Download Application number/Title: 24091 - Objectively assessed physical

Application number/Title: 24091 - Objectively assessed physical
activity, physical fitness and risk of cancer
Applicant PI: Dr Sebastian Baumeister
Applicant institution: University of Regensburg, Department of Epidemiology
and Preventive Medicine, Franz-Josef-Strauss-Allee 11, Regensburg D-93053.
Germany.
Funding body: University of Regensburg
Keywords provided by the Applicant PI to describe the research project:
Cancer, physical activity, fitness
Application Lay Summary:
1a: Physical activity reduces risk of cardiovascular disease and all-cause
mortality, as well as risk of breast, colon, and endometrial cancers. The
evidence is weaker for other cancers. Some of the knowledge gaps have
resulted from imprecise assessment of self-reported physical activity. The
value of objectively assessed physical activity and fitness for the prediction of
cancer risk has received little attention. We propose to examine associations
of the UK Biobank’s physical activity questionnaire and objective
measurements of physical activity (accelerometer) and fitness
(cardiorespiratory fitness, muscle strength) with cancer risk.
1b: In line with the UK Biobank’s overall goal to “provide lifestyle,
environmental and health follow-up data” to “improve the prevention,
diagnosis and treatment of illness and the promotion of health throughout
society”, the project will to deepen the causal understanding of physical
activity and fitness as a primary cause of cancer.
1c: In this prospective analysis, baseline and repeat assessments of selfreported physical activity, movement sensor data, cardiorespiratory fitness,
and muscle strength will be associated with overall cancer risk (and major
cancer types). The predictive capacity of these exposures will be compared.
Cardiorespiratory fitness and muscle strength will be regarded as
intermediate variables linking physical activity and cancer.
1d: Analyses will be based on participants who provided valid data on cancer
incidence or mortality and baseline or follow-up data on at least one of the
following: self-reported physical activity (n= 498,135), accelerometry
(n=103,720), grip strength (n= 495,786), and cardiorespiratory fitness (n=
67,702).