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1. To 2. To body 3. To 4. To supply oxygen to every cell of the body supply nutrients to every cell of the remove wastes remove carbon dioxide Blood ◦ Carries nutrients and wastes Heart ◦ Pumps the blood Vein/arteries ◦ Carries the blood to and from the body tissues ◦ Laid end-to-end would stretch 70,000-93,000 miles Lungs ◦ Exchange carbon dioxide for oxygen in the blood stream 8% of body weight 5x thicker than water ~ 100.4° F Dark red (bluish) when depleted, bright red when oxygenated Components ◦ Plasma Red blood cells White blood cells Platelets ◦ Fat globules ◦ Chemical substances (carbs, proteins, hormones) ◦ Gases (O2, CO2, N) Red blood cells ◦ Carry oxygen and carbon dioxide ◦ Contains hemoglobin, which carries the oxygen White blood cells ◦ Fight infections ◦ Fight cancer Platelets ◦ Responsible for clotting Carry blood AWAY from the heart to the body tissues ◦ Typically this blood is enriched with oxygen and nutrients (*there is one exception) Largest artery – the aorta ◦ comes directly from the heart ◦ branches into smaller and smaller arteries as it goes away from the heart and into the limbs, head, and skin Smallest artery – the capillary, ◦ groups with other capillaries to form capillary beds ◦ site of exchange of nutrients and wastes between the blood and the body tissues Aorta branches into: Thoracic/abdominal aorta to: ◦ Common Iliac arteries (hips/pelvis) to: Femoral (upper leg) and tibial (lower leg) arteries Arch of aorta branches into: ◦ Carotid and vertebral arteries (neck/head) ◦ Subclavian arteries (upper chest/upper arms) to: Axillary (under arm) and brachial (upper arm) arteries to: Ulnar and radial (lower arm) arteries Structure – 3 layers ◦ Muscle tissue ◦ Elastic fibers ◦ Connective tissue Each heartbeat pushes blood into the arteries, which expand to hold the blood, then contract behind it as the heart pumps the blood to the next section The structure prevents the arteries from collapsing when they are broken ◦ The arteries do constrict to reduce the size of the opening in order to minimize blood loss Carry blood back TO the heart ◦ Typically this blood is depleted of oxygen and is carrying wastes The largest vein is called the vena cava ◦ Inferior vena cava – blood coming from the lower body ◦ Superior vena cava – blood coming from the upper body The smallest vein is called a venule Venules connect with the capillary beds, then combine again and again until they form the largest veins Lower Body: ◦ Greater and lesser saphenous to: Femoral and deep femoral veins to: Common iliac veins to: Inferior vena cava to the heart Upper Body/Head: ◦ Axillary, brachial, and cephalic veins to: Subclavian and jugular veins to: Superior vena cava to the heart Structure is similar to arteries Blood pressure in the veins is less than in the arteries ◦ The walls are thinner, less elastic, and less rigid and will collapse if not filled with blood The pressure in the veins is barely able to overcome gravity ◦ In order to avoid pooling of blood or backflow in the veins, they have valves that hold the blood in place until the pressure builds up sufficiently to move the blood towards the heart ◦ Veins rely on help from skeletal muscles to function ARTERY VEIN Inner lining of elastic tissue Valve Elastic layer Smooth muscle layer Connective tissue layer The primary organ of the circulatory system An involuntary muscle A bit larger than a man’s fist Located to the left of the sternum, between the 2nd and 5th ribs ◦ Sits between the lungs ◦ Sits within the cardiac impression, which is a space made by a notch in each lung The heart is enclosed within a membranous sac called the pericardium, which protects the heart and anchors it in place ◦ Fibrous outer layer ◦ Serous inner layer ◦ Between the 2 layers is a watery lubricant that minimizes friction when the heart beats Superior vena cava Pulmonary veins Right atrium Tricuspid valve Right ventricle Inferior vena cava Aorta Pulmonary artery Left atrium Semi-lunar valve Mitral valve Left ventricle Cardiac muscle Each half of the heart has 2 chambers: The atrium ◦ Upper chambers ◦ Blood enters from body or lungs The ventricle ◦ Lower chambers ◦ Blood leaves for lungs or body Superior vena cava Inferior vena cava Pulmonary artery * Pulmonary veins* Aorta ◦ Brings depleted blood from head and upper torso and extremities ◦ Brings depleted blood from lower torso and limbs ◦ Carries depleted blood to the lungs ◦ Carries newly oxygenated blood from lungs to heart ◦ Carries oxygenated blood to the body Purpose of valves – to allow the blood to flow in only one direction Tricuspid valve - 3 flaps ◦ Allows blood to flow from right atrium into right ventricle Pulmonary valve ◦ Allows blood to flow from right ventricle into pulmonary artery Mitral valve – 2 flaps ◦ Allows blood to flow from left atrium into left ventricle Aortic (semi-lunar) valve ◦ Allows blood to flow from left ventricle into aorta Body → Inferior & superior vena cava → Right atrium → Tricuspid valve → Right ventricle → Pulmonary valve → Pulmonary artery →Lungs → Pulmonary veins → Left atrium →Mitral valve → Left ventricle → Aortic semi-lunar valve →Aorta →Body Body → Inferior & superior vena cava → Right atrium → Right Ventricle → Pulmonary artery → Lungs → Pulmonary veins → Left atrium → Left ventricle → Aorta → Body The movement of blood from the heart to the air sacs in the lungs and back to the heart Necessary for the blood to exchange carbon dioxide for oxygen 1. Air is taken into body through mouth and nose 2. Passes through larynx and down trachea 3. Passes into bronchi (air tubes) 4. Continues into bronchioles (smaller air tubes) 5. Disperses into alveoli (small, thin air sacs) where it waits to exchange oxygen for carbon dioxide Right ventricle pumps depleted blood into pulmonary artery * Pulmonary artery splits into right and left branches and pass into the lungs ◦ Right artery is wider and longer than the left artery and the right lung is larger (3 lobes) than the left lung (2 lobes) The pulmonary artery divides at the lungs into smaller and smaller capillaries until they end in large capillary beds surrounding the alveoli A very thin membrane separates the capillaries from the air sacs ◦ As a blood cell moves down the capillary, CO2 diffuses through the membrane into the alveoli and O2 passes from the alveoli to the blood cell The newly oxygenated blood passes out of the capillary beds and is taken up by the venules, which take the blood up to the right and left pulmonary veins* The veins unite to form 2 main trunks from each lung and empty the oxygenated blood into the left atrium of the heart Purpose of circulatory system Components of circulatory system Facts about the blood Function of arteries ◦ Largest artery and it’s location ◦ Smallest artery and it’s location Function of veins Differences between arteries and veins ◦ Differences in structure ◦ Differences in pressure Components of the heart How to label the heart Path of blood flow from the body, through the heart and lungs, and back into body Path of blood flow through lungs How CO2/O2 exchange occurs