Download BIOGRAPHICAL SKETCH Provide the following information for the

BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Susannah Graves, MD
eRA COMMONS USER NAME (credential, e.g., agency login): SKGRAVES
POSITION TITLE: Research Fellow, Infectious Diseases, Dept of Medicine, University of
California, San Diego
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as
nursing, include postdoctoral training and residency training if applicable. Add/delete rows as
necessary.)
INSTITUTION AND LOCATION
Harvard University
DEGREE
(if applicable)
Completion
Date
MM/YYYY
B.A. with
Honors
06/2003
Biology; Citation in
Spanish Language
06/2010
Medicine
07/2014
Internal Medicine
Anticipated
7/2017
Infectious Diseases
Anticipated
6/2017
Epidemiology
UCSF School of Medicine, San
M.D.
Francisco, CA
UCSD Internal Medicine, San Diego,
Internal Med
CA
Residency
UCSD Division of Infectious Diseases,
Infectious
Department of Internal Medicine, San
Disease
Diego, CA
Fellowship
San Diego State University, San Diego,
MPH
CA
FIELD OF STUDY
A. Personal Statement
In the academic year July 2012 – June 2013 I was based in Maputo, Mozambique as the Site
Director for the UCSD Department of Internal Medicine’s medical education partnership initiative (MEPI)
collaboration with the Faculty of Medicine at University of Eduardo Mondlane (UEM). During my tenure as
site-director I coordinated the academic and clinical activities of visiting UCSD residents and collaborated
with local firm chiefs and faculty at UEM to develop a clinical and academic curriculum for residents.
Additionally, I worked with colleagues to develop and execute a number of research studies (see
“Research Support” below).
Working with Mozambican residents, firm chiefs, and faculty on the wards and in the lab, I have
been able to see first-hand what my resourceful colleagues are able to do within the constraints of their
resources and identify opportunities for them to further their research and educational goals. The year I
was there, a distance-learning program in epidemiology and clinical research was initiated through the
MEPI partnership, which I helped to facilitate locally, reviewing protocol ideas and advising participants
on research question and protocol development, funding options and feasibility. Participants, who are
medical school faculty and residents, developed research protocols some of which are in various stages of
application for funding and IRB approval or protocol execution at this time.
Through my work in the hospital and at the University, I have built relationships with major
stakeholders in the education of the next generation of biomedical faculty including junior and senior
faculty in the Medicine and Pathology departments, the chief of Internal Medicine at Maputo Central
Hospital – Helder Lopes, as well as members of the newly-formed institutional bioethics committee and
medical school librarians, as well as many young physicians at the post-graduate (residency) level of
training and firm chiefs who are poised to launch into careers in academic medicine and teaching.
A major focus of mine at Maputo Central Hospital was the institution of tuberculosis (TB)control measures. Working within the newly commissioned TB control committee piloted by Dr. Elizabete
Nunes, we developed a TB control plan and began implementing an educational campaign, environmental
controls, and routine TB screening for health workers at Maputo Central Hospital. This program is poised
to expand into a more comprehensive infection control program at the Central Hospital and has the
support of the hospital director, Dr. João Fumane, who has dedicated resources for the implementation of
these projects with supplemental funding from locally active NGOs such as Jhpiego and ICAP.
Joining in this inter-institutional collaboration as a peer mentor for Mozambican PhD candidates
would provide me with an avenue to push forward my work on TB and infection control in Mozambique;
and with my mentoring experience and local alliances along with institutional support from UCSD and the
Maputo Central Hospital, I believe I could be an asset to this training collaboration.
B. Positions and Honors
Positions and Employment
2015
Reviewer, grant applications – Center for Aids Research (CFAR), UCSD
2014 – now
Clinical and Research Fellow – Division of Infectious Disease, UCSD Dept of Medicine
2012-2013
Assistant Clinical Professor – Maputo Clinical Site Director, UCSD Dept of Medicine
2010-2014
Medical Resident, Department of Internal Medicine, University of California, San Diego
2009
Research Assistant, TB Control Branch - California Department of Public Health
2008-2009
Research Assistant, Greiner Lab, Humanized Mouse Models of Disease, University of
Massachusetts Medical School, Worcester, MA.
2008-2009
Research Assistant, SFGH Emergency Department, University of California, San Francisco
2006
Student Researcher, Bluestone Lab, Diabetes Center, UCSF
2004, 2005
Teaching Fellow, Molecular Immunology Seminar, Harvard
2003-2005
Lab Technician, Dranoff Lab, Cancer Immunity Dana-Farber Cancer Institute, Harvard
2002
Laboratory Intern, Biewener Lab, Locomotion Physiology, Harvard
2001
Laboratory Intern, Androgen-based Therapies at AndroScience Corporation, San Diego, CA
Professional Memberships
2015 - now
American Thoracic Society, member
2014 – now
Infectious Disease Society of America (IDSA), member
Honors
2005
Certificate for Distinction in Teaching, Derek Bok Teaching Center, Harvard
C. Contribution to Science
1. In Mozambican hospitals, high rates of HIV infection and active pulmonary tuberculosis drives TB
transmission resulting in significant morbidity and even mortality of health workers. Together with Dr.
Elizabete Nunes and colleagues I designed and conducted a study employing active case finding along with
latent TB infection (LTBI) and HIV screening to identify health workers (HW) at high risk for active TB.
