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Ph+ acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation by Wolf-K. Hofmann, Letetia C. Jones, Nathan A. Lemp, Sven de Vos, Harald Gschaidmeier, Dieter Hoelzer, Oliver G. Ottmann, and H. Phillip Koeffler Blood Volume 99(5):1860-1862 March 1, 2002 ©2002 by American Society of Hematology Point mutations at the ATP-binding site of the ABL kinase.A 714-bp region of ABL that codes for the ATP-binding site and the kinase activation loop was PCR amplified using 2 primer pairs and directly sequenced in 30 complementary DNAs (including 9 paired sa... Wolf-K. Hofmann et al. Blood 2002;99:1860-1862 ©2002 by American Society of Hematology
