Download Helmut Leeb

PROPOSED PHYSICS PROGRAMME AT
THE PLANNED MedAustron FACILITY
H. Leeb and G. Badurek
Atomic Institute of the Austrian Universities
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
1
The Project MedAustron
Cancer is the 2nd important cause for death in Europe
In Austria 36.000 new cases per year
18% of the primary tumors cannot be destroyed at the place of its origin
although no metastases have been formed
There is justified hope that
most of these can be
successfully destroyed
by ion therapy
surgery
metastases
MedAustron is an Austrian
initiative for a facility for
hadron therapy
H. Leeb
Sept 7/8, 2007
radiation therapy
primary tumor
55% not healed
surgery and
radiation therapy
chemotherapy
45% healed
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
2
Characteristics of the Facility
The design project foresees irradiations with a proton and a
carbon-ion beam. The accelerator is not fixed yet, but the design
parameters are:
proton beam
carbon-ion beam
120-400(800) MeV
120-400 MeV
1x1010s-1
4x108s-1
The beam spot is about 1-4 mm2 and
allows to scan the tumor in size and
depths. The latter is controlled via
varying the energy of the beam.
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
3
Non-clinical Programme
Besides the use for cancer therapy, the accelerator facility will also
serve for non-clinical research. The following research topics are
envisaged at MedAustron
1. radiation biology
2. pre-clinical research
3. physics research
•Particle & High energy physics (Test of Detectors)
•Nuclear physics
•Atomic physics
•Materials science
•Dosimetry (cosmic & terrestrial)
•others …
These non-clinical research activities will only take place during night time
and holidays
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
4
Current layout of the MedAustron Facility
120 – 800 MeV
A
B?
10 m
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
5
Nuclear Physics Experiments
Assessment of feasibility with MedAustron beam parameters
N = f Ip  σL0d
M
p
incident flux
N reactions/s
f pulse frequency ( 1 Hz)
Ip particles/pulse
 specific mass density
M mol mass
σ cross section
L0 Loschmidt number
d target thickness
H. Leeb
Sept 7/8, 2007
g cm-3
N = 6.0×105  σd
A
barn
Protons
m
N = 2.4×104  σd
A
12C-ions
atomic mass number
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
6
European Accelerators for Nuclear Physics
The incident particle flux of most
European accelerators dedicated
for nuclear physics is 2-3 oders
of magnitude higher than the
expected flux at MedAutron !
Currently a further increase of
flux of stable isotope ions by 2
orders of magnitude is under
discussion !
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
7
Expected integral reaction rate
d = 1 m
1% statistical accuracy
A= 100  =10 g cm-3
p = 1010 s-1 (1H+) & 4×108 s-1 (12C6+)
H. Leeb
Sept 7/8, 2007
4250 s
(71 min)
170 s
Protons
12C-ions
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
8
Typical setup for the measurment of
angle-differential cross-sections
width of
detector entrance window
w2
Count rate: C = N
16 D2
target-detector
distance
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
9
Assumption
w = 10 mm
D = 150 mm
Ip = 1010 s-1
σ= 10-1 barn
d = 0.1 m
A = 100
 = 10 g cm-3
Differential cross-section
measurements
C = 21 s-1
Measurement time for
1% accuracy
200 min
8 min
Protons
H. Leeb
Sept 7/8, 2007
12C-ions
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
10
Nuclear physics standard experiments
are in principle feasible at MedAustron !
Systematic study of nuclear radii by elastic proton scattering
...
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
11
Atomic Collision Processes
with MedAustron Particle Beams
A possible approach to attosecond-physics ?
400 MeV/u
12C6+:
=1,4 → ~0,70 → v ~ 2,1×108 m/s
Atomic collision range  1 nm = 10-9 m
Collision time  5×10-18 s
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
12
U75+ → Ar
Arq+- recoil ions
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
Recoil-Rate
15,5 MeV/u
(3x1011 p/s)
Recoil-Energy/eV
GSI-UNILAC
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Electron yields at
collisions
of highly charged ions
(HCI) with surfaces
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
14
Materials Research with MedAustron
E.g. irradiation of various materials (e.g. polymeres)
with MeV Carbon ions to produce nano-capillaries
random
single ion
ordered
microprobe
Possible applications:
• Single nanopore membranes (biosensors)
• Templates to produce free standing
metal needles or carbon nanotubes etc.
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
15
Heavy Ion Microprobe
aperture
slits
ions
beam
switch
object
slits
50µm
beam
deflection
magnetic
lens
target
detector
electronics
+
computer
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
16
Cosmic Radiation Environment
Simulating major aspects of galactic
and solar radiation climate
→ 4He, 12C, 16O, 56Fe ion beams of a few
hundred MeV/u
Characterization of detector
response to heavy charged particles
→ Dose verification and radiation
transport models for interplanetary
space exploration
Improved dosimetric methodology for
terrestrial applications
→ Aircrew dosimetry, medical dosimetry,
H. Leeb
Sept 7/8, 2007
Ionization density dependence of high-temperature
ratio and relative thermoluminescent efficiency
[Adapted from M. Hajek et al., Radiat. Prot. Dosim. 120, 446 (2006)]
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
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Solid-State Nanodosimetry
Modelling of luminescence mechanisms
→ Charge state configuration after
absorption of high-LET ionizing radiation
Ionization density dependence of
radiobiological endpoints (DNA strand
breaks, apoptosis, …)
→ Pathways of bystander signal
transduction between neighbouring cells
Correlation of heavy ion-induced
physical and radiobiological parameters
→ Quasi-biological nanodosimetry
Competitor
C
C
h
C
e
C
e
R
Hole trap
h
Electron trap
R
C
Recombination centre
C
C
Charge state configuration in TL phosphor
after absorption of ionizing radiation
[Adapted from Y. S. Horowitz et al., Radiat. Prot. Dosim. 119, 45 (2006)]
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
18
Conclusions
•MedAustron can become a homebase for preparation of
experiments at international research facilities
•MedAustron can provide a useful training ground for
young scientists with up-to-date tools
•MedAustron may serve for exploration and testing of
new ideas and methods
•MedAustron may serve to run routine experiments
yielding important data in fields in which no beam time
at dedicated large research facilities can be allocated.
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
19
For a viable longlasting development
formal cooperation agreements with
partner laboratories are essential !
H. Leeb
Sept 7/8, 2007
Workshop on European Small-Scale AcceleratorFacilities, Aghios Nikolaos, Crete
20