Download the Cardiovascular Sciences Collaborative Programs

University of Toronto
Cardiovascular Sciences Collaborative Program
ANNUAL REPORT
2002 – 2003
FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: [email protected]
Web site: www.cscp.utoronto.ca
CONTENTS
DIRECTOR’S REPORT
MISSION STATEMENT
COLLABORATING DEPARTMENTS
COMMITTEES
- Executive
- Program
- Student
COURSES OFFERED
PROGRAM SPONSORED ACTIVITIES
- Annual Student Research Day
- Student Forum Night
- Human Biology Job Fair
- Summer Program
AWARDS
- Medtronic Travel Award
- Bigelow Book Prize
- Lorne Phenix Graduate Award
- Ontario Student Opportunity Trust Funds (OSOTF) Award
- Ontario Graduate Scholarships in Science and Technology (OGSST)
- Life Sciences Committee Summer Undergraduate Research Fellowships
ADVERTISING MATERIAL
FUTURE DIRECTION
STUDENTS
- Currently Enrolled
- Convocated/Follow-Up
- Awards
FACULTY
- Members
- Awards and Honors
- Peer Reviewed Funding
PUBLICATIONS
- Students
- Faculty
ACKNOWLEDGEMENTS
DIRECTOR’S REPORT
Cardiovascular sciences has a rich and illustrious history at the University of Toronto.
In order to further encourage graduate training in such a rich environment, the
Cardiovascular Sciences Collaborative Program (CSCP) was officially established and
recognized by Governing Council in 1992. Since then the CSCP continues to receive
resounding endorsement by the Ontario Council of Graduate Schools. Just this past
year, we underwent our 5-year School of Graduate Studies review where the Review
Committee unanimously recognized the significant contribution of the Program to the
University of Toronto and graduate training as a whole. Its interdisciplinary nature and
the fact that faculty and student research crosses the pillars of the CIHR as well as the
departments across a number of faculties makes this a truly model Program at the
University of Toronto. In keeping with this model, I would like to welcome our newest
member of the Program, the Department of Health Policy, Management & Evaluation.
I am proud to present this Annual Report that summarizes the achievements of the
Program’s students and faculty over the past academic year.
Administrative
The Executive Committee was restructured into a number of portfolios (described
below) where key faculty was recruited to assist and contribute with the expanding level
of Program activities allowing us to better serve our constituents. The Chairs of these
various subcommittees form the Executive Committee.
Scholarships & Awards Subcommittee (Chair: Dr. Margaret Rand)
Mandate: To oversee and adjudicate the various awards given out by the CSCP.
Dr. Rand has significant experience in this area as she recently finished a term as Chair
of the Grants Allocation Committee of the Heart & Stroke Foundation of Ontario.
Curriculum Subcommittee (Chair: Dr. Scott Thomas)
Mandate: To review status of graduate courses available to CSCP students;
recommend and implement any upgrades and/or new courses with cardiovascular
content; suggest any additional seminars of CME; integrate existing activities by other
departments into CSCP curriculum.
Dr. Thomas is an experienced teacher and supervisor with a strong appreciation of
graduate training.
Membership Subcommittee (Chair: Dr. Richard Weisel)
Mandate: To review and ensure that all appropriate and interested faculty are offered
the opportunity to join the CSCP; review faculty status (renewals and appointment
levels).
Dr. Weisel is one of our senior respected faculty who, as a world renowned scientist and
surgeon, offers his expertise to our growth.
Student Affairs Subcommittee (Chair: Dr. Lee Adamson)
Mandate: To ensure student satisfaction and promote student activities; link the student
group with the Program’s mandate; focus on student recruitment and associated
initiatives.
Dr. Adamson, another of our senior scientists, is well respected by the student body and
has years of graduate training experience.
Fundraising Subcommittee (Chair: Dr. Carin Wittnich)
Mandate: To explore and develop strategies to generate funds to support the CSCP
with a goal of stable infrastructure in 5 years.
Dr. Wittnich, as Founding director, has developed industry ties over the years in support
of the CSCP and will pursue this initiative with the assistance of connected CSCP
faculty and advisors.
The Executive Committee meets regularly to guide and promote the CSCP. This has
greatly contributed to the progress and growth the Program has made over the past
year and has ensured that this momentum continues.
Students
In this academic year we had 25 Masters and 15 PhD trainees active in the Program
(see graph below). We also had a number of our trainees who completed and
convocated. The PhD category was counterbalanced by new recruits and transfer
students while at the MSc level convocated numbers and students that transferred to
PhD exceeded the enrolment numbers, thus resulting in an apparent plateau. We will
be pursuing student recruitment with a number of initiatives in the upcoming year.
50
40
MSc
30
PhD
20
Total
10
0
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
The Student Committee continues to lead and drive Program student activities.
Specifically, their mandate is to (1) enhance trainee interaction through the organization
of both academic and social events and (2) to provide trainees with the tools to make
informed decisions about their graduate work in the form of mentoring and course
assessments. It is clear that the student body has established significant momentum
and they continue to expand in order to optimize participation and involve as many of
their colleagues as possible. They continue to organize a very successful “Annual
Student Research Day”, hold various social functions, and run the “Student Forum and
Dinner”. A new idea, Circulation Rounds, was established that features the research
programs of our individual faculty who host the event. Details can be found in the main
body of this report.
Our annual student interviews continue to show a high degree of satisfaction with the
Program. The increase in events targeted specifically for students resulted in more
effective student participation. The post-graduate follow-up illustrated that, once again,
the students have gone on to pursue either academic or research careers (see
Convocated section). As part of our ongoing tradition, bound copies of each graduating
student’s thesis is kept in the Program office (total: 35 MSc/MaSc and 13 PhD).
Student information on the web site continues to expand and we now also maintain
pictures and small bios of each active Program student.
Congratulations to the Student Committee, and in particular Ms. Kirsteen Burton, for
their hard work in successfully getting recognized as a Student Group. Plans are in the
works to become an official Student Association.
With such an enthusiastic and diverse group of students, it continues to be very exciting
to follow their initiatives!
Education
The JCV 3060H/3061H/3062H/3063H courses underwent a review by the Curriculum
Committee and they agreed that the ongoing and frequent course reviews continues to
ensure that leading edge technologies and research foci are represented. This is
considered critical if they are to continue to serve as our flagship courses for our
trainees. Enrolment continues to be strong in these courses and their popularity is
reflected in the strong student reviews. As well, the courses are more web-friendly with
outlines and seminar notes (password protected) available for downloading by students
registered in the courses.
Financial
Our efforts continue to be successful in increasing our endowment as well as raising
funds for student travel, bursaries and other student related activity. For example, the
Medtronic Travel Award makes it possible for students to attend scientific meetings and
present their work and the OSOTF bursary provides much needed financial relief to
deserving students. However, a stable infrastructure that is critical for continued
development, continues to elude us. In order to position the Program to be as
successful as possible in this venture, participating departments and faculties have
agreed to provide bridging funds. This also serves to reinforce to potential donors that
this is an extremely important initiative at the University.
A new sponsor is welcomed to the CSCP corporate family, Biovail Pharmaceuticals.
Our sponsors are to be recognized, once again, for their outstanding annual support of
education in the cardiovascular sciences at the University of Toronto.
Summary
As you continue to read through this report, you will see that the Program continues to
grow and enrich our trainee’s experiences. Specific details on all activities can be found
on our web site at www.cscp.utoronto.ca. I would like to once again recognize the
outstanding efforts of Miss Victoria Simpson, our Business Officer, for her hard work
and contribution that has made the Cardiovascular Sciences Collaborative Program the
success it is today.
Finally, I would like to take this opportunity to thank all our faculty and students for
another successful year and to those individuals who have continued to provide both
moral and tangible support for this Program.
Dr. Carin Wittnich, O.Ont.
Director, CSCP
Professor of Surgery & Physiology
Northrop Frye Scholar
MISSION STATEMENT
“The Cardiovascular Sciences Collaborative Program, approved by the University and
Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of
Graduate Studies, exists to give formal, organized expression to cardiovascular studies
and research at the graduate level. It builds on the strengths of all participating
academic units, and other agencies, to enhance the visibility of cardiovascular studies
and to facilitate collaborative, interdisciplinary training and research.”
The above mission is achieved by advertising and promoting the importance of, and
opportunities in, cardiovascular studies, by making known the results of such studies, by
recruitment of excellent students, and by coordinating the graduate collaborative
program in cooperation with the academic units in which they are registered. Students
in this collaborative program must fulfill the requirements of their home units as well as
the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences”
will appear on the student’s academic transcript and the Program will present the
student with a certificate and gift.
COLLABORATING FACULTIES
Medicine
Physical Education and Health
COLLABORATING GRADUATE UNITS
Department of Exercise Sciences
Department of Health Policy, Management & Evaluation
Department of Laboratory Medicine and Pathobiology
Department of Medical Biophysics
Department of Pharmacology
Department of Physiology
Department of Public Health Sciences
Department of Rehabilitation Science
Institute of Biomaterials and Biomedical Engineering
Institute of Medical Science
SUPPORTING CLINICAL DEPARTMENTS
Department of Anaesthesia
Department of Medicine
Department of Surgery
COMMITTEES
Executive
The Executive Committee consists of 4 members of the Program Committee
representing as wide a range of disciplines as possible and includes the Director. They
also act as Chairs of the various subcommittees as detailed in the Director’s Report.
The Executive Committee provides student counseling, screens applicants, provides
advice and acts as a Steering Committee. Meetings are held as needed.
Dr. C. Wittnich (Fundraising)
Dr. S.L. Adamson (Student Affairs)
Dr. M. Rand (Scholarships & Awards)
Dr. S. Thomas (Curriculum)
Dr. R. Weisel (Membership)
Program
The Program Committee consists of a representative from each collaborating
department as well as two student representatives. It administers the Program, selects
the Director, and generally meets twice per year.
Dr. C. Wittnich (Chair)
Dr. S.L. Adamson (Physiology)
Dr. D. Brooks (Rehabilitation Science)
Dr. D. Mazer (Anaesthesia)
Dr. R.I. Ogilvie (Pharmacology)
Dr. M. Ojha (Institute of Biomaterials and Biomedical Engineering)
Dr. M. Rand (Laboratory Medicine and Pathobiology)
Dr. S. Thomas (Exercise Sciences)
Dr. R.D. Weisel (Institute of Medical Science)
Dr. G. Wright (Medical Biophysics)
Renee Suen (Sr. Student Representative)
Kirsteen Burton (Jr. Student Representative)
Student
The Student Committee consists of the two student representatives from the Program
Committee (who act as Co-Chairs) and other students. They meet and oversee all
student activities of the Program.
