfante,
M. Varano. Ophthalmology, Fondazione G.B.
Bietti-IRCCS, Rome, Italy
5850 — D0161 Refractive Impact on the
Espion Multifocal ERG in Clinical Practice.
John Hamilton, A. M. Theogene, R. Munger, S. G.
Coupland. Ophthalmology, University of Ottawa
Eye Institute, Ottawa, ON, Canada *CR
5851 — D0162 Macular and Optic Nerve
Optical Coherence Tomography in Marfan
Patients: from the Marfan Eye Consortium of
Chicago. WanWan Xu1, S. Kurup2, A. A. Fawzi1,
M. K. Durbin4, I. H. Maumenee3, M. Mets2, 1.
1
Ophthalmology, Northwestern University,
Chicago, IL; 2Ophthalmology, Ann & Robert H.
Lurie Children’s Hospital of Chicago, Chicago, IL;
3
Ophthalmology and Visual Sciences, University
of Illinois at Chicago, Chicago, IL; 4Carl Zeiss
Meditec, Inc, Dublin, CA *CR
5852 — D0163 Multimodal imaging in
Persistent Placoid Maculopathy. Mohamed
G. Gendy1, A. A. Fawzi1, R. T. Wendel2, D. J.
Pieramici3, J. A. Miller4, D. M. Brown5, L. M.
Jampol1. 1Ophthalmology, Northwestern University,
Chicago, IL; 2Retina Consultants, Sacramento, CA;
3
California Retina Consultants, Bakersfield, CA;
4
Retina Consultants of Michigan, Southfield, MI;
5
Retina Consultants of Houston, Houston, TX *CR
5853 — D0164 Novel angiographic findings
in Susac syndrome identified by ultra-widefield
imaging technology. Priyanka Kumar, R. J.
Courtney, K. Baynes, C. Y. Lowder, J. P. Ehlers, R.
Rennebohm, S. K. Srivastava. Cole Eye Institute,
Cleveland Clinic Foundation, Cleveland, OH *CR
5854 — D0165 Development of a Premacular
Vitreous Pocket. Tadashi Yokoi, N. Azuma.
Ophthalmology, National Center for Child Health
and Development, Tokyo, Japan
5855 — D0166 Evaluation of subfoveal
choroidal thickness before and after cataract
surgery. Minoru Tanigawa, Y. Shimada, Y. Ochiai,
H. Ochiai, Y. Tsukahara, H. Yamanaka. ShinNagata Eye Institute, Kobe, Japan
5856 — D0167 Classification and Quantitative
Analysis of Geographic Atrophy Lesions
Using Spectral-Domain Optical Coherence
Tomography. Jinfeng Qu1, 2, M. Nittala2, A. Hariri2,
D. M. Wu2, S. Sadda2. 1Ophthalmology, People’s
Hospital of Peking University, Beijing, China;
2
Doheny Image Reading Center, Doheny Eye
Institute, Los Angeles, CA *CR
5857 — D0168 Spectral-Domain Optical
Coherence Tomography Findings of Eyes With
Idiopathic Macular Telangiectasia. Mounir
Benzerroug, S. Molva, D. Bremond-Gignac, S.
Milazzo. Ophthalmology, Amiens University
Hospital, Amiens, France
5858 — D0169 Assessing IOLMaster
Measurement of Eye Axial Length in Pathologic
Myopia Patients with Staphyloma. Jamie
Leong, R. H. Silverman, S. Chang, Q. V. Hoang.
Ophthalmology, Columbia University, New York,
NY *CR
5859 — D0170 Is the Integrity of the
Photoreceptor Layer A Prognostic Factor for
Visual Acuity Gain in Thick Macular Puckers?
Aranzazu Mateo Montoya1, B. Wolff1, V. Martinet1,
P. Cornut2, J. A. Sahel1. 1Retina, Fondation
Ophtalmologique Adolphe de Rothschild, Paris,
France; 2Hôpital Edouard Herriot, Lyon, France
*CR
5860 — D0171 Cyst Size Does Not Predict
Response to Therapy on OCT Imaging of
Macular Edema. Gautam Kamthan, R. M.
Lieberman. Mount Sinai School of Medicine, New
York, NY
5861 — D0172 Photoreceptor Changes
on Multi-Modal Adaptive-Optics Imaging
Correlate with Transient Abnormalities on
Autofluorescence and Indocyanine Green
Angiography in a Patient with Multiple
Evanescent White Dot Syndrome. John E.
Legarreta1, A. D. Legarreta1, 2, Z. Nadler1, L. T.
Labriola1. 1Ophthalmology, UPMC Eye Center/
University of Pittsburgh, Pittsburgh, PA; 2Duke
University, Durham, NC
5862 — D0173 Unique Features of Choroidal
Vasculature In Patients with Choroidal
Neovascular Membranes. Swetangi D. Bhaleeya,
D. J. D’Amico, S. Kiss. Ophthalmology, Weill
Cornell Medical Center, New York City, NY *CR
5863 — D0174 Choroidal thickness
after treatment of chronic central serous
chorioretinopathy: half-fluence photodynamic
therapy versus intravitreal injection of
bevacizumab. Yong Un Shin, B. Lee, D. Lee.
Ophthalmology, Hanyang University Medical
Center, Seoul, Republic of Korea *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
368
Thursday – Posters – 5864 – 5887
5864 — D0175 Steroid-associated central
serous chorioretinopathy, multidisciplinary
imaging. Byung Ro Lee, Y. Shin, S. Lee.
Ophthalmology, Hanyang Univ Hosp, Seoul,
Republic of Korea *CR
5872 — D0183 Ultra-wide field fluorescein
angiography in patients with diabetic
retinopathy. Taneto Tomiyasu, S. Hirahara, M.
Yoshida, M. Nozaki, Y. Ogura. Opthalmology,
Nagoya City Univ Medical School, Nagoya, Japan
5865 — D0176 Progression of Atrophy of
the Retinal Pigment Epithelium in Stargardt
Macular Dystrophy on Fundus Autofluorescence
Imaging. Emily Fletcher1, 2, Y. Wolfson1, B. E.
Munoz1, H. P. Scholl1, 3. 1Ophthalmology, Johns
Hopkins University, Baltimore, MD; 2Retina
Division, Gloucester Royal Hospital, Gloucester,
United Kingdom; 3Ophthalmology, Medical
University Graz, Graz, Austria
5873 — D0184 Repeatability and
Reproducibility of Spectral-domain Optical
Coherence Tomography in Measurement of
Retinal Thickness in Rats. TaeGi Kim, J. Yang, J.
Han, S. Yu, H. Kwak. Ophthalmology, Kyung Hee
University Hospital, Seoul, Republic of Korea
5866 — D0177 Macular Choroidal Thickness
Evaluation By SD OCT In Patients Affected
By Retinal Vein Occlusion. Davide Borroni, E.
Melardi, C. Gandolfi, M. Al Oum, S. Donati, M.
Chiaravalli, C. Azzolini. Department of Surgical
and Morphological Sciences, University of
Insubria-Circolo Hospital, Varese, Italy
Thursday, May 09, 2013 8:30 AM-10:15 AM
5867 — D0178 The Dissociation Between the
Ganglion Cell Analysis/Ganglion Cell Complex
and Peripapillary Retinal Nerve Fiber Layer
Thickness in Hereditary Retinal Disease. Sherry
J. Bass, A. Wong, J. Sherman. Clinical Sciences,
SUNY College of Optometry, New York, NY *CR
5868 — D0179 Myopia Progression
Accompanying with Myopic Disc Change at the
Convalescent Stage of Vogt-Koyanagi-Harada
Disease. Hiroyuki Takahashi, H. Takase, N.
Shimada, K. Ohno-Matsui, M. Mochizuki. Ophthal
& Visual Science, Tokyo Medical and Dental Univ,
Bukyo-ku, Japan *CR
5869 — D0180 Novel and safe technique for
smartphone fundus photography: Application
in human and animal eyes. Luis J. Haddock1, D.
Kim1, F. C. Delori2, S. Mukai1. 1Ophthalmology,
Massachusetts Eye and Ear Infirmary, Boston, MA;
2
Ophthalmology, Schepens Eye Research Institute,
Boston, MA
5870 — D0181 Comparing Optos OTI and
Heidelberg Spectralis SD-OCT in Patients with
Diabetic Macular Edema. Samia Fatum, M.
Sinczak, A. Sachdev, V. Chong. Ophthalmology,
Oxford University Hospitals NHS Trust, Oxford,
United Kingdom *CR
Anatomy/Pathology
521 Ocular and Orbital Tumors
Moderators: Seymour Brownstein and
Valerie A. White
5874 — D0237 Malignant Cancer After
Trauma or Presumed Trauma in Cats. Richard R.
Dubielzig. Pathobiol Sciences, Univ of WisconsinMadison, Madison, WI *CR
5875 — D0238 Canine Primary Ocular
Osteosarcomas and Chondrosarcomas. Felicia
D. Duke, R. R. Dubielzig. Pathobiological Sciences,
University of Wisconsin, Madison, WI *CR
5876 — D0239 AJCC TNM Collaborative
Internet Staging Validation For Ophthalmic
Tumors. Priya Selvakumar. 1The Ophthalmic
Oncology Task Force, American Joint Committee
on Cancer, Chicago, IL; 2Health Informatics
Research, Princess Margaret Cancer Centre,
Toronto, ON, Canada
5877 — D0240 Prognostic Factors Associated
with Histopathology in Intraocular and Ocular
Adnexal Lymphoma: A Twenty Years Review for
the University of Wisconsin Madison. Pimkwan
Jaru-ampornpan1, A. Azari1, M. Rezaei Kanavi1, 2,
H. Potter1, D. M. Albert1. 1Ophthalmology and
Visual Sciences, University of Wisconsin, Madison,
Madison, WI; 2Ophthalmic Research Center, Shahid
Beheshti University of Medical Sciences, Tehran,
Islamic Republic of Iran
5878 — D0241 Uveal Lymphoma: Comparison
of Diagnostic Imaging Studies. Mary E. Aronow1,
C. Portell2, J. Sweetenham2, A. D. Singh1. 1Cole
Eye Institute, Cleveland Clinic, Shaker Heights,
OH; 2Hematologic Oncology and Blood Disorders,
Cleveland Clinic, Taussig Cancer Institute,
Cleveland, OH
5880 — D0243 The Usefulness of Cell
Block Technique in Cytological diagnosis of
Primary Intraocular Lymphoma. Takako Ito1,
H. Yoshikawa1, A. Takeda1, T. Yoshimura1, S.
Hirakawa1, K. Sonoda2, T. Koga3, T. Ishibashi1.
1
Ophthalmology, Kyushu University, Fukuoka,
Japan; 2Ophthalmology, Yamaguchi University,
Yamaguchi, Japan; 3Pathology, Kyushu University,
Fukuoka, Japan
5881 — D0244 Distinct Profiles of Vitreous
micro RNA in Primary Vitreoretinal Lymphoma
and Uveitis. Jingsheng Tuo, D. Shen, C. Chan.
Laboratory of Immunology, National Eye Institute/
NIH, Rockville, MD
5882 — D0245 Using a Murine Xenograft
Model for Von Hippel-Lindau Disease-Associated
Retinal Hemangioblastomas to Test Novel
Therapies. Stanley Park1, 2, Y. Wang1, K. Huntoon3,
D. Shen1, Z. Zhuang3, C. Chan1. 1Immunopathology
Section, Laboratory of Immunology, NEI, NIH,
Bethesda, MD; 2Howard Hughes Medical Institute,
Chevy Chase, MD; 3Surgical Branch, NINDS, NIH,
Bethesda, MD
5883 — D0246 Transvitreal endoresection of
retinal hemangioblastoma after ligating feeder
vessels. Gibran S. Khurshid. Ophthal & Visual Sci,
Univ of Texas Medical Branch, Galveston, TX
5884 — D0247 Prognostic Factors after
Treatment of Patients with Retinal Capillary
Hemangioma(RCH). Hyesun Kim, J. Yi, H. Kwon,
C. S. Lee, S. lee. Department of Ophthalmology,
Yonsei University Severance Hospital, Seoul,
Republic of Korea
5885 — D0248 Safety and Efficacy
of Anti-VEGF Therapy for Choroidal
Neovascularization Overlying Choroidal
Osteoma. Mohammed A. Khan1, F. C. DeCroos2,
P. P. Storey2, J. Shields3, S. J. Garg2, C. L. Shields3.
1
Ophthalmology, Wills Eye Institute, Philadelphia,
PA; 2Retina Service, Wills Eye Institute,
Philadelphia, PA; 3Oncology Service, Wills Eye
Institute, Philadelphia, PA *CR
5886 — D0249 Effect of menopausal status
on the progression of orbital cavernous
hemangiomas. Anupam Jayaram, G. Lissner.
Ophthalmology, Northwestern University, Chicago,
IL
5887 — D0250 The effect of Transforming
growth factor-beta-induced protein (TGFBIp)
in lymphangiogenesis. Yong-Sun Maeng, T. Kim,
H. Lee, E. Kim. Ophthalmology, Yonsei University,
Seoul, Republic of Korea
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
369
Thursday Posters
8:30 am – 10:15 am
5871 — D0182 Improving the Analysis
of Choroidal Laser Doppler Flowmetry
Measurements; Application in Patients with
Retinal Diseases. Nattapon Boonarpha1, 2, G.
Czanner1, 3, A. Raj1, 2, Y. Zheng1, 2, M. Geiser4, C. E.
Riva5, J. Sahni1, 2, S. P. Harding1, 2. 1Department of
Eye and Vision Science, University of Liverpool,
Liverpool, United Kingdom; 2St. Paul’s Eye Unit,
Royal Liverpool University Hospital, Liverpool,
United Kingdom; 3Department of Biostatistics,
University of Liverpool, Liverpool, United
Kingdom; 4University of Applied Sciences of
Western Switzerland, Sion, Switzerland; 5Medical
School, University of Lausanne, Lausanne,
Switzerland *CR
Exhibit Hall D0237-D0262
5879 — D0242 Clinical and epidemiologyc
features of lymphoproliferative lesions in the
orbital and adnexal region at the Asociación
Para Evitar la Ceguera en México. Linda Guakil1,
G. Salcedo1, A. A. Rodríguez-Reyes2, R. Rubio1.
1
Orbit and Oculoplastics, Asociacion Para Evitar La
Ceguera En Mexico, Mexico, Mexico; 2Pathology,
Asociacion Para Evitar La Ceguera En Mexico,
Mexico, Mexico
5888 – 5905 – Thursday – Posters
5888 — D0251 RAS Mutations Coexist with
PIK3CA and MET Mutations in Lacrimal
Gland Epithelial Neoplasms. Bita Esmaeli1, V. T.
Yin1, K. Wani2, K. Aldape2, D. Bell2. 1Head & Neck
Surgery/Ophthal, UT MD Anderson Cancer Center,
Houston, TX; 2Pathology, UT MD Anderson Cancer
Center, Houston, TX
5889 — D0252 Screening of Optic Pathway
Gliomas in Children with Neurofibromatosis
Type-1. Raffaele Parrozzani1, M. Clementi2,
G. Orlando3, G. Miglionico3, E. Trevisson2, E.
Midena3, 1. 1GB Bietti Eye Foundation, IRCCS,
Rome, Italy; 2Department of Pediatrics, Clinical
Genetics, University of Padova, Padova, Italy;
3
Department of Ophthalmology, University of
Padova, Padova, Italy
5890 — D0253 Association of AJCC pT
category with outcome in sebaceous carcinoma
of the eyelid. Valerie A. White1, 2, K. Mulay3,
S. Agrawal4, S. Honavar4. 1Department of
Pathology and Laboratory Medicine, University
of British Columbia, Vancouver, BC, Canada;
2
Ophthalmology and Visual Science, University
of British Columbia, Vancouver, BC, Canada;
3
Ophthalmic Pathology, LV Prasad Eye Institute,
Hyderabad, India; 4Oculoplastic and Orbital
Surgery, LV Prasad Eye Institute, Hyderabad, India
5891 — D0254 Stratifin- A novel biomarker
in the prognosis of Ocular Surface Squamous
Neoplasia patients. Sheetal Chauhan1, S. Sen1, A.
Sharma2, S. Kashyap1, S. S. Chauhan3, R. Tandon4,
N. Pushker4, M. Vanathi4, R. Azad4. 1Ocular
Pathology, R.P.Centre, All India Institute of Medical
Sciences, New Delhi, India; 2Ocular Microbiology,
All India Institute of Medical Sciences, New Delhi,
India; 3Biochemistry, All India Institute of Medical
Sciences, New Delhi, India; 4Ophthalmology, All
India Institute of Medical Sciences, New Delhi,
India
Thursday Posters
8:30 am – 10:15 am
5892 — D0255 Incidence and immunostaining
pattern of oncocytomas of the caruncle - a single
center 12 year analysis. Sandra C. Bajorat1,
M. von Schoenfels1, I. Leuschner2, J. Roider1,
S. O. Koinzer1. 1Ophthalmology, University of
Kiel, University Medical Center, Kiel, Germany;
2
Pathology, University of Kiel, University Medical
Center, Kiel, Germany *CR
5893 — D0256 Classification Schemes for
Conjunctival Melanocytic Neoplasia: the
Effect of Immunohistochemistry on C-MIN
Scoring. Emilia H. DeMarchis1, P. Egbert2, J.
Kim3, 4. 1School of Medicine, Stanford University,
Palo Alto, CA; 2Department of Ophthalmology,
Stanford University, Stanford, CA; 3Department
of Pathology, Stanford University, Stanford, CA;
4
Department of Dermatology, Stanford University,
Stanford, CA
5894 — D0257 Immunohistochemical
Analysis with a Novel Red Chromagen of
Benign and Malignant Melanocytic Lesions
of the Conjunctiva. Seymour Brownstein1, 2,
K. Jiang1, 2, K. Lam1, 2, B. F. Burns2, J. Farmer2.
1
Ophthalmology, Ottawa Hospital, Ottawa, ON,
Canada; 2Pathology, Ottawa Hospital, Ottawa, ON,
Canada
5895 — D0258 Conjunctival Nevus:
Clinicopathological Review of 724 cases.
Stephanie De la O-Pérez1, H. A. RodríguezMartínez2, D. Ríos y Valles-Valles1, O. PérezOlvera2, A. Gómez-Leal1, A. Medina-Cruz2, M.
Y. Namba-Bando1, L. H. De La O-Cerna3, A. A.
Rodríguez-Reyes1. 1Ophthalmic Pathology Service,
Hospital “Dr. Luis Sánchez Bulnes”, Asociación
Para Evitar la Ceguera en México, Mexico
city, Mexico; 2Anatomopathological Research
Laboratory “Roberto Ruiz Obregón” Experimental
Medicine Department, Medical Faculty, National
Autonomous University of Mexico, General
Hospital of Mexico, Mexico City, Mexico; 3Eye
Bank, University Hospital, Autonomous University
of Coahuila, Torreón, Mexico
5896 — D0259 The Growth of Small
Choroidal Melanocytic Lesion after Intravitreal
Bevacizumab Injection. Hee Jung Kwon, H. Kang,
H. Kim, S. Lee, C. S. Lee. Ophthalmology, Institute
of Vision Research, Yonsei University College of
Medicine, Seoul, Republic of Korea
5897 — D0260 Clinical utility of SD-OCT
-Enhanced Depth Imaging in Evaluation of
Retinal and Choroidal Tumors of the Human
Eye. Peter G. Hovland. Colorado Retina Associates,
Denver, CO
5898 — D0261 Waardenburg Syndrome:
Iris and Choroidal Hypopigmentation findings
on Anterior and Posterior Segment Imaging.
Stephanie Nickerson, C. L. Shields, S. AL-Dahmash,
J. Shields. Ocular Oncology Service, Wills Eye
Institute, Philadelphia, PA
5899 — D0262 Does beta-ray emitting
therapy of ciliary body tumors decrease central
corneal endothelial cell density? Eva Suranyi1,
A. Berta2, L. Modis3, E. Szalai4, J. Damjanovich5.
1
Ophthalmology, University of Debrecen, Debrecen,
Hungary; 2Ophthalmology, University of Debrecen,
Debrecen, Hungary; 3Ophthalmology, University
of Debrecen, Debrecen, Hungary; 4Ophthalmology,
University of Debrecen, Debrecen, Hungary;
5
Ophthalmology, University of Debrecen, Debrecen,
Hungary
Exhibit Hall D0263-D0276
Thursday, May 09, 2013 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
522 Thyroid Eye Disease
Moderator: Huibert J. Simonsz
5900 — D0263 Signal intensity measurement
of magnetic resonance imaging for
extraocular muscles inflammation in thyroidassociated ophthalmopathy before and after
methylprednisolone pulse therapy. Tomoaki
Higashiyama, Y. Nishida, Y. Ichiyama, S. Muraki,
M. Ohji. Ophthalmology, Shiga University of
Medical Science, Otsu, Japan *CR
5901 — D0264 Subclinical alterations of
extraocular muscles in Graves’ Disease. Alberto
Cuccu1, I. Zucca1, M. Galantuomo1, S. Mariotti2, F.
Boi2, R. Vacca2, M. Fossarello1. 1Ophthalmology,
University of Cagliari, Cagliari, Italy; 2Medical
Science, University of Cagliari, Cagliari, Italy
5902 — D0265 Medical Histories and
Ophthalmic Features, including Orbital Images
of MRI, in Patients with Dysthyroid Optic
Neuropathy. Ai Kozaki, T. Inoue, C. Funaki,
K. Mizuno, R. Inoue, Y. Inoue. Ophthalmology,
Olympia Eye Hospital, Tokyo, Japan
5903 — D0266 Protocol for Protein Isolation
from Human Orbital Fat Tissue: Use for Western
Blots and Antigen Biomarker Identification in
Thyroid Eye Disease. Katie Mills1, M. Z. Radic2,
I. Neeli2, M. E. Phillips1, C. Cutler Peck1, B. N.
Wilkes1, J. C. Fleming1, A. Iannaccone1, N. C.
Kerr1. 1Ophthalmology, Hamilton Eye Institute,
Memphis, TN; 2Molecular Science, University of
TN, Memphis, TN
5904 — D0267 Palmitate induced secretion
of IL-6 and MCP-1 in orbital fibroblasts
derived from patients with thyroid-associated
ophthalmopathy. Ji-Sun Paik1, W. Cho2, E. Oh3,
4
, S. Lee3, 4, S. Yang1. 1Ophthalmology and Visual
Science, Seoul St. Mary’s Hospital, The Catholic
University of Korea, Seoul, Republic of Korea;
2
Ophthalmology and Visual Science, DaeJeon St.
Mary’s Hospital, the Catholic University of Korea,
Seoul, Republic of Korea; 3Institue of Hansen’s
Disease, College of Medicine, the Catholic
University of Korea, Seoul, Republic of Korea;
4
Pathology, College of Medicine, the Catholic
University of Korea, Seoul, Republic of Korea
5905 — D0268 Treatment of Esotropia
from Thyroid Eye Disease by Lateral Rectus
Resection. Daniel Greninger, P. H. Berg, E. A.
Steele. Ophthalmology, Oregon Health and Science
University, Portland, OR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
370
Thursday – Posters – 5906 – 5913
5906 — D0269 Lower Social Grade and Higher
Social Deprivation are Independently Associated
with Severe Thyroid Eye Disease. Matthew R.
Edmunds1, 2, J. A. Huntbach2, O. M. Durrani2.
1
Academic Unit of Ophthalmology, University
of Birmingham, Birmingham, United Kingdom;
2
Birmingham & Midland Eye Centre, Birmingham,
United Kingdom
5913 — D0276 Posterior conjunctival plication
to correct secondary ptosis after eyelid retraction
repair in Graves disease. Vinita Srivastava1, H. R.
Patel1, H. A. Shah1, 2, H. H. Lee1, 2, W. R. Nunery1, 3.
1
Dept of Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2Oculofacial Plastic
and Orbital surgery, Indianapolis, IN; 3Oculofacial
Plastic and Orbital surgery, Louisville, KY
5907 — D0270 Rapamycin enhances the
TNF-α-induced secretion of IL-6 and IL-8 by
suppressing PDCD4 degradation in orbital
fibroblasts. Won-Mo Lee1, J. Won2, J. Paik2,
W. Cho2, E. Oh3, 4, S. Lee3, 4, S. Yang2. 1SeongMo Eye Clinic, Dae Jeon, Republic of Korea;
2
Ophthalmology and Visual Science, the Catholic
University of Korea, Seoul, Republic of Korea;
3
Institute of Hansen’s Disease, The Catholic
University of Korea, Seoul, Republic of Korea;
4
Department of Pathology, The Catholic University
of Korea, Seoul, Republic of Korea
5908 — D0271 Readability Assessment of
Online Thyroid Eye Disease Patient Information.
Alastair K. Denniston1, 2, M. R. Edmunds1, 2.
1
Academic Unit of Ophthalmology, University
of Birmingham, Birmingham, United Kingdom;
2
University Hospitals Birmingham NHS Foundation
Trust, Birmingham, United Kingdom
5909 — D0272 Clinical and Biochemical
Characteristics of Thyroid-Associated
Ophthalmopathy in Korean Populations using
VISA and Fat/Muscle Typing. Young Ji Lee1,
S. Lee1, H. Lew2, J. Yoon1. 1Institute of Vision
Research, Department of Ophthalmology, Yonsei
University College Of Medicine, Seoul, Republic
of Korea; 2Department of Ophthalmology, CHA
University, Bundang CHA Medical Center,
Sungnam, Republic of Korea
5910 — D0273 Clinical Features of
Japanese Elderly Patients with Dysthyroid
Ophthalmopathy. Kahori Mizuno, A. Kozaki, C.
Funaki, G. Ito, R. Inoue, K. Nishiyama, T. Inoue,
Y. Inoue. Ophthalmology, Olympia Eye Hospital,
Tokyo, Japan
5911 — D0274 Thyroid Eye Disease With
Compressive Optic Neuropathy: Decompression
Versus Radiation. Sheila Goyal, M. A. Slabaugh, S.
Chang. Ophthalmology, University of Washington,
Seattle, WA
Thursday Posters
8:30 am – 10:15 am
5912 — D0275 Expression of GRα mRNA and
NF-kB in orbital fat and extraocular muscle
in Thyroid Eye Disease. Ivana L. RomeroKusabara1, 3, A. N. Cury2, 3, J. Vital Filho1, N. M.
Scalissi2, K. C. Melo3, G. Demartino3, C. A. Longui2,
3
, M. R. Melo3. 1Ophthalmology, Santa Casa of Sao
Paulo, Sao Paulo, Brazil; 2Endocrinology, Santa
Casa of Sao Paulo, Sao Paulo, Brazil; 3Molecular
Medicine Laboratoty, Physiology, Santa Casa of
Sao Paulo, Sao Paulo, Brazil
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
371
5914 – 5929 – Thursday – Papers/Minisymposium
6B
Thursday, May 09, 2013 10:30 AM-12:15 PM
Glaucoma
523 Structure/Function
Moderator: Claude F. Burgoyne
5914 — 10:30 Relationships among Visual
Cortex Metabolism, Retinal Morphology
and Visual Function in Early and Advanced
Glaucoma. Kevin C. Chan1, 2, I. P. Conner1, Z.
Safiullah2, S. Kim3, 2, G. Wollstein1, J. S. Schuman1, 2.
1
UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2Department
of Bioengineering, University of Pittsburgh,
Pittsburgh, PA; 3Department of Radiology,
University of Pittsburgh, Pittsburgh, PA *CR
5915 — 10:45 The relationship between cup/
disc ratio and estimated number of retinal
ganglion cells. Andrew J. Tatham1, R. N. Weinreb1,
L. M. Zangwill1, J. M. Liebmann2, C. A. Girkin3,
F. A. Medeiros1. 1Hamilton Glaucoma Center,
University California San Diego, La Jolla, CA;
2
Department of Ophthalmology, New York Eye
and Ear Infirmary, New York, NY; 3Department
of Ophthalmology, University of Alabama,
Birmingham, AL *CR, f
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5916 — 11:00 Machine Classifier Clustering
of Ocular Structure Measurements Poorly
Corresponds with Longitudinal Functional
Performance in Glaucoma. Jessica E. Nevins1,
D. Danks2, 3, G. Wollstein1, H. Ishikawa1, 4, L.
Kagemann1, 4, I. A. Sigal1, 4, J. S. Schuman1, 4.
1
UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2Department of
Philosophy, Carnegie Mellon University, Pittsburgh,
PA; 3Institute for Human & Machine Cognition,
Pensacola, FL; 4Department of Bioengineering,
Swanson School of Engineering, University of
Pittsburgh, Pittsburgh, PA *CR
5917 — 11:15 Posterior Lamina Cribrosa
Displacement at Different Stages of Glaucoma.
Sung Chul Park1, 2, R. L. Furlanetto1, C. F. Netto1,
Y. Liu1, 3, Y. Kung1, 3, S. Fernando-Sieminski4, J.
M. Liebmann1, 5, R. Ritch1, 2. 1Moise and Chella
Safra Advanced Ocular Imaging Laboratory,
Einhorn Clinical Research Center, New York Eye
and Ear Infirmary, New York, NY; 2Department
of Ophthalmology, New York Medical College,
Valhalla, NY; 3New York Medical College, New
York, NY; 4Ross Eye Institute, State University of
New York at Buffalo, Buffalo, NY; 5Department of
Ophthalmology, New York University School of
Medicine, New York, NY *CR
5918 — 11:30 Relating retinal ganglion cell
(RGC) function and retinal nerve fiber layer
(RNFL) retardance to progressive loss of RNFL
thickness (RNFLT). Brad Fortune, G. Cull, J.
Reynaud, C. F. Burgoyne. Discoveries in Sight
Research Laboratories, Devers Eye Institute and
Legacy Research Institute, Legacy Health, Portland,
OR *CR
5919 — 11:45 Why ISNT Rim Area Greater
for Superior Optic Disc? William H. Swanson1,
V. Malinovsky1, M. W. Dul2. 1School of Optometry,
Indiana University, Bloomington, IN; 2SUNY
College of Optometry, State University of New
York, New York, NY
5920 — 12:00 Retinal venous pulsatility is
reduced in regions of nerve fibre layer loss
in glaucoma. Mojtaba Golzan1, W. Morgan2, S.
