Download Functional domains of the BRCA2 protein

expert reviews
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Transcriptional activation domain
Nuclear localisation signal
BRC repeats
N
C
OCCR1
(3059—4075)
Binding to
P/CAF
OCCR2
(6503—6629)
Binding to
Rad51
Functional domains of the BRCA2 protein
Published in Expert Reviews in Molecular Medicine by Cambridge University Press (2001)
Figure 1. Functional domains of the BRCA2 protein. The diagram shows the C-terminal nuclear localisation
signal and N-terminal transcriptional activation domain; the latter interacts with P/CAF (p300/CBP-associated
factor). Binding to the repair protein Rad51 is mediated by BRC repeats. Mutations in the ovarian cancer
cluster regions (OCCRs) have been suggested to increase the risk of ovarian, but not breast, cancer; however,
this remains controversial. Modified figure reproduced, with permission from Elsevier Science, from Ref. 11
[Welcsh, P.L, Owens, K.N. and King, M.C. (2000) Insights into the functions of BRCA1 and BRCA2. Trends in
Genetics 16, 69-74] (fig001mgb).
Accession information: (01)00310-6a.pdf (short code: fig001mgb); 14 May 2001
ISSN 1462-3994 ©2001 Cambridge University Press
Functional domains of the BRCA2 protein
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