Download Rilexine Palatable Tablets

Broad spectrum antibiotic
in a palatable tablet for
the treatment of infections
caused by organisms
sensitive to cephalexin.
Indicated for the treatment
of pyoderma, urinary
tract infections and
osteomyelitis.
WHAT IS RILEXINE ONCE A DAY PASTE?
4
4
4
4
4
Broad spectrum antibiotic with rapid
bactericidal action
Excellent tissue diffusion and persistence
Simple Once a Day dosing
Palatable formulation
Safe for dogs and cats
WHY CHOOSE RILEXINE PALATABLE
TABLETS?
1. Bactericidal and broad spectrum activity
Rilexine is a broad spectrum cephalosporin antibiotic with bactericidal
activity against a wide range of Gram-positive and Gram-negative
bacteria. It is effective against Staphylococcus spp (particularly ß-lactamase
producing strains)1, Streptococcus spp, Escherichia coli, Salmonella spp,
Proteus spp, Klebsiella spp.
2. Excellent tissue diffusion and persistence
Rilexine binds very poorly to plasma proteins (< 15%) allowing it to
diffuse rapidly into the tissues2, where it concentrates at the site of
infection. In the dog the tissue half-life of Rilexine is four times greater
than its serum half-life2. Persistence in tissues is one reason that
cephalexin is a good antibiotic choice for infections in skin and bone.
3. Simple Once a Day dosing and palatability are more convenient
Numerous studies have shown Rilexine to be very effective in the
treatment of canine superficial3-6 and deep pyoderma7-9 when used
once a day (30mg/kg SID). Rilexine is the only cephalexin antibiotic
registered for Once a Day dosing for the treatment of canine pyoderma.
Once a Day dosing and palatable paste make it easier for the vet,
pet owner and the pet and can increase compliance and enhance
treatment success.
Time of Clinical Cure
25
20
15
BID dose
SID dose
10
5
0
Day 14
Day 28
Day 42
Once daily Rilexine is proven to be as effective as twice daily in the
treatment of canine superficial pyoderma. There was no difference
between the groups4.
Rilexine
Palatable Tablets
Once a Day Cephalexin Antibiotic Tablet
for Dogs and Cats
4. Safe
Rilexine has excellent tolerance and absence of chronic toxicity in dogs
and cats. Tolerance and safety have been well studied in dogs and cats;
up to five-fold the daily recommended dose10. Such dosages are safe
and well tolerated. This makes it ideal for long term use particularly in
cases of pyoderma where treatment durations of 4-8 weeks are not
uncommon.
WHEN TO USE RILEXINE PALATABLE
TABLETS?
1. Skin and soft tissue infections
Rilexine reaches high concentrations and persists in the skin making it an
ideal choice to treat skin and soft tissue infections. It is effective against
the common skin pathogens including Staph. intermedius (including
ß-lactamase producing strains)1. It also provides activity against secondary
infecting bacteria such as Proteus or E. coli.
2. Urinary Tract Infections
The excretion of high concentrations of active cephalexin in urine
provides high and sustained levels of the antibiotic for the treatment of
urinary tract infections (UTI). Rilexine is not metabolized and more than
90% of the administered dose of Rilexine is excreted unchanged in the
urine by glomerular filtration and active tubular secretion. This urinary
concentration allows very high levels of cephalexin in the urine (50 to
100 times higher than plasma levels). It is effective treatment against
the major bacteria encountered in UTI such E. coli, P. Morabilis, and
Klebsiella spp9.
1500
1200
Cephalexin
concentration 900
in urine
600
(µg/mL)
20
300
5
0
15
10
4-8
8-12
12-24
24-36
Collection period (hours after
administration)
20
0
0
4-8
8-12
12-24 24-36
= MIC90 of Escherichia coli isolated
from urinary tract infections 5,17,33
Rilexine
Palatable Tablets
QUICK REFERENCE GUIDE
Once a Day Cephalexin Antibiotic Tablets
for Dogs and Cats
3. Osteomyelitis and trauma cases
Rilexine is a good choice for trauma cases because of its broad spectrum
of activity and excellent diffusion into bone and joints. Rilexine is indicated
in the treatment and prevention of osteomyelitis at an increased dose
rate of 30mg/kg bid.
