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COMPARATIVE ANALYSIS OF SERUM INSULIN LIKE GROWTH FACTOR-1 (IGF-1) AND LIVER FUNCTION TESTS (LFTs) IN
APPARENTLY HEALTHY SUBJECTS AND CIRRHOTIC PATIENTS
JAGDESH, INAYAT-UR-RAHMAN, RAJ KUMAR CHOHAN, KHEMOMAL. A. KARIRA
ABSTRACT
OBJECTIVE: To observe the levels of IGF-1 either its synthesis in liver cirrhosis is altered or not and weather its levels
reflect the severity of the disease. Also to observe that is IGF-1, a good marker of hepatic function and the etiology of
cirrhosis does influence on IGF-1 levels.
STUDY DESIGN: Case control study
PLACE AND DURATION: This study was carried out from 4 August 2008 to 5 December 2009 at the Department of
Biochemistry, Basic Medical Sciences Institute, with the collaboration of Medical unit I, II and III, Department of
Medicine, Jinnah Post Graduate Medical Centre (JPMC), Karachi.
METHODOLOGY: In this study a total of 90 subjects were included randomly with their consent. 60 subjects suffering
from liver cirrhosis (Hepatitis B and C) were taken from Medical units of JPMC, Karachi and 30 age matched normal
healthy control subjects were selected from general population for comparison. subjects who were suffering from
Gastrointestinal system bleeding, Hepatic encephalopathy, hepatocellular carcinoma or any other malignancy, Any
kind of infectious disease, Diabetes mellitus, Chronic renal failure, Hypertension were excluded from the study.
Groups were compared using student's t-test and p < 0.01 was considered as statically significant.
RESULTS: The result showed that mean values of serum IGF-1 in liver cirrhosis caused by hepatitis-B and C virus were
found very significantly lower (p< 0.01) than normal healthy individuals. The mean values of AST, ALT and Alkaline
phosphatase, bilirubin, albumin and prothrombin time showed significant difference (p< 0.01) among hepatitis-B and
C liver cirrhotics when compared with normal control subjects. Whereas no influence of etiology of liver cirrhosis was
observed on IGF-1 level.
CONCLUSION: In this study we found significant decrease in IGF-1 whereas no influence of etiology of liver cirrhosis
on IGF-1 levels were observed.
KEY WORDS: Insulin like growth factor-1(IGF-1), Body Mass Index (BMI), liver function test (LFT), Alanine
aminotransferase (ALT), Aspartate aminotransferase (AST).