Graham1. 1Macquarie University, Sydney, NSW,
Australia; 2Lions Eye Institute, University of
Western Australia, Perth, NSW, Australia
6C
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retina
524 Imaging: Diagnostic and Function
Moderators: Timothy W. Olsen and
David J. Wilson
5921 — 10:30 SD-OCT Progressive Alterations
in a Family Affected with Müller Cell Sheen
Dystrophy. Valentina Franco-Cardenas, J. DalmaWeiszhausz, R. E. Martinez-Munoz, A. Dalma.
Retina, Asociacion para Evitar la Ceguera en
Mexico, Mexico City, Mexico
5922 — 10:45 Outer Retina Analysis by
Optical Coherence Tomography in Cone-Rod
Dystrophy Patients. Luiz H. Lima1, J. M. Sallum1,
R. F. Spaide2. 1Ophthalmology, Federal Unive of
Sao Paulo-UNIFESP, Sao Paulo, Brazil; 2Vitreous,
Retina, Macula Consultants of New York, New
York, NY *CR
5923 — 11:00 Atypical findings in Spectral
Domain Optical Coherence Tomography of
Ocular Toxoplasmosis with Active Lesions.
Florian M. Heussen, Y. Ouyang, Q. Shao, A. M.
Joussen, U. Pleyer. Ophthalmology, Charite University Medicine Berlin, Berlin, Germany *CR
5924 — 11:15 Short-term Spectral Domain
Optical Coherence Tomography Changes
after Phacoemulsification in Eyes with No
Pre-operative Macular Pathology. Yulia
Wolfson, W. Stark, S. B. Bressler, N. M. Bressler.
Ophthalmology, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR
5925 — 11:30 Macular vascular development
assessed by fluorescein angiography in
premature newborn patients with retinopathy
of prematurity. Alberto Hernandez-Vargas, G.
Salcedo-Villanueva, R. Romero Vera, S. Salinas
Longoria, F. Schoonewolff, V. Morales-Canton, J.
J. Fromow-Guerra, M. A. Martinez-Castellanos.
Assoc Para Evitar la Ceguera en Mexico, IAP,
Mexico, Mexico *CR
5926 — 11:45 Three-year multimodal imaging
and predictive value of retinal nerve fiber
layer axoplasmic debris in branch retinal
vein occlusion. Marion R. Munk1, S. Sacu1, R.
Dunavoelgyi1, M. Baratsits1, A. Montuoro2, G.
Matt1, C. G. Kiss1, W. Buehl1, U. Schmidt-Erfurth1.
1
Dept of Ophthalmology, Medical University
Vienna, Vienna, Austria; 2Vienna Reading Center,
Medical University Vienna, Vienna, Austria *CR
5927 — 12:00 Assessment of the inner segment/
outer segment layer in patients with macular
edema due to central retinal vein occlusion.
Barbara A. Blodi, S. Chen, Y. Huang, J. W. Pak, A.
Domalpally. Department of Ophthalmology and
Visual Science, University of Wisconsin, Madison,
WI *CR
606/607
Thursday, May 09, 2013 10:30 AM-12:15 PM
Immunology/Microbiology
525 Clinical and Translational Studies
in Ocular Inflammation
Moderators: Andrew D. Dick and Justine R. Smith
5928 — 10:30 Targeted B-cell Therapy with
Rituximab for the Treatment of Autoimmune
Retinopathy: Results of a Pilot Clinical Trial.
H Nida Sen1, M. D. Dalal1, L. Grange1, Y. Wang1,
J. R. Heckenlively2, P. R. Sherry1, C. Chan1, R.
B. Nussenblatt1. 1National Eye Institute, National
Institutes of Health, Bethesda, MD; 2Kellogg Eye
Center, University of Michigan, Ann Arbor, MI f
5929 — 10:45 IV Secukinumab Is An Effective
Treatment In Patients With Noninfectious Uveitis
Requiring Steroid Sparing Immunosuppressive
Therapy. Erik Letko1, S. Yeh2, C. L. Grosskreutz3,
U. Pleyer4, C. Foster5, M. G. Brigell6. 1Corneal
Consultants of Colorado, Denver, CO;
2
Ophthalmology Eye Center, Atlanta, GA; 3Global
Translational Medicine Head for Ophthalmology
Novartis Institutes for Biomedical Research,
Cambridge, MA; 4Ophthalmology University
Charite Berlin, Berlin, Germany; 5Ophthalmology
Ocular Immunol & Uveitis Foundation, Cambridge,
MA; 6Novartis Institutes for BioMedical Research,
Inc., Cambridge, MA *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
372
Thursday – Papers/Minisymposium – 5930 – 5944
5930 — 11:00 Clinical Characteristics and
Treatment Outcomes of Juvenile Idiopathic
Arthritis Associated Uveitis. Nisha Acharya1, 2,
S. Patel3, G. Homayounfar1, W. Enanoria1, 2, A.
Shakoor1, A. Chakrabarti3, D. A. Goldstein3, 4.
1
F.I. Proctor Foundation, University of California,
San Francisco, San Francisco, CA; 2Department
of Ophthalmology, University of California, San
Francisco, San Francisco, CA; 3Department of
Ophthalmology, University of Illinois College of
Medicine at Chicago, Chicago, IL; 4Department of
Ophthalmology, Northwestern Memorial Feinberg
School of Medicine, Chicago, IL *CR
5931 — 11:15 12-Month Results of the SAVE
Study - Sirolimus as Therapeutic Approach
to UVEitis: A Randomized Study to Assess
the Safety and Bioactivity of Intravitreal and
Subconjunctival Injections of Sirolimus in
Patients with Non-infectious Uveitis. Quan
Dong Nguyen1, 2, M. A. Ibrahim2, A. L. Watters2,
Y. J. Sepah2, M. G. Bittencourt2, J. Yohannan2, J.
Naor3, N. K. Shams3, D. V. Do2. 1Diseases of the
Retina & Uveitis, Johns Hopkins Univ, Wilmer Eye
Inst, Baltimore, MD; 2Retinal Imaging Research
and Reading Center, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD; 3Santen, Inc,
Emeryville, CA *CR, f
5932 — 11:30 The Course of Uveitis in
Pregnancy and the Postpartum. Lyndell Lim1, 5,
N. Chiam1, R. J. Stawell3, 4, L. Busija1, A. J. Hall2, 3.
1
Centre for Eye Research Australia, University
of Melbourne, East Melbourne, VIC, Australia;
2
Ophthalmology, The Alfred Hospital, Melbourne,
VIC, Australia; 3Eye Surgery Associates,
Melbourne, VIC, Australia; 4Ocular Immunology
Clinic, Royal Victorian Eye and Ear Hospital, East
Melbourne, VIC, Australia; 5Victoria Parade Eye
Consultants, East Melbourne, VIC, Australia *CR
5933 — 11:45 Visual outcomes in uveitis with
angiographic macular leakage treated with the
fluocinolone acetonide implant or standard
treatment. Thomas A. Albini1, D. A. Goldstein2,
D. Callanan3, Q. Nguyen4, S. K. Srivastava5.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Ophthalmology, Northwestern
Universty, Chicago, IL; 3Ophthalmology, Texas
Retina Associates, Dallas, TX; 4Ophthalmology,
Johns Hopkins University, Baltimore, MD;
5
Ophthalmology, Cleveland Clinic, Cleveland, OH
*CR, f
5934 — 12:00 Health utility in the Multicenter
Uveitis Steroid Treatment Trial. Elizabeth
A. Sugar1, 3, A. E. Burke2, 3, L. T. Drye2, 3, J.
Holbrook2, 3, J. H. Kempen5, 6, J. E. Thorne2, 4,
K. D. Frick7. 1Biostatistics, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 2Epidemiology, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 3Center for Clinical Trials, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 4Ophthalmology, The Johns Hopkins
University School of Medicine, Baltimore, MD;
5
Ocular Inflammation Service, The University of
Pennsylvania, Philadelphia, PA; 6Center for Clinical
Epidemiology and Biostatistics, Department of
Biostatistics and Epidemiology, The University
of Pennsylvania, Philadelphia, PA; 7Health Policy
and Management, The Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD *CR, f
608
Thursday, May 09, 2013 10:30 AM-12:15 PM
Anatomy/Pathology
526 Anatomy Challenges for the Future
5939 — 11:30 Sox9 regulates the formation
and branching morphogenesis of mouse ocular
glands. Ziyan Chen2, 1, J. Huang1, Y. Liu1, D. C.
Beebe1, 3. 1Ophthalmology and Visual Sciences,
Washington University in St. Louis, St. Louis,
MO; 2Zhongshan Ophthalmic Center, State Key
Laboratory of Ophthalmology, Sun Yat-sen
University, Guangzhou, China; 3Cell Biology and
Physiology, Washington University in St. Louis, St.
Louis, MO *CR
5940 — 11:45 Identification of Signaling
Pathways involved in Retina-Lens Tissue
Interactions using Embryos Over-Expressing
Pairedless Pax6 (Pax6ΔPD) Gene. Vijay K.
Kalaskar1, J. D. Lauderdale2. 1Neuroscience
Division of Biomedical & Health Sciences Institute,
University of Georgia, Athens, GA; 2Cellular
Biology, University of Georgia, Athens, GA
5941 — 12:00 Topical small molecule
translational bypass therapy rescues Pax6
aniridia mutant phenotype. Cheryl Y. GregoryEvans, X. Wang, A. Metcalfe, X. Shan, K. GregoryEvans. Ophthalmology, University of British
Columbia, Vancouver, BC, Canada
609
Moderators: Ludwig M. Heindl and
Robert J. Zawadzki
Thursday, May 09, 2013 10:30 AM-12:15 PM
5935 — 10:30 Anatomy of CD31+ blood
vessels and LYVE1+ macrophages in the adult
human sclera. Simona L. Schlereth1, F. Schroedl2,
R. Grajewski1, C. Cursiefen1, L. M. Heindl1.
1
Ophthalmology, University of Cologne, Cologne,
Germany; 2Paracelsus Medical University, Salzburg,
Austria *CR
527 Cataract II
5936 — 10:45 Optic Nerve Parameters in
Preterm and Full Term Infants Using Spectral
Domain Optical Coherence Tomography
(SDOCT). Amy Y. Tong1, R. S. Maldonado2,
D. Tran-Viet2, A. L. Rothman1, E. L. Yuan2, A.
M. Dubis2, S. Stinnett2, M. A. El-Dairi2, S. F.
Freedman2, C. A. Toth2. 1Duke University School
of Medicine, Durham, NC; 2Duke Eye Center,
Durham, NC *CR
5938 — 11:15 Canonical Wnt signaling is
required for lacrimal gland formation, eyelid
closure and to suppress corneal cell fate in mouse
conjunctival and eyelid epithelium. Jie Huang1, Y.
Liu1, D. C. Beebe1, 2. 1Ophthalmology, Washington
University, Brentwood, MO; 2Cell Biology and
Physiology, Washington University, St. Louis, MO
*CR
Moderators: Linda Musil and Michael Wormstone
5942 — 10:30 Effects of basic FGF on the
regeneration of lens in New Zealand Albino
rabbits. Zhenzhen Liu, M. Wu, Y. Zhu, W. Zhang,
X. Tan, S. Huang, F. Shang, Y. Liu. Lab of Cataract
Prevention and Treatment, Zhongshan Ophthalmic
Center, Guangzhou, China
5943 — 10:45 FGF2 Antagonizes the TGFβ2Induced Aberrant Expression of Tropomyosin
and α-Smooth Muscle Actin in Mouse and
Human Lens Epithelial Cells and Has a Role
in Posterior Capsule Opacity. Eri Kubo1,
N. Hasanova1, H. Osada1, E. Kiyokawa2, H.
Sasaki1, N. Fatma3, D. P. Singh3. 1Department of
Ophthalmology, Kanazawa Medical University,
Ishikawa, Japan; 2Department of Oncogenic
Pathology, Kanazawa Medical University, Ishikawa,
Japan; 3Department of Ophthalmology, University
of Nebraska Medical Center, Omaha, NE
5944 — 11:00 Increased Matrix Rigidity
Drives Repair Cell Transdifferentiation into
Myofibroblasts in a PCO Model. Janice L.
Walker1, 2, B. Bleaken1, M. Stepp3, 4, A. S. Menko1, 2.
1
Pathology, Anatomy & Cell Biology, Thomas
Jefferson University, Philadelphia, PA; 2Wills Vision
Research Center at Jefferson, Philadelphia, PA;
3
Department of Anatomy and Regenerative Biology,
The George Washington Universtiy, Washington,
DC; 4Department of Ophthalmology, The George
Washington Universtiy, Washington, DC
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
373
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5937 — 11:00 Expression of the
Lymphangiogenic Marker Podoplanin (D2-40)
in Human Fetal Eyes. Martina C. Herwig1, K.
Münstermann2, U. Klarmann3, K. U. Loeffler1, A.
M. Müller2. 1Dept. of Ophthalmology, University
of Bonn, Bonn, Germany; 2Dept. of Pediatric
Pathology, University of Bonn, Bonn, Germany;
3
Institute of Medical Biometry, University of Bonn,
Bonn, Germany
Lens
5945 – 5963 – Thursday – Papers/Minisymposium
5945 — 11:15 STEP Phosphatase and AMPA
Receptor GluA2 Regulation in DiabetesInduced Cataract in Rabbit. Peter Frederikse1,
C. Kasinathan1, M. Bhattacharyya1, N. J. Kleiman2.
1
University of Medicine and Dentistry of New
Jersey, Newark, NJ; 2Mailman School of Public
Health, Columbia University, New York City, NY
*CR
5946 — 11:30 APC-Coated Intraocular Lenses
Reduce the Occurrence of PCO in a Human
Anterior Chamber Model. Raffael Liegl, C. M.
Wertheimer, M. Kernt, A. Wolf, A. Kampik, K. EiblLindner. Ophthalmology, Ludwig-MaximiliansUniversity Munich, Muenchen, Germany *CR
5947 — 11:45 The study of surface properties
of intraocular lens by nanometric analysis.
Jun Kong1, 2, N. Yang1, X. Li1, Y. Lu1, J. Zhang1.
1
Ophthalmology, the 4th Affiliated Hospital of
China Medical University, Shenyang, China;
2
Ophthalmology, UCSD, San Diego, CA
5948 — 12:00 Epilepsy Cataract: Valproic
Acid Suppresses the Nrf2 Dependent Stress/
Antioxidant Protection. Toshimichi Shinohara1,
P. Periyasamy1, K. R. Bidasee2, M. Ayaki3, E.
Rajan1. 1Ophthalmol and Vis Sci, Univ of Nebraska
Medical Center, Omaha, NE; 2Pharmacology and
Experimental Neuroscience, Univ of Nebraska
Medical Center, Omaha, NE; 3Ophthalmology, Mita
Hospital, Tokyo, Japan
611-614
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retinal Cell Biology
528 Photoreceptor Degeneration
and Death
Moderators: Rong Wen and Xi-Qin Ding
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5949 — 10:30 Modulation of the rate of
retinal degeneration in T17M RHO mice
by reprogramming the Unfolded Protein
Response. Marina S. Gorbatyuk1, S. Choudhury2,
S. R. Nashine2, Y. Bhootada1, A. S. Lewin3, O.
Gorbatyuk3. 1Vision Sciences, UAB, Birmingham,
AL; 2Cell Biology and Anatomy, UNTHSC, Fort
Worth, TX; 3Molecular Genetics & Microbiology,
UF, Gainesville, FL *CR
5950 — 10:45 How long does a photoreceptor
take to die? Temporal characteristics of neuronal
cell death in the retina. Francois Paquet-Durand1,
A. Sahaboglu-Tekgöz1, O. Paquet-Durand2,
J. Dietter1, P. A. Ekstrom3, B. Hitzmann2, M.
Ueffing1. 1Experimental Ophthalmology, Institute
for Ophthalmic Research, Tuebingen, Germany;
2
Institute of Food Science and Biotechnology,
University of Stuttgart Hohenheim, Stuttgart,
Germany; 3Clinical Sciences, University of Lund,
Lund, Sweden
5951 — 11:00 Expression and localization
of cell cycle and proliferation genes in early
retinal degeneration models. Sem Genini, K. L.
Gardiner, G. D. Aguirre. Clinical Studies, Univ of
Pennsylvania, Sch Veterinary Med, Philadelphia, PA
5957 — 10:45 Risk factors for lacking adequate
refractive correction in the U.S., NHANES
1999-2008. Susan Vitale, R. Sperduto, E. Y. Chew,
F. L. Ferris. Div Epidemiol & Clin Applications,
National Eye Inst/NIH, Bethesda, MD *CR
5952 — 11:15 cGMP Accumulation Causes
Cone Degeneration in CNG Channel Deficiency.
Arjun Thapa1, J. Xu1, L. M. Morris1, H. Ma1, S.
Michalakis2, M. Biel2, W. Baehr3, A. M. Dizhoor4,
I. V. Peshenko4, X. Ding1. 1Cell Biology, Univeristy
of OKlahoma, Oklahoma City, OK; 2Center for
Integrated Protein Science Munich (CIPSM)
and Department of Pharmacy, Center for Drug
Research, Ludwig-Maximilians-Universität
München, München, Germany; 3The John A. Moran
Eye Center, University of Utah, Salt Lake CIty, UT;
4
Department of Basic Sciences and Pennsylvania
College of Optometry, Salus University, Elkins
Park, PA
5958 — 11:00 Heterogeneity of effects in
refractive error: lessons from the CREAM
Consortium genome-wide association metaanalysis. Christopher J. Hammond1, P. G. Hysi1,
V. J. Verhoeven2, C. C. Klaver2. 1Ophthalmology,
King’s College London, London, United Kingdom;
2
Ophthalmology & Epidemiology, Erasmus Medical
Center, Rotterdam, Netherlands *CR
5953 — 11:30 Exploration of the Mechanisms
of Cone Photoreceptor Death in the Deficiency
of Phosphodiesterase. Lynsie M. Morris1, Z. D.
Ma1, A. Thapa1, H. Ma1, S. Michalakis2, M. Biel2,
W. Baehr3, X. Ding1. 1Cell Biology, OU Health
Sciences Center, Oklahoma City, OK; 2Center for
Drug Research, Ludwig-Maximilians-Universität
München, Munich, Germany; 3John A. Moran Eye
Center, University of Utah, Salt Lake City, UT
5954 — 11:45 Genetic ablation of DHDDS
induces photoreceptor degeneration. Rong Wen,
Y. Li, Z. Wang, B. L. Lam, Y. Li. Bascom Palmer Eye
Inst, University of Miami, Miami, FL *CR
5955 — 12:00 Rip3 knockdown rescues
photoreceptor cell death in pde6c zebrafish
model of achromatopsia. Ishaq Ahmed
Viringipurampeer, Z. Mohammadi, X. Shan, K.
Gregory-Evans, C. Y. Gregory-Evans. Department
of Ophthalmology and Visual Sciences, University
of British Columbia, Vancouver, BC, Canada
615-617
Thursday, May 09, 2013 10:30 AM-12:15 PM
5959 — 11:15 The role of time outdoors on
the progression of refractive error in Australian
children. Kathryn A. Rose1, A. French1, P. Mitchell2,
I. G. Morgan3. 1Discipline of Orthoptics, University
of Sydney, Sydney, NSW, Australia; 2Department
of Ophthalmology, University of Sydney, Sydney,
NSW, Australia; 3Research School of Biology,
Australian National University, Canberra, ACT,
Australia *CR
5960 — 11:30 Influence of education on
penetrance of myopia genes. Caroline C.
Klaver1, 2, V. J. Verhoeven1, 2, G. H. Buitendijk1, 2, J.
R. Vingerling1, 2. 1Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 2Epidemiology,
Erasmus Medical Center, Rotterdam, Netherlands
*CR
5961 — 11:45 School readiness, behavioural
and emotional difficulties: the impact of
strabismus and its treatment. Phillippa
Cumberland1, 3, J. S. Rahi1, 2. 1MRC Centre for
Epidemiology of Child Health, UCL Institute of
Child Health, London, United Kingdom; 2UCL
Institute of Ophthalmology, London, United
Kingdom; 3Ulverscroft Vision Research Group,
London, United Kingdom
5962 — 12:00 The Magnitude and Symmetry
of Refractive and Corneal Astigmatism in
Children. John D. Twelker, J. M. Miller, D. H.
Messer, E. M. Harvey. Ophthal & Vision Science,
University of Arizona, Tucson, AZ
Clinical/Epidemiologic Research
529 Refractive Error and Visual
Function: What Affects How We See
618-620
Thursday, May 09, 2013 10:30 AM-12:15 PM
Physiology/Pharmacology
Moderators: Susan Vitale and Kathryn A. Rose
5956 — 10:30 Atherosclerosis, Inflammation
and Decline in Contrast Sensitivity: The Beaver
Dam Offspring Study. Karen J. Cruickshanks1, 2,
D. M. Nondahl1, D. S. Dalton1, G. Huang3, 2, B.
E. Klein1, R. Klein1, F. Nieto2, C. R. Schubert1.
1
Ophthalmology and Visual Sciences, U of WI
SMPH, Madison, WI; 2Population Health Sciences,
U of WI SMPH, Madison, WI; 3National Chiao
Tung University, Hsinchu, Taiwan
530 Gene Therapy and Delivery
Moderators: Tao L. Lowe and Caterina Gagliano
5963 — 10:30 Oral delivery of bioencapsulated
myelin basic protein ameliorate amyloid burden
and RGC loss in transgenic mouse model of
Alzheimer’s disease. Qiuhong Li1, A. Verma1,
P. Zhu1, P. K. Shil1, N. Kohli2, D. Westerveld2, H.
Daniell2. 1Ophthalmology, University of Florida,
Gainesville, FL; 2University of Central Florida,
Orlando, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
374
Thursday – Papers/Minisymposium – 5964 – 5981
5964 — 10:45 Treatment of Patients with
Leber Congenital Amaurosis Type 2 with an
AAV Vector Expressing RPE65. Tim Stout1, R. G.
Weleber1, M. McBride1, D. J. Wilson1, D. Peters1,
M. R. Humphries3, T. R. Flotte3, L. J. Jensen1, A.
Lauer1, J. D. Chulay2. 1Ophthalmology, Casey
Eye Institute-OHSU, Portland, OR; 2AGTC Inc,
Alachua, FL; 3School of Medicine, University of
Massachusetts, Worcester, MA *CR, f
5965 — 11:00 Sustained Therapeutic Reversal
of Canine Bestrophinopathy with Gene Therapy
using Recombinant AAV2. Karina E. Guziewicz1,
A. M. Komaromy2, S. Iwabe1, A. V. Cideciyan3,
E. V. Dutrow1, B. Zangerl4, W. A. Beltran1, S. G.
Jacobson3, W. W. Hauswirth5, G. D. Aguirre1.
1
Clinical Studies, University of Pennsylvania,
Philadelphia, PA; 2Department of Small Animal
Clinical Sciences, Michigan State University, East
Lansing, MI; 3Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA; 4Centre for
Eye Health, University of New South Wales,
Kensington, NSW, Australia; 5Department of
Ophthalmology, University of Florida, Gainesville,
FL *CR
5966 — 11:15 Vertical Gene Transfer of Mutant
Human G11778A ND4 in Next Generation MitoMice. Hong Yu, S. S. Ozdemir, T. Chou, V. Porciatti,
J. Guy. Ophthalmology, Bascom Palmer Eye Inst,
Univ of Miami, Miami, FL
5967 — 11:30 Gene Therapy with the
Mitochondrial Heat Shock Protein 70 (mtHSP70)
Chaperone Supresses Neurodegeneration and
Irreversible Visual Loss in Experimental Optic
Neurits. Venu Talla, S. S. Ozdemir, T. Chou, V.
Porciatti, J. Guy. Ophthalmology, Bascom Palmer
Eye Institute, University of Miami, Miller School of
Medicine, Miami, FL
5969 — 12:00 Gene therapy in Leber
congenital amaurosis due to rpe mutations:
results of the first six patients included in a
clinical trial. Guylene Le Meur1, P. Lebranchu2,
Y. Péréon3, S. Schmitt4, S. Bézieau5, P. Moullier6,
F. Rolling7, M. Weber8. 1CHU hotel dieu, Nantes,
France; 2CHU hotel Dieu, Nantes, France; 3CHU
hotel Dieu, Nantes, France; 4CHU hotel Dieu,
Nantes, France; 5CHU hotel Dieu, Nantes, France;
6
INSERM UMR 1089, Nantes, France; 7INSERM
UMR 1089, Nantes, France; 8CHU hotel Dieu,
Nantes, France f
Thursday, May 09, 2013 10:30 AM-12:15 PM
Low Vision Group
531 Beyond Large Print: Advances in
Accessibility and Technology for the
Visually Impaired - Minisymposium
Over the last 20 years technological innovation
has advanced at an amazing pace and in doing so
has revolutionized accessibility to information for
people with vision impairments. Presenters in this
symposium will provide an overview of how recent
and future advances in technology and computer
vision can be utilized by vision scientists to provide
immediate and potentially life-changing solutions
for individuals with vision impairments.
Moderators: James B. Nolan, Ava K. Bittner and
Alexandra R. Bowers
— 10:30 Introduction
— 10:40 Oberdorfer Award in Low Vision
Presentation
5970 — 10:45 Oberdorfer Award in Low
Vision – Using the Cloud and Emerging
Technologies to Provide On-demand Low Vision
Solutions Anytime, Anywhere, on Any Device.
Gregg Vanderheiden. Industrial Engineering and
Biomedical Engineering, University of WisconsinMadison, Madison, WI
5971 — 11:15 Accessibility and Vision
Rehabilitation Science: Tear Down That Wall!.
Aries Arditi. Visibility Metrics LLC, Chappaqua,
NY
5972 — 11:35 Computer Vision-based Assistive
Technology for the Visually Impaired. James
Coughlan. Smith-Kettlewell Eye Research Institute,
San Francisco, CA
5973 — 11:55 Using Text Detection to Help
Low Vision Users. Peter Hallinan. The Blindsight
Corporation, Berkeley, CA *CR
TCC 303
Thursday, May 09, 2013 10:30 AM-12:15 PM
Cornea
5975 — 10:45 Type III Intermediate Filament
Overexpression in the Genesis of Corneal
Fibrosis. Royce Mohan1, L. Cauley2, P. BargagnaMohan1. 1Neuroscience, University of Connecticut
Health Center Health Center, Farmington, CT;
2
Immunology, University of Connecticut Health
Center, Farmington, CT *CR
5976 — 11:00 Genome-wide transcriptional
analysis of differentially expressed genes in
diabetic, healing corneal epithelial cells. Fushin
X. Yu. Dept of Ophthalmology, Wayne State Univ/
Kresge Eye Inst, Detroit, MI
5977 — 11:15 Corneal epithelial-neuronal
signaling is compromised under environmental
stress. Vickery E. Trinkaus-Randall, A. Lee, K.
Derricks, M. Nugent. Ophthalmology L904, Boston
University Sch of Med, Boston, MA
5978 — 11:30 Ciliary neurotrophic Factor
accelerates corneal Nerve Regeneration in a
Murine Model. Rudolf F. Guthoff, M. Reichard, M.
Hovakimyan, O. Stachs. Ophthalmology, University
of Rostock, Rostock, Germany
5979 — 11:45 The Mechanotransducers
YAP and TAZ are Modulated by Substratum
Compliance in Corneal Stromal Cells and
during Corneal Wound Healing. Christopher J.
Murphy1, 2, S. M. Thomasy1, V. K. Raghuanthan1, C.
M. Reilly3, P. Russell1. 1Surgical and Radiological
Sciences, School of Veterinary Medicine, University
of California, Davis, Davis, CA; 2Ophthalmology
& Vision Science, School of Medicine, University
of California, Davis, Davis, CA; 3Pathology,
Immunology & Microbiology, School of Veterinary
Medicine, University of California, Davis, Davis,
CA *CR
5980 — 12:00 Anti-inflammatory therapy
changes fate of alkali burned corneas associated
with dry eye. Cintia S. De Paiva, F. S. Pelegrino,
E. A. Volpe, S. C. Pflugfelder. Ophthalmology,
Baylor College of Medicine, Houston, TX *CR
TCC 305
Thursday, May 09, 2013 10:30 AM-12:15 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
533 Disruptions to Visual Development:
Detection, Treatment and
Consequences
532 Corneal Wound Repair and Healing
Moderators: Susan A. Cotter and Agnes M. Wong
Moderators: Winston W. Kao and Peter S. Reinach
5974 — 10:30 Effect of Advanced Glycation
End Products on apoptosis of Human Corneal
Epithelial Cells. Xinyi Wu. Ophthal QiLu Hosp/
Ophthal, Shandong University, Jinan, Shandong,
China
5981 — 10:30 Beyond Screening for Risk
Factors…The Objective Detection of Strabismus
and Amblyopia. Susan E. Yanni1, R. M. Jost1, C. L.
Beauchamp2, D. R. Stager2, S. David3, L. Dao3, M.
R. Nolan1, E. E. Birch1, 4. 1Retina Foundation of the
Southwest, Dallas, TX; 2Pediatric Ophthalmology
and the Center for Adult Strabismus, Dallas, TX;
3
Pediatric Ophthalmology and Adult Strabismus,
Plano, TX; 4Ophthalmology, University of Texas
Southwestern Medical Center, Dallas, TX *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
375
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5968 — 11:45 AAV-mediated gene therapy
restores retinal function and vision in the
RPGRIP1-deficient dog. Lolita Petit1, E.
Lhériteau1, M. Weber2, G. Le Meur2, J. Deschamps3,
P. Moullier1, 4, F. Rolling1. 1Inst de Recherche
Therapeutique 1, Lab de Therapie Genique
INSERM UMR 1089, Nantes, France; 2Service
d’Opthalmologie, CHU-Hôtel Dieu, Nantes,
France; 3Emergency and Critical Care Unit,
ONIRIS, Nantes-Atlantic College of Veterinary
Medicine-Food Science and Engineering, Nantes,
France; 4Department of Molecular Genetics and
Microbiology, College of Medicine, University of
Florida, Gainesville, FL
TCC LL 4/5
5982 – 5987 – Thursday – Papers/Minisymposium
5982 — 10:45 Are Referrals From the
Plusoptix S09 Significantly More Accurate Than
the LEA/Random Dot E Screening System for
Preschool Children Ages 3-5. Joannah Vaughan,
R. Arao, T. Dale, M. F. Chiang, D. J. Karr. Casey
Eye Institute, Oregon Health & Science University,
Portland, OR *CR
5983 — 11:00 The relationship between
visual function and scores on the Beery VisualMotor Integration test in 4.5 year old children
born with developmental risk factors. Arijit
Chakraborty1, N. S. Anstice1, R. J. Jacobs1, J. E.
