Download Drug Information Sheet("Kusuri-no-Shiori") Injection Revised: 08

Drug Information Sheet("Kusuri-no-Shiori")
Injection
Revised: 08/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval
details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is
important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,
patients should understand their medication and cooperate with the treatment.
Brand name:PARAPLATIN INJECTION 450mg
Active ingredient:Carboplatin
Dosage form:injection
Print on wrapping:
Effects of this medicine
This medicine inhibits growth of cancer cells at a cell division level and destroy the cells.
It is usually used to treat head and neck cancer, small cell lung cancer, testicular tumor, ovarian tumor, uterine
cervical cancer, malignant lymphoma, non-small cell lung cancer, breast cancer and pediatric malignant solid tumor
(neuroblastoma, retinoblastoma, hepatoblastoma, central nervous system germ cell tumor, recurrent/refractory
Ewing's sarcoma family of tumor, nephroblastoma).
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have impaired renal/hepatic function, low level of white blood cells or other blood components, fever or
chicken pox.
・If you are pregnant, possibly pregnant or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal
effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<<
to be written by a healthcare professional>>
・In general, repeat the cycle of administering once a day or 2 days with a drug cessation period of 3 to 4 weeks.
・It may be administered over a long period according to your response to the treatment.
・In order to prevent nausea, medicines for nausea may be used in advance.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nausea/vomiting, loss of appetite, hives, loss of hair, general
malaise, fever, diarrhea, stomatitis, stomachache, constipation, rash, urine with blood, protein urea, edema, chill,
dehydration, weight loss, respiratory distress, peripheral neuropathy and headache. If any of these symptoms occur,
consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated
in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor
immediately.
・fever, chill, cough, nasal discharge, dizziness, bleeding tendency, continuous bleeding, bruise, dullness, easy
fatigability, shortness of breath, sore throat [myelosuppression such as pancytopenic]
・lips/nails turning bluish-purple, breathing difficulty/chest tightness, suddenly feeling unwell, dizziness [shock,
anaphylaxy]
・fever, cough, breathing difficulty/chest tightness [interstitial pulmonary disease]
・inability to pass urine, urine with blood [acute renal failure]
・jaundice [hepatic failure, hepatic function disorder, jaundice]
・severe stomachache, hematoma [gastrointestinal necrosis, gastrointestinal perforation, gastrointestinal bleeding,
gastrointestinal ulceration]
・severe stomachache, diarrhea [hemorrhagic enteritis, pseudomembranous colitis]
・loss of appetite, nausea/vomiting, severe constipation, stomachache, abdominal distention, retention of bowel
contents [paralytic ileus]
・decreased consciousness, numbness of limbs, breathing difficulty [cerebral infraction, lung infraction]
・numbness of limbs, breathing difficulty [thrombosis/embolism]
・palpitation, shortness of breath, chest pain, breathing difficulty [myocardial infarction, congestive heart failure]
・bleeding tendency, continuous bleeding, failure of urinating, yellowness in the skin or whites of the eyes, dizziness,
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purple spots in the skin [hemolytic-uremic syndrome]
・sudden respiratory distress [acute respiratory distress syndrome]
・bleeding tendency, continuous bleeding [disseminated intravascular coagulation]
・severe upper abdominal pain [acute pancreatitis]
・hearing loss [hearing impairment]
・unstableness while walking, speech disorder, memory loss, slow movement [leukoencephalopathy (reversible
posterior leukoencephalopathy)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your
doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
For healthcare professional use only
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For further information, talk to your doctor or pharmacist.
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