Ms. Renee Suen (Co-Chair)
Ms. Kirsteen Burton (Co-Chair)
Ms. Nesime Askin
Ms. Shathiyah Kulandavelu
Ms. Golnaz Karoubi
Ms. Rachel Mitchell
Mr. Clifford Lin
Mr. Ali Pourdjabbar
Ms. Nathalie Lapointe (Advisor)
COURSES OFFERED
BME1448H Cardiovascular Fluid Mechanics
EXS5508H Cardiovascular Disease and Exercise
JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart
Signal Transduction
JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the
Cardiovascular System
JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function
JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular
JEB1365H Ultrasound: Theory and Applications in Biology and Medicine
JTC1331H Biomaterials Science
LMP1015H Vascular Pathobiology
LMP1504H Biochemistry, Molecular Biology of Cardiovascular Diseases
PSL1060H Developmental Cardiovascular Physiology
PSL1462H Molecular Aspects of Cardiac Function
* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our
collaborating departments.
Suggested Courses (Considered valuable but does not fulfill Program requirements)
CHL5201
LMP1404S
PSL1052H
Introducing Biostatistics for Students in Biological Sciences
Cellular and Molecular Mechanisms of Disease
Fundamentals on Ion Channel Function
PROGRAM SPONSORED ACTIVITIES
Annual Student Research Day 2003
On Wednesday, February 26th, 2003, the
Cardiovascular Sciences Collaborative
Program held its 4th Annual Student Research
Day in the Medical Sciences Bldg. This was a
fun-filled day that was attended by CSCP
trainees and faculty. The day began with a
brief report from the Student Committee
highlighting successful events and activities
form the past year. Trainees then presented
their research concepts/designs/results in a 10
minute presentation followed by a question period. New to this year’s program was the
addition of a poster viewing opportunity.
SESSION I: Chair – Paul Fedak
Rohan Dharmakumar (PhD – Medical Biophysics)
“Magnetic Resonance Based Manometry Using Pressure Sensitive Microtubules”
Mona Shawky (MSc – Institute of Medical Science)
“Can a Chlamydia Pneumonia Vaccine Prevent its Effect on Atherosclerosis in LDL Knockout
Mice”
Matthew Gilman (MSc – Institute of Medical Science)
“Cardiac Output and Sleep Apnea”
Shawn Brady (MSc – Rehabilitation)
“Predicting Participation in Cardiac Rehabilitation in Individuals After Coronary Artery Bypass
Surgery (CABG)”
Rachel Mitchell (MSc – Institute of Medical Science)
“Depression in CABG Patients: The Effects of Female Sex and Co-Morbidity”
Eser Adiguzel (PhD – Laboratory Medicine and Pathobiology)
“Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collage VIII -/Mouse”
SESSION II: Chair – Karim Bandali
Ali Pourdjabbar (MSc – Institute of Medical Science)
“The Effect of Pre-Treatment with Angiotensin Receptor Blockers in a Model of Heart Failure After
Myocardial Infarction”
Golnaz Karoubi (MSc – Biomedical Engineering)
“Quantification of Single Cell Transgene Expression and Protein Secretion for Adherent Cells”
John Esposito (MSc – Rehabilitation)
“Cardiovascular Response to Submaximal Exercise in HIV-Associated Wasting”
Danny Ramzy (MSc – Institute of Medical Science)
“Bosentan, an Endothelin-1 Antagonist, Improves Cardiac Function After Prolonged Storage and
Orthotopic Transplantation”
David Ashburn (MSc – Institute of Medical Science)
“Analysis of Competing Time-Related Outcomes in Congenital Heart Disease”
POSTERS
Renee Suen (Supervisor: Dr. Duncan Stewart)
“Role of Endothelin-1 in Accelerated Atherosclerosis and Aortic Aneurysm Formation in Response to
Angiotensin II”
Shathiyah Kulandavelu (Supervisor: Dr. Lee Adamson)
“Maternal Cardiovascular Changes During Pregnancy in eNOS Knockout Mice”
Eser Adiguzel (Supervisor: Dr. Michele Bendeck)
“Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collagen VIII -/- Mouse”
Vaska Micevski (Supervisor: Dr. Donna Stewart)
“Gender-Bias in the Referral Patterns for Coronary Angiography Following Myocardial Perfusion Imaging”
The afternoon consisted of informal presentations by two leading cardiovascular
clinicians/scientists Dr. Lynda L. Mickleborough, Professor of Surgery (Cardiac
Surgeon) and Dr. Richard I. Ogilvie, Professor Emeritus of Medicine & Pharmacology
(Clinical Pharmacologist). These outstanding individuals shared their personal stories
related to their academic pursuits and careers. The presentations were followed by a
lively discussion in which students had an opportunity to discuss the trials and
tribulations of living a life devoted to education and research with these highly respected
and successful clinicians/scientists.
L-R: Dr. Richard Ogilvie, Ms. Vaska
Micevski, Dr. Lynda Mickleborough
This was then followed by the awards ceremony. The Director began by recognizing
this years’ students who successfully completed the Cardiovascular Sciences
Collaborative Program with a certificate and gift.
BR: Nikolaos Mamalias, Nesime
Askin, Akis Amfilochiadis, Dr. Carin
Wittnich
FR: Peter Papageorgiou, Nataly
Kogan, Saeid Babaei
Then the Director announced the winner of the Bigelow Book Prize, Dr. Paul Fedak,
where she called upon Dr. Bigelow to present Paul with the plaque and books. This
was followed by the presentation to the winner of the Lorne Phenix Graduate Award,
Mr. Jack Wallen. Mrs. Phenix was not able to attend the ceremony, so Dr. Wittnich
presented Jack with the certificate and cheque.
The day concluded with a reception where students and faculty mixed and mingled,
after which most of the students continued their interactions at a student planned social
event.
The Student Research Day is the flagship activity of the CSCP and met with resounding
success. This day would not have been possible without the extraordinary efforts of the
Planning Committee: Vaska Micevski (Chair), Golnaz Karoubi (member), Shathiyah
Kulandavelu (member), and Ali Pourdjabbar. The committee also gratefully
acknowledges the educational grant from Aventis Pharma and the support of Ms.
Victoria Simpson in making this a very successful day. Congratulations!
Student Forum Night
The first CSCP Student Forum and Dinner event was held on Tuesday, December 3,
2002 in the Debates Room of Hart House. The primary objective of this event was to
provide students in the CSCP program and potential CSCP recruits with an informal
evening of friendly and
informative sharing
of ideas and views that
affect them. The
evening began at
5:30pm. The
Student Committee
members were
introduced to the
student body by
Nathalie Lapointe, the
senior student
representative at the
time, followed by
the introduction and
proposal of the two
forum topics by the
Chair of Student
Forum, Renee Suen.
The two topics that
were proposed were: Science vs. Religion and the need for MCAT examination, and the
equivalent to enter into professional school. The topic of MCAT requirement was
selected by majority of the students and was moderated by the Chair, who stimulated
discussion and participation by asking questions. All students had to give their own
point of view. The presence and the participation of the students from the program was
excellent. At 7:00pm the Chair concluded the evening’s program and the students were
invited to take a short break prior to the dinner. The evening concluded around 8:30pm.
There is no doubt regarding the success of this event, as the feedback obtained from
student evaluation forms collected was exceptional. Congratulations to Renee Suen for
making this an outstanding event.
Human Biology Student Union Career Fair
The Cardiovascular Sciences Collaborative Program participated in the Human Biology
Undergraduate Student Association Career Fair on November 21, 2002. Various
graduate programs had displays and students in the Collaborative Program manned a
table and provided information to interested future graduate students.
Summer Program
This year’s Annual Cardiovascular Sciences Collaborative Program summer program
was a definite success. Student talks ranged from women’s health, sleep apnea, and
heart/organ transplantation to the effects of sex on cardiac development. Also this year,
we incorporated a number of field trips and guest speakers into the program that
enhanced the student’s summer experience. Our first guest speaker was Dr. Bhalerao,
a staff psychiatrist at St. Michael’s Hospital, who spoke on the psychological effects of
myocardial infarction in a variety of patient populations. His informal, integrative
question-based approach to the talk was very enjoyable. Our second guest speaker
was Dr. Margaret Rand, a researcher from the Hospital for Sick Children, who gave the
students an excellent, informative talk on platelets and their role in coagulation
homeostasis and vascular pathology. The summer’s first field trip was to the Toronto
Rehabilitation Institute’s Cardiac Centre (Rumsey Centre). The students sat in on an
introduction/orientation session with new patients and received a tour of the facility. In
addition, they also got the opportunity to meet and interact with the patients about their
experiences and got a first hand look at the benefits of cardiac rehabilitation. Our next
field trip was to Biovail Pharmaceuticals’ Research and Development Centre. This trip
provided the students a behind the scene insight into drug development, drug marketing
and the ordeals companies face before their drugs are approved. It also provided the
students information about future employment opportunities in pharmaceutical research
and drug development. This program is highly successful and with the addition of field
trips, it was enjoyed by all who participated.
June 6th
Dr. Wittnich, Director, CSCP
“Introduction & Video: William Harvey and the Circulation of Blood”
Rachel Mitchell (MSc – Institute of Medical Science)
"When a Woman's Heart is on the Table: Women and Bypass Surgery"
June 13th
Matthew Gilman (MSc – Institute of Medical Science)
"Effects of Continuous Positive Airway Pressure on Heart Rate Variability in
Heart Failure Patient with Obstructive Sleep Apnea"
June 20th
Cliff Lin (MaSc – Institute of Biomaterials and Biomedical Engineering)
“Tissue Engineering – Vascular Grafts”
June 27th
Danny Ramzy (MSc – Institute of Medical Science)
“Cardiac Transplantation”
July 4th
Dr. Shree Bhalerao, BSc, BA, PhD, MD, FRCPC
Assistant Professor, University of Toronto, Medical Psychiatry
“Psychological Aspects of Heart Disease”
July 11th
Summer Student Presentations – Project Introductions
July 16th
Toronto Rehabilitation, The Rumsey Centre Field Trip
July 25th
Biovail Pharmaceuticals Field Trip
August 1st
Nesime Askin (PhD – Department of Physiology)
“Does Sex Matter...A Scientific Investigation”
August 8th
Dr. Margaret Rand, Division of Hematology,
Hospital for Sick Children Research Institute, McMaster Bldg.
“The Bloody Story of Hemostasis and Thrombosis”
August 15th
Summer Student Presentations – Project Results
AWARDS
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This
award, established in 1995, helps to defray costs of travel for Program students
presenting their research work at recognized scientific meetings. Students supported
by this award this academic year were:
Fall 2002:
Karim Bandali, PhD, Physiology: “Ventricle Specific Postnatal Maturational Differences
in Glucose Transporter Expression in the Heart”, Canadian Cardiovascular Congress
2002 (Supervisor: Dr. C. Wittnich)
Renee Suen, PhD, Institute of Medical Science: “Role of Endothelin-1 in Accelerated
Atherosclerosis and Aneurysm Formation in Response to Angiotensin II”, Canadian
Cardiovascular Congress 2002 (Supervisor: Dr. D. Stewart)
Spring 2003:
David Ashburn, MSc, Institute of Medical Science: “Determinants of Mortality and Type
of Repair in Neonates with Pulmonary Atresia-Intact Ventricular Septum”, American
Association for Thoracic Surgery (Supervisor: Dr. J. Coles)
Shathiyah Kulandavelu, PhD, Physiology: “Cardiovascular Function During Pregnancy
in Mice and the Role of Endothelial Nitric Oxide Synthase”, Society of Gynecologic
Investigation 50th Annual Meeting (Supervisor: Dr. L. Adamson)
Roland Leung, MSc, Institute of Medical Science: “Procoagulant Surface Expression on
Activated Human Platelets Persists Despite Increased Aminophospholipid Translocase
Activity”, XIX Congress of The International Society on Thrombosis and Haemostasis
(Supervisor: Dr. M. Rand)
Bigelow Book Prize
This prize was established in 1995 by the Cardiovascular Sciences Collaborative
Program to recognize and honor a pioneer clinician and scientist in the field of
cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow curiosity, drive, and scientific integrity. The award is given in every year that a qualified
student is identified. Qualifications include sustained academic scientific excellence,
innovative experimental approaches, original discoveries and good scientific
productivity. Some weight is given to work that has recognizable clinical relevance,
especially that which promises to improve patient care. The Bigelow Book Prize
consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious
Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates
were identified and the final decision was made by the Program Committee.