Harding2, J. Paynter2, T. Wouldes3, B. Thompson1.
1
Optometry and Vision Science, University of
Auckland, Auckland, New Zealand; 2Liggins
Institute, University of Auckland, Auckland, New
Zealand; 3Psychological Medicine, University of
Auckland, Auckland, New Zealand *CR
5984 — 11:15 Comparison of
electroretinographical responses in albinism,
idiopathic infantile nystagmus and healthy
controls. Zhanhan Tu1, C. Degg2, I. Gottlob1, F. A.
Proudlock1. 1Opthalmology Group, University of
Leicester, Leicester, United Kingdom; 2Medical
Physics, University Hospitals of Leicester,
Leicester, United Kingdom
5985 — 11:30 Timing matters: Relationship
between age at initial surgery and monocular
grating acuity at 12 months in the Infant
Aphakia Treatment Study (IATS). E Eugenie
Hartmann1, M. J. Lynn2, S. R. Lambert3.
1
Department of Vision Sciences, Univ of Alabama
at Birmingham, Birmingham, AL; 2Department of
Biostatistics and Bioinformatics; Rollins School
of Public Health, Emory University, Atlanta,
GA; 3Department of Ophthalmology; School of
Medicine, Emory University, Atlanta, GA f
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5986 — 11:45 A prospective non-randomized
study on early vs standard surgery for infantile
esotropia in children: An interim report on
optokinetic response. Agnes M. Wong1, 2, H. C.
Goltz1, 2, A. Blakeman2, L. Colpa1. 1Ophthalmology
& Vision Sciences, Hospital for Sick Children,
Toronto, ON, Canada; 2Ophthalmology & Vision
Sciences, University of Toronto, Toronto, ON,
Canada f
5987 — 12:00 Factors Associated with
Poor Health-Related Quality of Life in Adult
Strabismus. Sarah R. Hatt, D. A. Leske, L.
Liebermann, J. M. Holmes. Ophthalmology, Mayo
Clinic, Rochester, MN
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
376
Thursday – Posters – 5988 – 6008
Exhibit Hall A0032-A0042
Thursday, May 09, 2013 10:30 AM-12:15 PM
Immunology/Microbiology / Cornea
534 Corneal Infection/Inflammation II
Moderator: Alison M. McDermott
5988 — A0032 Determining the Efficacy of a
Novel Targeted Therapeutic Approach Against
Herpes Simplex Virus-1 in an Organotypically
Cultured Corneal Model. Paul J. Park1, T. ValyiNagy3, D. Shukla1, 2. 1Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL; 2Microbiology and Immunology, University
of Illinois at Chicago, Chicago, IL; 3Pathology,
University of Illinois at Chicago, Chicago, IL
5989 — A0033 STAT3/SOCS3 axis modulates
CD8-mediated host immunity against HSV-1.
Fatemeh Navid1, C. Yu1, I. M. Dambuza1, G. Frank2,
C. Egwuagu1. 1Laboratory of Immunology, NEI,
Bethesda, MD; 2Cellular Biology Section, NIAID,
Bethesda, MD
5990 — A0034 Targeting host kinases as
potential therapeutic targets for the treatment
of herpes keratitis. Oleg Alekseev, J. AzizkhanClifford. Biochemistry & Molecular Biology, Drexel
Univ College of Medicine, Philadelphia, PA
5991 — A0035 Efficacy of HSV1-specific
meganucleases in a mouse model of relapsing
herpes keratitis. Marc Labetoulle1, 2, E. E.
Gabison3, A. Rousseau1, N. Huot2, D. Pasdeloup2,
S. Barradeau4, C. Mahiet4, B. Chapelier3, M.
Breckler2. 1Ophthalmology, Hopital Bicetre,
South Paris University, Le Kremlin Bicetre,
France; 2Laboratoire de Virologie Moleculaire
et Structurale, CNRS UPR 3296, Gif sur Yvette,
France; 3Institut de la Vision, Paris, France;
4
Genomic Vision, Bagneux, France *CR
5994 — A0038 Cytokine Profiling in Mouse
Cornea During Wound Healing in Response
to CAP37 Treatment. Anne Kasus-Jacobi1,
G. L. Griffith2, M. R. Lerner3, H. A. Pereira1, 2.
1
Pharmaceutical Sciences, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
2
Pathology, University of Oklahoma Health
Sciences Center, Oklahoma City, OK; 3Surgery,
University of Oklahoma Health Sciences Center,
Oklahoma City, OK
5995 — A0039 Expression of PAR1 and 2 on
Human Corneal Epithelial Cells and Induction
of Pro-inflammatory Cytokine Secretion by
Acanthamoeba MIP-133 and aPA. Hassan
Alizadeh1, 2, M. Abdi1, 2. 1Cell Biology and Anatomy,
UNTHSC Fort Worth TX, Fort Worth, TX; 2North
Texas Eye Research Institute, UNTHSC, Fort
Worth, TX
5996 — A0040 Role of ST2 Signaling in IL33 Induced Inflammation in Human Corneal
Epithelium. Jing Lin, G. Zhao, L. Zhang.
Ophthalmology, the Affiliated Hospital of Medical
College, Qingdao University, Qingdao, China
5997 — A0041 Antimicrobial Peptides in the
In Vitro Corneal Response to Fungal Pathogens.
Satya Sree N. Kolar, H. Baidouri, A. McDermott.
Optometry and Vision Sciences, University of
Houston, College of Optometry, Houston, TX
5998 — A0042 Corneal epithelial-cell necrosis
and apoptosis directly induced by fungal isolates
from patients with keratomycosis. Pablo L.
Goldschmidt1, R. Zemihi1, D. Ghoubay-Benallaoua1,
C. Temstet1, L. Batellier1, V. Borderie2, L. Laroche2,
C. Chaumeil1. 1Laboratoire, Centre Hospitalier
National d’Ophtalmologie des Quinze-Vingts, Paris,
France; 2Service 5, Centre Hospitalier National
d’Ophtalmologie des Qui, Paris, France
Exhibit Hall A0062-A0116
Thursday, May 09, 2013 10:30 AM-12:15 PM
Cornea / Visual Psychophysics / Physiological
Optics
5993 — A0037 Expression of NOD-like
receptors(NLRs) and NODs in corneal diseases.
Na-Kyung Ryoo1, 2, J. Ko2, H. Lee2, M. Kim1, W.
Wee1, J. Oh1, 2. 1Ophthalmology, Seoul National
University Hospital, Seoul, Republic of Korea;
2
Clinical Research Institute, Seoul National
University Hospital, Seoul, Republic of Korea
5999 — A0062 Toll-like Receptor Agonists
Stimulate Matrix Metalloproteinase-9
Production in Ocular Surface Cells. Rachel L.
Redfern, K. Stout, K. Dionne. College of Optometry,
University of Houston, Houston, TX
535 Dry Eye and Lacrimal Gland V
Moderators: De-Quan Li and Norihiko Yokoi
6000 — A0063 Corneal Epithelial Cell
Protective and Wettability-enhancing Properties
of Hyaluronic Acid + PEG 8000 in an Artificial
Tear Product. Stephen Davio, M. E. Cavet, K. L.
Harrington, A. Walsh, Z. Marlowe, B. Glass, P.
Sarkar. Pharmaceutical R&D, Bausch & Lomb,
Rochester, NY *CR
6002 — A0065 Comparison of two rodent
models of dry eye induced by Scopolamine.
Pierre-Paul Elena1, N. Cimbolini1, S. Antonelli1, L.
Feraille1, S. Barabino2, P. Margaron1. 1Iris Pharma,
La Gaude, France; 2Clinica Oculistica, Genova,
Italy *CR
6003 — A0066 The Composition of Fatty
Acids in Human Meibum. Tomo Suzuki1, 2, S.
Kamada1, 2, T. Tajika3, S. Fujiwara4, S. Kinoshita1.
1
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan; 2Ophthalmology, Kyoto
City Hospital, Kyoto, Japan; 3Senju Pharmaceutical
Co. LTD., Osaka, Japan; 4Shimadzu TechnoResearch, INC., Kyoto, Japan *CR
6004 — A0067 Topical atorvastatin for the
treatment of dry eye associated with blepharitis.
Stephanie L. Watson1, K. G. Ooi1, 2, F. A. Billson1, D.
Wakefield3. 1Ophthalmology, Save Sight Institute,
University of Sydney, Sydney, NSW, Australia;
2
Department of Ophthalmology, Prince of Wales
Hospital, Sydney, NSW, Australia; 3Department of
Pathology, School of Medical Sciences, University of
New South Wales, Sydney, NSW, Australia *CR, f
6005 — A0068 Optical quality after instillation
of three different eye drops for dry eye. Shizuka
Koh1, N. Maeda1, C. Ikeda1, 2, Y. Takai1, 2, H.
Fujimoto1, Y. Oie1, T. Soma1, M. Tsujikawa1, K.
Nishida1. 1Ophthalmology, Osaka University
Graduate School of Medicine, Suita, Japan;
2
Research & Development, Rohto Pharmaceutical
CO.,LTD, Kyoto, Japan *CR
6006 — A0069 Effects of diquafosol
sodium eye drops on tear film stability. Seika
Den1, H. Iseda1, M. Dogru1, 2, J. Shimazaki1, 2.
1
Ophthalmology, Tokyo Dental College, Chiba,
Japan; 2Ophthalmology, Keio University School of
Medicine, Tokyo, Japan *CR, f
6007 — A0070 A multi-lamellar sandwich
model of the tear film lipid layer, TFLL. Peter
E. King-Smith1, M. D. Bailey1, R. J. Braun2.
1
Optometry, Ohio State University, Columbus, OH;
2
Mathematical Sciences, University of Delaware,
Newark, DE
6008 — A0071 Observation of Spreading and
Mechanical Properties of the Tear Film Lipid
Layer Using A High Performance Video-Based
Interferometry System. Daniel R. Powell, P. E.
King-Smith, H. L. Chandler. Vision Science, Ohio
State University, Columbus, OH
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
377
Thursday Posters
10:30 am – 12:15 pm
5992 — A0036 Preclinical evaluation of new
therapies in a fungal keratitis rat model. M Livia
Bajenaru, A. C. Santos, M. J. Falter, M. Ruggeri, J.
Ponmattam, E. P. Hernandez, M. Abou Shousha, V.
L. Perez, D. Miller, E. C. Alfonso. Ophthalmology,
Univ of Miami, Bascom Palmer Eye Inst, Miami,
FL *CR
6001 — A0064 Change of Tear Secretion in the
Lacrimal Glands of High-Fat Diet-Fed C57BL/6J
Mice. Takaaki Inaba, M. Kawashima, A. Ito, M.
Watanabe, K. Shinmura, T. Kawakita, K. Tsubota.
Keio University, Tokyo, Japan *CR
6009 – 6034 – Thursday – Posters
6009 — A0072 Symptoms and Findings in a
Norwegian Cohort of Patients with Meibomian
Gland Dysfunction. Ola M. Rygh1, 2, J. Eidet1, 5,
X. Chen1, 5, T. P. Utheim1, 3, A. Thyholdt4, O.
Utheim1, 3, F. Stojanovic1, 5, A. Stojanovic1, 5, S.
Raeder1, 6. 1Torreoyneklinikken AS, Oslo, Norway;
2
Eye department, Hospital of Vestfold, Tonsberg,
Norway; 3Department of Medical Biochemistry,
Oslo University Hospital Ulleval, University of
Oslo, Oslo, Norway; 4dbConsult, Tromso, Norway;
5
Synslaser Kirurgi, Oslo, Norway; 6Department of
Clinical Medicine, University of Bergen, Bergen,
Norway
6010 — A0073 Effects of alkali burn of the
ocular surface on meibomian gland structure
in mice. Shin Mizoguchi1, Y. Okada1, R. Arita2,
S. Saika1. 1Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2Itoh Clinic, Tokyo,
Japan *CR
6011 — A0074 Effect of Collection Method
on the Lipid Composition of Meibum Samples.
Carolina Kunnen1, 2, S. H. Brown4, B. A. Holden1,
3
, P. Lazon De La Jara1, 2, E. B. Papas1, 3. 1Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
School of Optometry and Vision Science,
University of New South Wales, Sydney, NSW,
Australia; 3Vision CRC, Sydney, NSW, Australia;
4
School of Health Sciences, University of
Wollongong, Wollongong, NSW, Australia *CR
6012 — A0075 Infra-Red Imaging of
Meibomian Glands & Evaluation of the Lipid
Layer in Sjogren’s Syndrome Patients. Sruthi
Srinivasan, K. L. Menzies, L. W. Jones. School of
Optometry, University of Waterloo, Waterloo, ON,
Canada *CR
6013 — A0076 Analysis of a potential
Meibomian Gland Dysfunction-Specific
Symptom Questionnaire in an Independent
Sample. Justin T. Kwan1, M. M. Hom2, J. R. Paugh1.
1
Contact Lens, Dry Eye, Research, Southern
California College of Optometry, Fullerton, CA;
2
Private Practice, Azusa, CA *CR
Thursday Posters
10:30 am – 12:15 pm
6014 — A0077 Cigarrete Smoking And
Diabetes But Not Increased Levels Of
Cholesterol, Increase Lipid Peroxidation In
Human Tears. Soledad Benlloch-Navarro1,
V. Sanchez-vallejo1, I. Almansa1, E. Arnal2, D.
Silvestre1, M. Miranda1. 1Ciencias Biomédicas,
Universidad CEU Cardenal Herrera, Moncada,
Spain; 2Fundación Oftalmológica del Mediterráneo,
Valencia, Spain
6015 — A0078 Role of lipid emulsion eye drops
in the improvement of lipid layer thickness
measured with Lipiview. Lara Borrego1, 2,
F. Saenz-Frances1, D. Finis2, J. M. Benitezdel-Castillo1, G. Geerling2. 1Ocular Surface,
Hospital Clinico San Carlos, Madrid, Spain;
2
Ophthalmology, 2University Clinic Hospital,
Düsseldorf, Germany *CR
6016 — A0079 Benzalkonium chloride-induced
rat dry eye model mimics hyperosmolarity in
tear volume deficient dry eye disease. Davi L.
Marques1, M. Alves1, 2, C. Modulo1, L. Malki1, P.
Reinach1, E. M. Rocha1. 1Universidade de São
Paulo, Ribeirão Preto, Brazil; 2Pontific Catholic
University of Campinas, Campinas, Brazil
6017 — A0080 Debridement of the Lower
Lid Margin and Line of Marx is effective in
increasing meibomian gland function and patient
comfort. Caroline A. Blackie1, 2, D. R. Korb1, 2.
1
TearScience, Morrisville, NC; 2Korb Associates,
Boston, MA *CR
6018 — A0081 The effect of increased
periocular humidity on lipid layer thickness
and ocular comfort of symptomatic contact
lens wearers. Samuel Kim1, C. A. Blackie1, 2, D.
R. Korb1, 2. 1TearScience, Morrisville, NC; 2Korb
Associates, Boston, MA *CR
6019 — A0082 The Avian Membrana Nictitans:
Anatomy and Function. Charles S. Schobert, L. B.
Teixeira, R. R. Dubielzig. Dept of Pathobiological
Sciences, UW-Madison School of Vet Med,
Madison, WI *CR
6020 — A0083 Prevalence of incomplete
blinking in dry eye patients evaluated with tear
film interferometry. Joanne Shen. Mayo Clinic in
Arizona, Scottsdale, AZ
6021 — A0084 Expression of proinflammatory
cytokines in tears of aqueous-deficient dry eyes.
Yan Wang, J. Xiang, J. Xu. Ophthalmology, Eye and
ENT Hospital of Fudan University, Shanghai, China
6022 — A0085 Unraveling diagnostic correlates
indicative of Sjögren’s Syndrome. Eduardo
M. Rocha, D. Ribeiro, M. Alves, J. S. Paula, P.
Reinach. Ophthalmology, FMRP-USP, Ribeirao
Preto, Brazil
6023 — A0086 Validation of the Current
Symptoms Questionnaire (CSQ): a metaanalytical approach. Ping Situ1, T. L. Simpson2,
R. L. Chalmers1, Z. Wu1, C. G. Begley1. 1School
of Optometry, Indiana University Bloomington,
Bloomington, IN; 2School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada *CR
6024 — A0087 The Influence of Punctal
Occlusion on Osmolarity in Dry Eye Subjects.
Jessica Schonfeld, J. S. Pepose, M. A. Qazi. Pepose
Vision Institute, Chesterfield, MO *CR, f
6025 — A0088 Association between depression
and dry eye disease in an adult population.
Antoine Labbe1, 2, Y. Wang1, C. Baudouin2, J. B.
Jonas1, 3, L. Xu1. 1Ophthalmology, Beijing Institute
of Ophthalmology, Beijing TongRen Eye Hospital,
Beijing, China; 2Ophthalmology, CHNO National
Eye Center, Paris, France; 3Ophthalmology,
Medical Faculty Mannheim-Heidelberg, Mannheim,
Germany *CR
6026 — A0089 In vitro evaporation rate
and stability of four marketed artificial
tears. Constanca Coelho, F. Azancoth. Genetics
Laboratory, Lisbon Medical School, Lisbon,
Portugal *CR
6027 — A0090 Anterior segment OCT study
of the pre-corneal film and its relationship with
dry-eye patient`s symptoms and quantitative
tests of the tear film. Maurizio Fossarello, P. E.
Napoli, G. M. Satta, F. Coronella. Ophthalmology,
University of Cagliari, Cagliari, Italy
6028 — A0091 Evaluation of the Standard
Patient Evaluation of Eye Dryness (SPEED)
Questionnaire. Nancy J. Keir1, W. Ngo1, P. Situ5, D.
R. Korb3, 4, C. A. Blackie3, 4, T. L. Simpson2. 1School
of Optometry-CCLR, University of Waterloo,
Waterloo, ON, Canada; 2School of Optometry and
Vision Science, University of Waterloo, Waterloo,
ON, Canada; 3TearScience, Morrisville, NC; 4Korb
Associates, Boston, MA; 5School of Optometry,
Indiana University, Bloomington, IN *CR
6029 — A0092 Inhibition of Matrix
Metalloproteinases by Mapracorat, a Novel
Selective Glucocorticoid Receptor Agonist
(SEGRA), in Human Corneal Epithelial Cells.
Thomas R. Vollmer, K. L. Harrington, J. Zhang, M.
Richardson, M. E. Cavet. Preclinical Pharmacology,
Bausch + Lomb, Rochester, NY *CR
6030 — A0093 Histopathologic changes in
punctal stenosis. Gary J. Lelli1, A. D. Port3, Y.
Chen2. 1Ophthalmology, Weill Cornell Medical
College, New York, NY; 2Pathology and Laboratory
Medicine, Weill Cornell Medical College, New
York, NY; 3Weill Cornell Medical College, New
York, NY
6031 — A0094 Hyperosmolar dryness stress
on 3D HCE model: a new tool for pre-clinical
assessment of tear substitutes. Barbara De Servi1,
C. Olmiere2, M. Meloni1. 1VitroScreen, Milan, Italy;
2
Laboratoires Thea, Clermont-Ferrand, France *CR
6032 — A0095 Ocular manifestations and
treatment outcomes of patients with graftversus-host disease. Sankaranarayana Mahesh,
C. J. Rapuano, P. K. Nagra, K. M. Hammersmith.
Cornea, Wills Eye Institute, Phiiladelphia, PA
6033 — A0096 Thymosin Beta 4 Eye Drops
Significantly Improve Signs and Symptoms of
Severe Dry Eye in a Physician-Sponsored Phase
2 Clinical Trial. Gabriel Sosne1, S. P. Dunn2,
D. Crockford3, C. Kim1, E. Dixon3. 1Ophthal &
Anatomy & Cell Biol, Wayne State Univ Sch of
Med, Detroit, MI; 2Michigan Cornea Consultants,
Southfield, MI; 3RegeneRx Biopharmaceuticals,
Rockville, MD *CR, f
6034 — A0097 Biomarkers in the tear fluid
during chemical ocular injury in the rabbit
model.
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
378
Thursday – Posters – 6035 – 6057
6035 — A0098 Characterization of cultivated
Human Oral Mucosal Epithelial Cells (HOMEs)
in an autologous culture medium. Camilla Gram,
D. Krohn-Hansen, E. Gulliksen, K. Haug, J. K.
Slettedal, M. C. Moe, L. Drolsum, B. Nicolaissen,
A. Shahdadfar. Department of Ophthalmology, Oslo
University Hospital Oslo, Norway, Center for Eye
Research, Oslo, Norway
6044 — A0107 Effects of controlled heat
delivery to the eyelid margin & eyelid hygiene
on symptomatology and the tear film in MGD.
Michel Guillon1, 2, C. A. Maissa1, S. Wong1, A.
Lane1, B. Bossard1. 1OTG Research & Consultancy,
London, United Kingdom; 2School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom *CR
6036 — A0099 Effects of lens care solutions on
dynamic interfacial properties of human tear
lipids. Tatyana F. Svitova, M. C. Lin. Optometry
School, Univ of California, Berkeley, Berkeley, CA
*CR
6045 — A0108 A Software-based Approach
for the Analysis of Lissamine Staining of the
Conjunctiva. Keith J. Lane, J. D. Rodriguez, E.
Angjeli, G. W. Ousler. Clinical R & D, Ora, Inc.,
Andover, MA *CR
6037 — A0100 Efficacy of long-term treatment
with diquafosol sodium for dry eye due to laser
in situ keratomileusis. Ryohei Nejima, Y. Mori,
A. Masuda, Y. Maruyama, K. Minami, K. Miyata.
Miyata Eye Hospital, Miyakonojyo, Japan
6046 — A0109 Surgical Model for Evaporative
Loss Dry Eye Model in the New Zealand
White Rabbit. Anthony J. Johnson1, 3, P. Buttke3,
I. E. Kochevar2, H. H. Wang1, S. R. Cora1, S. L.
DeMartelaere3. 1Ocular Trauma Research, USAISR,
Fort Sam Houston, TX; 2Wellman Center for
Photomedicine, Massachusetts General Hospital,
Boston, MA; 3SAUSHEC Ophthalmology, San
Antonio Military Medical Center, Fort Sam
Houston, TX *CR
6038 — A0101 Effect of dynamic changes in
the tear film on the optical quality in normal
and dry eyes. Johan Hedström, B. Theagarayan.
Section of Optometry and Vision Science, Linnaeus
University, Kalmar, Sweden
6039 — A0102 Multidimensional scaling
of words used to characterize ocular surface
discomfort. Trefford L. Simpson, Y. Feng. School
of Optometry & Vision Science, University of
Waterloo, Waterloo, ON, Canada
6040 — A0103 Changes of Higher Order
Aberration depending on Ocular Surface
Indicators analyzed by Continuous Measurement
after Phacoemusification. Si-Hwan Choi, H. Lim.
chungnam national university hospital, department
of ophthalmology, daejeon, south korea, Daejeon,
Republic of Korea
6041 — A0104 Hyperosmolar conditions
Increase benzalkonium chloride (BAK) toxicity
in an in vitro cornea wound healing model and
an in vivo dry eye mouse model. Hong Liang1, 2,
C. Baudouin1, 2, P. Daull3, J. Garrigue3, F. BrignoleBaudouin1, 2. 1Ophthalmology-Hosp Paris, CHNO
Des Quinze-Vights, Paris, France; 2INSERM,
UMR_S968, Vision Institute, Paris, France;
3
Novagali Pharma, Evry, France *CR
6043 — A0106 Updated Fluorophotometry
Technique Correlates With Signs and Symptoms
of Dry Eye Better Than Schirmer’s Test. Colleen
Heckley1, E. Angjeli1, K. J. Lane1, C. Ahearn1, D. L.
Welch2, G. W. Ousler2. 1R&D, Ora, Inc., Andover,
MA; 2Ora, Inc., Andover, MA *CR
6048 — A0111 The Influence of Punctal
Occlusion on Osmolarity in Dry Eye Subjects.
David C. Eldridge, M. S. Berg, B. D. Sullivan, W. D.
Townsend. TearLab Corp, Bixby, OK *CR
6049 — A0112 Transcultural Validation
of McMonnies Questionnaire for Mexican
Population. Alejandro Babayan1, N. RamosBetancourt2, F. Beltran2, J. D. Martinez2, C.
Santacruz Valdes3, C. Ramírez-Assad2, E. M.
Mora Juarez2, E. Hernandez-Quintela2. 1Cornea,
Fundacion Hospital “Nuestra Senora de la Luz”,
Mexico City, Mexico; 2Cornea, Asociación para
evitar la ceguera en Mexico, Mexico, Mexico;
3
Cornea, Instituto de Oftalmología Conde de
Valenciana, Mexico, Mexico
6050 — A0113 Transcultural Validation
of Ocular Surface Disease Index (OSDI)
Questionnaire for Mexican Population.
Francisco Beltran1, 2, N. Ramos-Betancourt1, 2,
J. D. Martinez1, 2, C. Santacruz Valdes3, 2, A.
Babayan4, 2, C. Ramírez-Assad2, E. M. Mora Juarez2,
E. Hernandez-Quintela1, 2. 1Cornea, Asociación
Para Evitar la Ceguera en México, Mexico City,
Mexico; 2Colegio de Investigación en Ciencias
Visuales, MARVO, Mexico City, Mexico; 3Cornea,
Instituto de Oftalmología Conde De Valenciana,
Mexico City, Mexico; 4Cornea, Hospital Fundación
“Nuestra Señora de la Luz”, Mexico City, Mexico
6052 — A0115 Use of Artificial Tears vs Cold
Compresses for the Treatment of Dry Eye.
Andrew A. Kao, R. Latkany. Ophthalmology, The
New York Eye and Ear Infirmary, New York City,
NY *CR, f
6053 — A0116 Long-Term Effects of Cataract
Surgery on Tear Film Parameters. Anat Galor1, 2,
V. D. Venincasa1, W. J. Feuer2, H. Florez1, 4, D.
J. Lee3. 1Miami Veterans Affairs Medical Center,
Miami, FL; 2Ophthalmology, Bascom Palmer,
Miami, FL; 3Department of Epidemiology and
Public Health, University of Miami, Miami, FL;
4
Department of Endocrinology and Geriatrics,
University of Miami, Miami, FL *CR
Exhibit Hall B0065-B0077
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Psychophysics / Physiological Optics
536 Inner Retina and Blood Vessels
Moderators: Toco Y. Chui and Richard B. Rosen
6054 — B0065 Future Insights on an Ocular
Hypertension Model in the White Leghorn
Chicken. Jennifer L. Choi1, R. T. Tzekov2, 3, S.
S. Choi1. 1New England College of Optometry,
Boston, MA; 2The Roskamp Institute, Sarasota, FL;
3
Department of Ophthalmology, University of South
Florida, Tampa, FL
6055 — B0066 Detection of flow velocity
fluctuations associated with erythrocyte
aggregation in diabetic retinopathy by using
adaptive optics scanning laser ophthalmoscopy.
Akihito Uji, M. Hangai, S. Ooto, S. Arichika, T.
Murakami, N. Yoshimura. Ophthalmology, Kyoto
Univ Graduate Sch of Med, Kyoto City, Japan *CR
6056 — B0067 Adaptive contrast enhancement
in capillary shadow region of AOSLO images
using blood cell flow information. Hiroshi
Imamura1, T. Yuasa1, H. Sonobe1, A. Uji2, S. Ooto2,
M. Hangai2, N. Yoshimura2. 1Canon Inc, Ohta-ku,
Japan; 2Ophthalmology, Kyoto University Graduate
School of Medicine, Kyoto City, Japan *CR
6057 — B0068 Study of epimacular membranes
using adaptative optics high resolution
imaging. Hassiba Bouakkaz1, S. Ayello-Scheer1,
A. Leseigneur1, C. Devisme1, J. A. Sahel1, 2,
M. Paques1, 2. 1Centre Hospitalier National
d’Ophtalmologie des Quinze Vingts, Paris, France;
2
Institut de la Vision, Paris, France *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
379
Thursday Posters
10:30 am – 12:15 pm
6042 — A0105 Internal Standard Dilution
Indicator Protocol (ISDIP): A Newer Method for
the Quantitative Assessment in Tear Lipidomic
Studies. Anju Sirohiwal1, J. S. Titiyal1, S. P.
Garg1, S. Sen1, 2, S. Baskar Singh1, 3, S. Ghose1, T.
Velpandian1, 4. 1Ophthalmology, All India Institute
of Medical Sciences, New Delhi, India; 2Ocular
Pathology, All India IInstitute of Medical Sciences,
New Delhi, India; 3Biophysics, All India IInstitute
of Medical Sciences, New Delhi, India; 4Ocular
Pharmacology and Pharmacy, All India IInstitute of
Medical Sciences, New Delhi, India
6047 — A0110 Clinical Correlations Among
Dry Eye Tests, Physical And Metabolic Findings
In Diabetes Mellitus Patients. Peter S. Reinach1, 2,
J. F. Faustino2, M. Alves2, D. Ribeiro2, J. S. Paula2,
E. M. Rocha2. 1Biological Sciences, SUNY College
of Optometry, New York, NY; 2Oftalmologia,
Otorrinolaringologia e Cirurgia de Cabeça e
Pescoço., Universidade de São Paulo, Ribeirão
Preto, Ribeirao Preto, Brazil
6051 — A0114 Anterior Segment Optical
Coherence Tomography changes of ocular
surface after topical anti-inflammatory therapy
in dry eyes. Pietro E. Napoli, M. Fossarello, F.
Coronella, G. M. Satta. Eye Clinic, University of
Cagliari, Cagliari, Italy
6058 – 6075 – Thursday – Posters
6058 — B0069 Parietal morphometry of
retinal arterioles in health and hypertension
using adaptive optics. Edouard Koch1, 2, D.
Rosenbaumm3, X. Girerd3, F. Rossant4, M. Paques1.
1
Clinial Investigation Center, Quinze-Vingts
Hospital-INSERM, Paris, France; 2Ophthalmology,
Versailles Hospital, Versailles, France; 3Cardiology,
Pitié Salpétrière Hospital, Paris, France; 4Institut
Supérieur d’Electronique de Paris, ISEP, Paris,
France *CR, f
6059 — B0070 Investigation of the
correlation among diameter of retinal vessel
and arteriosclerosis risk factors including
hypoadiponectinemia. Kei Homma1, R. Kawasaki2,
Y. Tanabe1, K. Saito1, A. Sugano1, A. Hozawa3, K.
Takeo4, I. Kubota5, T. Kayama6, H. Yamashita1.
