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GROUP NAME: Team Members: Peripheral Nerve Recovery Your team is the world’s premier group of tissue engineers called in to duty to repair the injury of the President. While bowling in the White House, the president slips and falls, resulting in the 12lb bowling ball landing square on his forearm. The president has lost feeling and sensation in his right hand due to the bowling ball crushing his hand and damaging the median nerve. You task is to use tissue engineering to develop a construct that can be used to regrow the nerve and fix his hand. Choose from each of the categories to create your method. cells Tissue Engineering Scaffold Signals Name of your Technique:_________________________________________ Each option has pros and cons so choose accordingly. Describe what components in the scaffold were used and what signals (if any): ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ Why did you choose this specific Combination? ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ ___________________________________________________________________ PTEI ACTIVITY SIGNALS Description Pros Cons Laminin A protein found in most organs; induces migration and adhesion; enhances response to growth factors Substrate for Schwann cells Easy to obtain Inhibits neuron growth when used with netrin; at high concentrations, it can impede nerve growth and cause scar tissue Hard to isolate and obtain Gelatin Gelatinous substrate for Schwann cells Cheap Not as effective as other substrates, such as PCL SCAFFOLD Description Pros Cons Collagen Natural substrate Less effective than PCL PCL Gelatinous substrate for Schwann cells Thin strings of nylon can be used as substrate through 3d gels Nerve Extra Cellular Matrix (no cells) from pigs Cheap, very biocompatible Very effective Easy to obtain Non-biodegradable Contains natural signals and structures ( proteins) to promote nerve growth Mild immune response (possible) Pros Cons Easily diffuses, allowing directional growth of axons Essential in nerve regeneration Cannot be used with laminin Fibronectin Nylon Decellularized Nerve GROWTH Description FACTORS/STIMULANTS A protein that aids in Netrin axon growth Neural growth factor Brain-derived neutrophic factor (BDNF) A molecule that promotes growth of nerve cells A molecule that promotes growth of nerve cells Biocompatible Promotes Nerve Growth Expensive Hard to effectively incorporate into conduit Difficult to obtain PTEI ACTIVITY Fibroblast growth factors Promotes Schwann cell Promotes Nerve repair, May cause swelling growth (not necessarily Improves blood supply nerve growth) to nerve