1995 – Dr. John S. Ikonomidis
1996 – Ms. Shona M. Torrance
1997 – Dr. Vivek Rao
1998 – Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
2000 – Dr. Michael Borger
2001 – Dr. Saeid Babaei
2002 – Mr. Wm. Jack Wallen
2003 – Dr. Paul W.M. Fedak
L-R: Dr. Carin Wittnich, Dr.
Richard Weisel (Supervisor), Dr.
Wilfred Bigelow, Dr. Paul Fedak
Dr. Fedak is dedicated toward a career as an academic cardiac surgeon with a focus on
developing novel therapeutic approaches to treat patients with congestive heart failure.
His PhD thesis outlines an important role for TIMP-3 as a key regulator of the
remodeling process in the failing heart and he is now focused on translating these novel
findings into experimental gene and cell therapies for patients with heart failure. His
other research interests include the pathophysiology and treatment of bicuspid aortic
valve disease, endothelial dysfunction during allograft preservation for transplantation,
and the mechanisms underlying the benefits of cell transplantation for cardiac
dysfunction.
This award is presented at the Annual Student Research Day and we are extremely
pleased the Dr. Bigelow continues to participate in the award ceremony and interacts
with the trainees.
Lorne Phenix Graduate Award
This award was made possible by a generous donation in the memory of Mr. Lorne
Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on
the issue of heart disease – which is still the #1 killer of both men and women in
Canada. In addition, women who have heart problems are at least equal if not at
greater risk than men and Mrs. Phenix hopes that this award will serve to encourage
trainees to pursue this area of research to address this particular problem. It is awarded
to a graduate student in the Faculty of Medicine on the basis of research and academic
excellence. The award consists of a cash prize and certificate and is presented to the
recipient at the Annual Student Research Day. Appropriate candidates are identified
and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award
is presented at the Annual Student Research Day.
2001 – Wm. Jack Wallen, PhD
2002 – Wm. Jack Wallen, PhD
Dr. Carin Wittnich (Supervisor),
Jack Wallen
Jack Wallen is a PhD candidate in the Department of Physiology, University of Toronto,
working in the laboratory of Dr. Carin Wittnich. His research focuses on the role of
gender on development of myocardial pathology. Initial work found that female rats had
significantly higher baseline glycogen levels in both myocardium and liver than agematched males (Am J Clin Nutr 1997). As well, females had a greater degree of
myocardial hypertrophy, in both the presence and absence of systemic hypertension
(Hypertension 2000). This response was dependent on the hormone status of the
animals and for any given diastolic pressure, females always exhibited greater
hypertrophy. More recent published evidence shows that steroid hormones exert
dramatic gender dependent effects on whole-body metabolism in both normotensive (J
Nutr 2001) and hypertensive rats (J Nutr 2002). The work to date has identified
significant gender differences which could increase female risk in the presence of heart
disease.
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards that have resulted from the Ontario
government’s “matching” program. Under the program every dollar of donation received
for student assistance has been matched by the government as well as the university
on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program
participates in this program. There are two major conditions for all OSOTF awards;
recipients must be Ontario residents and demonstrate financial need. However, the
Program has additional eligibility criteria that must be adhered to, including excellence
in science and academic performance. One competition is held per academic year.
The applications are handled centrally through the Office of the Associate Dean, InterFaculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and
are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee
recommendations are then forwarded to the OSOTF Awards Committee (Faculty of
Medicine). This year’s recipient was Ms. Kirsteen Burton, MSc, Public Health Sciences
(Supervisor: Dr. George Tomlinson)
Ontario Graduate School Science and Technology (OGSST)
The OGSST program is designed to encourage excellence in graduate studies in
science and technology. The program is supported through funds provided by the
Ministry of Training, Colleges and Universities and by funds raised by the University of
Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate
students at the University of Toronto who are pursuing cardiovascular/stroke research.
Students must have maintained an overall A- average over the last two years of study at
the post-secondary level and exhibit research ability/potential, good communication
skills and interpersonal/leadership abilities.
2002-2003 Awardees
Name
Kalam Chan
Nathalie Lapointe
Jenny Le
Elsa Liu
Rachel Mitchell
Ali Pourdjabbar
Randy Rizek
Mona Shawky
Paul Van Slyke
Degree
MSc
PhD
MSc
MSc
MSc
MSc
MSc
MSc
PhD
Dept.
PSL
IMS
IMS
LMP
IMS
IMS
PSL
IMS
MBP
Supervisor
Michelle Bendeck
Jean Rouleau
Peter Liu
David Courtman
Donna Stewart
Jean Rouleau
Robert Tsushima
Peter Liu
Dan Dumont
Life Sciences Committee Summer Undergraduate Research Fellowships
These fellowships are awarded to support research at the University of Toronto to assist
undergraduate students seeking training for graduate level research. Funds were
awarded to the Cardiovascular Sciences Collaborative Program for 5 undergraduate
trainees. All candidates put forward by the Program were awarded funding.
Shivalika Handa – Supervisor: Dr. Mansoor Husain
Ashley Misquitta – Supervisor: Dr. Avrum Gotlieb
Julia Warden – Supervisor: Dr. Gregory Wilson
Juliana Yanan Li – Supervisor: Dr. Robert Tsushima
Horia Pribiag – Supervisor: Dr. Carin Wittnich
ADVERTISING MATERIAL
The Cardiovascular Sciences Collaborative Program maintains and updates its web site
(www.cscp.utoronto.ca) on a regular basis. Faculty information is updated whenever
we are notified of relevant changes. This year Victoria Simpson revamped the entire
website look to optimize efficient use by visitors. The Program students took an active
part in creating their own sections, including short bios on each student, course
summaries/surveys to help other students pick courses suitable for their needs, and
they are working on a bulletin board section to keep everyone updated on
cardiovascular activities. Collaborating departments are encouraged to provide
hypertext links to the Collaborative Program on their web site.
The Program distributes brochures at the various campus activities and the
collaborating departments are encouraged to have links with the CSCP’s web site and
distribute brochures.
FUTURE DIRECTION
For the 2003-2004 academic year, we plan to continue our current activities and pursue
the following priorities:
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Continue developing endowments to provide permanent infrastructure support
Firm up a 5-year plan for the program
Create a Cardiovascular Resource Centre
Aggressive recruitment targeting PhD students
Recruit clinical residents doing 1-2 years of research into a formal graduate
program where appropriate
Graduate training grant application (CIHR)
Further develop the student section in the Program’s web site
Further develop CME programs in cardiovascular sciences
Continue developing web-based course learning materials
STUDENTS
Student
I. Eser Adiguzel
David Ashburn
Nesime Askin
Karim Bandali
Shawn Brady
Kirsteen Burton
Andrew Campbell
status)
Asim Cheema
Rohan Dharmakumar
John Esposito
Paul Fedak
Warren Foltz
Matthew Gilman
Golnaz Karoubi
Shathiyah Kulandavelu
Nathalie Lapointe
Roland Leung
Negin Liaghati-Nasseri
status)
Clifford Lin
Sarah McCutcheon
Sandra Merklinger
Vaska Micevski
Rachel Mitchell
Ali Pourdjabbar
Danny Ramzy
Sonja Reichert
status)
Clea Senechal
Mona Shawky
Renee Suen
Shona Torrance
status)
Jack Wallen
Li Yang
Supervisor
M. Bendeck
J. Coles
C. Wittnich
C. Wittnich
S. Thomas/D. Brooks
G. Tomlinson
D. Stewart
Degree
MSc
MSc
PhD
PhD
MSc
MSc
PhD
Department
LMP
IMS
PSL
PSL
REH
CHL
IMS (inactive
B. Strauss
G. Wright
S. Thomas
R. Weisel
G. Wright
D. Bradley
D. Courtman
L. Adamson
J. Rouleau
M. Rand
S. Fremes
PhD
PhD
MSc
PhD
PhD
MSc
PhD
PhD
PhD
MSc
MSc
IMS
MBP
REH
IMS
MBP
IMS
BME
PSL
IMS
IMS
IMS (inactive
D. Courtman
S. Thomas
M. Rabinovitch
D. Stewart
D. Stewart
J. Rouleau
V. Rao
J. Goodman
MaSc
MSc
MSc
PhD
MSc
MSc
MSc
MSc
BME
REH
IMS
IMS
IMS
IMS
IMS
EXS (inactive
P. Liu
P. Liu
D. Stewart
C. Wittnich
MSc
MSc
PhD
PhD
IMS
IMS
IMS
IMS (inactive
C. Wittnich
D. Stewart
PhD
PhD
PSL
LMP
Convocated Students/Follow-Up
Anjum Khan, MSc, Institute of Medical Science (Supervisor: Dr. B. Strauss)
“Atrial Remodeling in Congestive Heart Failure”
(Working in industry or hospital as a clinical researcher)
Akis A. Amfilochiadis, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Studies on the Mechanism of Action of “New Pressor Protein”: Participation of a
Systemic Bradykinin-Mediated Pathway Stimulating the Sympatho-Adrenal System and
Potentiated by Ace Inhibition”
(Continuing graduate studies – PhD, University of Toronto)
Peter C. Papageorgiou, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Studies on the Mechanism of Action and Clinical Relevance of Human Plasma “New
Pressor Protein”: Its Relationship to Coagulation β-FXIIa and Role of the Kidney and
Adrenal Medulla”
(Continuing graduate studies – PhD, University of Toronto)
Nesime Askin, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich)
“The Role of Gender and Ovarian Cycling on Skeletal Muscle Metabolism During
Ischemia”
(Continuing graduate studies – PhD, University of Toronto)
Carol Kolb, MSc, Department of Physiology (Supervisor: Dr. L. Adamson)
“Echogenicity of Fetal and Maternal Blood and Selected Tissues at 19MHz-55MHz In
Vivo in Mice”
(Working in clinical studies)
Neelesh Jain, MaSc, Institute of Biomaterials & Biomedical Engineering (Supervisor:
Dr. K.W. Johnston)
“The Role of Endothelial Cell Shape and Nuclear Factor-κB in Subclinical Human
Atherosclerosis”
(Completing General Surgery Residency - 2004)
Nataly Kogan, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Cardiovascular and Sympathoadrenal effects of “New Pressor Protein”: Role of