1
Ophthalmology, Yamagata Univ Sch of Medicine,
Yamagata, Japan; 2Public Health, Yamagata Univ
Sch of Medicine, Yamagata, Japan; 3Tohoku Univ
Sch of Medicine, Sendai, Japan; 4Neurology,Hemat
ology,Metabolism,Endocrinology and Diabetology,
Yamagata Univ Sch of Medicine, Yamagata,
Japan; 5Cardiology,Pulmonology,and Nephrology,
Yamagata Univ Sch of Medicine, Sendai, Japan;
6
Neurosurgery, Yamagata Univ Sch of Medicine,
Yamagata, Japan *CR
6060 — B0071 Noninvasive Imaging of Retinal
Pericytes and Endothelial Cells in Living Human
Eyes. Toco Y. Chui, T. Gast, S. A. Burns. Optometry,
Indiana University, Bloomington, IN
6061 — B0072 Adaptive Optics Measurements
of Retinal Arterial Wall Thickness in both
Normotensive and Hypertensive Subjects. Jake
Hillard1, T. Y. Chui1, D. A. Sapir2, T. Gast1, S. A.
Burns1. 1School of Optometry, Indiana University,
Bloomington, IN; 2Medical School, Indiana
University, Bloomington, IN
Thursday Posters
10:30 am – 12:15 pm
6062 — B0073 Distribution of vessels with
dark tails in the parafoveal capillary network
monitored by adaptive optics scanning laser
ophthalmoscopy. Shigeta Arichika, A. Uji, M.
Hangai, S. Ooto, N. Yoshimura. Kyoto University,
Kyoto, Japan *CR
6063 — B0074 In vivo imaging of Hypertensive
Retinopathy using Fluorescence Adaptive Optics
Scanning Light Ophthalmoscopy. Michael
Dubow1, 2, A. Pinhas1, 2, N. Shah1, Y. N. Sulai3, P.
Garcia1, N. K. Scripsema4, J. Carroll5, A. Dubra5, R.
B. Rosen1. 1New York Eye and Ear Infirmary, New
York City, NY; 2Mount Sinai School of Medicine,
Mount Sinai Hospital, New York City, NY;
3
University of Rochester, Rochester, NY; 4New York
Medical College, Valhalla, NY; 5Medical College of
Wisconsin, Milwaukee, WI *CR
6064 — B0075 Normal retinal vasculature
imaged using fluorescence adaptive optics
scanning light ophthalmoscopy (FAOSLO).
Nishit Shah1, M. Dubow1, 2, A. Pinhas1, 2, N. K.
Scripsema1, A. Dubra3, 4, Y. N. Sulai6, 3, D. H.
Scoles5, 3, R. B. Rosen1. 1Ophthalmology, New York
Eye and Ear Infirmary, New York, NY; 2Mount
Sinai Hospital, Mount Sinai School of Medicine,
New York, NY; 3Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 4Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
5
Biomedical Engineering, University of Rochester,
Rochester, NY; 6The Institute of Optics, University
of Rochester, Rochester, NY *CR
6065 — B0076 Histopathologic Features
of Diabetic Microangiopathy Imaged
Using an Adaptive Optics Scanning Laser
Fluorescein Angiography. Richard B. Rosen1, 2,
A. Dubra3, R. Weitz1, J. Carroll3, M. Dubow1,
4
, A. Pinhas1, 4, N. Shah1, Y. N. Sulai3, 5, N. K.
Scripsema1, 2, J. B. Walsh1, 2. 1Ophthalmology,
New York Eye & Ear Infirmary, New York, NY;
2
Ophthalmology, New York Medical College,
Valhalla, NY; 3Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 4Ophthalmology,
Mount Sinai School of Medicine, New York,
NY; 5Ophthalmology, University of Rochester,
Rochester, NY *CR
6066 — B0077 Microangiopathic Features
of Central Retinal Vein Occlusion Imaged
Using Fluorescence Adaptive Optics Scanning
Light Ophthalmoscopy. Alexander Pinhas1, 2, N.
Shah1, M. Dubow1, 2, M. Mehta1, P. Garcia1, N. K.
Scripsema1, 3, J. Carroll4, 5, Y. N. Sulai6, A. Dubra4, 7,
R. B. Rosen1. 1Ophthalmology, New York Eye and
Ear Infirmary, New York, NY; 2Mount Sinai School
of Medicine, New York, NY; 3New York Medical
College, Valhalla, NY; 4Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 5Cell
Biology, Neurology and Anatomy, Medical College
of Wisconsin, Milwaukee, WI; 6The Institute
of Optics, University of Rochester, Rochester,
NY; 7Biophysics, Medical College of Wisconsin,
Milwaukee, WI *CR
Exhibit Hall B0138-B0179
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retinal Cell Biology / Visual Neuroscience
537 Cell Biology of the Retina and
RPE II
Moderator: Peter F. Hitchcock
6067 — B0138 Increasing body weight
correlates with loss of ERG in mice with Bardet
Biedl Syndrome. Arlene V. Drack1, S. Bhattarai1,
E. M. Stone1, K. Wang3, D. Gratie1, E. Heon2, V. C.
Sheffield1, R. F. Mullins1. 1Ophthalmology, Univ of
Iowa Hospitals, Iowa City, IA; 2Ophthalmology,
Sickkids Toronto, Toronto, ON, Canada;
3
Biostatistics, University of Iowa, Iowa City, IA
*CR
6068 — B0139 Enforced Expression of Snail
Gene Resulted in Retinal Pigment EpithelialMesenchymal Transition. Hui Li, F. Wang, M.
Li. Tenth People’s Hospital of Tongji University,
Shanghai, China
6069 — B0140 Effects of thrombin on tight
junction-associated molecules in polarized RPE
cells. Hiroto Terasaki, M. Shirasawa, H. Otsuka, S.
Sonoda, T. Sakamoto. Ophthalmology, Kagoshima
University, Kagoshima, Japan
6070 — B0141 Retinal changes in
Hemiparkinson rat. Soon Il Kwon1, C. Cho2, I.
Kim3. 1ophthalmology, HALLYM Sacred heart
HOSPITAL, Hallym University, Anyang, Republic
of Korea; 2neurosurgery, HALLYM Sacred heart
HOSPITAL, Hallym University, Anyang, Republic
of Korea; 3Anatomy, College of Medicine, The
Catholic University of Korea, Seoul, Republic of
Korea
6071 — B0142 Iron Upregulates Melanogenesis
Genes in the RPE. Natalie Wolkow1, A.
Maminishkis4, J. Iacovelli3, J. C. Lee2, S. S.
Miller4, J. L. Dunaief1. 1Scheie Eye Institute, The
Raymond and Ruth Perelman School of Medicine
at the University of Pennsylvania, Philadelphia,
PA; 2Pennsylvania College of Optometry, Salus
University, Elkins Park, PA; 3Schepens Eye
Research Institute, Harvard Medical School,
Boston, MA; 4National Eye Institute, National
Institutes of Health, Bethesda, MD *CR
6072 — B0143 The Role of Glucocorticoid
Receptor Signaling in Normal and Damaged
Avian Retina. Donika Gallina, A. J. Fischer. The
Ohio State University, Columbus, OH
6073 — B0144 Polyvinyl Alcohol-based
Encapsulation of Müller Cells Improves Release
of Brain-Derived Neurotrophic Factor. Yuko
Shinohara, M. Takii, T. Nakamura, M. Nakatani, K.
Ohtsuki. Bioengineering Institute, NIDEK Co Ltd,
Gamagori, Japan *CR
6074 — B0145 AMPK-NF-κB axis modulates
visual function during inflammation. Mamoru
Kamoshita1, S. Kubota1, K. Yuki1, S. Miyake1, N.
Nagai1, K. Umezawa2, K. Tsubota1, Y. Ozawa1.
1
Ophthalmology, Keio University School of
Medicine, Shinjyuku, Japan; 2Molecular Target
Medicine Screening, Aichi Medical University
School of Medicine, Nagakute, Japan *CR
6075 — B0146 Elastin-like polypeptide (ELP)
fused to an αB crystallin mini-chaperone protects
RPE cells from oxidant injury. Parameswaran
G. Sreekumar1, W. WANG2, J. A. MacKay2, C.
Spee3, S. J. Ryan1, 3, R. Kannan1, 3, D. R. Hinton4, 1.
1
Arnold and Mabel Beckman Macular reserach
Center, Doheny Eye Institute, Los Angeles, CA;
2
Pharmacology and Pharmaceutical Sciences,
University of Southern California, Los Angeles,
CA; 3Ophthalmology, Keck School of Medicine of
the University of Southern California, Los Angeles,
CA; 4Pathology, Keck School of Medicine of the
University of Southern California, Los Angeles,
CA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
380
Thursday – Posters – 6076 – 6096
6076 — B0147 Rod and Cone Photoreceptors
in the Mouse Retina Express Cfh. Sharon L.
Oltjen1, J. Estep2, P. G. FitzGerald2, Q. Gong2,
L. M. Hjelmeland1. 1Ophthalmology, University
of California-Davis, Davis, CA; 2Cell Biology &
Human Anatomy, University of California-Davis,
Davis, CA *CR
6077 — B0148 Disruption of cell-cell junctions
and induction of pathological cytokines in the
retinal pigment epithelium of light-exposed
mice. Toshio Narimatsu1, 2, S. Miyake1, S. Kubota3,
M. Hirasawa2, N. Nagai1, 2, K. Tsubota2, Y.
Ozawa1, 2. 1Laboratory of Retinal Cell Biology,
Keio University School of Medicine, Shinjukuku, Japan; 2Department of Ophthalmology, Keio
University School of Medicine, Shinjuku-ku, Japan;
3
Ophthalmology and Visual Science, Washington
University School of Medicine in St.Louis, St.
Louis, MO *CR
6078 — B0149 Age-Dependent Ocular Changes
in Sirt6 Knockout Mice. Alexey Obolensky1, V.
Peshti2, Y. Kanfi2, H. Y. Cohen2, E. Banin1. 1Center
for Retinal and Macular Degenerations, Department
of Ophthalmology, Hadassah-Hebrew University
Medical Center, Jerusalem, Israel; 2The Mina and
Everard Goodman Faculty of Life Sciences, BarIlan University, Ramat-Gan, Israel
6079 — B0150 Hyaluronan and Tissue
Inhibitor of Metalloproteinases-3 in Sorsby’s
Fundus Dystrophy and AMD. Alecia Cutler1,
B. Anand-Apte1, V. L. Bonilha1, D. Hatipoglu1, H.
Stoehr2. 1Ophthalmic Research, Cleveland Clinic
Foundation, Cleveland, OH; 2Institute of Human
Genetics, University of Regensburg, Regensburg,
Germany *CR
6080 — B0151 Best Vitelliform Macular
Dystrophy Mutants Oligomerize with Wild Type
Bestrophin-1 and Exhibit Differential Effects
on Protein Trafficking. Adiv A. Johnson1, Y.
Lee1, K. Yu4, C. H. Hartzell4, L. Y. Marmorstein1, 2,
A. D. Marmorstein1, 3. 1Ophthalmology and
Vision Science, University of Arizona, Tucson,
AZ; 2Department of Physiology, University of
Arizona, Tucson, AZ; 3College of Optical Sciences,
University of Arizona, Tucson, AZ; 4Department
of Cell Biology and Center for Neurodegenerative
Disease, Emory University, Atlanta, GA
6084 — B0155 Expression of RPE primary cilia
in adult mice. Guillermo L. Lehmann-Mántaras, R.
Schreiner, E. de la Fuente, E. J. Rodriguez-Boulan.
Ophthalmology, Weill Cornell Medical College,
New York, NY
6085 — B0156 Involvement of LC3-dependent
phagocytosis and MREG in the degradation of
disk membranes by the RPE. Kathleen BoeszeBattaglia1, F. P. Stefano1, V. S. Lopes3, A. Bragin1,
B. Jun4, W. C. Gordon4, I. R. Rodriguez2, N. G.
Bazan4, D. S. Williams3, L. S. Frost1. 1Biochemistry,
University of Pennsylvania, Philadelphia, PA;
2
National Eye Institute, Bethesda, MD; 3Jules
Stein Eye Institute- UCLA School of Medicine,
Los Angeles, CA; 4Neuroscience, LSUHNO, New
Orleans, LA
6086 — B0157 Flow Cytometry Approach
to Study NGF and p75 in Retinal Cells from
Reeler mice. Bijorn O. Balzamino1, R. Marino2,
G. Esposito1, F. Biamonte3, F. Keller2, A. Micera1.
1
Lab Ophthalmology, IRCCS GB Bietti Foundation,
Rome, Italy; 2Laboratory of Developmental
Neuroscience and Neural Plasticity, University
Campus Bio-Medico, Rome, Italy; 3Institute of
Histology and Embryology, Catholic University of
the Sacred Heart “A. Gemelli”, Rome, Italy
6087 — B0158 Spinules of cone horizontal
cells in European sea bass are more numerous
in the dorsal and nasal peripheral retina. Are
spinules biological detectors to peripheral vision
of teleosts? Joaquin De Juan, B. Boughlala, N.
Martinez-Ruiz. Dept Biotecnologia, Universidad de
Alicante, San Vicente del Raspeig, Spain
6089 — B0160 Hypertension-induced Ang II
promotes tube formation via MCP-1/MCPIP
induction. Maria E. Marin Castano1, W. Lee1, E.
P. Hernandez1, F. Praddaude2, C. Pecher2, S. W.
Cousins3. 1Ophthalmology, University of Miami,
Miami, FL; 2Physiology and Pharmacology,
University Paul Sabatier/INSERM-U 338, Toulouse,
France; 3Ophthalmology, Duke University Eye
Center, Durham, NC *CR
6090 — B0161 Inflammation Exacerbates
Hydroxychloroquine-Induced Retinotoxicity
in Human Retinal Pigment Epithelial Cells.
Matthew G. Trese1, 2, Y. Li1, H. Gao1, X. Qiao1.
1
Department of Ophthalmology, Henry Ford Health
System, Detroit, MI; 2Michigan State University,
College of Osteopathic Medicine, Detroit, MI
6091 — B0162 A synaptic scaffold complex
unique to horizontal cell processes contacting
photoreceptors. Alejandro Vila1, 2, C. M. Whitaker1,
J. O’Brien1, 2. 1Dept. of Ophthalmology & Visual
Science, Houston, TX; 2The University of Texas
Graduate School of Biomedical Sciences, Houston,
TX
6092 — B0163 A Surface Proteome of Primary
Fetal Human RPE Cells. Jason Silver1, D. R.
Riordon2, F. Hua1, O. S. Memon1, A. Maminishkis1,
R. L. Gundry3, S. S. Miller1, K. R. Boheler2, K.
Bharti1. 1National Eye Institute, National Institutes
of Health, Bethesda, MD; 2National Institute of
Aging, National Institutes of Health, Bethesda, MD;
3
Medical College of Wisconsin, Milwaukee, WI
6093 — B0164 The Role of 7-Ketocholesteryl
Esters on 7KCh-Mediated Cytotoxicity and
Inflammation in ARPE-19 cells. Jung W. Lee, J.
Huang, I. R. Rodriguez. Mechanisms of Retinal
Diseases Section, LRCMB, National Eye Institute/
NIH, Bethesda, MD
6094 — B0165 Blockade of Vascular
Endothelial Protein Tyrosine Phosphatase:
A Novel Approach to Stabilizing the Retinal
Vasculature. Ji-kui Shen1, P. A. Campochiaro1,
C. Seidel1, A. Dong1, M. Frye2, J. McClung3, S. F.
Hackett1, B. Howard4, D. Vestweber2, K. Peters5.
1
Ophthalmology, Wimer Eye Institute, Baltimore,
6088 — B0159 Functional and molecular
MD; 2Department of Cell Biology, Max-Planckcharacterization of ex vivo cultured neuronalInstitute of Molecular Biomedicine, Muenster,
and glial- like cells from internal limiting
Germany; 3Department of Medicine, Division
membrane. Xhevat Lumi1, S. Andjelic1, E. Johnsen2, of Cardiology Duke University Medical Center
M. Moe2, M. Hawlina1, G. Petrovski1, 3. 1Eye
Durham, Durham, NC; 4Procter & Gamble,
Hospital, University Medical Centre, Ljubljana,
Cincinnati, OH; 5Aerpio Therapeutics, Cincinnati,
Slovenia; 2Centre for Eye Research,Department
OH *CR
of Ophthalmology, Oslo University Hospital and
6095 — B0166 Optical Coherence Tomography
University of Oslo, Oslo, Norway; 3Stem Cells
(OCT) and histologic examination of a mouse
and Eye Research Laboratory, Departments of
model of chorioretinal coloboma. Sajag Bhattarai,
Ophthalmology and Biochemistry and Molecular
D. Gratie, M. Stunkel, M. G. Anderson, R. F.
Biology, Medical and Health Science Center,
Mullins, A. V. Drack. University of Iowa, Iowa City,
University of Debrecen, Debrecen, Hungary
IA *CR
6096 — B0167 Life and Death of Retinal Cells
in Optic Nerve Sectioned Chick Eyes. Stacey
Chong1, C. F. Wildsoet2, V. Choh1. 1Vision Science,
University of Waterloo, Waterloo, ON, Canada;
2
School of Optometry, University of California,
Berkeley, Berkeley, CA
6082 — B0153 Structural and Functional
Properties of Photoreceptor Mitochondria in
Awake and Hibernating Ground Squirrels. Talia
R. Kaden1, 2, J. Du1, A. R. Goel1, D. Lu1, W. Li1.
1
Retinal Neurophysiology, NEI, Bethesda, MD;
2
Yale University School of Medicine, New Haven,
CT
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
381
Thursday Posters
10:30 am – 12:15 pm
6081 — B0152 Paraoxonase-1 (PON1) in
retinal physiology and pathophysiology.
Jadwiga Oczos1, 2, B. Kloeckener-Gruissem2, 4,
W. Berger2, 3, C. Grimm1, 3. 1Lab for Retinal Cell
Biology, Department of Ophthalmology, University
of Zurich, Zurich, Switzerland; 2Institute of
Medical Molecular Genetics, University of Zurich,
Schwerzenbach, Switzerland; 3Zurich Center for
Integrative Human Physiology (ZIHP), University
of Zurich, Zurich, Switzerland; 4Department of
Biology, ETH Zurich, Zurich, Switzerland
6083 — B0154 Cross-talk Between Retinal
Pigment Epithelial Cells and Mast Cells via
Secreted Mediators, Especially Mast Cell
Tryptase. Rei Wakasa1, H. Kawano2, A. Matsuda2,
H. Ushio3, T. Sakuma1, A. Murakami2, N. Ebihara1.
1
Ophthalmology, Juntendo Uneversity Urayasu
Hospital, Urayasu City, Japan; 2Ophthalmology,
Juntendo University School of Medicine, Bunkyoku, Japan; 3Allergy Research Center, Juntendo
Uneversity School of Medicine, Bunkyo-ku, Japan
*CR
6097 – 6115 – Thursday – Posters
6097 — B0168 Physical support of the inner
retina enhances cell survival in adult porcine
retinal explants. Linnea T. Taylor, K. M. Arner,
I. Holmgren Taylor, F. K. Ghosh. Ophthalmology,
Lund University, Lund, Sweden
6098 — B0169 Potential phototoxicity of
indocyanine green in retinal pigment epithelial
cells after its angiography. Tomohito Sato1, Y.
Karasawa1, S. Ishikawa1, M. Taguchi1, T. Muraoka1,
M. Ito2, M. Takeuchi1. 1Ophthalmology, National
Defense Medical College, Tokorozawa, Japan;
2
Developmental Anatomy and Regenerative
Biology, National Defense Medical Collage,
Tokorozawa, Japan
6099 — B0170 Differential overexpression of
Homer 1 isoforms is associated with hallmarks
of disease and decline in visual performance
in a preclinical model of glaucoma. Simon
Kaja1, Y. Naumchuk1, S. L. Grillo1, P. K. Borden1,
P. Koulen1, 2. 1Ophthalmology / Vision Research
Center, Univ of Missouri-Kansas City, Kansas City,
MO; 2Basic Medical Science, Univ of MissouriKansas City, Kansas City, MO
6100 — B0171 Activation of the retinal
renin angiotensin system via beta-adrenergic
stimulation of renin expression in the RPE. Olaf
Strauss1, V. T. Todorov2, J. Stindl3, J. R. Martins4.
1
Experimental Ophthalmology, Charite, University
Medicine, Eye Hospital, Berlin, Germany;
2
Nephrology, Inner Medicine III, University Carl
Gustav Carus, Dresden, Germany; 3Experimental
Ophthalmology, Eye Hospital, University Medicine
Regensburg, Regensburg, Germany; 4Institute
of cellular and molecular pharmacology, Sophia
Antipolis University of Nice, Nice, France
Thursday Posters
10:30 am – 12:15 pm
6101 — B0172 Characterization of the
blue light toxicity spectrum on A2E-loaded
RPE cells in sunlight normalized conditions.
Emilie Arnault1, 2, C. Barrau3, C. Nanteau1, 2, P.
Gondouin1, 2, V. Fontaine1, 2, T. Villette3, J. A. Sahel2 4
, S. A. Picaud1, 2. 1Institut de la Vision, U968,
INSERM, Paris, France; 2Institut de la Vision,
UMR_S968, UPMC Université Paris 06, Paris,
France; 3Essilor International, Paris, France; 4Centre
Hospitalier National d’Ophtalmologie des QuinzeVingts, Paris, France *CR
6102 — B0173 Increased Levels of DJ-1 are
present in cells exposed to carboxyethylpyrrole
(CEP), and in Retina, RPE, Bruch’s Membrane
and Drusen from AMD donor eyes. Vera L.
Bonilha, M. E. Rayborn, X. Yang, K. G. Shadrach,
J. G. Hollyfield. Ophthalmology, Cole Eye Inst/
Cleveland Clin Lerner Ctr, Cleveland, OH
6103 — B0174 Mechanisms of VEGF
upregulation in human RPE cells: Role of
oxidized phospholipids and the ATF4 arm of the
unfolded protein response. Andreas Pollreisz1,
T. Afonyushkin2, O. V. Oskolkova2, F. Gruber3, V.
N. Bochkov2, U. Schmidt-Erfurth1. 1Department
of Ophthalmology, Medical University Vienna,
Vienna, Austria; 2Department of Vascular Biology
and Thrombosis Research, Medical University
Vienna, Vienna, Austria; 3Department of
Dermatology, Medical University Vienna, Vienna,
Austria *CR
6104 — B0175 Epithelial Membrane Protein
2 (EMP2) Modulates VEGF During Hypoxia in
ARPE-19 Cells. Ann M. Chan1, S. A. Morales1, Y.
Qin1, M. Wadehra2, L. K. Gordon1. 1Jules Stein Eye
Institute, University of California, Los Angeles, Los
Angeles, CA; 2Pathology and Laboratory Medicine,
University of California, Los Angeles, Los Angeles,
CA *CR
6105 — B0176 Identification of Interacting
Protein Partners of TOPORS in the Retina.
Barbara Czub1, A. Z. Shah1, G. Alfano1, L. Valdés
Sánchez2, C. Chakarova1, S. S. Bhattacharya1, 2.
1
Genetics, UCL Institute of Ophthalmology,
London, United Kingdom; 2Cellular Therapy and
Regenerative Medicine, Andalusian Centre for
Molecular Biology and Regenerative Medicine
(CABIMER), Seville, Spain f
6106 — B0177 Conditional Depletion of Retinal
VLC-PUFAs Causes Retinal Dysfunction.
Martin-Paul G. Agbaga1, 4, B. Hopiavuori3, 4, F.
Li1, 4, J. McRae1, 4, R. S. Brush1, 4, M. A. Mandal1, 3,
L. D. Marchette1, 2, M. H. Elliott1, 3, R. Ayyagari5,
R. E. Anderson1, 2. 1Ophthalmology, Univ of
Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2Cell
Biology, University of Oklahoma Health Sciences
Center, Oklahoma City, OK; 3Oklahoma Center
for Neuroscience, University of Oklahoma Health
Sciences Center, Oklahoma City, OK; 4Dean McGee
Eye Institute, Oklahoma City, OK; 5ophthalmology,
Shiley Eye Center, University of California, San
Diego, CA *CR
6107 — B0178 Inhibition of retinoblastoma
tumor progression using catalytic antioxidant
naoparticles. Kathryn E. Klump1, R. Towner3, 1,
S. Seal6, 5, M. Dyer4, J. F. McGinnis2, 1. 1Oklahoma
Ctr for Neuroscience, Univ of Oklahoma Hlth
Sciences Ctr, Oklahoma City, OK; 2Cell Biology,
Ophthalmology, Univ of Oklahoma Hlth Sciences
Ctr, Oklahoma City, OK; 3Oklahoma Medical
Research Foundation, Oklahoma City, OK;
4
Developmental Neurobiology, St. Jude Children’s
Research Hospital, Memphis, TN; 5Mechanical
Materials and Aerospace Engineering, University
of Central Florida, Orlando, FL; 6Nanoscience and
Technology Ctr, University of Central Florida,
Orlando, OK *CR
6108 — B0179 Independent roles of methionine
sulfoxide reductase A in mitochondrial ATP
synthesis and in protection from oxidative stress
of the retinal pigment epithelium. Silvia C.
Finnemann, J. Vargas, Y. Dun. Biological Sciences,
Fordham University, Bronx, NY
Exhibit Hall B0180-B0189
Thursday, May 09, 2013 10:30 AM-12:15 PM
Biochemistry/Molecular Biology
538 Apoptosis and Cell Stress
Moderator: Nichole D. Joachim
6109 — B0180 Rag1 expression in RGCs
is involved in programmed cell death. Takao
Hirano1, T. Hayashi2, T. Murata1. 1Depart of
Ophthalmology, Shinshu University, Matsumoto,
Japan; 2Department of Molecular and Cellular
Immunology, Shinshu University, Matsumoto,
Japan
6110 — B0181 Apoptotic retinal ganglion cell
death in an autoimmune glaucoma model is
accompanied by antibody depositions. Stephanie
C. Joachim1, C. Mondon1, S. Kuehn1, S. Reinehr1, F.
H. Grus2, B. H. Dick1. 1Experimental Eye Research
Institute, Ruhr University, Bochum, Germany;
2
Experimental Ophthalmology, University Medical
Center, Mainz, Germany
6111 — B0182 Epigenetic Regulation of Rod
Photoreceptor Development. Sarah Cheng, H.
Yang, A. Swaroop. N-NRL, Bldg 6, National Eye
Institute, Bethesda, MD
6112 — B0183 Histone Deacetylase 3 (HDAC3)
plays an important role in retinal ganglion
cell death after acute optic nerve injury.
Heather Schmitt1, 2, C. Schlamp1, R. W. Nickells1.
1
Ophthalmology and Visual Sciences, University
of Wisconsin-Madison, Madison, WI; 2Cellular and
Molecular Pathology, University of WisconsinMadison, Madison, WI
6113 — B0184 Dicer is required for survival
of mature rod photoreceptors. Thomas
Sundermeier1, N. Zhang1, D. Mustafi1, H. Kohno2, K.
Palczewski1. 1Pharmacology, Case Western Reserve
University, Cleveland, OH; 2Ophthalmology and
Visual Sciences, Case Western Reserve University,
Cleveland, OH *CR
6114 — B0185 Transient Upregulation and
then Downregulation of BACE 1 and PS-1
in ER Stress Induced Apoptosis of Retinal
Ganglion Cells in vitro. Bingqian Liu, J. Ge. State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China
6115 — B0186 Progranulin Mutant Mice
Exhibit Accumulation of Intraneuronal
Lipofuscin Aggregates in the Retina. Brian
P. Hafler1, Z. A. Klein2, S. Strittmatter2.
1
Ophthalmology and Visual Science, Yale School
of Medicine, New Haven, CT; 2Program in Cellular
Neuroscience, Neurodegeneration, and Repair, Yale
School of Medicine, New Haven, CT
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
382
Thursday – Posters – 6116 – 6138
6116 — B0187 C1qa deficiency exacerbates
RGC loss in a mouse glaucoma model. Qiong
Ding1, M. G. Anderson2, A. Cook1, M. H. Kuehn1.
1
Ophthalmology and Visual Sciences, U of
Iowa, Iowa City, IA; 2Molecular Physiology and
Biophysics, U of Iowa, Iowa City, IA
6117 — B0188 Unveiling the retina’s realm
with retinal oxygenation. Veronica A. Kon
Graversen, M. Landers. Retina, University of North
Carolina at Chapel Hill, Chapel Hill, NC
6118 — B0189 RNA Structure-Function Issues
in Realizing Catalytically-Active Hammerhead
Ribozymes in Cells. Jack M. Sullivan1, 2,
T. A. Kolniak3. 1Research Service, Veterans
Administration Western NY Healthcare System,
Buffalo, NY; 2Ophthalmology, Pharm/Tox, Phys/
Biopys, SUNY Eye Institute, SUNY at Buffalo,
Buffalo, NY; 3Program in Neuroscience, SUNY at
Buffalo, Buffalo, NY *CR
Exhibit Hall B0190-B0215
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Neuroscience / Visual Psychophysics /
Physiological Optics
539 Advancing Functional Assessment
of the Visual System
Moderator: Paul J. DeMarco
6119 — B0190 L:M Cone Ratio of Japanese
Derived with ERG Flicker Photometry Method.
Yasuki Yamauchi1, K. Yatsu1, J. A. Kuchenbecker2,
M. Neitz2, J. Neitz2. 1Dept. Informatics,
Yamagata University, Yonezawa, Japan; 2Dept.
Ophthalmology, University of Washington Medical
School, Seattle, WA *CR
6120 — B0191 Change in Flash
Electroretinogram Morphology from Scotopic
to Photopic Conditions. Kate A. Godwin, P.
J. DeMarco. Psychological & Brain Sciences,
University of Louisville, Louisville, KY
6121 — B0192 Dark-adapted 15-Hz Flicker
Electroretinograms Measured With Rodisolating Stimuli. Swetha Dhanireddy1, J. C. Park2,
P. R. Nolan2, D. Cao2, J. McAnany2. 1American
University of Antigua, St. Johns, Antigua and
Barbuda; 2Ophthalmology and Visual Sciences,
University of Illinois at Chicago, Chicago, IL
6124 — B0195 High throughput testing of
absolute behavioral threshold in mice. Charles
P. Ratliff, L. Faktorovich, A. P. Sampath. Zilkha
Neurogenetic Institute, University of Southern
California, Los Angeles, CA
6125 — B0196 Electrical measurements
of pigment bleaching in vivo. Christopher
Kessler1, E. N. Pugh1, 2, M. E. Burns1, 3. 1Center
for Neuroscience, UC Davis, Davis, CA; 2Human
Anatomy and Cell Biology, UC Davis, Davis, CA;
3
Ophthalmology & Vision Science, UC Davis,
Davis, CA
6126 — B0197 Contributions of Non-Visual
Sensory Signals to the Murine Flash ERG.
