Download Gynae Oncology Research New Zealand highlights

Peter Sykes ANZGOG 2013
Modest Contribution to
International Gyn oncology
Research
 International multicentre trials
 NZ multicentre trials
 Laboratory research
 Commercial research.
ANZGOG trials
Other International collaborative
trials
 LACE (Univ of Queensland) (chch)
 Chorus(MRC)
(chch)
 Novartis Phase 2 trial of dovitinib in metastatic
endometrial cancer. This group of patients have
progressed after one line of chemotherapy and
stratifies according to FGFR2 mutational status. PI
Peter Fong
 TRINOVA-2: Amgen sponsored Phase 3 trial of PLD vs
PLD plus AMG386 in relapsed platinum resistant
ovarian cancer. PI peter Fong
NZ Publications 2011,2012.
 Over 40 publications
 Otago Univ
from NZ researchers
 ADIS international
Drug evaluation
 Auckland univ.
Drug delivery(pro
drugs), tumour biology,
granulosa cell tumours.
 Aukland hospital.
Vulval cancer. Cervical
cancer.
(DN WEL CHCH)
tumour biology,
Palliative care,
epidemiology, inequality
 Victoria university,
Tumour biology
 Massey university,
epidemiology, inequality
 Waikato hospital
HDR physics
NZ HPV (GSK) study
 Women 18 years of age with
ICC stage 1B or higher diagnosed
between 2004 and 2010.
 paraffin embedded specimens
where consent from the patient
(or her next of kin if she was
deceased) could be obtained.
 Demographic details were
recorded.
 Cervical specimens underwent
histopathological review and
HPV DNA detection (DDL
Diagnostic Laboratory, the
Netherlands).
PREVALENCE AND TYPE DISTRIBUTION OF HUMAN
PAPILLOMAVIRUS (HPV) IN 242 NEW ZEALAND WOMEN
WITH INVASIVE CERVICAL CANCER
100
Percentage of all confirmed ICC cases
90
80
70
60
50
40
30
20
10
0
<30 years N=14 30-39 years N=53 40-49 years N=55 50-60 years N=40 >60 years N=65
 Among NZ women with confirmed
ICC, 88.5% were infected with HPV.
 HPV-16 and HPV-18 were the most
frequently detected HPV types
 Similar to international data, types 31,
45, 52 and 33 were frequently
detected non-16/18 types
 We observed a negative association
between stage II disease (and higher)
and infection with HPV-16/18 or with
HPV-18 compared to other HPV
types.
 Minor variation of non-HPV16/18
prevalence was observed between
Maori and non-Maori women .
Ongoing NZ Collaborations
 NZGCG
 Sentinel nodes in
 PRINCESS
endometrial cancer?
 Ongoing ANZGOG trials
Predicting regression in
CIN2, 9 centers
 Australia and NZ audit of
sentinel node biopsy in
vulval carcinoma.
NZ highlights
 Anzgog
participation
 Significant
research interest
in gynae cancer
 Cooperative
studies achieved
 Promising future