Angiotensin Converting Enzyme, Neutral Endopeptidase and Substance P”
(Continuing graduate studies – PhD, University of Toronto)
Tommaso Gori, MSc, Institute of Medical Science (Supervisor: Dr. J. Parker)
“New Evidence Concerning the Role of Oxygen Free Radicals and Nitric Oxide
Synthase Dysfunction in the Development of Nitrate Tolerance”
(Clinical medicine in Italy)
Awards and Honors
Nesime Askin
Natural Sciences and Engineering Research Council of
Canada (NSERC-PGS-B)
University of Toronto Open
Gordon Cressy Student Leadership Award
Karim Bandali
Heart & Stroke Foundation of Canada Research Doctoral
Award
Medtronic Travel Award, Cardiovascular Sciences
Collaborative Program, UofT
Teaching Award, Department of Physiology, UofT
Kirsteen Burton
Ontario Student Opportunity Trust Fund (OSOTF) Award,
Cardiovascular Sciences Collaborative Program
Medicine/Community Health Ontario Graduate Scholarship
in Science & Technology (OGSST), Faculty of Medicine
David E. Hastings, Ontario Scholarship in Science &
Technology (OGSST), Faculty of Medicine (declined)
Heart & Stroke Foundation of Ontario, Ontario Scholarship in
Science & Technology (OGSST), Faculty of Medicine
(declined)
Kenzie Macdonald Award, Faculty of Physical Education and
Health
T-Holders Student Assistance Award, Faculty of Physical
Education and Health
Matthew Gilman
University of Toronto Open Fellowship Award
Merck Frosst Canada Fellowship
Best Clinical Poster Presentation (Respirology)
Golnaz Karoubi
Heart & Stroke/Richard Lewar Centre of Excellence Student
Fellowship, UofT
The Whittiker Foundation Scholarship
1st Place, Graduate Poster Category, Heart & Stroke/Richard
Lewar Centre of Excellence Annual Cardiovascular Scientific
Day
1st Place, Oral Presentation Category, Canadian
Biomaterials Society
Shathiyah Kulandavelu
University of Toronto Open, Department of Physiology, UofT
Al & Hannah Perly Graduate Student Scholarship, Faculty
of Medicine, University of Toronto
Canada Life Assurance Company Graduate Fellowship in
Medical Research, Mount Sinai Hospital
Genesis Research Foundation/Government of Ontario/
Physiology Graduate Scholarship
Medtronic Travel Award, Cardiovascular Sciences
Collaborative Program, UofT
1st Place Oral Presentation, 30th Annual Fetal and Neonatal
Physiological Society Conference, Alberta
Nathalie Lapointe
Best Paper, Canadian Society of Pharmacology
Heart & Stroke Foundation of Ontario
Institute of Medical Science
Vaska Micevski
Canadian Council of Cardiovascular Nurses, 2002 Annual
Meetings and Scientific Sessions, Poster Presentation
Winner – Research Category
Community Outreach Heart Health Risk Reduction Trials
(COHRT). Heart & Stroke Foundation of Ontario, 2001-2006
(Co-Investigator)
Rachel Mitchell
Canadian Federation of University Women: First Runner Up
for the CFUW Memorial Scholarship
OSOTF: Al & Hannah Perly Graduate Student Scholarship
University of Toronto Open Fellowship, Institute of Medical
Science
Ontario Graduate Scholarship in Science & Technology
Ali Pourdjabbar
Government of Ontario/Heart and Stroke Foundation of
Ontario Graduate Scholarship in Science and Technology
Renee Suen
Heart & Stroke/Richard Lewar Centre of Excellence
Fellowship, UofT
Medtronic Travel Award, Cardiovascular Sciences
Collaborative Program, UofT
1st Prize Oral Presentation – PhD Category, Ontario
Hypertension Society Spring Conference
Jack Wallen
Heart and Stroke Foundation/Richard Lewar Centre of
Excellence Fellowship, UofT
Medical Research Council of Canada/K.M. Hunter Doctoral
Research Award
Gordon Cressy Student Leadership Award, University of
Toronto Alumni Association, UofT
Volunteer Service Award, 5 Year Pin, Ontario, Canada
Li Yang
Dutkevich Foundation Student Travel Award, UofT
Student Presentation Award (2nd Prize), Heart &
Stroke/Richard Lewar Centre of Excellence Annual
Research Day, UofT
CIHR/Rx&D Research Program Studentship, CIHR/CHS/
Pfizer (declined)
Trainee Abstract Award, American Heart Association
Doctoral Research Award, Heart & Stroke Foundation of
Canada
PhD Oral Presentation Award, Department of Laboratory
Medicine and Pathobiology, UofT
Next Generation CIHR/BioContact Quebec (declined)
PUBLICATIONS – STUDENTS
Afroze T, Yang LL, Wang C, Gros R, Kalair W, et al: Calcineurin reinforces the Ca2+
signal at the G1/S transition in the vascular smooth muscle cell cycle. Am J Physiol Cell
Phsiol, 2003;285(1):C88-C95.
Babaei S, Karoubi G, Stewart D: Angiogenesis? The answer is NO. Cardiovasc Res,
2002;56(3):489.
Belanger MP, Wallen WJ, Askin N, Wittnich C: Effect of hypertension on reproductive
organ weights in different strains of rats. Contemp Topics, 2003;42:16-18.
Cheema A, Nili N, Li CW, Whittingham HA, et al: The effects of intravascular
cryotherapy on vessel wall repair in a rabbit angioplasty model. Cardiovasc Res,
2003;59(1):222-233.
Fitchett D, Kutryk M, Cheema A, Stewart D: Electromechanical mapping of the left
ventricle for the assessment of myocardial viability. A platform for intramyocardial
injection of gene therapy to promote myocardial angiogenesis. IJBEM, 2002;4:75-76.
Foltz WD, Al-Kwifi O, Sussman MS, Stainsby JA, Wright GA: Optimized spiral imaging
for measurements of myocardial T2 relaxation. Mag Resonance Med, 2003;49:10891097.
Foltz WD, Huang H, Fort S, Wright GA: Vasodilator response assessment in porcine
myocardium using MR relaxometry. Circulation, 2002;106:2714-2719.
Hyman I, Guruge S, Makarchuk MJ, Cameron J, Micevski V: Promotion of healthy
eating among new immigrant women in Ontario, Canada. J Dietetic Prac Res,
2002;63(2):125-129.
Lapointe N, Blais C Jr, Adam A, Parker T, Sirois MG, Gosselin H, Clement R, Rouleau
JL: Comparison of the effects of an angiotensin-converting enzyme inhibitor and a
vasopeptidase inhibitor after myocardial infarction in the rat. J Am Coll Cardiol,
2002;39:1692-1698.
Lapointe N, Nguyen QT, Desjardins JF, Marcotte F, Pourdjabbar A, Moe G,
Calderone A, Rouleau JL: The effects of pre-peri-and post-myocardial infarction
treatment with omapatrilat in rats: Effects on survival, ventricular arrhythmias and
remodelling. Am J Physiol Heart Circ Physiol, 2003;285:H398-H405.
Lapointe N, Rouleau JN: Cardioprotective effects of vasopeptidase inhibitors. Can J
Cardiol, 2002;18:415-420. Review.
Li C, Cantor WJ, Nili N, Robinson R, Fenkell L, Tran YL, Whittingham HA, Tsui W,
Cheema AN, et al: Arterial repair after stenting and the effects of GM6001, a matrix
metalloproteinase inhibitor. J Am Coll Cardio, 2002;39:1852-1858.
Marleau S, Lapointe N, Massicotte J, Cemeus C, Jasmin G, et al: Effect of chronic
treatment with bovine recombinant growth hormore on cardiac dysfunction and lesion
progression in UM-X7.1 cardiomyopathic hamsters. Endocrinology, 2002;143:48464855
Nili N, Cheema A, Barolet A, Babaei S, Hickey R, Eskandarian MR, Giordano FJ,
Strauss BH: Decorin inhibition of PDGF-stimulated vascular smooth muscle cell
function: Potential mechanism for inhibition of intimal hyperplasia after balloon
angioplasty. Am J Pathol, 2003;163(3):869-878.
Pourdjabbar A, Lapointe N, Rouleau JN: Angiotensin receptor blockers: Powerful
evidence with cardiovascular outcomes? Can J Cardiol, 2002;18(SuppA):7A-14A.
Review.
Rouleau JL, Pitt B, Dhalla NS, Dhalla KS, Swedberg K, Hansen MS, Stanton E,
Lapointe N, Packer M for the Canadian PROFILE investigators: Prognostic importance
of the oxidized product of catecholamines, adrenolutin, in patients with severe heart
failure. Am Heart J, 2003;145(5):926-932.
Wallen WJ, Belanger MP, Wittnich C: Preischemic administration of ribose to delay the
onset of irreversible ischemic injury and improve function: Studies in normal and
hypertrophied hearts. Can J Physiol Pharmacol, 2003;81:40-47.
Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis
GF: Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and
increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a
vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II
type I receptor blocker. Circulation, 2003;107:1923-1929.
Yang LL, Linrong T, Newman ER: Structure of the LRP-regulated serA promoter of E.
coli K-12. Mol Microbio, 2002;43(2):323-333.
Yang LL, Husain M, Stewart DJ: The role of endothelin-1 in myocardial inflammation
and fibrosis. IN: Inflammation and Cardiac Diseases. (Ed) Feuerstein GZ. Birkhauser
Verlag Switzerland, 2003;371-384.
FACULTY
Members
Faculty are divided into 3 categories (Full, Associate, Affiliate) depending on their SGS
status. Details on faculty research interests and contact information are available on
the web site. Departmental affiliations listed are those within the CSCP.
Name
Full
Departmental Affiliation(s)
Location
Lee Adamson
Khosrow Adeli
Peter Backx
Michelle Bendeck
Douglas Bradley
Dina Brooks
BME/IMS/PSL
LMP
IMS/Medicine/PSL
LMP/Medicine
IMS/Medicine
REH
John Coles
Philip Connelly
David Courtman
Paul Dorian
C. Ross Ethier
IMS/Surgery
LMP/Medicine
BME/Surgery
IMS/Medicine/PCL
BME
John S. Floras
Christopher Forrest
Stephen Fremes
Jack M. Goodman
Len S. Goodman
Avrum I. Gotlieb
Aleksander Hinek
Chris Hudson
Mansoor Husain
K. Wayne Johnston
Peter G. Kalman
Fred Keeley
B. Lowell Langille
Gary F. Lewis
Ren-Ke Li
Peter Liu
Marius Locke
Peter McLaughlin
Donald A.G. Mickle
David Naylor
Matadial Ojha
John Parker
Tom Parker
Margaret Rand
Michael Sefton
Arthur S. Slutsky
Michael J. Sole
Donna E. Stewart
IMS/Medicine
IMS/Surgery
IMS/Surgery
EXS
EXS
LMP
IMS/LMP
IMS
IMS/LMP/Medicine
BME/IMS/Surgery
IMS/Surgery
LMP
LMP
IMS/Medicine
IMS/LMP/Surgery
IMS/Medicine
EXS/CHL
IMS/Medicine
LMP/Surgery
IMS/Medicine/CHL/Surgery
BME/Surgery
IMS/Medicine
IMS/Medicine
IMS/LMP
BME
IMS/Medicine/Surgery
IMS/Medicine/PSL
Anesthesia/IMS/Surgery/Medicine
Mount Sinai Hospital
Hospital for Sick Children
UofT - HSRLCE
UofT - MSB
Toronto General Hospital
UofT – Rehabilitation
Science
Hospital for Sick Children
St. Michael’s Hospital
St. Michael’s Hospital
St. Michael’s Hospital
UofT – Mechanical
Engineering
Mount Sinai Hospital
Hospital for Sick Children
SWCHSC - Sunnybrook
UofT - Physical Ed & Health
Def & Civil Inst Environ Med
Toronto General Hospital
Hospital for Sick Children
Toronto Western Hospital
Toronto General Hospital
Toronto General Hospital
Community
Hospital for Sick Children
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
UofT – Physical Ed & Health
Toronto General Hospital
Toronto General Hospital
UofT - MSB
UofT – Rosebrugh Bldg.