Naoyuki Tanimoto1, V. Sothilingam1, G. Gloeckner1,
E. Bryda2, P. Humphries3, M. Biel4, M. W. Seeliger1.
1
Division of Ocular Neurodegeneration, Institute for
Ophthalmic Research, Centre for Ophthalmology,
Tuebingen, Germany; 2Department of Veterinary
Pathobiology, College of Veterinary Medicine,
University of Missouri, Columbia, MO; 3Ocular
Genetics Unit, Trinity College Dublin, Dublin,
Ireland; 4Department of Pharmacy, Center for
Integrated Protein Science Munich, LudwigMaximilians Universitaet Muenchen, Munich,
Germany
6127 — B0198 Impact of the spectral output
of “white” LEDs on the murine flash ERG.
Mathias W. Seeliger1, K. Narfstrom2, N. Tanimoto1.
1
Div of Ocular Neurodegeneration, Ctr Ophthal Inst
Ophthalmic Rsrch, Tuebingen, Germany; 2Dept
of Vet Med & Surgery, University of Missouri,
Columbia, MO
6128 — B0199 Comparison of transretinal
mouse rod ERG with local ERG across
photoreceptor outer segments. Teemu T. Turunen,
A. O. Koskelainen. Department of Biomedical
Engineering and Computational Science, Aalto
University School of Science, Espoo, Finland
6129 — B0200 Adapting Commercial In
Vivo Electroretinogram System for Ex Vivo
Recordings. Vladimir J. Kefalov, F. Vinberg.
Ophthalmology & Visual Sciences, Washington
University School of Medicine, Saint Louis, MO
6130 — B0201 Voltage-gated sodium
channels amplify both light and dark adapted
electroretinograms in mice. Ben Smith, P. D. Cote,
F. Tremblay. Dalhousie University, Halifax, NS,
Canada
6131 — B0202 Binocular pattern
electroretinograms in the mouse. Tsung-Han
Chou1, 2, J. A. Toft-Nielsen2, J. E. Bohorquez2, O.
Ozdamar2, V. Porciatti1. 1Bascom Palmer Eye Inst,
Univ of Miami, Miller Sch of Med, Miami, FL;
2
Biomedical Engineering, University of Miami,
Miami, FL
6132 — B0203 Recording and Manipulation
of the Pattern Electroretinogram in a Mouse
Eyecup Preparation. Eric C. Gustafson, A.
L. Silberschmidt, M. Esguerra, R. F. Miller.
Neuroscience, University of Minnesota,
Minneapolis, MN
6133 — B0204 Spatial differences in corneal
potentials in healthy rat eyes evaluated with
multi-electrode electroretinography (meERG).
John R. Hetling, H. Tajalli, Y. Krakova, Z. Derafshi.
Bioengineering, University of Illinois at Chicago,
Chicago, IL *CR
6134 — B0205 Multifocal Electroretinography
with simultaneous fundus imaging in mice.
R Michael Dutescu1, S. Skosyrski1, N. Kociok1,
I. Semkova1, S. Mergler1, J. Atorf2, A. M.
Joussen1, J. J. Kremers2. 1Ophthalmology,
Charité-Universitätsmedizin, Berlin, Germany;
2
Ophthalmology, University Hospital Erlangen,
Erlangen, Germany *CR
6135 — B0206 Topography and aging of
the scotopic mfERG. Athanasios Panorgias1,
E. E. Sutter2, J. S. Werner1, 3. 1Ophthalmology &
Vision Science, University of California Davis,
Sacramento, CA; 2Electro-Diagnostic Imaging Inc,
Redwood City, CA; 3Neurobiology, Physiology and
Behavior, University of California Davis, Davis,
CA *CR
6136 — B0207 Slow flash multifocal
electroretinograms in the foveola. Yoshiaki
Shimada1, A. Nakamura2, A. Tanikawa2, M.
Horiguchi2. 1Ophthalmology, Fujita Health Univ
Banbuntane Hosp, Nagoya, Japan; 2Ophthalmology,
Fujita Health Univ School of Medicine, Toyoake,
Japan
6137 — B0208 Validation of a Novel Fast and
Robust Automated Technique for Calculation of
the EOG Arden Ratio, Using R. Marc Sarossy1, 3,
M. H. Lee2, M. Bach4. 1ODC, Royal Victorian Eye
and Ear Hospital, East Melbourne, VIC, Australia;
2
Faculty of Medicine, Nursing and Health Sciences,
Monash University, Clayton, VIC, Australia;
3
CERA, University of Melbourne, Melbourne, VIC,
Australia; 4Universitäts-Augenklinik, Freiburg,
Germany
6138 — B0209 The Uncertainty Classifier:
Use of a Novel Statistical Classifier with
Fuzzy Classification Boundaries to Evaluate
Performance of Automated Electrooculogram
(EOG) testing. Matthew H. Lee1, M. Sarossy2,
M. Triglia3. 1Faculty of Medicine, Nursing and
Health Sciences, Monash University, Clayton,
VIC, Australia; 2Ocular Diagnostic Clinic, Royal
Victorian Eye and Ear Hospital, East Melbourne,
VIC, Australia; 3Victorian Institute of Forensic
Mental Health, Clifton Hill, VIC, Australia
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
383
Thursday Posters
10:30 am – 12:15 pm
6122 — B0193 Recovery of human rod
photoreceptors following prolonged illumination,
assessed using the electroretinogram. Omar A.
Mahroo1, 2, R. Sakalauskaite2, C. J. Hammond1,
T. D. Lamb3. 1Ophthalmology, King’s College
London, London, United Kingdom; 2Physiology,
Development and Neuroscience, University
of Cambridge, Cambridge, United Kingdom;
3
Department of Neuroscience, John Curtin School
of Medical Research and ARC Centre of Excellence
in Vision Science, Australian National University,
Canberra, ACT, Australia
6123 — B0194 The Spatial Distribution of
L- and M-Cone Driven ERGs Reflecting Parvoand Magnocellular Activity. Bruno D. Gomes1,
G. S. Souza1, 2, M. D. Filho1, G. Pangeni3, L. L.
Silveira1, 2, J. J. Kremers3. 1Instituto de Ciencias
Biologicas, Universidade Federal do Para, Belem,
Brazil; 2Nucleo de Medicina Tropical, Univerdidade
Federal do Para, Belem, Brazil; 3Department of
Ophthalmology, University Hospital Erlangen,
Erlangen, Germany
6139 – 6164 – Thursday – Posters
6139 — B0210 Chromatic pseudo-random
VECP: spatial frequency tuning and visual
acuity estimative. Givago S. Souza1, 2, I. V.
Martins1, B. D. Gomes1, L. L. Silveira1, 2. 1Insituto
de Ciencias Biologicas, Universidade Federal do
Para, Belem, Brazil; 2Nucleo de Medicina Tropical,
Universidade Federal do Para, Belem, Brazil
6140 — B0211 Optimization of Check Size and
Contrast on the Visual-Evoked Potential (VEP)
in Visually-Normal Individuals. Naveen K. Yadav,
K. J. Ciuffreda. Vision Sciences, SUNY, College of
Optometry, New York, NY
6141 — B0212 Macular pigment-based
luminance artifacts do not account for band-pass
temporal tuning of the chromatic visual evoked
potential (cVEP). Rafal M. Skiba, C. S. Duncan, C.
Jones, A. M. Jackson, M. A. Crognale. Psychology,
University of Nevada, Reno, Reno, NV
6142 — B0213 Chromatic and achromatic
contribution to the multifocal visual evoked
potentials. Monique Smyth4, 3, C. G. Kilemi6, 3,
G. S. Souza1, 2, C. D. Araujo2, E. C. Lacerda2, M.
M. Jacob2, B. D. Gomes2, M. E. Fitzgerald3, 5,
L. L. Silveira1, 2. 1Núcleo de Medicina Tropical,
Universidade Federal do Pará, Belém, Brazil;
2
Instituto de Ciências Biológicas, Universidade
Federal do Pará, Belém, Brazil; 3Christian Brothers
University, Memphis, TN; 4Rhodes College,
Memphis, TN; 5University of TN Health Science
Center, Memphis, TN; 6Coppin State University,
Baltimore, MD
6143 — B0214 Effect of Test Duration on the
Visual-Evoked Potential (VEP) and Alpha Wave
Responses. Kevin T. Willeford, N. K. Yadav, K. J.
Ciuffreda. SUNY State College of Optometry, New
York, NY
6144 — B0215 Effect of Simulated Octant
Visual Field Defects on the Visual-Evoked
Potential (VEP). Diana P. Ludlam, N. K. Yadav,
K. J. Ciuffreda. Vision Sciences, SUNY College of
Optometry, New York, NY
Exhibit Hall B0216-B0235
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Neuroscience
540 Bipolar and Horizontal Cells
Thursday Posters
10:30 am – 12:15 pm
Moderator: Bart G. Borghuis
6145 — B0216 Tetraphasic Horizontal Cell
in the Retina of Goldfish. Kenkichi Fukurotani.
Faculty of Engineering, University of Toyama,
Toyama, Japan
6157 — B0228 Two Distinct Patterns of Input
Exist Among ON Cone Bipolar Cells and Predict
Their Spatial Responding. Robert Purgert, P. D.
Lukasiewicz. Washington University in St. Louis
School of Medicine, St. Louis, MO
6146 — B0217 Presence of the Gpr179nob5
mutation in C3H-derived transgenic mice. Jasmin
Balmer1, 2, R. Ji3, R. G. Gregg3, N. S. Peachey4,
V. Enzmann1. 1Department of Ophthalmology,
University of Berne, Berne, Switzerland;
2
Graduate School for Cellular and Biomedical
Sciences, University of Berne, Berne, Switzerland;
3
Department of Biochemistry & Molecular
Biology, University of Louisville, Louisville, KY;
4
Department of Ophthalmic Research, Cleveland
Clinic, Cleveland, OH
6147 — B0218 The luminal and spatiotemporal
dependence of mouse optokinetic contrast
sensitivity on rod pathway components.
Cameron Cowan1, M. E. van der Heijden2, E. M.
Lo2, D. Paul4, J. Lem3, D. E. Bramblett5, S. M.
Wu2. 1Neuroscience, Baylor College of Medicine,
Houston, TX; 2Ophthalmology, Baylor College of
Medicine, Houston, TX; 3Ophthalmology, Tufts
Medical Center, Boston, MA; 4Neurobiology,
Harvard University, Boston, MA; 5Medical
Education, Texas Tech UHSC, El Paso, TX
6148 — B0219 Intracellular calcium acts
on two separate targets to reduce the gain
mGluR6 signaling in rod bipolar cells. Katherine
Fehlhaber, A. P. Sampath. Neuroscience, University
of Southern California, Los Angeles, CA
6154 — B0225 Adaptation to background
light permits contrast coding at rod bipolar
cell synapses. Jiangbin Ke1, Y. V. Wang2, M. S.
Cembrowski4, H. Riecke5, W. L. Kath5, 6, J. B.
Demb2, 3, J. H. Singer1. 1Department of Biology,
University of Maryland, College Park, MD;
2
Department of Cellular and Molecular Physiology,
Yale University, New Haven, CT; 3Department
of Ophthalmology and Visual Science, Yale
University, New Haven, CT; 4Howard Hughes
Medical Institute, Janelia Farm Research Campus,
Ashburn, VA; 5Department of Engineering Sciences
and Applied Mathematics, Northwestern University,
Evanston, IL; 6Department of Neurobiology and
Physiology, Northwestern University, Evanston, IL
6155 — B0226 Quantifying the Effect of Light
Activated Outer and Inner Retinal Inhibitory
Pathways on Exocytosis from Mixed Bipolar
Cells. Mikhail Y. Lipin, J. Vigh. Department of
Biomedical Sciences, Colorado State University,
Fort Collins, CO
6156 — B0227 Cell type-specific Synaptic
Connections of Bipolar and Ganglion Cells in
the Mouse Retina. Sonja Neumann, L. Hüser,
S. Haverkamp. Max Planck Institute for Brain
Research, Frankfurt am Main, Germany
6149 — B0220 Metabotropic glycine receptors
can enhance bipolar cell output in rat retina.
Jay Garaycochea, M. Slaughter, J. Myers.
Neuroscience, University at Buffalo, Buffalo, NY
6158 — B0229 CaV3.1 (T-Type) Calcium
Channels in Bipolar Cells of the Macaque
Retina. Theresa Puthussery, J. Gayet, W. R. Taylor.
Ophthal-Casey Eye Inst, Oregon Health & Science
Univ, Portland, OR
6150 — B0221 Possible roles of glutamate
transporter EAAT5 in mediating mouse
cone on-bipolar cell light responses. Dennis
Y. Tse1, I. Chung1, 2, S. M. Wu1. 1Ophthalmology,
Baylor College of Medicine, Houston, TX;
2
Ophthalmology, Gyeongsang National University,
Jinju, Republic of Korea
6159 — B0230 CACNA1S expression,
structure and function in retinal depolarizing
bipolar cells. Thomas A. Ray1, N. Hasan1, M. A.
McCall2, R. G. Gregg1. 1Biochemistry & Molecular
Biology, University of Louisville, Louisville, KY;
2
Ophthalmology and Visual Sciences, University of
Louisville, Louisville, KY
6151 — B0222 Modeling of electroretinography
b-wave amplitudes validates a critical role of
tonic GABAC receptor-carried chloride currents
in sensitizing and light adapting rod bipolar
cell light responses. Rolf Herrmann1, 2, B. Lee2,
E. C. Solessio3, V. Y. Arshavsky2. 1Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI;
2
Ophthalmology, Duke University, Durham,
NC; 3Ophthalmology, SUNY Upstate Medical
University, Syracuse, NY
6160 — B0231 Contribution of RGS proteins
to the light responses of ON-bipolar neurons.
Ignacio Sarria, K. A. Martemyanov. Neuroscience,
The Scripps Research Institute, Jupiter, FL
6152 — B0223 Ca2+ and Ca2+-activated Clcurrents of Presynaptic Terminals of Bipolar
Cells: A Comparative Study on Mouse and
Goldfish Retinas. Ji Hyun Jeon, S. Paik, I. Kim.
Department of Anatomy, The Catholic University of
Korea, Seoul, Republic of Korea
6153 — B0224 Temporal Filtering in Cone
Bipolar Cells in the Mouse Retina is Partially
Subtype Specific. Tomomi Ichinose1, 2, J. A. Cohn2.
1
Anatomy & Cell Biology / Ophthalmology, Wayne
State Universtiy School of Medicine, Detroit, MI;
2
Ophthalmology & Visual Sciences, Washington
University School of Medicine, St. Louis, MO
6161 — B0232 The role of ionotropic glutamate
receptors in dopamine-induced, GABA-driven
rod bipolar cell sensitization. Amanda M. Travis1,
S. J. Heflin2, R. Herrmann2, V. Y. Arshavsky2, 1.
1
Pharmacology, Duke University, Durham, NC;
2
Ophthalmology, Duke University, Durham, NC
6162 — B0233 The Effect of PKCα on the
Electroretinogram. Wei-Hong Xiong, M. TekmenClark, S. Lolich, R. M. Duvoisin, C. W. Morgans.
Physiology & Pharmacology, Oregon Health &
Science University, Portland, OR
6163 — B0234 Steady-state Ca modulates
rod bipolar cell exocytosis. Qun-Fang Wan, H.
Ruth. Department of Neurobiology and Anatomy,
University of Texas Medical School at Houston,
Houston, TX
6164 — B0235 Abnormalities of retinal
synaptic ribbons induced by L-AP4. Jun Zhang,
N. Oesch, J. Diamond. Synaptic Physiology
Section, NINDS/NIH, Bethesda, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
384
Thursday – Posters – 6165 – 6179
Exhibit Hall C0050-C0100
Thursday, May 09, 2013 10:30 AM-12:15 PM
Genetics / Visual Neuroscience
541 Genetic Risk Factors for Common
Eye Disorders with Complex Inheritance
Moderators: Stephanie A. Hagstrom and
Margaret A. Pericak-Vance
6165 — C0050 Is AMD a Disease or a
Disorder? A Systems Biology Attempt to Subtype
AMD on the Basis of Gene Expression. Mones
S. Abu-Asab1, C. Chan2, 1. 1Histopathology Core,
National Eye Institute, Bethesda, MD; 2Laboratory
of Immunology, National Eye Institute, Bethesda,
MD
6166 — C0051 Population Attributable Risk
of Known AMD Genetic Risk Factors Based on
the 1000 Genomes Project. Joe M. Butler1, Y. C.
Yang2, L. I. Paraoan1. 1Eye and Vision Science,
Institute of Ageing and Chronic Disease, University
of Liverpool, Liverpool, United Kingdom;
2
Ophthalmology, Wolverhamptom Med Inst-New
Cross, Wolverhamptom, United Kingdom *CR
6167 — C0052 Association of PTX3
polymorphisms with age-related macular
degeneration and polypoidal choroidal
vasculopathy. Jianhuan Chen1, 2, H. Chen1, W.
Chen1, M. Zhang1, C. Pang1, 2. 1Joint Shantou
International Eye Center, Shantou University & the
Chinese University of Hong Kong, Shantou, China;
2
The Chinese University of Hong Kong, Hong
Kong, China
6170 — C0055 Association of Family History
with Genetic Risk Factors in Patients with
Age-Related Macular Degeneration. Nicole T.
Saksens1, Y. T. Lechanteur1, S. K. Verbakel1, J. M.
Groenewoud2, C. J. Boon1, 3, A. I. Den Hollander1, 4,
C. B. Hoyng1. 1Ophthalmology, Radboud University
Nijmegen Medical Center, Nijmegen, Netherlands;
2
Epidemiology, Biostatistics and Health Technology
Assessment, Radboud University Nijmegen
Medical Center, Nijmegen, Netherlands; 3Oxford
Eye Hospital, John Radcliffe Hospital, University
of Oxford, Oxford, United Kingdom; 4Human
Genetics, Radboud University Nijmegen Medical
Center, Nijmegen, Netherlands
6171 — C0056 Interaction analysis of
exogenous estrogen in age-related macular
degeneration (AMD) finds novel associations
within the VEGF, Complement, and TGFB
pathways. Monique D. Courtenay1, W. Cade1,
S. G. Schwartz2, J. L. Kovach2, A. Agarwal3, G.
Wang1, J. L. Haines4, M. A. Pericak-Vance1, W. K.
Scott1. 1Hussman Institute of Human Genomics,
University of Miami, Miami, FL; 2Bascom Palmer
Eye Institute, University of Miami, Miami, FL;
3
Ophthalmology, Vanderbilt University, Nashville,
TN; 4Center for Human Genetics Research,
Vanderbilt University, Nashville, TN *CR
6172 — C0057 Genetic interaction mapping
of AMD identifies potential gene-disease
associations. Lee Kiang, J. Huang, R. E. Tsuchida,
K. T. Jayasundera. Kellogg Eye Center, University
of Michigan, Ann Arbor, MI
6173 — C0058 Cfh genotype interacts with
dietary glycemic index to modulate early agerelated macular degeneration-like features in
mice. Sheldon Rowan1, K. Weikel1, M. Chang1,
B. Nagel2, J. Thinschmidt3, M. B. Grant3, S. J.
Fliesler4, 5, D. Smith1, A. Taylor1. 1Human Nutrition
Research Center on Aging, Tufts University,
Boston, MA; 2Department of Pathology, Saint
Louis University, Saint Louis, MO; 3Department
of Pharmacology and Therapeutics, University
of Florida, Gainesville, FL; 4Research Service,
VAWNYHS, Buffalo, NY; 5Departments of
Ophthalmology & Biochemistry, SUNY-Buffalo &
SUNY Eye Institute, Buffalo, NY
6174 — C0059 Overexpression of HtrA1 and
Smoking Evokes Choroidal Neovascularization
and Retinal Deposit in Aged Mice. Mao
Nakayama, D. Iejima, M. Akahori, T. Iwata.
National Institute of Sensory organs, Nat’l Hosp
Org Tokyo Med Ctr, Tokyo, Japan
6175 — C0060 Contribution of CFH Y402H
polymorphism and CFHR3/CFHR1 deletion
to age-related macular degeneration in Brazil.
Monica B. Melo1, D. D. Sacconi1, G. Ananina1,
F. E. Hirata2, P. H. Rim2, A. M. Torigoe2, M. J.
Silva1, J. C. Vasconcellos2. 1CBMEG, University
of Campinas, Campinas, Brazil; 2Ophthalmology,
University of Campinas, Campinas, Brazil
6176 — C0061 Novel CFH variants in
patients with age-related macular degeneration.
Maheswara R. Duvvari1, J. P. van de Ven1, E.
B. Volokhina2, N. T. Saksens1, C. J. Boon1, L. H.
Hoefsloot3, L. van den Heuvel2, C. B. Hoyng1, A.
I. Den Hollander1, 3. 1Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands; 2Pediatrics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
3
Human Genetics, Radboud University Nijmegen
Medical Centre, Nijmegen, Netherlands
6177 — C0062 Targeted Sequencing,
Augmented with Public Resources, Identifies
a Rare C3 Allele Associated with Large Risk
of Age-related Macular Degeneration. Xiaowei
Zhan1, 2, D. E. Larson3, 4, R. S. Fulton3, 4, C. Wang5,
D. Stambolian6, E. Y. Chew7, E. Mardis3, 4, A.
Swaroop7, G. Abecasis1, 2. 1Biostatistics, University
of Michigan, Ann Arbor, MI; 2Center of Statistical
Genetics, University of Michigan, Ann Arbor, MI;
3
The Genome Institute, Washington University, St.
Louis, MO; 4Department of Genetics, Washington
University, St. Louis, MO; 5Department of
Biostatistics, Harvard University, Boston, MA;
6
Department of Ophthalmology and Human
Genetics, University of Pennsylvania, Philadelphia,
PA; 7National Eye Institute, Bethesda, MD *CR
6178 — C0063 Three New Genetic Loci
(R1210C mutation in CFH, SNPs in COL8A1
and RAD51B) are Related to Progression to
Advanced Stages of Age-Related Macular
Degeneration. Johanna M. Seddon1, 2, R.
Reynolds1, Y. Yu1, S. Raychaudhuri3, 4, B. Rosner5.
1
Ophthalmic Epidemiology and Genetics Service,
New England Eye Center, Tufts Medical Center,
Boston, MA; 2Ophthalmology, Tufts University
School of Medicine, Boston, MA; 3Divisions of
Rheumatology and Genetics, Brigham and Women’s
Hospital, Harvard Medical School, Boston, MA;
4
Program in Medical and Population Genetics,
Broad Institute of Harvard and MIT, Boston, MA;
5
Channing Laboratory, Boston, MA *CR
6179 — C0064 Investigating Age-related
Macular Degeneration in the Amish. Joshua
D. Hoffman1, L. D’Aoust1, L. Jiang1, R. Laux1,
A. Agarwal3, W. K. Scott2, M. A. Pericak-Vance2,
J. L. Haines1. 1Ctr for Human Genetics Resrch,
Vanderbilt Univ Medical Center, Nashville,
TN; 2Hussman Institute for Human Genomics,
University of Miami, Miami, FL; 3Ophthalmology,
Vanderbilt Univ Medical Center, Nashville, TN *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
385
Thursday Posters
10:30 am – 12:15 pm
6168 — C0053 Genetic determinants of
Age-related Macular Degeneration in Diverse
Populations: the Population Architecture using
Genomics and Epidemiology (PAGE) Study.
Nicole Restrepo1, T. Garrett2, P. Buzkova3, R. A.
Jensen3, B. E. Klein4, R. Klein4, T. Wong5, E. Tai6, D.
Crawford1. 1Center for Human Genetics Research,
Vanderbilt University, Nashville, TN; 2Department
of Epidemiology, University of North Carolina,
Chapel Hill, Chapel Hill, NC; 3Department of
Biostatistics, University of Washington, Seattle,
WA; 4Office of Population Genomics, National
Human Genome Research Institute, Bethesda,
MD; 5Department of Ophthalmology and Visual
Sciences, University of Wisconsin, Madison, WI;
6
Singapore Eye Research Institute, Singapore
national Eye Centre, Singapore, Singapore *CR
6169 — C0054 Association between
δ-sarcoglycan gene (SGCD) polymorphisims
and age-related macular degeneration (AMD)
in Mexican patients. Javier F. Estrada1, A. B.
Luna-Angulo1, L. G. Cortes-Ballinas1, R. CoralVázquez2, A. Rendon4, D. C. Guadarrama5, H.
Rangel-Villalobos3, J. C. Zenteno5. 1Biochemistry
and Molecular Biology, Universidad Panamericana,
México, Mexico; 2seccion de estudios de posgrado
e investigacion.Escuela de Medicina IPN, IPN,
Mexico, Mexico; 3genetica, Unioversidad de
Guadalajara, Guadalajara, Mexico; 4Centre de
Recherche, Institut de la Vision, Paris, France;
5
Genética, Instituto de oftalmología Conde de
Valenciana, Mexico, Mexico
6180 – 6196 – Thursday – Posters
6180 — C0065 Genetic Risk Score Predicts of
Severity of Age-related Macular Degeneration.
Jonathan L. Haines1, A. Agarwal1, J. N. Cooke
Bailey1, J. D. Hoffman1, J. McGrath1, L. M. Olson1,
J. L. Kovach2, S. G. Schwartz2, W. K. Scott3, M. A.
Pericak-Vance3. 1Ctr Human Genetics Res-Med
Ctr, Vanderbilt University, Nashville, TN; 2Bascom
Palmer Eye Institute, Naples, FL; 3Human Genetics,
University of Miami, Miami, FL *CR
6181 — C0066 The association of elastin
gene variants with two angiographic subtypes
of polypoidal choroidal vasculopathy. Shigeru
Honda, S. Yanagisawa, A. Miki, W. Matsumiya,
A. Negi. Kobe University Graduate School of
Medicine, Kobe, Japan
6182 — C0067 Associations of C3 with
neovascular age-related macular degeneration
and polypoidal choroidal vasculopathy. Ke
Liu, L. Chen, P. Tam, C. Pang. Department of
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China
6183 — C0068 Polymorphisms association
of CFH, BF, C3, FHR 1-3 and ARMS2 genes
with geographic atrophy progression in AgeRelated Macular Degeneration. Sergio Recalde,
P. Fernandez, L. Garcia-Garcia, J. M. Caire, A.
I. Hernández, V. Fernandez-Garcia, M. MorenoOrduña, A. Garcia-Layana. Ophthalmology,
Universidad de Navarra, Pamplona, Spain
Thursday Posters
10:30 am – 12:15 pm
6184 — C0069 Genotype Analysis for Single
Nucleotide Polymorphisms Profile of Eyes with
Vascularized Pigment Epithelial Detachment
due to AMD. Clement K. Chan1, 2, D. Sarraf3, P.
Abraham4, D. H. Nguyen5, S. G. Lin1, M. Lalezary1,
K. Zhang5, 6. 1Vitreoretina, Southern California
Desert Retina Consultants, Palm Desert, CA;
2
Department of Ophthalmology, Loma Linda
University, Loma Linda, CA; 3Retinal Disorders
and Ophthalmic Genetics Division, Jules Stein Eye
Institute, University of California, Los Angeles, Los
Angeles, CA; 4Retina Section, Black Hills Regional
Eye Institute, Rapid City, SD; 5Department of
Ophthalmology, University of California, San
Diego, San Diego, CA; 6Institute of Genomic
Medicine, Shiley Eye Center, University of
California, San Diego, San Diego, CA *CR, f
6185 — C0070 Pharmacogenetic associations in
neovascular age-related macular degeneration.
Results from the IVAN study. Andrew J. Lotery1, 2,
J. Gibson3, A. J. Cree1, S. M. Downes4, S. P.
Harding5, C. Rogers6, B. C. Reeves6, S. Ennis3, U.
Chakravarthy7. 1Clinical & Experimental Sciences,
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 2Southampton
Eye Unit, University Hospital Southampton
NHS Foundation Trust, Southampton, United
Kingdom; 3Human Development and Health,
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 4Oxford Eye
Hospital, Oxford University Hospitals NHS Trust,
Oxford, United Kingdom; 5Department of Eye and
Vision Science, University of Liverpool, Liverpool,
United Kingdom; 6School of Clinical Sciences,
University of Bristol, Bristol, United Kingdom;
7
The Institute for Ophthalmology and Vision
Science, The Queen’s University of Belfast, Belfast,
United Kingdom *CR, f
6186 — C0071 The Role of Genetics in
Response to Anti-VEGF Therapy for Wet AMD.
Jaclyn L. Kovach1, A. Agarwal2, S. G. Schwartz1, M.
A. Brantley2, W. Cade3, J. L. Haines4, M. A. PericakVance3. 1Ophthalmology, Bascom Palmer Eye
Institute, Naples, FL; 2Ophthalmology, Vanderbilt
Eye Insitute, Nashville, TN; 3Institute for Human
Genomics, University of Miami Miller School of
Medicine, Miami, FL; 4Human Genetics, Vanderbilt
University School of Medicine, Nashville, TN *CR
6187 — C0072 VEGF-A and VEGFR-2 Gene
Polymorphisms and Response to Anti-VEGF
Therapy in the Comparison of AMD Treatments
Trials (CATT). Stephanie A. Hagstrom1, 2, G.
Ying3, G. J. Pauer1, G. M. Sturgill-Short1, J.
Huang3, M. G. Maguire3, D. F. Martin1. 1Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
2
Ophthalmology, Cleveland Clinic Lerner College
of Case Western Reserve University, Cleveland,
OH; 3Ophthalmology, University of Pennsylvania,
Philadelphia, PA *CR, f
6188 — C0073 Enhancer elements show
enrichment for AMD-associated genetic variants.
Lakshmi P. Pulagam1, N. J. Morris1, P. Benchek1,
P. Scacheri2, S. K. Iyengar1, 2. 1Epidemiology and
Biostatistics, Case Western Reserve University,
Cleveland, OH; 2Genetics and Genome Sciences,
Case Western Reserve University, Cleveland, OH
6189 — C0074 Early Biomarkers of AMD
(EBAMD) Study - Design and Baseline Data:
IRB-11-5677. Steven G. Pratt1, S. P. Richer2, C.
