Download Synthetic Biology for Programmers

Synthetic Biology for Programmers
Joshua D. Bruning
Examples
 Photographic film
 Water that changes pH when exposed to arsenic
 Salmonella that secretes spider silk proteins instead of toxins
 Toggle switch
Science + Engineering
 Convergence of biology and engineering
Representation
 Base = bit
Wetware
 Software that Builds Hardware
Reading (Sequencing)
 Partial analysis (~1 million bp)
 2008: ~$1,000
 2009: ~$300-$500
 Full human genome (~3 billion bp)
 2008: ~$350,000
 2009: ~$99,000
Writing (Synthesizing)
 $1/bp
 phiX-174: $5,386
 Smallpox: $186,102
 Human: ~$3,000,000,000
Abstraction
 Systems
 Devices
 Parts
 DNA
BioBricks
 Open-source genetic parts
 http://partsregistry.org
 Long-term goal: to build a synthetic living organism that is
completely understood
Refactoring
 Genetic programming vs. Structural programming
 Bacteriophage T7
Emulation
 Graph theory
 Boolean networks
 Ordinary differential equations
 Stochastic differential equations
 Master equations
Social Issues
 Risk/Security
 What’s wrong with the DNA God gave us?
 Economics/Patents
 Organization