Mount Sinai Hospital
Toronto General Hospital
Hospital for Sick Children
UofT – Wallberg Bldg.
Mount Sinai Hospital
Toronto General Hospital
Toronto General Hospital
Duncan Stewart
Bradley Strauss
Scott G. Thomas
George Tomlinson
Robert Wald
Richard D. Weisel
Gregory Wilson
Carin Wittnich
Graham Wright
IMS/LMP/Medicine
LMP/Medicine
EXS/PSL
CHL
IMS/Medicine
IMS/Surgery
IMS/LMP/PSL/Surgery
IMS/PSL/Surgery
MBP
St. Michael’s Hospital
St. Michael’s Hospital
UofT – Physical Ed & Health
Toronto General Hospital
Mount Sinai Hospital
Toronto General Hospital
Toronto General Hospital
UofT - MSB
SWCHSC - Sunnybrook
Tai-Wing Wu
Erik L. Yeo
LMP
IMS/Medicine
Toronto General Hospital
Toronto General Hospital
CHL
IMS/Surgery
IMS/Surgery
LMP
IMS/Medicine/PSL
IMS
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
Community
UofT - MSB
Hospital for Sick Children
LMP/Medicine
Surgery
Anaesthesia
Anesthesia
Anaesthesia
Medicine/PCL
Medicine
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
St. Michael’s Hospital
Toronto General Hospital
Toronto Western Hospital
Toronto General Hospital
IMS/LMP/Medicine
IMS/Surgery
UofT – Banting Institute
Toronto General Hospital
Associate
Jane Irvine
Tom Lindsay
Vivek Rao
Nisar A. Shaikh
Robert Tsushima
Lori West
Affiliate
Jagdish Butany
Chris M. Feindel
Joel Fisher
David Mazer
Patricia Murphy
Richard I. Ogilvie
Len Schwartz
Retired
C-C. Liew
Lynda Mickleborough
New Positions
All the best to Dr. Jean L. Rouleau in his new position as Dean of Medicine at the
University of Montreal
Awards and Honors
Michelle Bendeck
Premier’s Research Excellence Award (PREA) (2000-2005)
Dept of Laboratory Medicine & Pathobiology, University of Toronto
Doug Bradley
Senior Scientist Award, Canadian Institutes of Health Research
Research Group Winner of Poster Presentation Award,
Electophysiology Section, 2002 American Heart Association
Meeting
Member, Editorial Board, American Journal of Respiratory and
Critical Care Medicine
Member, Editorial Board, Sleep
Member, Editorial Board, Brazilian Journal of Pulmonology
Dina Brooks
Member, Profile Column in Contact
Nominated by the Lung Association for the University of Toronto,
Faculty of Medicine Educational Excellence for Community Health
Care Award, March 2003.
Rising Star Award, Department of Physical Therapy, University of
Toronto, 2002
Paul Dorian
St. Michael’s Hospital Electrophysiology Professorship 2003
C. Ross Ethier
Tier I Canada Research Chair in Computational Technology
Mansoor Husain
Appointment to Board, Canadian Hypertension Society
Appointment to Executive, Corporate Officer, Ontario Hypertension
Society
Appointment to Co-Chair, Scientific Review Committee “II”, Heart &
Stroke Foundation of Canada
Premier’s Research Excellence Award
E.D. Wigle Teaching Award
Len Goodman
Associate Fellow, Aerospace Medical Association
Gary Lewis
Canada Research Chair in Diabetes, 2001-2006
Career Investigator Award (first renewal), Heart & Stroke
Foundation of Canada, 2003-2008
Thomas Lindsay
External Referee, Heart & Stroke Foundation of Canada
Traveling Award, Peripheral Vascular Surgery Society
David Naylor
Peterson Honour Lecture, Society for General Internal Medicine
(USA)
Research Achievement Award, Canadian Cardiovascular Society
Margaret Rand
Chair, Grant Allocation Committee, Heart & Stroke Foundation of
Ontario
Vivek Rao
Second Robert E. Gross Scholarship, American Association
of Thoracic Surgery
New Investigator Award, Canadian Institutes of Health Research
Leonard Schwartz Assessor, College of Physician and Surgeons of Ontario
Member, Antiplatelet Trialists, Oxford
Steering Committee, NIH Funded BARI 2D Trial
Donna Stewart
Symonds Award and Lecture, American Psychiatric Association
Margaret Mead Memorial Award & Lecture – Australia
Distinguished Fellow, American Psychiatric Association
Distinguished Lecturer World Psychiatric Congress, Japan
Master Educator Clinical Consultation, American Psychiatric Assoc.
Duncan Stewart
Recipient of the 2003 University of Toronto, Department of
Medicine, Research Award
MacDonald Lecturer, Queen’s University
Richard Weisel
John Foerster Lecturer Award, Inst. of Cardiovascular Sciences
Award
Council on Cardiothoracic and Vascular Surgery Mentor Award,
American Heart Association
Carin Wittnich
Appointed to the Board of Governors, Michener Institute
Queen’s Jubilee Medal
Graham Wright
I.I. Rabi Award Finalist, ISMRM papers Competition, 2002
(Co-author, Primary Author - M. Sussman)
Walter Berdon Award for Basic Science Paper in Pediatric
Radiology, 2003 (Co-author, Primary Author - L. Nield)
Lauterbur Award, Society of Computed Body Tomography and
Magnetic Resonance, Excellent Scientific Paper, 2003
Peer Reviewed Funding
Adamson SL: Genes Regulating Cardiovascular Function During Pregnancy in Mice.
Canadian Institutes of Health Research, 2001-2004
Adamson SL, Foster FS (co-applicant) In: MRC Group in Development and Fetal
health, Co-ordinator: S.J. Lye: Cardiovascular Phenotyping of Juvenile Mice using
Ultrasound Biomicroscopy.
Canadian Institutes of Health Research, 2000-2004
Adamson SL: Generation and Physiological Analysis of Genome-wide Mutations in
Mice.
Canadian Institutes of Health Research, 1999-2004
Adeli K (PI), Lewis G (Co-PI): Effects of Atorvastatin on Insulin Sensitivity: In Vivo
Animal and Human Models.
Canadian Institutes of Health Research, 2002-2004
Adeli K (PI), Lewis G (Co-PI): Rosiglitazone Effects on Hepatic and Intestinal
Lipoprotein Production in Insulin Resistant States.
Natural Science and Engineering Research Council of Canada, 2003-2004
Al-Radi O (PI), Weisel RD (Co-PI): Cell Transplantation for Diabetic Cardiomyopathy.
Physicians’ Services Incorporated Foundation, 2002-2003
Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Improving the
Accuracy of Cardiac Report Cards.
Canadian Institutes of Health Research, 2003-2005
Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Examining the
Accuracy of Cardiac Report Cards.
Heart & Stroke Foundation of Canada, 2003-2005
Backx P (PI), Husain M (Co-PI): Role of ACE2 in the Regulation of Cardiac and
Vascular Function.
Canadian Institutes of Health Research, 2003-2008
Bendeck M: The Role of Discoidin Domain Receptors in Atherosclerosis.
Canadian Institutes of Health Research, 2003-2007
Bendeck M: Tetracyclines in the Treatment of Vascular Disease.
Heart and Stroke Foundation of Ontario, 2001-2004
Bendeck M: Responses of Vascular Smooth Muscle Cells to Extracellular Matrix in
Atherosclerosis and Restenosis.
Canadian Institutes of Health Research, 2000-2003
Bendeck M: Ministry of Energy Science and Technology Ontario and Department of
Laboratory Medicine and Pathobiology.
Premier’s Research Excellence Award (PREA), 2000-2005
Bradley TD (PI): Senior Scientist Award
Canadian Institutes of Health Research, 2000-2005
Bradley TD (PI), Floras J (Co-Investigator): Cardiopulmonary Interactions in Health
and Disease.
Medical Research Council of Canada, 2002-2005
Bradley TD, Floras J (Co-Investigator), Logan AG, Remmers JE, Fleetham JA,
Ferguson K, Kimoff RJ, Series F (Co-Applicants): Multicentre Trial of Continuous Positive
Airway Pressure (CPAP) for Chronic Therapy of Heart Failure.
Medical Research Council of Canada/Canadian Institutes of Health Research,
University-Industry Grant, 1998-2004
Brooks D: New Investigator Award.
Canadian Institutes of Health Research, 2001-2006
Brooks D, Goldstein R: Individualized Pulmonary Rehabilitation (PR) After Acute
Exacerbation (AE) of COPD.
Ontario Thoracic Society, 2003-2004
Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study.
Collaborative Research Program, 2003-2004
Brooks D: Effect of a Rollator on Activity Levels and Health-Related Quality of Life in
Individuals with Chronic Obstructive Pulmonary Disease (COPD).
Harman Fund West Park Health Care Centre, 2002-2004
Brooks D, Goldstein R: Effect of a Rollator on Activity Levels and Health-Related
Quality of Life in Individuals with Chronic Obstructive Pulmonary Disease (COPD).
Physician Services Inc., 2002-2004
Brooks D: The Quality of Clinical Practice Guidelines in Physical Therapy.
Physiotherapy Foundation, 2002-2003
Brooks D, Thomas S: Prediction of Participation in Cardiac Rehabilitation by Coronary
Artery Bypass Graft Patients from Pre-Operative Measures.
Toronto Rehabilitation Foundation, 2002-2003
Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study.
Toronto Rehabilitation Foundation, 2002-2004
Cernacek P (AP), Rouleau JL, Stewart DJ (Co-Ap’s): Endothelin Blockade in Heart
Failure and Hypertrophy: Which Receptor and When?
Medical Research Council of Canada, 2000-2004
Cicutto L, Brooks D: Self-Care and Adherence Issues in Managing Chronic
Obstructive Pulmonary Disease: A Provincial Survey.
Ontario Respiratory Care Society, 2003
Cheung AM, Cameron JI, Hyman I, Franche R-L, Stewart DE: Predicting Emotional
Distress in Family Caregivers: Analysis of the Longitudinal National Population Health
Survey Data.