4. Respiratory infections
Rilexine’s broad-spectrum of activity covers the main bacterial
pathogens responsible for causing respiratory infections such as
Streptococci, Staphylococci, Klebsiella and E.coli. Its poor plasma
protein-binding results in high cephalexin concentrations in
lung tissue.
HOW TO USE USE RILEXINE PALATABLE
TABLETS
Dogs and Cats: 30 mg/kg bodyweight once a day (or 15 mg/kg
twice daily).
In refractory cases, dose may be increased to 30 mg/kg twice daily.
Duration of treatment is at least three days but may be extended
at the discretion of the veterinarian. Long-term treatment may be
necessary for skin and urinary tract infections.
PROPERTIES
• Broad-spectrum and bactericidal
• Activity against a wide range of Gram-positive and
•
•
•
Gram-negative bacteria
Simple Once a Day dosing
Safe for dogs and cats
Palatable
INDICATIONS
For the treatment of infections caused by organisms sensitive to
cephalexin, including pyoderma, abscess urinary tract infections,
trauma, osteomyelitis, surgical prophylaxis and respitory infections in
cats and dogs.
COMPOSITION
Each tablet contains:
Cephalexin (as monohydrate)
PRESENTATION
Tablets: Liver flavoured palatable tablets:
CONTRA-INDICATIONS
• 75 mg: 256’s
• 300 mg: 259’s
• 600 mg: 105’s, 301’s.
Hypersensitivity to cephalexin is rare. However, Rilexine should not
be administered to animals which are known to be hypersensitive
to cephalexin.
STORAGE
Penicillin and cephalosporin may cause sensitisation (allergy)
following injection, inhalation, ingestion or skin contact. Sensitivity to
penicillin may lead to cross sensitivity to cephalosporin and
vice versa.
Do not handle this product if you know you are sensitized.
SIDE EFFECTS
Side effects are unusual and transitory; nausea and vomiting
may occur in dogs. Give with food to minimize risk of nausea
and vomiting.
References
1. Giguere et al. Antimicrobial Therapy in Veterinary Medicine, 4th Ed. 2006.
2. Cadorniga R. & Al. – Penetration of Antibiotic into Interstitial Tissue Fluid. Following Parenteral Administration
of Lysine Cephalexin – Drug Res., 1979, 29 (2), 1547 – 1549.
3. Salomon C., Guaguère E. and Maynard L. Comparison of two dose rates of cephalexin in the treatment
of superficial pyoderma in dogs. 15th ESVD Congress, Maastricht, Sept. 1998.
4. Toma S., Colombo S., Cornegliani L., Perisico P., Galzerano M., Gianino M., Noli C. Efficacy and tolerability
of once-daily cephalexin in canine superficial pyoderma: an open controlled study. JSAP, 2008 49(8) 384-391.
5. Lucas R., Sanches C., Flocke M., Pelgrini G., and Reme C. Efficacy of three Cefalexin regimens for the treatment
of superficial folliculitis in dogs. 6th World Congress of Veterinary Dermatology, Hong Kong Nov. 2008.
6. Cadot P., Salomon C. and Coll. Treatment of superficial pyoderma in dogs: cephalexin in a single dose
versus marbofloxacin. 26th World Veterinary Congress WVA, Lyon, Sept. 1999.
7. Maynard L., Bousquet E., and Medaille C., Clinical efficacy of Cephalexin administered by oral route at two dosages
in the treatment of deep pyoderma in dogs. ESVD Congress, Nice, Sept 2002.
8. Guaguère E., Maynard L., Salomon C., and Coll. Cephalexin in the treatment of canine pyoderma: comparison
of two dose rates. 3rd World Congress of Veterinary Dermatology, Edinburgh Sept. 1996
9. Guaguère E., Salomon C., Cadot P. and Jasmin P. Comparison of two protocols of administration of cephalexin
in the treatment of deep pyoderma in dogs.
4th World Congress of Veterinary Dermatology, San Francisco, Aug. 2000. Published in Veterinary
Dermatology 2000, 11, 14-40.
10. Registration file.
Customer Support
Tel: 1800 009 847
www.virbac.com.au
Store below 30°C (room temperature).
LEGAL CATEGORY
Schedule 4
APVMA NUMBER
• 54343 (75 mg)
• 54342 (300 mg)
• 54341 (600 mg)
75mg; 300mg; 600mg