Perry1, 3, G. Ruteledge4, C. Podella2. 1Scripps
Health/Scripps Memorial Hospital/Scripps Mericos
Eye Institute/Scripps Clinical Research Service, La
Jolla, CA; 2Eye Clinic, Capt James A Lovell FHCC,
North Chicago, IL; 3Ophthalmology, University
of Iowa, Iowa City, IA; 4Biology, University of
California, Irvine, CA f
6190 — C0075 Association of the SOD activity,
rs1061170 in CFH and rs1531289 in VEGFR2
with protein levels in North Indian age related
macular degeneration patients. Neel Sharma1,
A. Gupta2, S. Prabhakar1, R. Singh2, S. Sharma3,
A. Anand1. 1Neurology, Post Graduate Institute
of Medical Education and Research, Chandigarh,
India; 2Ophthalmology, Post Graduate Institute
of Medical Education and Research, Chandigarh,
India; 3Statistics, Panjab University, Chandigarh,
India
6191 — C0076 AMD-associated variants
at chromosome 10q26 locus and ARMS2/
HTRA1gene expression. Gaofeng Wang1, B.
Court1, P. Gay1, S. R. Dubovy2, J. L. Kovach2,
S. G. Schwartz2, A. Agarwal3, W. K. Scott1, J. L.
Haines4, M. A. Pericak-Vance1. 1Hussman Inst for
Human Genomics, Univ of Miami Miller Sch of
Med, Miami, FL; 2Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 3Ophthalmology, Vanderbilt University,
Nashville, TN; 4Center for Human Genetics
Research, Vanderbilt University, Nashville, TN *CR
6192 — C0077 Differential gene expression of
RPE and choroid in old Cfh transgenic mice.
Cynthia X. Wang, B. Aredo, X. Chen, R. UfretVincenty. Ophthalmology, UTSW Medical Center,
Dallas, TX
6193 — C0078 GSTM1 and GSTM5
Polymorphisms and Expression in AMD. Allan
A. Hunter, Z. Smit-McBride, R. Anderson, E.
Kim, S. S. Park, L. M. Hjelmeland, L. S. Morse.
Ophthalmology, University of California, Davis,
Sacramento, CA *CR
6194 — C0079 Mitochondrial DNA
Heteroplasmy in Retinas of AMD Patients. Hui
Cai1, P. L. Nagy2, R. Allikmets1, 2. 1Ophthalmology,
Columbia University Medical Center, New
York, NY; 2Pathology & Cell Biology, Columbia
University Medical Center, New York, NY
6195 — C0080 Comparison Between
Haplogroup H and L Cybrids in ROS/RNS
Production and Gene Expression Further
step in understanding the pathogenesis of
Age-related Macular Degeneration. Mohamed
Tarek1, J. Cáceres del Carpio1, C. A. Ramirez1,
P. Falatoonzadeh1, S. Atilano1, D. Malik1, S.
Jazwinski2, M. V. Michael2, B. D. Kuppermann1, C.
M. Kenney1. 1Gavin Herbert Eye Institute, Irvine,
CA; 2Tulane Center For Aging, Tulane University,
New Orleans, LA *CR
6196 — C0081 Genetic Testing for AgeRelated Macular Degeneration in an Armenian
Population. Abraham Abraamyan1, B. Zanke3, P.
Ramamoorthy2, K. W. Small1. 1Macula & Retina
Institute, Glendale, CA; 2Advanced Diagnostics
Laboratory, Denver, CO; 3Arctic Dx - Macula Risk,
Bonita Springs, FL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
386
Thursday – Posters – 6197 – 6214
6197 — C0082 Global Review and Metaanalysis of Diabetic Retinopathy Genetic Studies
Highlight Gaps in the Pathogenesis between
Various Populations. Shi Song Rong, P. Tam, C.
Pang, L. Chen. Dept. Ophthalmology & Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, China
6198 — C0083 Relating risk genotypes
for diabetic retinopathy with color vision
performance. Mirella Gualtieri1, D. M. Bonci2,
V. D. Duarte Garcia2, S. Juel3, F. Damico5, M.
Neitz4, D. F. Ventura1, 2. 1Experimental Psychology,
University of Sao Paulo, Sao Paulo, Brazil;
2
Neuroscience & Behavio, University of Sao
Paulo, Sao Paulo, Brazil; 3Minority Health and
Health Disparities International Research Training
Program, Menphis, TN; 4Ophthalmology, University
of Washington, Seattle, WA; 5Ophthalmology,
University of Sao Paulo, Sao Paulo, Brazil *CR
6199 — C0084 MicroRNA-126 Regulates Heme
Oxygenase-1-Mediated Alterations in Diabetic
Retinopathy. Jiawen Fan, G. Xu, T. Jiang, Y. Qin,
X. Wang. Ophthalmology Department, Eye and ENT
Hospital of Fudan Univ, Shanghai, China
6200 — C0085 Identification of Risk Alleles
in the Erythropoietin gene for Proliferative
Diabetic Retinopathy in Type I and Type II
Diabetics. Stephen Juel3, D. M. Bonci1, 2, M.
Gualtieri1, 2, V. D. Duarte Garcia1, 2, M. Neitz4, D. F.
Ventura1, 2. 1Psicologia Experimental, Universidade
de São Paulo, São Paulo, Brazil; 2Núcleo de
Neurociências e Comportamento, Universidade
de São Paulo, São Paulo, Brazil; 3Minority
Health International Research Training Program,
Christian Brothers University, Memphis, TN;
4
Ophthalmology, University of Washington, Seattle,
WA *CR
6201 — C0086 Expression Of VEGF-A Gene
In Normal Retina And In PVR Retina. Claudio
Azzolini1, I. S. Pagani2, D. Borroni1, 2, C. Pirrone2,
D. Pigni2, M. Al Oum1, R. Vinciguerra1, S. Donati1,
G. Porta2. 1Morphological and Surgical Sciences,
University of Insubria - Circolo Hospital, Varese,
Italy; 2Department of Clinical and Experimental
Medicine, University of Insubria, Varese, Italy
6202 — C0087 Thrombophilic mutations and
risk of retinal vein occlusion. Silvia R. Mendes,
A. F. Campos, D. Beselga, A. Neves, J. Campos,
D. Castanheira. Ophthalmology, Leiria, Leiria,
Portugal
6205 — C0090 Transcriptional regulation
of synaptotagmin 11 in retinal ganglion cells.
Gillian C. Shaw1, 2, C. A. Berlinicke1, D. J. Zack1.
1
Ophthalmology, Johns Hopkins University,
Baltimore, MD; 2Molecular and Comparative
Pathobiology, Johns Hopkins University, Baltimore,
MD *CR
6206 — C0091 Systems Genetics of Intraocular
Pressure—Mice to Humans: The Use of
BXD Murine Reference Panel for Identifying
Novel Genetic Modulators of Glaucoma
and Bidirectional Translation. Monica M.
Jablonski1, 2, S. Swaminathan1, H. Lu1, J. L. Wiggs3,
R. W. Williams2, L. Lu2. 1Hamilton Eye Institute,
Univ Tennessee Health Sci Ctr, Memphis, TN;
2
Anatomy & Neurobiology, The University of
Tennessee Health Science Center, Memphis, TN;
3
Ophthalmology, Harvard Medical School MEEI,
Boston, MA *CR
6207 — C0092 Genetic variation of superoxide
dismutases in patients with primary open-angle
glaucoma. Dragana Celojevic1, S. Nilsson2, A.
Petersen1, G. Tasa3, E. Juronen3, M. Zetterberg1.
1
Institute of Neuroscience & Physiology, University
of Gothenburg, Gothenburg, Sweden; 2Institute
of Mathematical Sciences, Chalmers University
of Technology, Gothenburg, Sweden; 3Institute of
General and Molecular Pathology, University of
Tartu, Tartu, Estonia
6208 — C0093 COCH Variants are not
Associated with Primary-open Angle Glaucoma
or Intraocular Pressure in Caucasians.
Danyi Wang1, B. Fan1, Y. Liu2, M. A. Hauser2,
R. Allingham3, J. L. Haines4, J. L. Wiggs1.
1
Ophthalmology, Harvard Med Sch, Massachusetts
Eye & Ear Infirmary, Boston, MA; 2Ophthalmology
& Medicine, Duke University Medical Center,
Durham, NC; 3Ophthalmology, Duke University
Medical Center, Durham, NC; 4Center for Human
Genetics Research, Vanderbilt University School of
Medicine, Nashville, TN *CR
6209 — C0094 Family-based Genomewide Association Study in South Indian
Consanguineous Pedigrees confirms association
between ZNF469 and central corneal thickness.
Baojian Fan1, N. Soumittra2, S. Sripriya2, D. S.
Friedman3, V. Lingam4, J. L. Haines5, R. J. George4,
J. L. Wiggs1. 1Dept of Ophthalmology, Harvard
Med Sch Massachusetts Eye & Ear Infirmary,
Boston, MA; 2Vision Research Foundation, Sankara
Nethralaya, Chennai, India; 3Ophthalmology, Johns
Hopkins Medical School Wilmer Eye Institute,
Baltimore, MD; 4Medical Research Foundation,
Sankara Nethralaya, Chennai, India; 5Center for
Human Genetic Research, Vanderbilt University
School of Medicine, Nashville, TN *CR
6210 — C0095 Fine mapping of the RXRACOL5A1 locus for central corneal thickness.
Xiaoyi Gao1, Y. Liu2, W. Gauderman3, M. Torres1, T.
Haritunians4, J. Z. Kuo4, K. Taylor4, J. I. Rotter4, R.
Varma1. 1Department of Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL; 2Department of Medicine, Duke University,
Durham, NC; 3Department of Preventive Medicine,
University of Southern California, Los Angeles,
CA; 4Medical Genetics Institute, Cedars-Sinai
Medical Center, Los Angeles, CA *CR
6211 — C0096 Validation of APLP2 as
Potential Candidate Gene for Human Myopia
Linked to Chromosome 11q24.3. Andrei V.
Tkatchenko1, 2, P. Singh2, A. Kumar2, 1, T. V.
Tkatchenko1. 1Anatomy & Cell Biology, Wayne
State University, Detroit, MI; 2Ophthalmology,
Wayne State University, Detroit, MI
6212 — C0097 UV-Independent p53 Mutations
in Sebaceous Carcinoma of the Eyelid. Rehan M.
Hussain1, J. L. Matthews1, S. R. Dubovy1, G. Wang2.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Human Genetics, John P. Hussman
Institute for Human Genomics, Miami, FL
6213 — C0098 Genome-wide Analysis of
Ocular Adnexal Lymphoproliferative Disorders
Using High Resolution Single Nucleotide
Polymorphism Array. Hiroki Takahashi1, Y. Usui1,
R. Mitsuhashi1, N. Yamakawa1, A. Sato-Otsubo2, Y.
Sato2, S. Ogawa2, A. Arai3, H. Goto1. 1Department of
Ophthalmology, Tokyo Medical University, Tokyo,
Japan; 2Cancer Genomics Project, The University of
Tokyo, Tokyo, Japan; 3Department of Hematology,
Tokyo Medical and Dental University, Tokyo, Japan
6214 — C0099 Rb1 knockdown selectively
induces cone precursor proliferation and
tumor formation dependent on cone-specific
signaling. Xiaoliang L. Xu1, P. K. Bradford4, H.
P. Singh2, D. H. Abramson3, S. C. Jhanwar1, D.
Cobrinik2. 1Department of Pathology, Memorial
Sloan Kettering Cancer Center, New York, NY;
2
Department of Pediatrics, Memorial Sloan
Kettering Cancer Center, New York, NY; 3Ocular
Oncology Service, Memorial Sloan Kettering
Cancer Center, New York, NY; 4Albert Einstein
College of Medicine, New York, NY *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
387
Thursday Posters
10:30 am – 12:15 pm
6203 — C0088 Association study of IL23RIL12RB2 and IL10 gene polymorphisms with
susceptibility to Vogt-Koyanagi-Harada disease
in a Japanese population. Akira Meguro1, T.
Kawagoe1, M. Nakahara1, 2, H. Fukasaku1, 2, S.
Ohno3, N. Mizuki1. 1Department of Ophthalmology,
Yokohama City Univ School of Med, Yokohama,
Japan; 2Fukasaku Eye Clinic, Yokohama, Japan;
3
Ocular Inflammation and Immunology, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan
6204 — C0089 Genetic Screening of TSPAN12,
NDP and FZD4 Genes in Indian Patients with
Retinopathy of Prematurity. Inderjeet Kaur1, S.
Rathi1, G. R. Musada1, S. Jalali2, R. Kekunnaya3,
P. Gaddam4, S. Chakrabarti1. 1Kallam Anji Reddy
Molecular Genetics Lab, LV Prasad Eye Institute,
Hyderabad, India; 2Smt.Kannuri Santhamma Centre
for Vitreo Retinal Diseases, LV Prasad Eye Institute,
Hyderabad, India; 3Jasti V Ramanamma Children’s
Eye Care Centre, LV Prasad Eye Institute,
Hyderabad, India; 4Fernandez Hospital, Hyderabad,
India
6215 – 6232 – Thursday – Posters
6215 — C0100 Downregulation of MITF Leads
to Uveal Melanoma Cell Apoptosis and Cell
Cycle G1 Arrest. Lihua Wang, X. Chen, J. Wang,
D. Yan. 1School of Ophthalmology and Optometry,
Wenzhou Medical College, Wenzhou, China
Exhibit Hall C0101-C0134
Thursday, May 09, 2013 10:30 AM-12:15 PM
Glaucoma
542 Genetics II
Moderators: Janey L. Wiggs and David A. Mackey
6216 — C0101 The association of single
nucleotide polymorphisms in the connective
tissue growth factor gene with pseudoexfoliation
syndrome/glaucoma. Wool Suh1, C. Kee2.
1
Ophthalmology, Hallym University Sacred Heart
Hosp, Anyang, Kyeonggi-do, Republic of Korea;
2
Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea
6217 — C0102 CYP1B1 mutations, a major
contributor to juvenile-onset open angle
glaucoma. Khaled K. Abu-Amero1, 3, J. Morales2,
L. Ali Aljasim2, D. P. Edward2. 1Ophthalmology,
College of Med, King Saud Univ, Riyadh, Saudi
Arabia; 2King Khalied Eye Specilaist Hospital,
Riyadh, Saudi Arabia; 3Ophthalmology, College of
Medicine, Jacksonville, FL
Thursday Posters
10:30 am – 12:15 pm
6218 — C0103 Last results of the Spanish
Multicenter Genetic Glaucoma Group. Elena
Milla1, 5, S. Duch2, M. Carballo3, M. Gamundi4.
1
Institut Comtal d’Oftalmologia and Hospital Clinic,
Barcelona, Spain; 2Glaucoma, Institut Comtal
d’Oftalmologia, Barcelona, Spain; 3Hospital de
Terrassa, Barcelona, Spain; 4Hospital de Terrassa,
Barcelona, Spain; 5Spanish Multicenter Genetic
Glaucoma Group, 18 Spanish Eye Centers, Spain,
Spain
6219 — C0104 Identification of S1 RNA
Binding Domain-1 SRBD1 as a Major Gene
Determining Glaucoma in Dogs. Nobuyuki
Kanemaki1, K. T. Tchedre2, M. Imayasu2, A.
Meguro3, N. Mizuki3. 1Veterinary Teaching Hospital,
Azabu University, Sagamihara, Japan; 2Central
R&D Laboratory, Menicon Co., Ltd., Kasugai,
Japan; 3Department of Ophthalmology, Yokohama
City University School of Medicine, Yokohama,
Japan *CR
6220 — C0105 MYOC Variants In POAG
In Black South Africans. Susan E. Williams1,
T. Wainstein2, T. R. Carmichael1, M. Ramsay2.
1
Ophthalmology, University of the Witwatersrand,
Johannesburg, South Africa; 2Human Genetics,
University of the Witwatersrand, Johannesburg,
South Africa
6221 — C0106 Genetic Susceptibility
Variations and Visual Field Progression in
Chinese Patients with Primary Angle Closure
Glaucoma. Xin Wei1, 2, C. Khor3, 4, J. S. de
Leon2, E. N. Vithana2, 4, M. E. Nongpiur2, 4, S.
Perera2, T. Aung2, 4. 1Duke-National University of
Singapore Graduate Medical School, Singapore,
Singapore; 2Singapore Eye Research Institute,
Singapore National Eye Center, Singapore,
Singapore; 3Human Genetics, Genome Institute of
Singapore, Singapore, Singapore; 4Department of
Ophthalmology, National University Health System
& National University of Singapore, Singapore,
Singapore *CR
6222 — C0107 The Association Between
Ocular Biometric Parameters and the Three
Novel Primary Angle Closure Glaucoma (PACG)
Susceptibility Loci. Monisha E. Nongpiur1, 2,
C. Khor3, 4, L. Xu5, J. B. Jonas6, J. Wang5, T. Y.
Wong1, 7, E. N. Vithana1, T. Aung1, 7. 1Glaucoma,
Singapore Eye Research Inst, Singapore, Singapore;
2
DUKE-NUS Graduate Medical School, Singapore,
Singapore; 3Genome Institute Of Singapore,
Singapore, Singapore; 4Centre for Molecular
Epidemiology, Singapore, Singapore; 5Beijing
Institute of Ophthalmology, Beijing, China;
6
Ophthalmology, Medical Faculty MannheimHeidelberg, Mannheim, Germany; 7Ophthalmology,
Yong Loo Lin School of Medicine, Singapore,
Singapore *CR
6223 — C0108 Protein tyrosine phosphatase
Meg2 deficient mice - A powerful model to
study glaucoma disease? Jacqueline Reinhard1,
S. Wiemann1, S. C. Joachim2, H. Schmid2, B.
Denecke3, Y. Wang4, G. P. Downey5, 6, A. Faissner1.
1
Cell Morphology & Molecular Neurobiology,
Ruhr-University Bochum, Bochum, Germany;
2
Experimental Eye Research Institute, RuhrUniversity Bochum, Bochum, Germany;
3
Interdisciplinary Center for Clinical Research,
RWTH Aachen University, Aachen, Germany;
4
Department of Medicine, University of Toronto,
Toronto, ON, Canada; 5Department of Medicine,
National Jewish Health, Denver, CO; 6Departments
of Medicine and Integrated Department of
Immunology, University of Colorado, Aurora, CO
6224 — C0109 Association of Glutathione S
Transferases Polymorphisms with Glaucoma: A
Meta-analysis. Yibo Yu, K. Yao. Eye Center, Second
Affiliated Hospital, College of Medicine, Zhejiang
University, Hangzhou, China
6225 — C0110 Predicting Gene Networks and
Transcription Factors in TNFα Treatment of
Trabecular Meshwork Cells. Dongseok Choi1,
L. Hayashi2, K. Carr1, M. J. Kelley2, T. S. Acott2.
1
Biostatistics, Public Hlth & Preventive Med,
Oregon Health & Science Univ, Portland, OR;
2
Casey Eye Institute, Oregon Health & Science
Univ, Portland, OR
6226 — C0111 Mouse Genomic Loci
Modulating Ganglion Cell Loss in Glaucoma.
Eldon E. Geisert1, S. G. Hart1, X. Wang1, J. L.
Wiggs2. 1Ophthalmology, Univ of Tennessee Health
Sci Ctr, Memphis, TN; 2Ophthalmology, Harvard
Medical School, Boston, MA
6227 — C0112 Association between primary
open-angle glaucoma and genetic variants
associated with normal tension glaucoma.
Fumihiko Mabuchi1, Y. Sakurada1, K. Kashiwagi1,
Z. Yamagata2, H. Iijima1. 1Ophthalmology,
University of Yamanashi, Chuo, Japan; 2Health
Sciences, University of Yamanashi, Chuo, Japan
6228 — C0113 Analysis of Ophthalmic Clinical
Data Association for CDKN2B-AS1 Genotype in
Normal Subjects. Yoko Ikeda1, K. Mori1, M. Ueno1,
M. Nakano2, Y. Tokuda2, N. Omi2, R. Sato2, K.
Yoshii3, K. Tashiro2, S. Kinoshita1. 1Ophthalmology,
Kyoto Prefectural Univ of Med, Kamigyo-ku,
Japan; 2Genomic Medical Sciences, Kyoto
Prefectural University of Medicine, Kyoo, Japan;
3
Judo Therapy, Takarazuka University of Medical
and Health Care, Takarazuka, Japan *CR
6229 — C0114 The Role of Protein-Coding
Variants in South Africans with Exfoliation
Glaucoma. Yutao Liu1, 2, X. Qin1, J. Gibson1, S. E.
Williams3, R. M. Rautenbach4, T. R. Carmichael3,
A. E. Ashley-Koch1, R. Allingham2, M. A. Hauser1, 2.
1
Medicine, Duke University Medical Center,
Durham, NC; 2Ophthalmology, Duke University
Medical Center, Durham, NC; 3Neurosciences,
University of the Witwatersrand, Johannesburg,
South Africa; 4Surgical Sciences, Stellenbosch
University, Stellenbosch, South Africa *CR
6230 — C0115 Mouse Genomic Loci
Modulating Corneal Thickness. XiangDi
Wang1, S. G. Hart1, J. L. Wiggs2, E. E. Geisert1.
1
Ophthalmology, University of Tennessee Health
Science Center, Memphis, TN; 2OphthalmologyHarvard Medical School, Mass Eye & Ear
Infirmary, Boston, MA
6231 — C0116 Identification and
Characterization of Genetic Factors Responsible
for Cavitary Optic Disc Anomalies. Ralph
J. Hazlewood1, B. Roos1, R. A. Honkanen2, L.
M. Jampol3, W. L. Alward1, Y. H. Kwon1, E. M.
Stone1, 4, J. H. Fingert1, 5. 1Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
2
Ophthalmology, State University of New York at
Stony Brook, Stony Brook, NY; 3Ophthalmology,
Feinberg School of Medicine, Northwestern
University, Chicago, IL; 4Howard Hughes Medical
Institute, Iowa City, IA; 5Anatomy and Cell
Biology, University of Iowa, Iowa City, IA *CR
6232 — C0117 Association Study of Multiple
Gene Polymorphisms with the Risk of AdultOnset Primary Open-Angle Glaucoma in a
Mexican Population. Jesus Cabral1, B. Buentello1,
D. C. Guadarrama1, J. C. Zenteno1, 4, C. Elizondo2,
A. Miranda3. 1Research Unit Genetics, Institute
of Ophtalmology Conde De Valenciana, Mexico
City, Mexico; 2Glaucoma Department, Institute
of Ophtalmology Conde De Valenciana, Mexico
City, Mexico; 3Department Of Genetics, National
Institute of Rehabilitation, Mexico City, Mexico;
4
Department of Biochemistry, National Autonomous
University of Mexico, Mexico City, Mexico
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
388
Thursday – Posters – 6233 – 6249
6233 — C0118 A genetic variant in TMCO1 is
strongly associated with primary open angle,
primary angle closure and pseudoexfolation
glaucoma. Shazia Micheal1, 2, H. Ayub2, 1, M. I.
Khan2, 3, B. Bakker1, F. E. Schoenmaker-Koller1,
M. Ali4, F. Akhtar4, R. Qamar1, 5, A. I. Den
Hollander1, 3. 1Ophthalmology, UMC St Radboud,
Nijmegen, Netherlands; 2Biosciences, COMSATS
Institute of Information Technology, Islamabad,
Pakistan; 3Human Genetics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
4
Glaucoma, Al-Shifa Trust Eye Hospital,
Rawalpindi, Pakistan; 5Shifa College of Medicine,
Shifa Tameer-e-Millat University, Islamabad,
Pakistan
6239 — C0124 Rare Genetic Variants in
African Americans with Primary Open Angle
Glaucoma. Allison E. Ashley-Koch1, X. Qin1, J.
Gibson1, Y. Liu1, 2, J. L. Wiggs3, J. E. Richards4,
S. E. Moroi4, C. A. Girkin5, R. Allingham2, M.
A. Hauser1, 2. 1Center for Human Genetics,
Duke University Medical Center, Durham, NC;
2
Department of Opthalmology, Duke University
Medical Center, Durham, NC; 3Massachusetts Eye
and Ear Infirmary, Harvard Medical School, Boston,
MA; 4Department of Ophthalmology and Visual
Sciences, University of Michigan Medical School,
Ann Arbor, MI; 5Department of Ophalmology,
University of Alabama at Birmingham School of
Medicine, Birmingham, AL *CR
6234 — C0119 The association between CAV1/2
region loci and their relation with primary
open angle glaucoma. Stephanie Loomis1, 2, L.
R. Pasquale1, 2, J. H. Kang2, M. A. Hauser4, 5, B.
Yaspan3, J. L. Haines3, J. L. Wiggs1. 1Department
of Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA; 2Department of Medicine,
Channing Division of Network Medicine, Boston,
MA; 3Center for Human Genetics Research,
Vanderbilt University, Nashville, TN; 4Department
of Ophthalmology, Duke University, Durham, NC;
5
Department of Medicine, Duke University Medical
Center, Durham, NC *CR
6240 — C0125 Secondary Glaucoma
in transthyretin (TTR)-related Familial
Amyloid Polyneuropathy. Antoine Rousseau1,
E. Barreau1, G. Kaswin1, M. Mgarrech1, M.
Théaudin2, C. Cauquil2, D. Adams2, M. Labetoulle1.
1
Ophthalmology, Bicetre Hospital, South Paris
University, Le Kremlin Bicêtre, France; 2Neurology,
Bicetre Hospital, South Paris University, Le
Kremlin Bicêtre, France *CR
6235 — C0120 Next Generation Sequencing
Identifies Novel Variants of Mitochondrial
DNA in Normal-Tension Glaucoma Patients.
Dong Myung Kim1, J. Jeoung1, M. Seong2, S.
Park2. 1Ophthalmology, Seoul National University
Hospital, Seoul, Republic of Korea; 2Laboratory
Medicine, Seoul National University Hospital,
Seoul, Republic of Korea
6236 — C0121 Revisit the association of CAV1/
CAV2 with primary open-angle glaucoma. Li Jia
Chen, P. Tam, C. Pang. Ophthalmology & Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, China
6238 — C0123 POAG blood and hyaluronic
acid challenged monocytes upregulate CD44s
and isoforms: A new biomarker? Paulius Kuprys1,
A. Grybauskas1, K. Skuran1, P. A. Knepper1, 2.
1
Ophthalmology and Visual Sciences, Univerisity of
Illinois at Chicago, Chicago, IL; 2Ophthalmology,
Northwestern University Medical School, Chicago,
IL
6242 — C0127 Expanded Phenotype of
Axenfeld Spectrum: Congenital Hypothyroidism
and Glaucoma. Elena Bitrian1, E. W. McPherson2,
A. L. Grajewski1, 3. 1Ophthalmology, University of
Minnesota, Minneapolis, MN; 2Genetics, Marshfield
Clinic, Marsfield, WI; 3Pediatric Glaucoma, Bascom
Palmer Eye Institute, Miami, FL *CR
6243 — C0128 Candidate regulatory
lysyl oxidase-like 1 (LOXL1) variants in
pseudoexfoliation syndrome/glaucoma are
associated with differential LOXL1 expression.
Matthias Zenkel1, F. Pasutto2, J. Onderka1, A. W.
Krysta1, A. Moessner1, F. E. Kruse1, U. SchlotzerSchrehardt1. 1Department of Ophthalmology,
University Erlangen Nuernberg, Erlangen,
Germany; 2Department of Human Genetics,
University Erlangen Nuernberg, Erlangen, Germany
6246 — C0131 Exome chip analysis identifies
rare variants associated with primary open angle
glaucoma. William K. Scott1, M. D. Courtenay1, D.
L. Budenz3, R. K. Lee2, J. L. Haines4, M. A. PericakVance1. 1Hussman Institute of Human Genomics,
University of Miami, Miami, FL; 2Bascom Palmer
Eye Institute, University of Miami, Miami, FL;
3
Ophthalmology, University of North Carolina,
Chapel Hill, NC; 4Center for Human Genetics
Research, Vanderbilt University, Nashville, TN *CR
6247 — C0132 Association between IL1A,
IL1B and TNFA polymorphisms and glaucoma
in a Brazilian population. Mariana Oliveira1, 2, J.
C. Vasconcellos2, 1, V. P. Costa2, G. Ananina1, M. B.
Melo1. 1Center of Molecular Biology and Genetic
Engineering, University of Campinas, UNICAMP,
Campinas, Brazil; 2Department of Ophthalmology,
Faculty of Medical Sciences, University of
Campinas, UNICAMP, Campinas, Brazil
6248 — C0133 Functional Analysis of LOXL1
Missense Variants in the Pathophysiology of
Pseudoexfoliation Syndrome/Glaucoma. Ursula
Schlotzer-Schrehardt1, T. Sasaki2, M. Zenkel1,
F. E. Kruse1, A. W. Krysta1. 1Department of
Ophthalmology, University of Erlangen-Nürnberg,
Erlangen, Germany; 2Department of Experimental
Medicine I, University of Erlangen-Nürnberg,
Erlangen, Germany
6249 — C0134 Mapping of two modifier loci
for glaucoma severity on chromosome 20. Vincent
Raymond1, 2, P. Belleau1, S. Dubois1, R. Arseneault1.
Shink1, 2, J. Anctil3, G. Côté3, M. A. Walter4, M.
Amyot5. 1Neurosciences, CHU de Québec/CHUL
(Université Laval Hospital) Research Centre,
Québec City, QC, Canada; 2Molecular Medicine,
Université Laval, Québec City, QC, Canada;
3
Ophthalmology, Université Laval, Québec City,
QC, Canada; 4Medical Genetics, University of
Alberta, Edmonton, AB, Canada; 5Ophthalmology,
Université de Montréal, Montréal, QC, Canada
6244 — C0129 Spatial Distribution of
Mutations in ASB10 and MYOC. Colin Marrs1, S.