National Health Research and Development Program (NHRDP), 2000-2003
Cheung AM, Cameron J, Stewart DE, Coyte PC, Streiner DL, Feldberg GD: When
Homecare Ends and Institutional Care Begins: A Longitudinal Study of Stroke Survivors
and their Family Caregivers.
Social Sciences and Humanities Research Council (SSHRC), 2001-2004
Demeules M, Stewart DE (Co-PI’s), Payne J, Vissandjee B (Co-Investigators),
Kazanjion A, Maclean H, Mao Y (Authors): Canadian Women’s Health Surveillance
Report: A Multidimensional Look at the Health of Canadian Women.
Canadian Population Health Initiative, 2001-2003
Dorian P: Optimizing ACLS: Prolonging Action Potential Duration and Preventing Cell
Injury in Experimental Cardiac Arrest.
Heart & Stroke Foundation of Ontario, 2003-2005
Ethier CR: Computational Hemodynamics.
National Science and Engineering Research Council, 2001-2005
Ethier CR: The Hydrodynamics of Aqueous Humor Outflow.
National Institutes of Health (subgrant), 1998-2002
Ethier CR: Factors Controlling Aqueous Outflow Resistance in Glaucoma.
Canadian Institutes of Health Research, 2001-2004
Ethier CR: In Vivo Testing and Licensing of a Glaucoma Shunt Valve.
Canadian Institutes of Health Research (Proof of Principle Fund), 2003-2004
Flanagan JG (PI), Ethier CR: The Role of Lamina Cribrosa Biomechanics and
Ischemia in Glaucomatous Optic Neuropathy.
Canadian Institutes of Health Research, 2001-2005
Floras J: Career Investigator Award (CI4817).
Heart & Stroke Foundation of Ontario, 2001-2006
Floras J: Cardiovascular Regulation in Men and Women with Heart Failure and
Hypertension.
Heart & Stroke Foundation of Ontario, 2002-2007
Floras J: Peptidergic and Purinergic Modulation of the Autonomic Nervous System in
Humans.
Canadian Institutes of Health Research Operating Grant, 2002-2007
Floras J (PI), Chan C, Miller J, Pierratos A (Co-Investigators): By What Mechanisms
Does Conversion from Conventional Intermittent Dialysis to Nocturnal Hemodialysis
Lower Blood Pressure?
Canadian Institutes of Health Research, 2002-2005
Friesen J (PI), Sefton MV (Co-investigator): Centre for Cellular and Biomolecular
Research.
CFI, 2000-2005
Gagnon AJ (PI), Oxman-Martinez J, Janssen PA, Stewart DE, Wahoush O, et al (CoPI’s): Development of Migration and Reproductive Health Studies.
Canadian Institutes for Health Research, 2003-2004
Gagnon A, Oxman-Martinez J, Stewart DE, et al: Pregnancy and Child Bearing in
Refugees: Transitional Health (PACBIRTH) Phase 1.
Canadian Institutes for Health Research, 2002-2004
Gagnon AJ, Oxman-Martinez J, Stewart DE, et al: Needs of Refugee Mothers After
Pregnancy (NORMAP-ERS) Phase 1.
Canadian Institutes for Health Research, 2002-2003
Geddes L (PI), Brooks D (Co-PI): Is Ventilatory Muscle Training Effective? A
Systematic Review.
Ontario Lung Association, 2002-2003
Goodman J, Allison K: Patterns of Physical Activity in Youth.
Heart & Stroke Foundation of Ontario, 2002-2007
Goodman J: Aerobic and Resistance Training in Coronary Patients
Toronto Rehabilitation Institute, 2002-2003
Gotlieb A (PI), Bendeck M (Co-Investigator): Heart Valve Repair: Regulation by Cells
and Matrix.
Heart and Stroke Foundation of Ontario, 2002-2005
Gotlieb AI, Langille BL (Co-Applicant): The Endothelium in Atherogenesis: Influences
of Hemodynamic Stresses.
Canadian Institutes of Health Research, 2001-2006
Gotlieb AI, Langille BL (Director): Member, Cell Biology of Atherosclerosis, Program
Grant.
Heart & Stroke Foundation of Ontario, Infrastructure Support, 2000-2005
Grace SL (PI), Brooks D (Co-PI): Evaluating an Education Tool to Increase Referral of
Women to Cardiac Rehabilitation.
Toronto Rehabilitation Foundation, 2002-2003
Grace SL, Stewart DE, (PI’s), Abramson B, Brooks D, Jaglal S, Scholey P, Suskin N,
Arthur H, Evindar E (Co-Applicants): An Evidence-Based Health Services Evaluation of
Informational and Management Continuity in Heart Patients.
Canadian Health Services Research Foundation, 2003-2006
Graham SJ (PI), Black S, Bronskill M, Grady C, Henkelman M, McIlroy W, Plewes D,
Stainsz G, Warner E, Wright G (Co-Investigators): Centre for Research Using
Magnetic Resonance at Sunnybrook and Women’s College Health Sciences Centre.
Canadian Institute of Health Research, 2002-2005
Henkelman M, Bronskill M, Foster S, Plewes DB, Yaffe M, Rowlands J, Wright GA:
Medical Imaging for Cancer.
National Cancer Institute of Canada, 2001-2006
Hudson C: The Establishment of a Multi-Disciplinary Laboratory for the Research of
Sight-Threatening Diabetic Retinopathy.
Canadian Foundation for Innovation (New Opportunities Scheme), 2000-2005
Hudson C: A Prospective, Long-Term Study of the Natural History of Diabetic Macular
Edema (DEM).
Premier’s Research Excellence Awards, 2000-2003
Hudson C: Pre-Clinical Detection and Improved Monitoring Sight-Threatening Diabetic
Retinopathy.
Canadian Institutes of Health Research (New Investigator Award), 2001-2006
Husain M (PI): Molecular Regulation of Vascular Smooth Muscle Cell Proliferation.
Clinician-Scientist Award – Phase II.
Canadian Institutes of Health Rsearch, 2001-2004
Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular
Smooth Muscle Cell Biology.
Canadian Institutes of Health Research, 2003-2008
Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular
Pathophysiology.
Heart & Stroke Foundation of Ontario, 2003-2006
Husain M (PI): c-Myb-Dependent Vascular Smooth Muscle Proliferation.
Canadian Institutes of Health Research, 2001-2004
Husain M (PI): Conditional Expression of PMCA Isoforms in Arterial Smooth Muscle of
Transgenic Mice.
Heart & Stroke Foundation of Ontario, 2000-2003
Irvine J (PI), Dorian P (Co-PI): Psychological Support for Implantable Defibrillator
Patients.
Heart & Stroke Foundation of Ontario, 2003-2006
Iwanochko M (PI), Floras J (Co-Investigator), Urowitz M (Co-Applicant): Endothelial
Dysfunction in SLE: Its Contribution to Abnormalities in Coronary Perfusion and the Role
of ACE Inhibition.
Heart & Stroke Foundation of Ontario, 2001-2003
Katz J, Gagliese L, Snijdelaar D, Stewart DE, Macrae H, Taddio A, Sandler P: Gender
Differences in Pain and Analgesic Response to Kappa & Mu Opioids After Surgery.
Canadian Institutes for Health Research, 2000-2003
Keeley FW: Post-Transcriptional Regulation of Vascular Elastin Synthesis in
Development and Disease.
Medical Research Council of Canada (CIHR), 2001-2006
Keeley FW: Recombinantly Expressed Polypeptides of Human Elastin as a Novel Tool
for Investigations of the Structure and Assembly of Elastin.
Heart & Stroke Foundation of Ontario, 2001-2004
Keeley FW: Characterization of Extracellular Matrix Proteins in Lamprey Cartilage (In
collaboration with Dr. G.M. Wright, Department of Anatomy and Physiology, Atlantic
Veterinary College, University of Prince Edward Island).
Natural Science and Engineering Research Council of Canada, 2001-2005
Langille BL (Director), Bendeck M, Cybulsky, M, Husain M, Gotlieb A, Marsden P,
Stewart D, Strauss B, Ward M (Co-Investigators): The Cell Biology of Atherosclerosis
Group Grant
Heart and Stroke Foundation of Ontario, 2000-2005
Lewis G (PI): VLDL Overproduction in Insulin Resistant/Hyperinsulinemic States.
Canadian Institutes of Health Research, 2001-2004
Lewis G (PI): Mechanism of Enhanced HDL Particle Catabolism in
Hypertriglyceridemic States.
Heart & Stroke Foundation of Ontario, 2002-2005
Lewis G (PI): Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated
Insulin Secretion.
Canadian Diabetes Association, 2003-2005
Lewis G (PI): Mechanisms of Insulin Sensitization with Vasopeptidase Inhibitors.
Heart & Stroke Foundation of Ontario, 2003-2006
Lewis G (Co-PI): Glucose Toxicity: Prevention of Diabetes Complications and
Preservation of Pancreatic Beta Cell Function.
Canadian Institutes of Health Research, 2002-2007
Li R-K (PI): Cell Transplantation for Diabetic Cardiomyopathy.
Canadian Diabetes Association, 2002-2004
Li R-K (PI): Autologous Tissue-Engineered Grafts for Congenital Heart Surgery.
Canadian Institutes of Health Research, 2003-2008
Li R-K (PI): Vasculogenesis Induced by Cell Transplantation.
Heart & Stroke Foundation of Ontario, 2003-2007
Lindsay TF: Ruptured Abdominal Aortic Aneurysm: Early Organ Injury Prevention
Strategies.
The Physicians Services Incorporated Foundation, 2002-2004
Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ
(Members): Determinants of Host Susceptibilities of Heart Failure.
Canadian Institutes of Health Research Group Grant, 2000-2003
Liu P (AP), Backx P, Husain M, Parker T, Rabinovitch M, Rouleau JL, Sole MJ,
Stewart DJ (Co-Ap’s): The Determinants of Host Response and Susceptibility in the
Development of Health Network.
Canadian Institutes of Health Research, 2001-2004
Liu P (Ap), 31 (Co-Ap’s) including Wittnich C: A Training Program in Cardiovascular
Research: Molecules to Humans, Heart Failure to Prevention (TACTICS).
Canadian Institutes of Health Research, 2002-2007
Logan AG (PI), Bradley TD (Co-Investigator): Uncontrolled Systolic Hypertension and
Obstructive Sleep Apnea.
Heart & Stroke Foundation of Ontario, 2001-2004
Magee L, von Dadelszen P, Guyatt G, Koren G, Ross S, Stephenson M, Stewart DE:
Measuring Quality of Life in Nausea and Vomiting of Pregnancy (NVP): Assessment of
the Measurement of a New Evaluation Questionnaire.
The Vancouver Foundation, 2001-2002
McIlroy W, Brooks D, Thomas SG, et al: Early Exercise Intervention After Stroke:
Influence on Functional Capacity, Sensorimotor Recovery and Risk of future Strokes.
Canadian Institutes of Health Research, 2003-2006
Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ
(Members): Determinants of Host Susceptibilities of Heart Failure.