Nearly 700 HW were enrolled and screened with symptom questionnaires, X-ray, skin and Quantiferon
testing and HIV antibody testing, and we found 4 active cases of TB during our initial screen. Additionally
we found that 62% of health workers had LTBI, and 2/3 of these were identified as “high risk” given
concurrent HIV infection or Quantiferon >1.0 in addition to a positive skin test. All of these were offered
isoniazid preventive therapy and an analysis of the follow-up results is underway. A multivariate analysis
showed that duration of service at MCH for >10 years had a significant positive association with TB
infection (OR 1.67, 95%CI 1.21 – 2.30), as did service in the departments of Surgery (OR 4.25, 95%CI 2.337.75), Emergency and Critical Care (OR 3.36, 95%CI 1.41-7.97), Pathology (OR 2.76, 95%CI 1.42-5.38), and
Obstetrics (OR 1.98, 95%CI 1.15-3.41) when compared with the Internal Medicine department suggesting
occupational risk and targets for high-priority for intervention. The results of this research were used to
gain support from hospital leadership to fund the introduction of environmental controls (UV lights to
clean air) and administrative support for ongoing TB monitoring of health workers. They were also
presented at several national and international conferences (below) and a manuscript is in preparation.
My role in this work, is outlined in “(Nunes) 1/5/11 - 1/5/13” in the Research Support section below.
1. Graves SK, David C, Viegas S, Torriani F, Hassane A, Amade S, Paleve S, Nunes E. Tuberculosis and HIV
infection in health workers in the Maputo Central Hospital, the national reference hospital of
Mozambique. Oral presentation, 44th Union World Conference on Lung Health in Barcelona, Spain, Oct
30, 2014.
2. Graves SK, Lee K, Viegas S, Lederer P, Hassane A, David C, Cossa A, Nunes E. Tuberculosis screening
campaign and control measures to decrease transmission of occupational TB in health workers at the
flagship public hospital of Mozambique. Oral presentation, 44th Union World Conference on Lung
Health in Paris, France, Nov 3, 2013.
3. Nunes E, Graves S, Lee K, Cossa A, Hassane A, Lederer P, Pondo J, Viegas S, Torriani F. Tuberculosis
Screening in Healthcare Workers at Maputo Central Hospital. IDSA ID Week Conference, San Diego, CA
October, 2012.
2. While in Maputo, as the site director for the UCSD-UEM MEPI collaboration, I developed a computerresource based introductory evidence-based-medicine (EBM) curriculum for Mozambican Internal
Medicine residents and medical students at Maputo Central Hospital / UEM. Working together with local
medical residents and visiting US residents, we conducted a local educational needs-assessment for
residents and medical students. With this information, we developed a problem based training module on
how to use online resources newly available at their institution to answer clinical questions about
patients. This training dovetailed with existing educational courses available locally on how to access
research articles using HINARI, a program set up by WHO together with major publishers to provide
access to biomedical literature. Additionally, we developed a library portal:
http://medicinahcm.org/biblioteca.html from which relevant online resources could be accessed.
Additionally, we negotiated to obtain VPN account access to our institution’s online library resources
(linked on the website).
A list of my peer-reviewed published articles can be found here:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1HMimEGnJC5kG/bibliograpahy/43851241/public/?sort=da
te&direction=ascending
D. Research Support
Ongoing Research Support
5 P30 AI036214 (Patel) 2014-2016
Role: Co-Investigator (No Salary)
Mortality in HIV patients with severe sepsis in Maputo Central Hospital.
Major Goal: To assess current management of septic patients at Maputo Central Hospital, and identify
areas for improvement in early recognition and treatment of sepsis.
Maputo Central Hospital, Mozambique
Responsibilities: Designed protocol in collaboration with PI, obtained funding and IRB approval, helped
design electronic mobile data collection tool. Data collection is ongoing. Plan to assist with data analysis
and manuscript writing.
Completed Research Support
1R24TW008908 (Schooley) 9/30/2010-9/29/2015
Role: Site Director, Maputo Mozambique
Universidade Eduardo Mondlane-UCSD Medical Education Partnership
Major Goal: To develop the infrastructure for medical education and medical research at the Universidade
Eduardo Mondlane in Maputo, Mozambique
Responsibilities: described above in Personal Statement.
5 P30 AI36214 (Liu, YT)
1/5/11 - 1/5/13
Role: Co-Investigator (No Salary)
Etiologic role of HPV in conjunctival squamous cell carcinoma in Mozambique
Major Goal: To determine the etiologic role in squamous cell carcinoma of the eye using cases and controls
from the Opthalmology clinic at Hospital Central Maputo in Maputo, Mozambique.
Responsibilities: Assisted with development of SOP, database development and data management, This
study had difficulties with enrolling sufficient numbers of control patients, which delayed completion, and
an amendment was made to the protocol to allow inclusion of controls undergoing cataract surgery. Data
collection and analysis is ongoing.
5 P30 AI 36214 (Nunes)
1/5/11 - 1/5/13
Role: Co-Investigator (No Salary)
Tuberculosis screening in healthcare workers at Maputo Central Hospital
Major Goal: To assess the prevalence and incidence of active and latent tuberculosis in Health Workers at
Maputo Central Hospital in Mozambique.
Responsibilities: Collaborated on protocol design, grant application writing and submission, SOP
development, as well as with data collection, analysis. To date, I have written two abstracts that have been
presented orally at an international conference and one poster presentation at a US research conference
(see presentations above), and manuscript is in progress.