J. Garnai1, N. Lopes1, D. M. Reed1, K. E. Branham1,
M. I. Othman1, S. E. Moroi1, J. R. Heckenlively1,
H. S. Pawar1, J. E. Richards1, 2. 1Ophthalmology
and Visual Sciences, University of Michigan, Ann
Arbor, MI; 2Epidemiology, University of Michigan,
Ann Arbor, MI *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
389
Thursday Posters
10:30 am – 12:15 pm
6237 — C0122 Clinical Profile Of A Large
Family With Primary Open Angle Glaucoma
(POAG) In South Indian Population. Mohideen
A. Kader1, R. Ramakrishnan1, S. Krishnadas2,
P. Namburi3, P. Sundaresan3, A. L. Robin4, P. Y.
Ramulu5, J. H. Fingert6. 1Glaucoma, Aravind Eye
Hospital, Tirunelveli, India; 2Glaucoma, Aravind
Eye Hospital, Madurai, India; 3Genetics, Aravind
Medical Research Foundation, Madurai, India;
4
John Hopkins University, Baltimore, MD; 5Wilmer
Eye Institute, Baltimore, MD; 6Department of
Ophthalmology and Visual Sciences, Carver
College of Medicine, University of Iowa, Iowa City,
IA *CR
6241 — C0126 Identification and expression
of candidate genes in pseudoexfoliation. Kamesh
Dhamodaran1, R. S. Shetty1, M. Subramani1, V.
Patil2, B. K. Shetty2, D. Das1. 1Stem Cell Research
Laboratory, Narayana Nethralaya Post Graduate Inst
of Ophthalmology, Bangalore, India; 2Cataract and
Refractive Lens Surgery, Narayana Nethralaya Post
Graduate Inst of Ophthalmology, Bangalore, India
6245 — C0130 Conserved anatomic features
in sibling pairs concordant for angle closure.
Palaniswamy Krishnamurthy1, R. Venkatesh1, P. Y.
Ramulu2, S. Kavitha1, D. S. Friedman2, H. Quigley2,
R. Wojciechowski3, F. Seager2. 1Aravind Eye
Hospital, Pondicherry, India; 2Wilmer Eye Institute,
Baltimore, MD; 3Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD *CR
6250 – 6268 – Thursday – Posters
Exhibit Hall D0058-D0070
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retina
543 Proliferative Vitreoretinopathy
Moderators: Francesco Boscia and
Dov Weinberger
6250 — D0058 Comparison of Gene Expression
Profile of Epiretinal Membranes obtained from
Eyes with Proliferative Vitreoretinopathy to that
of Secondary Epiretinal Membranes. Shigeo
Yoshida, R. Asato, T. Nakama, K. Ishikawa, S.
Nakao, Y. Sassa, H. Enaida, Y. Oshima, T. Ishibashi.
Ophthalmology, Kyushu University, Fukuoka-shi,
Japan
6251 — D0059 miR-135b Regulates TGFβ1-Mediates Retinal Pigment EpithelialMesenchymal Transition. Fang Wang, H. Li, M.
Li. Tenth People’s Hospital of Tongji University,
Shanghai, China
6252 — D0060 β-catenin signaling in RPE in
experimental PVR. Kazuhiko Umazume1, 2, L. Liu1,
K. McDonald1, H. Goto2, H. J. Kaplan1, S. Tamiya1.
1
Ophthalmology & Visual Sciences, University of
Louisville, Louisville, KY; 2Ophthalmology, Tokyo
Medical University, Tokyo, Japan
6253 — D0061 Periostin Promotes the
Generation of Fibrous Membranes in
Proliferative Vitreoretinopathy. Keijiro Ishikawa1,
S. Yoshida1, S. Nakao1, T. Nakama1, T. Kita1, Y.
Sassa1, 2, H. Enaida1, Y. Oshima1, T. Kono2, T.
Ishibashi1. 1Ophthalmology, Kyushu University,
Fukuoka, Japan; 2Ophthalmology, Fukuoka
University Chikushi Hospital, Fukuoka, Japan
Thursday Posters
10:30 am – 12:15 pm
6254 — D0062 Suppression of Retinal
Pigment Epithelial Cell Proliferation, Migration
and Epithelial-mesenchymal transition by
Proteasome Inhibition, a Potential Defense
against Proliferative Vitreoretinopathy. Chuan
Chen1, Y. Zhu1, Y. Lin1, Z. Liu1, M. Wu1, D. W. Li2, B.
Cheng1. 1Zhongshan Ophthalmic Center, Sun Yatsen University, Guangzhou, China; 2Biochemistry
and Molecular Biology, University of Nebraska
Medical Center, Omaha, NE
6255 — D0063 Factor Xa and thrombin induce
epithelial to mesenchymal transition by retinal
pigment epithelial cells via PDGF-signaling.
Jeroen Bastiaans1, J. C. van Meurs2, 3, C. van Holten
- Neelen1, P. M. Van Hagen1, 4, N. Nagtzaam1, H.
Hooijkaas1, W. A. Dik1. 1Immunology, Erasmus
MC, Rotterdam, Netherlands; 2The Rotterdam Eye
Hospital, Rotterdam, Netherlands; 3Ophthalmology,
Erasmus MC, Rotterdam, Netherlands; 4Internal
Medicine, Erasmus MC, Rotterdam, Netherlands
6256 — D0064 Aquaporin-1 Expression in
Membranes from Proliferative Vitreoretinopathy
and in Epiretinal Membranes. Laure E. Caspers1,
E. Motulsky1, 2, D. Salik1, 2, X. Janssens1, 3, B. Pion1, 3,
N. Bolaky2, F. Gregoire2, J. Perret2, F. Willermain1, 4,
C. Delporte2. 1Ophthalmology, CHU Saint-Pierre
Hospital - ULB, Brussels, Belgium; 2Laboratory of
Pathophysiological and Nutritional Biochemistry,
Université Libre de Bruxelles (ULB), Brussels,
Belgium; 3Ophthalmlogy, Saint-Anne SaintRémi Hospital, Brussels, Belgium; 4I.R.I.B.H.M,
Université Libre de Bruxelles (ULB), Brussels,
Belgium
6262 — D0070 Novel Anti-CTGF RNAi
Therapy for Treatment of Proliferative
Vitreoretinopathy (PVR) and other Ocular
Disorders. Geoffrey P. Lewis2, M. Byrne1, S. K.
Fisher2, J. Cardia1, L. Pandarinathan1, K. Bulock1,
L. Libertine1, P. A. Pavco1. 1RXi Pharmaceuticals,
Westborough, MA; 2Neuroscience Research
Institute, Univ of California Santa Barbara, Santa
Barbara, CA *CR
6257 — D0065 Distribution of MDM2 T309G
polymorphism in European patients with
Proliferative Vitreoretinopathy. Retina 4 project.
Salvador Pastor1, 2, I. Rodriguez-Hernandez2, J.
Rojas Spano1, R. Gonzalez-Sarmiento2, J. Pastor1.
1
Ophthalmology, IOBA-University of Valladolid,
Valladolid, Spain; 2Medicine, Molecular Medicine
Unit, IBMCC and IBSAL, Salamanca, Spain
Retina
6258 — D0066 Epithelial cells promote
fibroblast-mediated contraction of collagen gels
by secreting bFGF. Maryada Sharma, H. Lei,
S. Pennock, A. Kazlauskas. The Schepens Eye
Research Institute, Massachusetts Eye and Ear
Infirmary, Department of Ophthalmology, Harvard
Medical School, Boston, MA
6259 — D0067 Analysis of vitreous hyaluronan
status in viteroretinal diseases. Koichi Nishitsuka1,
M. Narumi1, Y. Kashiwagi2, T. Shibata3, J. Gong3,
H. Furukawa3, H. Yamashita1. 1Ophthalmology/
Vis Sci, Yamagata University Sch of Med,
Yamagata-shi, Japan; 2Yonezawa Women’s Junior
College, Yonezawa, Japan; 3Mechanical Systems
Engineering, Graduate School of Science and
Engineering, Yamagata University, Yonezawa,
Japan *CR
6260 — D0068 Effect of SAHA on Fibrotic
Change in Primate Retinal Pigment Epithelium
Cells and Vitreous Cells. Hiroki Hatanaka1, N.
Okumura2, 1, N. Koizumi2, E. Mizuhara2, H. Hirano2,
J. Hamuro1, S. Kinoshita1. 1Ophthalmology, Kyoto
Prefectural Univ of Med, Kyoto, Japan; 2Biomedical
Engineering, Faculty of Life and Medical Sciences,
Doshisha University, kyotanabe, Japan *CR
6261 — D0069 Immunospecific targeting of
fibronectin towards an anti-fibrotic therapy,
with special emphasis on proliferative
vitreoretinopathy (PVR). Manni LuthraGuptasarma1, M. Sharma1, 3, S. Sharma1, A. Tiwari1,
V. Gupta2, A. Gupta2. 1Immunopathology, PGIMER
Chandigarh, Chandigarh, India; 2Ophthalmology,
PGIMER Chandigarh, Chandigarh, India; 3The
Schepens Eye Research Institute; Department of
Ophthalmology and Visual Sciences, Harvard
Medical School, Boston, MA *CR
Exhibit Hall D0079-D0129
Thursday, May 09, 2013 10:30 AM-12:15 PM
544 AMD IV, RE
Moderator: Amani A. Fawzi
6263 — D0079 The Rod Intercept: An
Improved Method for Estimating Rod-Mediated
Dark Adaption Speed. John G. Edwards1, G. R.
Jackson2. 1MacuLogix, Inc, Atlanta, GA; 2Penn
State College of Medicine, Hershey, PA *CR
6264 — D0080 Specular Photomicrographic
Assessment of the Effect of Anti-VEGF
intravitreal injections on corneal thickness and
endothelial cell density (CD) and morphology.
Fayssal El-Jabali, G. Papastergiou, M. D. Bennett,
K. E. Waite. Ophthalmology - Retina, Retina
Institute of Hawaii, Honolulu, HI
6265 — D0081 Retinal and choroidal thickness
changes over time in patients with neovascular
age-related macular degeneration treated with
anti-VEGF. Thais S. Mendes, M. Menghini,
A. L. Levison, S. Rofagha, R. B. Bhisitkul.
Ophthalmology, UCSF, San Francisco, CA *CR
6266 — D0082 Is foveal RPE autofluorescence
a predictor of visual outcome in wet Age Related
Macular Degeneration patients treated with
Ranibizumab? Maria Dimitry, N. Jain, L. North,
M. N. Chandran, G. Menon. Frimley Park Hospital,
Frimley, United Kingdom *CR
6267 — D0083 Intravitreal anti-VEGF therapy
for vascularized serous pigment epithelial
detachment in age-related macular degeneration.
Lucia Finocchio, D. Bacherini, F. Giansanti, G.
Giacomelli, C. Mazzini, L. Vannozzi, I. Biagini, G.
Virgili, U. Menchini. Department of Specialistic
Surgical Sciences, Eye Clinic, University of
Florence, Florence, Italy
6268 — D0084 Outer Retinal Tubulations
in the Comparison of AMD Treatments Trials
(CATT). Joo Yong Lee1, 2, F. A. Folgar1, C. A.
Toth1, G. J. Jaffe1. 1Duke Eye Center, Durham, NC;
2
Ophthalmology, Asan Medical Center, University
of Ulsan, Seoul, Republic of Korea *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
390
Thursday – Posters – 6269 – 6287
6269 — D0085 Retinal Pigment Epithelium
Atrophy in Patients Receiving Intravitreal
Anti-Vascular Endothelial Growth Factor
Therapy for Neovascular Age-Related Macular
Degeneration. Luna Xu1, 2, S. Mrejen1, 4, R. GallegoPinazo1, 5, J. J. Jung1, 3, M. Marsiglia1, 4, S. Boddu3,
K. Freund1, 3. 1Vitreous Retina Macula Consultants
of New York, New York, NY; 2Department
of Medicine, St. Vincent’s Medical Center,
Bridgeport, CT; 3Department of Ophthalmology,
New York University School of Medicine, New
York, NY; 4LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Hospital,
New York, NY; 5Department of Ophthalmology,
University and Polytechnic Hospital La Fe,
Valencia, Spain *CR
6270 — D0086 Aflibercept (Eylea) Effect
on Macula Thickness and Visual Acuity in
Exudative AMD Patients Recalcitrant to
Ranibizumab and Bevacizumab. Vincent Hau, M.
Samuel, M. Davis, K. Lin, T. Chang. Retina Institute
of California, Riverside, CA *CR
6271 — D0087 Comparison of Treatment
Schedules in an Integrated Analysis of the VIEW
Studies. Papp András1, B. Sommerauer2, O. Sowade2.
1
Department of Ophthalmology, Semmelweis
University Budapest, Budapest, Hungary; 2Bayer
Healthcare, Berlin, Germany *CR, f
6272 — D0088 Early fluid clearance
following intravitreal ranibizumab injection for
neovascular age-related macular degeneration.
Kathy Jao1, D. S. Chauhan2. 1Department of
Medicine, University of Melbourne, Melbourne,
VIC, Australia; 2Vision Retinal Institute Eastern,
Melbourne, VIC, Australia *CR
6273 — D0089 ForeseeHome in AREDS2Home Monitoring of AMD patients: Study
Design, Enrollment, Baseline Characteristics
and Initial Device Usage. Michael J. Elman1, 2, S.
B. Bressler2, T. E. Clemons3, E. Y. Chew4. 1Elman
Retina Group PA, Baltimore, MD; 2Johns Hopkins
University School of Medicine, Baltimore, MD;
3
Emmes Corporation, Bethesda, MD; 4National Eye
Institute, Bethesda, MD *CR
6276 — D0092 Association Between Required
Length of Intravitreal Anti-VEGF Therapy in
Exudative Age-Related Macular Degeneration
and Initial Central Macular Thickness as
Measured by Optical Coherence Tomography.
Blake Isernhagen, S. R. Fransen. Dean McGee Eye
Institute, Oklahoma City, OK
6277 — D0093 Quantification of the area of
retinal pigment epithelium tears in age-related
macular degeneration. Christoph R. Clemens,
F. Alten, C. Baumgart, P. Heiduschka, N. Eter.
Ophthalmology, University Eye Hospital, Muenster,
Germany *CR
6278 — D0094 Correlation Between Fluid
Status at Week 12 and Week 52 Following
Intravitreal Aflibercept Injections in the VIEW
Study of wAMD Patients. Jeffrey L. Marx1, D.
M. Moshfeghi2, S. M. Hariprasad3, J. S. Heier4.
1
Department of Ophthalmology, Lahey Clinic,
Peabody, MA; 2Department of Ophthalmology,
Stanford University, Palo Alto, CA; 3Department of
Ophthalmology, University of Chicago, Chicago,
IL; 4Ophthalmic Consultants of Boston and Tufts
University School of Medicine, Boston, MA *CR, f
6279 — D0095 Wide Field Fluorescein
Angiography in Silicone Oil Filled Eyes.
Goran Bencic1, M. Zoric-Geber1, Z. Vatavuk1,
T. R. Friberg2. 1University Department of
Ophthalmology, University Clinical Hospital
“Sestre milosrdnice”, Zagreb, Croatia; 2Retina
Service, UPMC Eye Center, University of
Pittsburgh, Pittsburgh, PA *CR
6280 — D0096 Impact of reticular
pseudodrusen on macular function. Giuseppe
Querques, N. Massamba, M. Srour, E.
Boulanger-Scemama, L. Querques, E. H. Souied.
Ophthalmology, University Paris Est Creteil, Cretil,
France *CR
6281 — D0097 Photoreceptor Abnormalities
in Intermediate Age-Related Macular
Degeneration. Sam Sadigh1, A. V. Cideciyan1, A.
M. Sumaroka1, W. Huang1, X. Luo1, M. Swider1,
J. D. Steinberg1, D. Stambolian2, S. G. Jacobson1.
1
Ophthalmology, Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA; 2Ophthalmology
and Genetics, University of Pennsylvania,
Philadelphia, PA
6282 — D0098 Individual Retinal Pigment
Epithelium Cells can be Imaged In Vivo in Age
Related Macular Degeneration. Ethan A. Rossi1,
D. R. Williams1, 2, A. Dubra4, 5, L. R. Latchney3,
M. A. Folwell1, W. Fischer3, H. Song1, M. M.
Chung3, 1. 1Center for Visual Science, University of
Rochester, Rochester, NY; 2The Institute of Optics,
University of Rochester, Rochester, NY; 3Flaum Eye
Institute, University of Rochester, Rochester, NY;
4
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 5Biophysics, Medical College of
Wisconsin, Milwaukee, WI *CR
6283 — D0099 Photoreceptor Structure in
Patients with Increased Genetic Risk for AgeRelated Macular Degeneration. Megan E. Land3,
R. F. Cooper4, E. Berg5, T. Kitchner6, J. Young1, K.
E. Stepien1, T. B. Connor1, D. Page7, M. Brilliant6,
J. Carroll1, 2. 1Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 2Cell Biology,
Neurobiology & Anatomy, Medical College of
Wisconsin, Milwaukee, WI; 3Medical College
of Wisconsin, Milwaukee, WI; 4Biomedical
Engineering, Marquette University, Milwaukee,
WI; 5Computer Sciences, University of Wisconsin
Madison, Madison, WI; 6Center for Human
Genetics, Marshfield Clinic Research Foundation,
Marshfield, WI; 7Biostatistics & Medical
Informatics, University of Wisconsin Madison,
Madison, WI *CR
6284 — D0100 Cellular Features of Retinal
Pigment Epithelial Atrophy after Regression of
Choroidal Neovascularization. Mina M. Chung1, 2,
H. Song2, 1, L. R. Latchney1, M. A. Folwell2, W.
Fischer1, E. A. Rossi2. 1Flaum Eye Institute,
University of Rochester, Rochester, NY; 2Center for
Visual Science, University of Rochester, Rochester,
NY *CR
6285 — D0101 The role of Optical Coherence
Tomography (OCT) for the diagnosis,
monitoring, and guiding of treatment for
neovascular Age-related Macular Degeneration
(nAMD): an evidence synthesis study. Noemi
Lois1, A. Azuara-Blanco2, G. Mowatt2, M. M.
Castillo de Chacon2, A. Elders2, C. Ramsay2, J.
Burr3. 1Ophthalmology Department, Grampian
Univ Hosp/NHS Trust, Aberdeen, United Kingdom;
2
Health Services Research Unit, University of
Aberdeen, Aberdeen, Scotland, United Kingdom;
3
School of Medicine, University of St Andrews, St
Andrews, United Kingdom
6286 — D0102 Towards Automated Assessment
of AREDS Severity Scale and Simple Scale Using
RTVue® Spectral Domain Optical Coherence
Tomography Tools. Qienyuan Zhou1, Y. Wolfson2,
V. Chaikitmongkol2, 3, N. M. Bressler2. 1Optovue,
Inc., Fremont, CA; 2Retina Division, Wilmer Eye
Institute, Johns Hopkins School of Medicine,
Baltimore, MD; 3Department of Ophthalmology,
Chiang Mai University, Chiang Mai, Thailand *CR
6287 — D0103 Detachment of CNV from
Bruch membrane due to contraction of
fibrovascular membrane in AMD. Ryo Mukai, T.
Sato, S. Kishi, N. Hanyuda. Ophthalmology, Gunma
Graduate school of medicine, Gunma, Japan *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
391
Thursday Posters
10:30 am – 12:15 pm
6274 — D0090 Predictive Factors for
Visual Acuity “Gain and Maintain” after
Ranibizumab Treatment for Age-Related
Macular Degeneration and Polypoidal Choroidal
Vasculopathy. Yuji Oshima, S. Shiose, M. Yasuda,
K. Kano, A. Yoshida, K. Ishikawa, S. Notomi, S.
Yoshida, T. Ishibashi. Ophthalmology, Kyushu
Univ, Faculty of Med, Fukuoka, Japan *CR
6275 — D0091 Morphologic effects of antiVEGF therapy on retinal pigment epithelium
(RPE) and choroidal vasculature (CV) in
neovascular age-related macular degeneration
(AMD). Ursula Schmidt-Erfurth1, C. Schuetze1,
S. M. Waldstein1, B. S. Gerendas1, C. Simader1,
L. Zhang3, M. D. Abramoff3, M. Sonka3, B.
Baumann2, C. K. Hitzenberger2. 1Department of
Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Center for Medical Physics and
Biomedical Engineering, Medical University
of Vienna, Vienna, Austria; 3Iowa Institute for
Biomedical Imaging, University of Iowa, Iowa City,
IA *CR
6288 – 6310 – Thursday – Posters
6288 — D0104 Optical Coherence Tomography
and fluorescein angiography in the diagnosis
of choroidal neovascularization of age-related
macular degeneration. Ramin Tadayoni1,
V. Gualino1, 5, S. Y. Cohen1, 2, G. Quentel2, B.
Haouchine1, 3, A. Erginay1, P. Massin1, E. Vicaut4, A.
Gaudric1. 1Ophthalmology, Lariboisiere University
Hospital, Paris, France; 2Centre d’imagerie et de
laser, Paris, France; 3Centre d’exploration de la
vision, Rueil Malmaison, France; 4Clinical Research
Unit, Lariboisiere University Hospital, Paris,
France; 5Clinique du docteur Cave, Montauban,
France *CR, f
6289 — D0105 Optical Coherence
Tomographic Findings in Wet Age-Related
Macular Degeneration Refractory to
Bevacizumab after Intravitreal Aflibercept
Therapy. Carmel Moazez1, 2, K. Attaran-Rezaei2, C.
H. Sell2, 1, S. Bryan2, S. De Souza2, A. J. Gordon2,
H. M. Kwong2, R. Reddy2, B. Shirkey2, M. C.
Ziemianski2. 1University of Arizona College of
Medicine-Phoenix, Phoenix, AZ; 2Associated Retina
Consultants, Phoenix, AZ
6290 — D0106 Inner Retinal Layers Damage
in Age-related Macular Degeneration. Ulfah
Rimayanti, K. Yamane, M. Latief, H. Mochizuki,
J. Hirata, Y. Kiuchi. Ophthalmology and Visual
Science Department, Hiroshima University,
Hiroshima, Japan
6291 — D0107 Comparison of spectral domain
and time domain OCT for qualitative and
quantitative fluid assessments in the Comparison
of AMD Treatments Trials (CATT). Francisco A.
Folgar1, C. A. Toth1, G. Ying2, M. G. Maguire2, G. J.
Jaffe1. 1Ophthalmology, Duke University, Durham,
NC; 2Ophthalmology, University of Pennsylvania,
Philadelphia, PA *CR, f
6292 — D0108 Optical coherence tomographic
correlates of angiographic subtypes of occult
choroidal neovascularization. Amirhossein
Hariri1, F. M. Heussen1, 2, M. Nittala1, S. Sadda1.
1
Doheny Eye Inst/Univ of Sthrn California, Los
Angeles, CA; 2Charite - University Medicine Berlin,
Berlin, Germany *CR
Thursday Posters
10:30 am – 12:15 pm
6293 — D0109 One-year macular volume
change of the neurosensory retina in
intermediate AMD by SDOCT semi-automated
segmentation. Eric L. Yuan1, F. A. Folgar1, S. J.
Chiu2, S. Farsiu1, 2, C. A. Toth1, 2. 1Ophthalmology,
Duke University, Durham, NC; 2Biomedical
Engineering, Duke University, Durham, NC *CR
6294 — D0110 Vitelliform-Like Lesions
Associated with Type 1 Choroidal
Neovascularization. Sabah Shah1, 2, V. P. Shah2,
1
, K. Freund2, 1. 1Ophthalmology, New York
University, New York, NY; 2Vitreous-RetinaMacula Consultants of New York, New York, NY
*CR
6295 — D0111 The Role of Anti-VEGF
Therapy in the Development and Progression
of Geographic Atrophy in Patients with Wet
Age-Related Macular Degeneration. Justin Shaw,
P. H. Scharper. Ophthalmology, Sinai Hospital of
Baltimore, Krieger Eye Institute, Baltimore, MD
6296 — D0112 OCT Minimum Intensity as a
Predictor of Geographic Atrophy Enlargement.
Paul F. Stetson1, Z. Yehoshua2, C. A. Garcia Filho2,
G. Gregori2, P. J. Rosenfeld2. 1Carl Zeiss Meditec,
Dublin, CA; 2Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL *CR, f
6297 — D0113 Progression of Geographic
Atrophy Predicted by SD-OCT En Face Imaging
of the Outer Retina. Renata Portella Nunes1, 2,
Z. Yehoshua1, A. A. Moshfeghi1, G. Gregori1,
P. F. Stetson3, W. J. Feuer1, P. J. Rosenfeld1.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Ophthalmology, Federal University of Sao
Paulo, Sao Paulo, Brazil; 3Research and Development,
Carl Zeiss Meditec, Dublin, CA *CR, f
6298 — D0114 Assessment of linearity of
growth in time in geographic atrophy secondary
to age-related macular degeneration. Jordi M.
Mones1, 2, M. Biarnes1, 2. 1Centro Medico Teknon,
Institut de la Macula de la Retina, Barcelona, Spain;
2
Barcelona Macula Foundation, Barcelona, Spain
*CR, f
6299 — D0115 Enhanced Depth Imaging
Optical Coherence Tomography of the Choroid
in eyes with Geographic Atrophy secondary to
Age-related Macular Degeneration. Athanasios
Bezatis1, E. Becker1, C. K. Brinkmann1, S. SchmitzValckenberg1, R. Fimmers2, M. Fleckenstein1, F.
G. Holz1. 1Ophthalmology, University of Bonn,
Bonn, Germany; 2Institute for Medical Biometry,
Informatics and Epidemiology, Bonn, Germany
*CR
6300 — D0116 A lack of delayed intraocular
pressure elevation after intravitreal injections
of ranibizumab for age-related macular
degeneration. Yusuke Ichiyama, T. Sawada, M.
Kakinoki, O. Sawada, Y. Saishin, H. Kawamura, M.
Ohji. ophthalmology, Shiga University of Medical
Science, Otsu, Japan *CR
6301 — D0117 Longterm effect of multiple
intravitreal anti VEGF injection on intraocular
pressure. Yoon Jeon Kim, K. Sung, Y. Chung, K.
Lee, S. Joe, J. Lee, J. Kim, Y. Yoon. Asan Medical
Center, Seoul, Republic of Korea *CR
6302 — D0118 Effect of an Intravitreal AntiVEGF Injection on the Dynamics of the Anterior
Segment. Jonathan Naysan1, T. Suthar1, R. M.
Lieberman2, J. Jonisch1, 3. 1Ophthalmology, North
Shore - Long Island Jewish, Great Neck, NY;
2
Ophthalmology, Mount Sinai University Medical
Center, New York, NY; 3Ophthalmology, Long
Island Vitreoretinal Consultants, Great Neck, NY
6303 — D0119 Intraocular pressure monitoring
in patients with ranibizumab development. Anna
Plyukhova, M. A. Karpilova, A. V. Kuznetsov, I. V.
Andreeva, O. A. Gabina, M. V. Budzinskaya, V. P.
Erichev, S. E. Avetisov. State Research Institute
of Eye Diseases of Russian Academy of Medical
Sciences, Moscow, Russian Federation *CR
6304 — D0120 Persistent ocular hypertension
following intravitreal injections. Emilie Agard, H.
El Chehab, I. Douma, G. Ract-Madoux, C. Dussart,
C. Dot. Ophthalmology, Hopital Desgenettes, Bron,
France f
6305 — D0121 Evaluating safety and efficacy
of intravitreal Ranibizumab injection in AMD
patients and recommendations to improve the
standards of AMD service. Yasir Khan, M. Kim,
S. Kang, S. George. Medical Retina, Western Eye
Hospital, Imperial College London, London, United
Kingdom *CR
6306 — D0122 The UNVEIL (Utilizing
raNibizumab intraVitrEal Injection in
reaL-world setting) study interim results:
Effectiveness and safety of ranibizumab in the
treatment of neovascular age-related macular
degeneration under real-life conditions in
patients from Africa, Asia and the Middle East.
Mohamed Mahgoub1, N. K. Yadav2, V. Mester3,
K. E. Legodi4, H. Kim5, E. Wu6, S. Hristoskova6,
S. DiTommaso6. 1Ophthalmology, Ain Shams
University, Cairo, Egypt; 2Narayana Nethralaya,
Bangalore, India; 3Ophthalmology, Samaya
Specialized Center, Abu Dhabi, Saudi Arabia;
4
Ophthalmology, Medforum Medi-clinic, Pretoria,
South Africa; 5Ophthalmology, Kangnam Sacred
Heart Hospital, Hallym University, Seoul, Republic
of Korea; 6Novartis Pharma AG, Basel, Switzerland
*CR
6307 — D0123 Role of biomechanical
properties of fibrous coat of the eye in
intraocular pressure changes in patients after
intravitreal ranibizumab injections. Pilot study.
Ekaterina Chikun, M. A. Karpilova, A. V. Kuznetsov,
I. V. Andreeva, O. A. Gabina, A. Plyukhova, M. V.
Budzinskaya, V. P. Erichev, S. E. Avetisov. State
Research Institute of Eye Disease of Russian
Academy of Medical Sciences, Moscow, Russian
Federation *CR
6308 — D0124 Efficacy and Safety of 0.5 mg
or 2.0 mg Ranibizumab in Patients with Wet
Age-Related Macular Degeneration: HARBOR
2-Year Results. David W. Faber1, Z. Li2, P. Lai2.
1
Rocky Mountain Retina Consultants, Salt Lake
City, UT; 2Genentech, South San Francisco, CA
*CR, f
6309 — D0125 Association of Systemic
Anticoagulation and Rate of Intraocular
Hemorrhage Following Intravitreal Anti-VEGF
Therapy for Age-related Macular Degeneration.
Joanna Olson1, I. U. Scott1, 2, D. Kerchner1, A.
Kunselman2. 1Penn State Hershey Eye Center,
Hershey, PA; 2Department of Public Health
Sciences, Penn State College of Medicine, Hershey,
PA *CR
6310 — D0126 Microbial spectrum of
endophthalmitis following intravitreal injection
versus pars plana vitrectomy. Michael Dollin, P.
P. Storey, J. D. Pitcher, J. Vander, J. Hsu, S. J. Garg.
Wills Eye Institute, Philadelphia, PA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
392
Thursday – Posters – 6311 – 6333
6311 — D0127 Index of Non Circularity
as a Predictor for Progression in Eyes with
Geographic Atrophy (GA). Ronald P. Danis, A.
Domalpally, E. Corkery, R. A. Shaw, A. R. Narkar, J.
White. Ophthalmology & Visual Sciences, Univ of
Wisconsin-Madison, Madison, WI *CR
6312 — D0128 Predictors for the progression
of geographic atrophy in patient with age-related
macular degeneration : fundus autofluorescence
study with modified fundus camera. Yong Jin
Jeong1, I. Hong1, J. Chung1, H. Kim1, S. Park1, 2.
