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From: Histone Deacetylase Inhibition–Mediated Differentiation of RGC-5 Cells and Interaction with Survival Invest. Ophthalmol. Vis. Sci.. 2007;48(6):2845-2857. doi:10.1167/iovs.06-1364 Figure Legend: HDAC inhibition upregulates Brn-3a and Brn-3b expression. RGC-5 cells were treated with 500 nM TSA, 316 nM SS, or medium alone (Ctrl) in the presence of RGC survival factors. Cell lysates were immunoblotted for Brn-3a and Brn-3b 48 hours after treatment. Band density was normalized to actin. TSA treatment resulted in Brn-3a and Brn-3b levels 1.4- and 2.0-fold those of control cells, respectively, whereas staurosporine treatment resulted in the downregulation of Brn-3b to 0.6-fold that of control cells. Date of download: 8/11/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.
