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Neuro-Fatigue Fatigue is usually defined as a sense of weakness, described by patients as exhaustion, tiredness, and lack of energy. Neuro-fatigue is somewhat different in that it involves mental fatigue caused by the alterations of chemicals in different parts of the brain, or chemical imbalances within the brain caused by the injury. Individuals with a brain injury describe neuro-fatigue as complete and utter exhaustion, an absolute shut down of thinking and feeling, an inability to move or produce any action and mental confusion. Neuro-fatigue can be worsened when combined with: Lack of regular sleep Psychiatric problems including depression and anxiety-related disorders Metabolic or endocrine problems like diabetes mellitus and hypothyroidism Chronic pain issues Drugs such as sedatives Nutritional or blood concerns such as low vitamin B12 and leukemia Effects of chronic stress, which may also be greatly increased from, brain injury It is recommended that testing such as blood counts, urinalysis, glucose tolerance tests and chest X-rays be conducted to rule out other health problems before assuming that the fatigue is strictly a result of the brain injury. Treatment of these conditions may reduce the fatigue intensity. If the results of diagnostic tests eliminate the possibility of other health issues, the tiredness an individual with a traumatic brain injury is experiencing is probably due to neurofatigue. Neuro-fatigue is a common and often a complex problem with multiple causes, which can have a significant impact on the individual with a brain injury. It is generally worse in the immediate months following injury and may lessen with time. One should seek medical assistance to address this potentially debilitating condition. Useful strategies to reduce neuro-fatigue include: Regular aerobic exercises such as walking swimming, bike riding and exercise classes Regular sleep, going to bed and getting up at the same time every day Rest as needed, scheduled throughout the day, especially following activities Good nutrition and balanced diet Avoidance of alcohol and recreational drugs Compensatory strategies that conserve energy Pacing oneself Taking medications as prescribed, on time in the correct amounts, every day