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Combating Livestock Disease through International Partnerships Moredun Research Institute 20th February 2014 GALVmed purpose, mission & vision Purpose of GALVmed Protecting Livestock – Improving Human Lives Mission of GALVmed To make a real difference to the livelihoods of resource-poor livestock keepers by facilitating provision of animal health tools, within a sustainable economic framework Vision of GALVmed Better livestock health contributing to a transformational improvement in the livelihoods of poor livestock keepers Building bridges…. Slide 2 …but some are a work in progress Slide 3 GALVmed modus operandi Animal Health Industry Governments GALVmed Research Institutions Universities Livestock Keepers Donors Potential Solutions Solutions Pro Poor Impact through sustainable Animal Health Identified Need Innovation Centre for Ticks & Tick-borne Diseases • Lilongwe, Malawi • Centre of Excellence for Africa in Ticks & Tick-borne diseases • Vaccine production (predominantly East Coast Fever vaccine) • Consultancy • Knowledge transfer • African Union owned • Highly qualified & motivated staff • Adequate infrastructure • Chronically under-funded A Malawi-based organisation meeting Africa’s needs East Coast fever (ECF) • Single biggest killer of cattle in Africa • >25 million cattle at risk, kills more than 1 million cattle yearly • Carried by ticks • Up to 40-50% mortality in cattle • Survivors are robustly protected The impact of ECF • 11 countries of eastern, central and southern Africa Sudan Ethiopia Somalia Uganda Kenya DRC • Cost per year: c.US$260 million Tanzania Zambia Malawi Angola Zimbabwe Mozambique Namibia Botswana South-Africa How good is the ECF-ITM vaccine? • Developed by scientists at ILRAD several years ago • Highly effective: life time immunity after one injection • Based on old, rather crude technology • Infection & treatment • Expensive to administer (vaccine + concurrent treatment: $6-10) • Difficult to manage cold chain (liquid nitrogen) • Great basis for building a private sector veterinary service • Veterinarian required for administration • Technical expertise is required • Farmers recognise the value of the vaccine Infection & Treatment Method How has GALVmed helped to empower CTTBD? Still plenty more to do…. Vaccine Cost of Goods Breakdown (Materials) Rabbits + feed Pick up Monitoring Infectivity Cattle Diluent Cost of Goods = Materials (variable) 47% + Labour (fixed) 4% + Overheads (fixed) 46% + Depreciation (fixed) 3% Slide 11 Partnerships to improve Vaccine • • Diluent simplification GALVmed/ CTTBD/ Institute for Tropical Medicine, Antwerp Release of vaccine without involving cattle • Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • • Release of vaccine without involving cattle GALVmed/ CTTBD/ Institute for Tropical Medicine, Antwerp Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • • Produce more batches (open up new markets) CTTBD confirming vaccine suitability for new markets Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • Produce more batches (open up new markets) • • Thermostability – removal of liquid nitrogen Collaboration with 2 biotechs Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • • Smaller pack sizes in line with needs of small-scale farmer CTTBD testing smaller pack sizes Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • • Validate need for strains CTTBD/ Inst for Tropical Medicine confirming needs Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle Not yet addressed – no funding Reduce length of production cycle from 18 months • Partnerships to improve Vaccine • Diluent simplification • Release of vaccine without involving cattle • Produce more batches (open up new markets) • Thermostability – removal of liquid nitrogen • Smaller pack sizes in line with needs of small-scale farmer • Validate need for strains • Reliable source of “clean” cattle • Reduce length of production cycle from 18 months Sheep & Goat Diseases • Peste des petits ruminants • Contagious caprine pleuropneumonia • Sheep & goat pox Cattle Diseases • Lumpy Skin Disease • Trypanosomosis • Rift Valley fever • Brucellosis • Contagious Bovine Pleuropneumonia Pig & Poultry Diseases • Newcastle Disease • Porcine cysticercosis • African swine fever • Classical swine fever Partnerships & Working with & through the Scottish Life Sciences Community • BBI Solutions • GENECOM • University of Dundee • University of Edinburgh Protecting livestock – improving human lives Photo: Hameed Nuru