Canadian Institutes of Health Research Group Grant, 2003-2008
Nag S (AP), Stewart DJ (Co-Ap): Regulation of Cerebrovascular Hemeostasis and
Repair by Angiogenic Factors.
Heart & Stroke Foundation of Canada, 2002-2004
Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s), Angus J, Rouleau JL, Franche R-L,
Rosser W, Alter D, Picard L, Michel I, Crichton T, Haider L, Micevski V, Grace SL (CoApplicants): Community Outreach and Heart Health Risk Reduction Trials (COHRT)
Component Study 1: Efficacy of group outreach methodology.
Heart & Stroke Foundation of Ontario, 2002-2006
Parker JD (PI), Floras J (Co-Investigator): Investigations Concerning the Control and
Modulation of Cardiac and Renal Sympathetic Activity in Chronic Heart Failure.
Heart & Stroke Foundation of Ontario, 2001-2004
Peltier R (PI), Ethier CR: PsciNet II Computing Upgrade.
CFI/OIT/Compaq Canada, 2002-2003
Plewes DB (PI), Wright GA (Co-Investigator): Centre for Research using Magnetic
Resonance at Sunnybrook and Women’s College Health Sciences Centre.
Medical Research Council of Canada, 1999-2002
Rabinovitch M, Keeley F (Directors), Bruneau B, Hinek A, Husain M, Wilson G
(Members): Interdisciplinary Program in Cardiovascular Development and Disease.
Canadian Institutes of Health Research Group Grant, 2000-2005
Rand ML, Freedman: The Procoagulant Surface of Activated Platelets: Persistence In
Vitro and In Vivo.
Heart & Stroke Foundation of Ontario, 2001-2004
Rose, Hudson C: The Impact of Age and Exogenous Insulin on Retinal Capillary Blood
Flow and Autoregulation.
Vision Science Research Program, 2002-2005
Rose, Hudson C: Age-Related Changes in Retinal Vascular Auto-Regulation in Normal
and Atherosclerotic Patients.
Heart & Stroke Foundation of Canada, 2002-2005
Rowlands J, Wright G, Cohen E, Fremes S, Fort S, Stewart D, Foster S, Burns P,
Chauhan V, Wilson G: Imaging Research Centre for Cardiac Intervention.
Canadian Foundation for Innovation, 2002-2006
Rukholm E, Angus J, Nolan RP, Picard L, Michel I, Rouleau JL, Franche R-L, Stewart
DE, Alter D: Component Study 2: Cultural and Socio-Geographic Moderators of Risk
Factor Reduction.
Stewart DE, Angus J, Nolan RP, Picard L, Michel I, Rukholm E, Franche R-L, Alter D,
Grace S: Component Study 3: Gender-Based Mediators of Risk Factor Reduction.
Toronto Rehab Research Institute, 2002
Schwartz L (PI), Detre K (UofPittsburgh), Frye R (Mayo Clinic) (Collaborators): BARI 1
Extension.
NHLBI, 1996-2002
Schwartz L (PI), Steiner G, Detre K, Frye R (Collaborators): BARI 2D.
National Institutes of Health, 2001-2009
Schwartz L (Co-Investigator): Psychological Factors in Restenosis.
Medical Research Council, 2002-2003
Sefton M (PI), Gotlieb AI, Yeo, E (Collaborators): Modular Tissue Engineering
Components for Vascularized 3-D Constructs.
National Institutes of Health (US), 2002-2005
Sefton M, Semple J, et al: Establishment of an Advanced Reconstructive Tissue
Engineering Centre.
ORDCF, 2001-2006
Sefton MV (PI), Gorczyniki R: Immunoisolation of Mammalian Cells in a Synthetic
Polymer.
Canadian Institutes of Health Research, 2000-2003
Sefton MV (PI): Tissue Engineering.
Natural Science and Engineering Research Council of Canada, 1999-2007
Sefton MV (PI): The New Institute of Biomaterials and Biomedical Engineering.
Whitaker Foundation, 2000-2003
Sefton MV (PI): Biomaterial-Induced Blood Vessels: Wound Dressing.
Materials & Manufacturing Ontario (with Rimon Therapeutics), 2001-2002
Sefton MV (PI), et al: McLaughlin Centre for Biomaterials and Tissue Engineering.
Ontario Innovation Trust, 2001-2006
Sefton MV (PI), Levy GA: Training Program in Regenerative Medicine.
Canadian Institutes of Health Research, 2002-2007
Singer P, Cheung AM, Deber R, Dickens B, Flood, Lemmens T, Mullen M, Mykitiuk R,
Robertson A, Stewart DE, Till J: Canadian Program on Genomics and Global Health:
International and Comparative Perspectives on Health Systems and Insurance
Implications of New Genetic Testing.
Genome Canada, 2001-2006
Slutsky AS: Biotrauma: Physiological Mechanisms, Biological Consequences.
Medical Research Council of Canada, 1999-2004
Slutsky AS, St. Michael’s Hospital: Critical Care Unit for Research Excellence
(CCURE). (Group Grant including approx. 20 critical care physicians/specialists from
southern Ontario).
Canada Foundation for Innovation/Ontario Innovative Trust, 2002-2006
Slutsky AS, Zhang H: Cytokines and Oxygen Free Radicals.
Plasma and Protein Therapeutics Association, 2002-2003
Stewart D (PI), Husain M (Co-PI): Targeted Over-Expression of Inducible NO
Synthase: Relevance for the Pathogenesis of Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2002-2005
Stewart D (PI), Husain M (Co-PI): Pathophysiological Relevance of Endothelin-1
Over-Expression.
Canadian Institutes of Health Research, 2001-2004
Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in
Diabetes Education Service Use and its Impact on Diabetes Management Outcomes.
Canadian Diabetes Association, 2003-2005
Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in
Diabetes Education Service Use.
University of Toronto Banting and Best Diabetes Centre, 2003-2005
Stewart DE, Bercovitz K, Poland BD, Cohen JE, Selby PL, Ferrence RG: Reducing
Environmental Tobacco Smoke Exposure in Private Places: A Qualitative Study of
Postpartum Women, Partners, and Tobacco Control Advocates.
Canadian Tobacco Control Research Initiative (SSHRC), 2001-2004
Stewart DE, Ahmad F: Popular Health Promotion Strategies Among Chinese and East
Indian Immigrant Women.
Social Sciences and Humanities Research Council (SSHRC), 2001-2003
Stewart DJ: Clinical Relevance of Endothelial Dysfunction.
Medical Research Council of Canada, 1995-2002
Stewart DJ (AP), Courtman D (Co-Ap): Microvascular Endothelial Cell Loss in
Pulmonary Hypertension.
Canadian Institutes of Health Research, 2002-2006
Stewart DJ, et al: Multicentre Randomized Double Blind Placebo Control Clinical Trial
of DNA for VEGF165 in the Treatment of Angina Pectoris.
Canadian Institutes for Health Research, 2001-2004
Stewart DJ (AP), Husain M (Co-Ap): Targeted Over-Expression of Inducible NO
Synthase: Relevance for the Pathogenesis of Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2002-2005
Stewart DJ, et al: Cardiovascular Gene Therapy Initiative.
Canadian Foundation for Innovation Fund 2000, 2001-2004
Stewart DJ: Biological and Therapeutic Potential of Angiopoietins.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ (AP), Fitchett DH, Batchelor WB (Co-Ap’s): Controlled Trial of VEGF DNA
in Severe Angina.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ (AP), Husain M (Co-Ap): Pathophysiological Relevance of Endothelin-1
Overexpression.
Canadian Institutes for Health Research, 2001-2005
Stewart DJ: Gene and Cell-Based Therapies for Cardio-Respiratory Disorders.
Heart & Stroke Foundation of Canada/CIHR New Frontiers Program, 2001-2004
Thomas SG, Brooks D: Predicting Participation in Cardiac Rehabilitation After
Coronary Artery Bypass Surgery.
TRI Research Fund, 2002-003
Thomas SG, Franche R-L: Cardiac Rehabilitation and Readiness to Return to Work in
Patients with Cardiovascular Disease.
Toronto Rehab. Institute. Toronto Cardiac Care Network, 2002-2003
Weisel RD: Protection from Perioperative Ischemia.
Heart & Stroke Foundation of Ontario, 2002-2003
Weisel RD: Endothelin, Perioperative Ischemia and Diabetes.
Canadian Diabetic Association, 2002-2003
Wilson GJ, Backx PH: Ischemic Preconditioning of the Myocardium: Role of Cell
Volume Regulation.
Heart and Stroke Foundation of Ontario, 2002-2006
Wilson GJ, Courtman DW: Acellular Matrix: Tissue Engineering Approaches for
Pediatric Cardiovascular Reconstruction.
Canadian Institutes for Health Research, 2000-2003
Wittnich C: Impact of Gender on Myocardial Pathology and Ischemia/Reperfusion.
Heart & Stroke Foundation of Ontario, 2001-2004
Wittnich C: Oxygen Stress in Newborn Hearts.
Heart & Stroke Foundation of Ontario, 2002-2006
Wright GA, et al...Merchant N, Mickleborough L, Wittnich C: Magnetic Resonance
Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 1999-2003
Wright GA: Magnetic Resonance Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 2000-2006
Wright GA, Merchant N, Rubin BB: Magnetic Resonance Imaging for Ischemia.
Medical Research Council of Canada, 2000-2005
Wright GA, Prato F: Ontario Consortium for Cardiac Imaging.
Ontario Research and Development Challenge Fund, 2000-2005
Verma S (PI), Weisel RD (Co-Applicant): C-Reactive Protein: Biochemical, Cellular and
Pharmacological Perspectives.
GlaxoSmithKline, 2002-2003
Yau, TM (PI), Weisel RD (Co-Applicant): Insulin Cardioplegia for Poor Left Ventricular
Function.
Heart & Stroke Foundation of Ontario, 2002-2003
Zingg DW (PI), Ethier CR: Development and Application of LES Algorithms for
Simulation of Turbulent Flows.
Connaught Foundation, 2002-2005
PUBLICATIONS - FACULTY
Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC:
Interactions between trophoblast cells and the maternal and fetal circulation in the
mouse placenta. Dev Biol, 2002;250(2):358-73.
Afroze T, Husain M: c-Myb-mediated transcription of multiple Ca2+ transporters at the
G1/S transition point of vascular smooth muscle cells. Recent Res Devel Biol Chem,
2002;273-285. (ISBN 81-7736-153-8)
Afroze T, Yang LL, Wang C, Gros R, Kalair W, Hoque ANE, Mungrue I, Zhu Z, Husain
M: Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in mouse
vascular smooth muscle cell cycle. Am J Physiol: Cell Physiol, 2003;285(1):C88-95.
Ahmad F, Gupta H, Rawlins J, Stewart DE: Preferences for gender of family
physicians among Canadian European-descent and South Asian immigrant women.
Fam Pract, 2002;19:146-53.
Akhyari P, Fedak PWM, Weisel RD, Lee JYJ, Verma S, Mickle DAG, Li R-K:
Mechanical stretch regimen enhanced the formation of bioengineered autologous
cardiac muscle grafts. Circulation (Suppl), 2002;106:I137-I142.