1
Ophthalmology, Kangdong Sacred Heart Hospital,
Seoul, Republic of Korea; 2Ophthalmology,
Columbia University Medical Center, New York,
NY
6313 — D0129 Directional kinetics of
geographic atrophy progression in age-related
macular degeneration with foveal sparing.
Monika Fleckenstein1, A. Böker1, C. K. Brinkmann1,
S. Schmitz-Valckenberg1, R. Fimmers2, F. G. Holz1.
1
Department of Ophthalmology, University of Bonn,
Bonn, Germany; 2Institute for Medical Biometry,
Informatics and Epidemiology, University of Bonn,
Bonn, Germany *CR, f
Exhibit Hall D0185-D0236
Thursday, May 09, 2013 10:30 AM-12:15 PM
Physiology/Pharmacology / Biochemistry/
Molecular Biology / Visual Neuroscience
545 Retina: Physiology and
Pharmacology
Moderators: Teresio Avitabile and
Michele Reibaldi
6314 — D0185 Functional Expression Of
TRPV Channels In The Retinal Endothelium.
Jennifer E. McNaughten, M. McGahon, G.
McGeown, T. M. Curtis. Queens University Belfast,
Belfast, United Kingdom
6316 — D0187 Protective effects of an PPAR-γ
agonist on retinal ischemia/reperfusion injury in
rats. Xiaoyan Zhang, Y. Xiao, Y. Zhang, J. Zhang,
W. Ye. Ophthalmology, Huashan Hospital affiliated
to Shanghai Fudan University, Shanghai, China
6317 — D0188 Spectroscopic Investigation
of Agonist-Induced Rearrangements of Cyclic
Nucleotide-Regulated Ion Channels. William N.
Zagotta1, M. C. Puljung1, S. Stoll2. 1Physiology and
Biophysics, University of Washington, Seattle, WA;
2
Chemistry, University of Washington, Seattle, WA
6319 — D0190 Increased Expression of
Endothelin B Receptors Precedes Retinal
Ganglion Cell Death in a Rodent Model of
Glaucoma. Alena Z. Minton1, 2, N. Phatak1, 2,
D. L. Stankowska1, 2, S. He1, 2, H. Ma3, R. R.
Krishnamoorthy1, 2. 1Cell Biology & Anatomy,
University of North Texas Health Science Center,
Fort Worth, TX; 2North Texas Eye Research
Institute, Fort Worth, TX; 3Pharmacology &
Neuroscience, University of North Texas Health
Science Center, Fort Worth, TX
6320 — D0191 Vitreous penetration of orally
administered acetazolamide in humans. Armin
Afshar, R. Jager. Ophthalmology & Visual Science,
University of Chicago, Chicago, IL
6321 — D0192 Quality of fixation in major
depressive disorder and the influence of
antipsychotic medication. Serena Fragiotta1, P.
Grenga2, D. Domanico2, A. Cutini1, S. Valente1,
V. De Rosa1, E. M. Vingolo1. 1University of Rome
La Sapienza, Latina, Italy; 2S.M.Goretti Hospital,
latina, Italy
6322 — D0193 Translational Regulation
of RPE65 Expression by microRNA. William
Samuel1, R. K. Kutty1, T. Duncan1, C. Jaworski1,
T. Hara2, A. Lal2, T. Redmond1. 1Laboratory of
Retinal Cell and Molecular Biology, National Eye
Institute / National Institutes of Health, Bethesda,
MD; 2Genetics Branch, National Cancer Institute /
National Institutes of Health, Bethesda, MD
6323 — D0194 Decreased Protein Expression
of P2X2 in the Retina of Type 1 Diabetic Rats
Treated with Suramin and PPADS. Juan E.
Gallo2, 1, J. Mancini2, 1, G. A. Ortiz2, J. O. Croxatto3.
1
Ophthalmology, Hospital Universitario Austral,
Pilar, Argentina; 2Nanomedicine & Vision Group,
Universidad Austral, Pilar, Argentina; 3Ocular
Pathology, Fundacion Oftalmologica Argentina
“Jorge Malbran”, Buenos Aires, Argentina *CR
6324 — D0195 Intracellular pH of Retinal
Ganglion Cells During Systemic Hypoxia. Verleen
K. McSween, S. Viswanathan, J. A. Bonanno, S.
A. Burns, S. Li. School of Optometry, Indiana
University, Bloomington, IN
6325 — D0196 Further Studies on the
Inhibition of [3H]D-Aspartate Release by
Hydrogen Sulfide Donors in Isolated Bovine
Retina. Pratik Bankhele1, J. Jamil1, A. Salvi1, Y.
Njie-Mbye2, M. S. Kulkarni2, S. E. Ohia2, C. A.
Opere1. 1Creighton University, Omaha, NE; 2Texas
Southern University, Houston, TX
6326 — D0197 Asymmetrical vitreous status
in unilateral epimacular membrane observed
by swept-source optical coherence tomography.
Danjie Li, H. Itakura, S. Kishi. Ophthalmology,
Department of Ophthalmology, Gunma University
School of Medicine, Maebashi, Japan
6327 — D0198 The Retina of the Cognitively
Impaired Beagle Dog in Alzheimer’s Disease.
Laura Emptage1, B. Milgram3, 5, H. Dobson3, 4,
Z. Leonenko1, 6, M. C. Campbell1, 2. 1Physics and
Astronomy, University of Waterloo, Waterloo,
ON, Canada; 2School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 3CanCog Technologies, Fergus, ON,
Canada; 4University of Guelph, Guelph, ON,
Canada; 5University of Toronto at Scarborough,
Scarborough, ON, Canada; 6Biology, University of
Waterloo, Waterloo, ON, Canada *CR
6328 — D0199 Acid Sphingomyelinase:
a novel target for ischemia-induced retinal
degeneration. Jie Fan1, B. X. Wu2, C. E. Crosson1.
1
Ophthalmology-Storm Eye Inst, Medical Univ of
South Carolina, Charleston, SC; 2Microbiology &
Immunology, Medical University of South Carolina,
Charleston, SC *CR
6329 — D0200 Retinal Expression of
α-1-Antitrypsin (A1AT) in diabetic and
non-diabetic rats. Gustavo A. Ortiz1, 3, J.
Mancini1, 3, E. Chuluyan2, J. E. Gallo1, 3. 1Ciencias
Biomédicas, Universidad Austral, Pilar, Argentina;
2
Farmacología, Universidad de Buenos Aires,
Buenos Aires, Argentina; 3Nanomedicine & Vision
Group, Universidad Austral, Pilar, Argentina *CR
6330 — D0201 Dietary profile and vitamin
A intake in patients with Stargardt Disease
and Retinitis Pigmentosa. Alba Miele1, A. Sodi1,
G. Abbruzzese1, V. Murro1, F. Sofi3, 2, F. Cesari2,
A. Gori2, R. Abbate2, A. Casini3, U. Menchini1.
1
Specialistic Surgical Sciences, Eye Clinic,
University Of Florence, Italy, Florence, Italy, Italy;
2
Medical and Surgical Critical Care, University Of
Florence, Florence, Italy; 3Agency of Nutrition,
University Of Florence, Florence, Italy
6331 — D0202 Hypothermia protects retinal
ganglion cells against ischemia. Maximilian
Schultheiss, M. Blak, T. Dorfi, J. Hofmann, K.
Bartz-Schmidt, S. Schnichels, M. S. Spitzer.
Department of Ophthalmology, University of
Tuebingen, Tuebingen, Germany *CR
6332 — D0203 Effect of Storage Temperature
and Antioxidant Concentration on
Catecholamine Stability. Randolph D. Glickman1,
J. Berry1, 2, N. C. Kumar1. 1Dept of Ophthalmology,
Univ of Texas Hlth Sci Ctr SA, San Antonio, TX;
2
Medical School, Baylor College of Medicine,
Houston, TX
6333 — D0204 Establishment of a retinal
ischemia organ culture model. Sven Schnichels,
M. Blak, T. Dorfi, J. Hofmann, K. Bartz-Schmidt, F.
Ziemssen, M. Schultheiss, M. S. Spitzer. University
Eye Hosp Tuebingen, Centre for Ophthalmology
Tuebingen, Tuebingen, Germany *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
393
Thursday Posters
10:30 am – 12:15 pm
6315 — D0186 Further Studies On The Role Of
Arachidonic Acid Metabolites In The Regulation
Of Potassium-Induced [3H]D-Aspartate Release
From Isolated Bovine Retinae By 5-epi-5-F3tIsoprostane. Jamal Jamil1, P. Bankhele1, A. Salvi1,
T. Durand3, J. Galano3, A. Guy3, Y. Njie-Mbye2, S.
E. Ohia2, C. A. Opere1. 1Creighton.edu, Omaha,
NE; 2Texas Southern University, Houston, TX;
3
Universities of Montpellier I and II, Montpellier
cedex, France
6318 — D0189 Evaluation of homocysteine
and its metabolic cofactors in patients with
non proliferative and proliferative diabetic
retinopathy. Giulia Malaguarnera1, C. Gagliano1,
M. D. Toro1, F. Drago2, T. Avitabile1. 1Department
of Ophthalmology, university of Catania, Catania,
Italy; 2Department of Clinical Biomedicine,
university of Catania, Catania, Italy
6334 – 6356 – Thursday – Posters
6334 — D0205 Effects Of Propofol Over
Circular Retinal Spreading Depression. Vinicius
V. Oliveira1, R. Fleming1, N. S. Calixto2, S.
Cronemberger2, A. Dantas1. 1Biophysics Institute,
Federal Univ of Rio de Janeiro, Rio de Janeiro,
Brazil; 2Ophthalmology, Federal Univ of Minas
Gerais, Belo Horizonte, Brazil
6335 — D0206 Roles of Nitric Oxide in Delta
Opioid-Receptor Agonist (SNC 121) Mediated
Retina Neuroprotection in Chronic Glaucoma
Rat Model. Yasir Abdul, S. Husain. Ophthalmology,
Medical Univ of South Carolina, Charleston, SC
6336 — D0207 Perinatal hypoxia-ischemia
impairs retinal ganglion cell function and
optokinetic behavior in a rat model. Nikolay P.
Akimov, R. C. Renteria. Department of Physiology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX
6337 — D0208 The effect of RGS9
overexpression on flicker responses of mouse
bipolar cells. Christopher Fortenbach1, C. Kessler1,
M. E. Burns1, 2. 1Center for Neuroscience and
Department of Cell Biology and Human Anatomy,
University of California at Davis, Davis, CA;
2
Ophthalmology & Vision Science, University of
California, Davis, Davis, CA
6338 — D0209 C-peptide injection had
synergitic effect to precultured islets transplant
in prevention of diabetic retinopathy. Chunzhi
Dou1, 2, S. Y. Wu3, X. Zhang5, T. Dou6, G. Shuyan4.
1
Ophthalmology, Emory University, Suwanee,
GA; 2Biology, Georgia University System,
Lawrenceville, GA; 3Department of Surgery,
Norman Bethune Medical School, Jilin University,
Changchun, China; 4Department of Ophthalmology,
Norman Bethune Medical School, Jilin University,
Changchun, China; 5Endocrinology, Dehui County
Hospital, Dehui, China; 6Clinical Chemistry,
Genova Diagnostics, Duluth, GA
Thursday Posters
10:30 am – 12:15 pm
6339 — D0210 Comparison of
Dexmedetomidine vs. Propofol in Vitreoretinal
Surgery Under Local Block. Linda Y. Huang1, A.
Patel2, M. Antoniello2, C. Schoenberg2, D. Grech2,
A. Davidow2, T. Xia2, N. Bhagat1. 1Ophthalmology
and Visual Sciences, UMDNJ-New Jersey Medical
School, Newark, NJ; 2Anesthesiology, UMDNJNew Jersey Medical School, Newark, NJ *CR, f
6340 — D0211 Sitagliptin prevents bloodretinal barrier breakdown, inflammation
and neuronal cell death in the retina of type
1 diabetic animals. Andreia Gonçalves1, E. C.
Leal2, A. Paiva3, C. F. Ribeiro1, F. Reis1, A. F.
Ambrosio2, 4, R. Fernandes1. 1Lab Pharmacology
and Experimental Therapeutics, IBILI - Faculty
of Medicine, University of Coimbra, Coimbra,
Portugal; 2Centre for Neuroscience and Cell
Biology, University of Coimbra, Coimbra, Portugal;
3
Histocompatibility Centre of Coimbra, Coimbra
University Hospitals, Coimbra, Portugal; 4Centre
of Ophthalmology and Vision Sciences, IBILI
- Faculty of Medicine, University of Coimbra,
Coimbra, Portugal
6341 — D0212 Inhibition of the diabetesinduced increased TGF-β signaling in retinal
vessels leads to an abnormal endothelial
phenotype. Zeina Dagher, J. Vaz, M. Goodridge, C.
Gerhardinger, M. Lorenzi. Schepens Eye Research
Institute, Massachusetts Eye & Ear, Boston, MA
6342 — D0213 Expression of 2PK+ leak
channels in ganglion cells of the mouse retina.
Steven Hughes, R. G. Foster, S. N. Peirson, M.
W. Hankins. Nuffield Department of Clinical
Neurosciences, University of Oxford, Oxford,
United Kingdom
6343 — D0214 Glucocorticoids Inhibit
p38MAPK Activation and Neuronal Apoptosis in
Early Diabetic Retinopathy. Xinyuan Zhang1, B.
Bao2, M. C. Gillies3. 1Tongren Eye Center, Beijing
Tongren Hospital, Beijing, China; 2Pathology, The
University of Sydney, Sydney, NSW, Australia;
3
Ophthalmology, The University of Sydney, Sydney,
NSW, Australia *CR
6344 — D0215 The molecular mechanisms
of store-operated calcium entry in Müller glia.
Tunde Molnar1, A. M. Frye1, P. Barabas1, D. A.
Ryskamp2, 1, D. Krizaj1, 3. 1Ophthalmology and
Visual Sciences, Moran Eye Institution, University
of Utah School of Medicine, Salt Lake City, UT;
2
Interdepartmental Program in Neuroscience,
University of Utah, Salt Lake City, UT; 3Department
of Physiology, University of Utah, Salt Lake City,
UT
6345 — D0216 Contribution of GPCRs and
NADPH oxidase to increased generation of
superoxide by retinal photoreceptor cells in
elevated glucose. Yunpeng Du1, M. Cramer1, K.
Palczewski2, T. S. Kern1, 3. 1Medicine, Case Western
Reserve University, Cleveland, OH; 2Pharmacology,
Case Western Reserve University, Cleveland,
OH; 3Stokes Veterans Administration Hospital,
Cleveland, OH *CR
6346 — D0217 Pro-NGF induces endothelial
cell death via the P75 neurotrophin receptor
(P75NTR) in a mouse model of oxygeninduced retinopathy (OIR). Nicholas Sitaras1, 2,
H. Saragovi4, S. Chemtob3, 2, P. Sapieha2.
1
Pharmacology, Maisonneuve-Rosemont Hospital,
Montréal-Est, QC, Canada; 2Ophthalmology,
Maisonneuve-Rosemont Hospital, Montreal, QC,
Canada; 3Pharmacology, CHU Sainte-Justine,
Montreal, QC, Canada; 4Pharmacology and
Therapeutics, Lady Davis Institute, Montreal, QC,
Canada *CR
6347 — D0218 Inner nuclear layer microcystic
changes in optic nerve atrophy: a prospective
study. Benjamin Wolff, V. Vasseur, C. Basdekidou,
J. A. Sahel, C. Vignal, M. Mauget-Faÿsse. Professor
Sahel Dept, Fondation ophthalmologic Rothschild,
Paris, France *CR
6348 — D0219 Adrenergic but not purinergic
receptors affect ion transport across the mouse
retinal pigment epithelium. Thor Eysteinsson,
S. B. Skarphedinsdottir, S. Arnason. Physiology,
University of Iceland, Reykjavik, Iceland *CR
6349 — D0220 Increased Endothelin A
Receptor Expression in Rat Model of Ocular
Hypertension. Nolan R. McGrady1, 2, A. Z.
Minton1, 2, R. R. Krishnamoorthy1, 2. 1Cell Biology &
Anatomy, UNT Health Science Center, Fort Worth,
TX; 2North Texas Eye Research Institute, Fort
Worth, TX
6350 — D0221 Protective Effects of Chitosan
on Ischemia-Reperfusion Injury in Rat Retina.
Sheng-Li Cho1, C. Yang2. 1National Taiwan
University College of Medicine, Taipei, Taiwan;
2
Department of Ophthalmology, National Taiwan
University Hospital, Taipei, Taiwan
6351 — D0222 Water-dispersible hesperetin
prevents ganglion cell loss in the retina after
retinal ischemia reperfusion injury. Akito
Shimouchi1, H. Yokota1, T. Nagaoka1, S. Ono1,
H. Takumi2, S. Narayanan3, R. B. Caldwell3, 4, A.
Yoshida1. 1Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan; 2Institute of Health
Science, Ezaki Glico Co., Ltd, Osaka, Japan;
3
Vascular Biology Center, Medical College of
Georgia, Augusta, Georgia; 4VA Medical Center,
Augusta, Georgia *CR
6352 — D0223 Hypoxia Affects Polarized
Secretion of Amyloid Precursor Protein from
Retinal Pigmented Epithelial Cells. Mary C.
McGahan, S. Nagar, M. Lall. Dept of Molec
Biomed Sci, North Carolina State University,
Raleigh, NC
6353 — D0224 Stimulation of the AMPA
Receptor in Retinal Ganglion Cells Increases
Phosphorylation of CREB. Yong H. Park1, 2, B.
H. Mueller1, 2, H. Ma1, 2, T. Yorio1, 2. 1Pharmacology
& Neuroscience, UNT Health Science Center, Fort
Worth, TX; 2North Texas Eye Research Institute,
Fort Worth, TX
6354 — D0225 Specific Expression of
Erythrocyte tropomodulin in the retina of
E-Tmod+/lacZ and E-Tmod-/- mice. Lin Xie1,
L. Sung2. 1Department of Ophthalmology, DaPing
Hospital of the Third Military Medical University,
Chongqing, China; 2Department of Bioengineering,
and Center for Molecular Genetics, University of
California, San Diego, CA
6355 — D0226 The Effects Of Brimonidine On
Retinal Spreading Depression. Renata Fleming1,
V. V. Oliveira1, G. Alencar1, N. S. Calixto2, S.
Cronemberger2, P. Gardino1, A. Dantas1. 1Instituto
de Biofísica Carlos Chagas Filho, Universidade
Federal do Rio de Janeiro, Rio de Janeiro, Brazil;
2
Universidade Federal de Minas Gerais, Belo
Horizonte, Brazil
6356 — D0227 Protective Effects of Renin
Inhibitor in Retinal Ischemia-reperfusion Injury.
Kazuyuki Hirooka, K. Tenkumo, E. Nitta, T. Fujita,
F. Shiraga. Ophthalmology, Kagawa Univ Faculty
of Medicine, Kita-gun, Japan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
394
Thursday – Posters – 6357 – 6381
6357 — D0228 Brn3b mediated regeneration
of the optic nerve in a rodent model of glaucoma.
Dorota L. Stankowska, A. Z. Minton, R. R.
Krishnamoorthy. Cell Biology and Anatomy, North
Texas Eye Research Institute, University of North
Texas Health Science Center, Fort Worth, TX
6358 — D0229 Extracellular Hsp70
Mediates Ischemia-Induced Retinal Damage
Through A Tlr4-Dependent Pathway. Galina
Dvoriantchikova, A. C. Santos, X. Dvoriantchikova,
E. P. Hernandez, D. V. Ivanov. Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL
6359 — D0230 AP-1 and C/EBPβ Regulate
Endothelin B (ETB) Receptor in Retinas of
Rats in Response to Elevated Intraocular
Pressure. Shaoqing He1, A. Z. Minton1, H. Ma2, R.
R. Krishnamoorthy1. 1Cell Biology and Anatomy,
University of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2Pharmacology and Neurosciences, University
of North Texas Hlth Sci Ctr, Fort Worth, TX
6360 — D0231 Mineralocorticoid receptor
antagonists for the treatment of central serous
chorioretinopathy: Mechanistic rationale.
Francine F. Behar-Cohen1, 3, I. Celerier2, E.
Bousquet3, 1, J. P. Jeanny3, F. Jaisser2, N. Farman2.
1
Ophthalmology, Hotel Dieu de Paris, Universite
Paris Descartes, Paris, France; 2UMRS872 Team1,
Inserm, Paris, France; 3UMRS 872 Team 17,
Inserm, Paris, France *CR
6361 — D0232 Ocular changes in a rat model
of Alzheimer’s Disease. YuChun Tsai1, B. Lu1, S.
Girman1, C. Svendsen1, R. M. Cohen2, S. Wang1.
1
Cedars-Sinai Medical Center, Los Angeles, CA;
2
Memory Disorders Center, Cedars-Sinai Medical
Center, Los Angeles, CA
6362 — D0233 QLT091001, a 9-cis-retinal
analog, is well tolerated by retinas of mice with
impaired visual cycles. Tadao Maeda1, Z. Dong3,
H. Jin3, O. Sawada2, S. Gao2, G. Palczewska3, K.
Palczewski2. 1Ophthalmology & Visual Sciences,
Case Western Reserve University, Cleveland, OH;
2
Pharmacology, Case Western Reserve University,
Cleveland, OH; 3Polgenix Inc., Cleveland, OH *CR
6363 — D0234 Topical Bromfenac 0.1%
suppresses Concanavalin-A Induced Blood
Retinal Barrier Breakdown. Hiroaki Takahashi, T.
Kida, S. Kozai, H. Tokushige. Research Laboratory
for Drug Development, Senju Pharmaceutical Co,
Ltd, Kobe, Japan *CR
Exhibit Hall D0277-D0293
Thursday, May 09, 2013 10:30 AM-12:15 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
546 Oculoplastics: Eyelids
Moderator: Benjamin Thompson
6366 — D0277 A retrospective study of
chalazia in an urban tertiary care setting.
Christopher Lo, A. Y. Wu. Ophthalmology, Mount
Sinai, New York, NY
6367 — D0278 Clinical Pathology of Pediatric
Ptosis. Femida Kherani, E. Sanders, H. Sarnat.
University of Calgary, Calgary, AB, Canada
6368 — D0279 Comparison Of 10%
Phenylephrine Test with Manual Elevation Test
in Patients with Bilateral Involutional Ptosis.
Ivana Pereira, S. Matayoshi. Ophthalmology,
University Sao Paulo, Sao Paulo, Brazil
6369 — D0280 Ptosis following long term
topical steroid use after cornea graft surgery.
Amanjeet Sandhu, L. C. Clarke, F. C. Figueiredo.
Ophthalmology, Royal Victoria Infirmary,
Newcastle upon Tyne, United Kingdom
6370 — D0281 Effect of brow fixation in
evaluation of eyelid position and levator
palpebrae superioris function. Elysa A. Brown, A.
Y. Ting, I. Koreen, R. Yeatts. Ophthalmology, Wake
Forest Medical Center, Winston Salem, NC
6371 — D0282 Management of Malignant
Eyelid Tumors by Primary Reconstruction:
Evaluation of Long-term Outcomes. Yinan
Han1, J. Qian1, Y. Yuan1, Y. Bi1, Y. Yao1, K. Xue1,
C. Wei2, J. Guo1. 1Ophthalmology, Eye and ENT
Hospital of Fudan University, Shanghai, China;
2
Ophthalmology, Yijishan Hospital of Wannan
Medical College, Wuhu, China
6372 — D0283 Simplified horizontal mattress
full-thickness eyelid defect repair. Julia E.
Reid1, C. N. Czyz2, K. R. Everman2, K. V. Cahill2,
J. A. Foster2, S. X. Zhang-Nunes2. 1Department of
Ophthalmology and Visual Sciences, The Ohio
State University, Columbus, OH; 2The Eye Center
of Columbus, Columbus, OH
6373 — D0284 Horizontal Tarsal Transposition
Flap and Lateral Canthal Fixation for Repair
of Large, Central Lower Eyelid Defects.
Clifton Blake Perry, K. D. Carter, R. C. Allen.
Ophthalmology, University of Iowa, Iowa City, IA
6374 — D0285 A modified staged surgical
intervention for blepharophimosis-ptosisepicanthus inversus syndrome: 125 cases
with encouraging results. Xin Song, X. Fan.
Ophthalmology, Ninth People’s Hospital, Shanghai
Jiao Tong University School of Medicine, Shanghai,
China
6375 — D0286 Lower eyelid surgical approach
in facial paralysis. Fabiola Ogaz, G. Salcedo, R.
O. Prieto, A. Buigues, L. Guakil. Asociacion para
Evitar la Ceguera en Mexico, mexico, Mexico
6376 — D0287 Comparison of Fasanella-Servat
and Small-Incision Techniques for Involutional
Ptosis Repair. Mahsa A. Sohrab, G. Lissner.
Ophthalmology, Northwestern University, Chicago,
IL
6377 — D0288 Frontalis Suspension for
Blepharoptosis Surgery, Is there a best material?
Cristian M. Montecinos, R. O. Prieto, A. Ceriotto,
A. Buigues, A. I. Ortiz, G. Salcedo. APEC, Distrito
Federal, Mexico
6378 — D0289 Use of Histoacryl as a Spacer in
the Recession of Upper Eyelid Retraction. Imtiaz
A. Chaudhry1, O. Al-Shaikh2, W. A. Al-Rashed3,
F. A. Shamsi4, Y. O. Arat5, M. Boniuk6. 1Houston
Oculoplastics Associates, Memorial Herman
Medical Plaza Texas Medical Center, Houston, TX;
2
Oculoplastic and Orbit Division, King Khaled Eye
Specialist Hospital, Riyadh, Saudi Arabia; 3Vice
Dean, Faculty of Medicine, Imam Ibn Mohammad
Saud Islamic University, Riyadh, Saudi Arabia;
4
Research Department, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 5Department of
Ophthalmology, University of Wisconsin School of
Medicine, Madison, WI; 6Ophthalmology, Baylor
College of Medicine, Houston, TX
6379 — D0290 Use of Omentum for
Engineering in vivo Levator Palpebrae
Superioris: A Pilot Study. Sara L. Duke, P. Bu, D.
K. Yoo. Ophthalmology, Loyola University Chicago,
Maywood, IL
6380 — D0291 Biointegration of Osteomesh®
Polycaprolactone Implants in the Rabbit Eyelid.
Livia Teo1, S. Teoh2, L. Seah1. 1Oculoplastics,
Singapore National Eye Center, Singapore,
Singapore; 2Division of Bioengineering, School of
Chemical and Biomedical Engineering, Nanyang
Technological University, Singapore, Singapore
*CR
6381 — D0292 The Effects of Temperaturesensitive Guardix SG® in Adhesiolysis of
Experimentally Induced Lid Adhesion Rabbits.
Hee-Bae Ahn1, H. Jung1, M. Roh2, W. Ryu1, Y.
Kwon1. 1ophthalmology, Dong-A university, Busan,
Republic of Korea; 2pathology, Dong-A university,
Busan, Republic of Korea
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
395
Thursday Posters
10:30 am – 12:15 pm
6364 — D0235 Overexpression of the
POU Domain Transcription Factor, Brn3b
Causes Neurite Outgrowth in Cultured PC 12
Cells. Nitasha Phatak, D. L. Stankowska, R. R.
Krishnamoorthy. UNT Health Science Center, Fort
Worth, TX
6365 — D0236 MicroRNAs in vitreous humor
from patients with ocular disease : preliminary
results. Caterina Gagliano1, A. Russo2, M.
Ragusa4, R. Caltabiano3, L. Puzzo3, T. Avitabile2,
A. Longo2, M. D. Toro2, M. Purrello4, M. Reibaldi2.
1
Ophthalmology, NEST (Neurovisual Science
Technology), Catania, Italy; 2Opthalmology,
University of Catania, Catania, Italy; 3Pathological
Anatomy, University of Catania, Catania, Italy;
4
Molecular Biology, University of Catania, Catania,
Italy
6382 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6382 — D0293 The Efficacy of Seprafilm®
Graft with Adhesiolysis in Experimentally
Induced Lid Adhesion in Rabbits. Hyemi Jung1,
H. Ahn1, M. Roh2, W. Ryu1, Y. Kwon1. 1Department
of Ophthalmology, Dong-A University College of
Medicine, Busan, Republic of Korea; 2pathology,
Dong-A University College of Medicine, Busan,
Republic of Korea
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
396
Thursday – Keynote – 6383
6B
Thursday, May 09, 2013 2:00 PM-3:15 PM
548 ARVO/Alcon Keynote Series
The Global Burden of Diseases, Injuries, and Risk
Factors Study 2010 (GBD 2010) is a systematic,
scientific effort to quantify the comparative
magnitude of health loss due to diseases, injuries
and risk factors by age, sex and geography for
specific points in time. Drawing on the efforts of
a multitude of people, including almost 500 coauthors around the world, the study represents the
largest review of epidemiological data sources
relevant to burden of disease. After a complete
systematic assessment of the data on all diseases
and injuries, we have expanded the number of data
sources in our analysis significantly. GBD studies
for 1990 and 2000 examined 108 diseases and
causes in 8 regions and 170 diseases and causes
in 14 regions respectively. The GBD 2010 study
expands the scope much further to 291 diseases
and injuries and 67 risk factors in 21 individually
distinct but collectively comprehensive global
regions. At the same time, we have improved upon
estimation methods significantly. Amongst the
important differences: we have utilized population
level surveys to help derive health severity weights;
have used highly advanced published methods
to establish mortality by age and sex; and have
radically improved the modeling techniques
used for estimating incidence, prevalence and
causes of death. We have created new estimates
for 1990 using these techniques and the widely
expanded data available to us so that we can assess
comparable time trends with the best possible
science. This presentation will highlight key
findings from the GBD 2010, with a focus on
vision loss in the context of the other diseases,
injuries and risk factors studied, to demonstrate
this impairment’s global impact over the past two
decades and implications for future vision research.
Murray is a scholar in global health and public
health at the University of Washington and is the
director of IHME. He previously served as director
of the Harvard Initiative for Global Health and
executive director of the Evidence and Information
for Policy Cluster at the World Health Organization.
At IHME, Murray’s work has included studying
adult and child mortality, costs of various health
interventions, and continuing work with colleagues
at Harvard, WHO and elsewhere on the global
burden of disease project.
Thursday Keynote
2:00 pm – 3:15 pm
6383 — 2:00 Global Burden of Disease Study
2010: Key Findings and Implications for Vision
Research. Christopher Murray. Institute for Health
Metrics and Evaluation, University of Washington,
Seattle, WA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
397
NOTES
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