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Embryonic Stem Cells
Blastocyst
Forms Placenta
Becomes Baby
Inner-Cell-Mass Cell
Ectoderm
Mesoderm
3 Primary Tissue Types
Endoderm
Primary Tissue Layers
Ectoderm
skin
eyes
nerves
Mesoderm
bones
blood
muscles
Endoderm
lungs
There are over 200 cell types in the adult body
liver
Lining of gut
Mesenchymal Stem Cells
Muscle
Skin
Fat Cells
Nerves
Tendons / Cartilage
Reconstruction Surgeries
Repair of cardiac tissue
Repair of nerve damage
Skin grafts after burn or
Reconstructive surgery
Joint & Back Repair
Trachea & Lung
Blood Vessels
Tissue Repair and Regrowth
Trachea Replacement
Lung Diseases
Mesenchymal Stem Cells
Bone
Retinal Photoreceptors
Corneal Repair
Bone regrowth
Regain sight after injury
Teeth
Liver
Insulin secreting cells
Repair or Replace Teeth
Liver Disease
Diabetes
Potential of MSC’s from Teeth
What can these cells do functionally?
There are several papers which have shown the ability of the MSC’s
from teeth both the lab and in animal to differentiate down these
pathways.
Adipogenesis or fat production
Neurogenic
Osteogenic
Odontogenic
Myogenic
SHED: stem cells from human exfoliated deciduous teeth.
Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S.
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12.
Chondrogenic