Allison KR, Adlaf EM, Dwyer JJM, Goodman J: Physical activity patterns in Canadian
youth. Can J Public Health, 2003;94:272-274.
Al-Radi OO, Rao V, Li R-K, Yau T, Weisel RD: Cardiac cell transplantation: Closer to
bedside. Ann Thorac Surg, 2003;75:S674-S677.
Alter D, Naylor CD, Austin P, Benjamin T, Tu J: Geography and service supply do not
explain socioeconomic gradients in angiography use after acute myocardial infarction.
CMAJ, 2003;168(3):261-4.
Austin LA, Ahmad F, McNally MJ, Stewart DE: Breast and cervical cancer screening in
Hispanic women: A literature review using health belief model. Womens Health Issues,
2002;12:122-28.
Babaei S, Stewart DJ, Picard P, Monge JC: Effects of vasocare therapy on the
initiation and progression of atherosclerosis. Atherosclerosis, 2002;162:45-53.
Babaei S, Stewart DJ: Overexpression of endothelial NO-synthase induces
angiogenesis in a co-culture model. Cardiovasc Res, 2002;55:190-200.
Babaei S, Teichert-Kuliszewska K, Zhang Q, Jones N, Dumont DJ, Stewart DJ:
Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide. Am J
Pathol, 2003;162:1927-1936.
Barbone A, Rao V, Oz MC, Naka Y: LVAD Support in patients with bioprosthetic
valves. Ann Thorac Surg, 2002;74:232-234.
Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ: Pharmacological
preconditioning in rabbit myocardium is blocked by chloride channel inhibition.
Cardiovasc Res, 2002;55(3):660-671.
Belanger MP, Askin N, Wittnich C: Multiple “in vivo” liver biopsies using a freezeclamping technique. J Invest Surg, 2002;15(2):109-112.
Bendeck MP: Targeting pericellular proteolysis in vascular disease (Editorial), Circ
Res, 2002;91:861-862.
Bergman B, Ahmad F, Stewart DE: Physician health, stress and gender at a university
hospital. J Psychosom Res, 2003;54:171-178.
Billia F, Carter K, Rao V, Gorzynkski R, Feindel CM, Ross HJ: TGF-β expression is
significantly lower in hearts preserved with blood/insulin versus crystalloid cardioplegia.
J Heart and Lung Transplant, 2002;21:918-922.
Bonert M, Myers JG, Fremes S, Williams J, Ethier CR: A numerical study of blood flow
in CABG side-to-side anastomoses. Ann Biomed Eng, 2002;30:599-611.
Borger MA, Yau TM, Rao V, Scully HE, David TE: Reoperative mitral valve
replacement: Importance of preservation of the subvalvular apparatus. Ann Thorac
Surg, 2002;74:1482-1487.
Bradley TD, Tkacova R. Hall MJ, Ando S, Floras JS: Augmented sympathetic neural
response to simulated obstructive apneas in heart failure. Clin Sci, 2003;104:231-238.
Bradley TD, Floras JS: Sleep apnea and heart failure. Part I: Obstructive sleep apnea.
Circulation, 2003;107:1671-1678.
Bradley TD, Floras JS: Sleep apnea and heart failure. Part II: Central sleep apnea.
Circulation, 2003;107:1822-1826.
Bradley TD, Floras JS, Usui K: Continuous positive airway pressure in patient with heart
failure (reply). N Engl J Med, 2003;349:94-95.
Brooks D, Solway S, Weinacht K, Wang D, Thomas S: An outdoor six-minute walk
test to evaluate functional status among individuals with chronic obstructive pulmonary
disease. Arch Phys Med Rehab, 2003;84(6):873-876.
Brooks D, Solway S: ATS guidelines on the six minute walk test (Letter to the Editor).
Am J Respir Crit Care Med, 2003;167:1287.
Brooks D, Hunter JP, Parsons J, Livsey E, Quirt J, Devlin M: Reliability of the twominute walk test in individuals with transtibial amputation. Arch Phys Med Rehab,
2002;83:1562-1565.
Brooks D, DeRosie J, Mousseau M, Avendaño M, Goldstein RS: Home mechanical
ventilation: long-term follow up in patients with thoracic restriction and neuromuscular
disease. Can Respir J, 2002;9:99-106.
Brooks D, Krip B, Mangovski-Alzamora S, Goldstein RS: The effect of postrehabilitation programs among individuals with COPD. Eur Respir J, 2002;20:1-10.
Brooks D, Newbold N, Kozar L, Rivera M: The flutter device and expiratory pressures.
J Cardiopulmonary Rehab, 2002;202:53-57.
Brooks D, Parsons J, Newton J, Dear C, Silaj E, Sinclair L, Quirt J: Discharge criteria
from peri-operative physical therapy. Chest, 2002;121:488-494.
Brooks D, Parsons J, Newton J: Profile of cardiorespiratory physical therapy among
students and clinicians in Toronto. Can Nurses’ Respir Soc and Can Physiotherapy
Cardio-Respiratory Soc Bulletin, 2003;1S-5S.
Brooks D, Tonack M, King A, Simson H, Gould M: Ventilator users reveal important
elements to quality of life. Advance for Managers of Respiratory Care, 2002;11:20-22.
Cameron JI, Franche RL, Cheung AM, Stewart DE: Lifestyle interference and
emotional distress in family caregivers to advanced cancer patients. Cancer,
2002;94:521-27.
Carpentier A, Patterson BW, Leung N, Lewis GF: Sensitivity to acute insulin-mediated
suppression of fasting plasma free fatty acids is not a determinant of VLDL triglyceride
secretion in healthy humans. Diabetes, 2002;51:1867-1875.
Carpentier A, Taghibiglou C, Leung N, Szeto L, Van-Inderstine S, Uffelman K,
Buckingham R, Adeli K, Lewis GF: Ameliorated hepatic insulin resistance is
associated with normalization of microsomal transfer protein (MTP) expression and
reduction in VLDL assembly and secretion in the fructose-fed hamster. J Biol Chem,
2002;277(32):28795-28802.
Carpentier A, Leung N, Giacca A, Hanley AJG, Harris S, Hegele RA, Zinman B, Lewis
GF: Free Fatty Acid-mediated desensitization of glucose-stimulated insulin secretion in
non-diabetic Oji-Cree Individuals from the Sandy Lake Community of Ontario. A
Population at Very High Risk for Developing Type 2 Diabetes. Diabetes, 2003;52:14851495.
Chan C, Floras JS, Miller JA, Pierratos A: Improvement in ejection fraction by
nocturnal hemodialysis in end-stage renal failure patients with coexisting heart failure.
Nephrology Dialysis Transplantation, 2002;17:1518-1521
Cheng DC, Wall C, Djaiani G, Peragallo RA, Carroll J, Li C, Naylor CD: Randomized
assessment of resource use in fast-track cardiac surgery 1-year after hospital
discharge. Anesthesiology, 2003;98(3):651-7.
Cheng KC, Zhang H, Lin CY, Slutsky AS: Ventilation with negative airway pressure
induces a cytokine response in isolated mouse lung. Anesth Analgesic, 2002;94:15771582.
Cohen G, Christakis GT, Joyner CD, Morgan CD, Tamariz M, Hanayama N, Mallidi H,
Szalai JP, Katic M, Rao V, Fremes SE, Goldman BS: Are stentless valves
hemodynamically superior to stented valves? A prospective randomized trial. Ann
Thorac Surg, 2002;73:767-778.
Cohen MM, Schei B, Ansara D, Gallop R, Stuckless N, Stewart DE: A history of
personal violence and postpartum depression: Is there a link? Arch Women Ment
Health, 2002;4:83-92.
Crow AR, Leytin V, Starkey AF, Rand ML, Lazarus AH: CD154 (CD40 ligand) deficient
mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates.
J Thromb Haemost, 2003;1:850-852.
Crystal E, Kahn S, Roberts R, Thorpe K, Gent M, Cairns JA, Dorian P, Connolly S, on
behalf of CAMIAT investigators: Chronic amiodarone therapy and the risk of
complications after cardiac surgery: Results from the Canadian Amiodarone Myocardial
Infarction Arrhythmia Trial (CAMIAT). J Thorac Cardiovasc Surg, 2003;125:633-7.
Cunningham CH, Wright GA, Wood ML: High order multi-band encoding in the heart.
Mag Resonance Med, 2002;48(57):753-64.
D’Alessandro DA, Rao V, DiGiorgi PL, Naka Y, Oz MC: Current options for mechanical
heart technology. J Card Surg, 2002;17:81-88.
Dagenais GR, Armstrong PW, Theroux P, Naylor CD: CCS Ad Hoc Committee for
Revising the CCS Grading of Stable Angina. Revisiting the Canadian Cardiovascular
Society grading of stable angina pectoris after a quarter of a century of use. Can J
Cardiol, 2002;18(9):941-944.
Delgado DH, Luu L, Edwards J, Cardella C, Rao V, Ross HJ: Should moderate acute
rejection of a cardiac transplant graft be treated? Clin Transplant, 2002;16:217-221.
Delgado DH, Rao V, Ross HJ: Donor management in cardiac transplantation. Can J
Cardiol, 2002;18:1217-1223.
DePerrot M, Imai Y, Volgyesi GA, Waddell TK, Liu M, Mullen JB, McRae K, Zhang H,
Slutsky AS, Ranieri VM, Keshavjee S: Effect of ventilator-induced lung injury on the
development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc
Surg, 2002;124(6):1137-1144.
Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of
MR measures of pressure with microbubbles. Mag Reson Med, 2002;47:264-273.
Dhillon B, Badiwala MV, Li S-H, Li R-K, Weisel RD, Mickle DAG, Fedak PWM, Rao V,
Verma S: Caveolin: A key target for modulating nitric oxide availability in health and
disease. Mol Cell Biochem, 2003;247:101-109.
Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ: Enhanced cell
volume regulation: A key protective mechanism of ischemic preconditioning in rabbit
ventricular myocytes. J Mol Cell Cardiol, 2003;35(1):45-58.
DiGiorgi P, Rao V, Oz MC: Which patient, which pump? J Heart Lung Transplant,
2003;22:221-235.
Dorian P, Dunnmon P, Elstun L, Newman D: The effect of isoproterenol on the class III
effect of azimilide in humans. J Cardiovasc Pharmacol Ther, 2002;7:211-7.
dos Santos C, Chant G, Slutsky AS: Pharmacotherapy of acute respiratory distress
syndrome (a review). Expert Opinion Pharmacotherapy, 2002;3(7):875-888.
Emmett L, Iwanochko, RM, Barolet A, Freeman M, Lee D, Husain M: Reversible
regional wall motion abnormalities on exercise Tc-99m gated cardiac SPECT predict
high-grade angiographic stenoses. J Am Coll Cardiol, 2002;39:991-998.
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ACKNOWLEDGEMENTS:
The Cardiovascular Sciences Collaborative Program would like to thank the following
industry sponsors for their generous support.
Industry Sponsors
Biovail Pharmaceuticals Canada
Bristol-Myers Squibb Company
Medtronic Canada
Merck Frosst Canada Inc.
Solvay Pharmaceuticals