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SEMINAR
1. Title : Generation of Nucleic Acid Biopolymers with Complex Functionalities
2. Speaker : Prof. Seung Soo Oh (Department of Materials Sci. and Eng. at POSTECH)
3. Time : 16:00 – 17:00, Thursday, March 31, 2016
4. Place : e+ Lecture Hall (room 83188), 2nd Research Building, Sungkyunkwan University
5. Summary : Over the last few decades, nucleic acids (e.g., DNAs and RNAs) have
proven to be an exceptionally versatile material beyond genetic information storage.
As a sequence controlled polymer, they fold into a unique structure and create a
variety of functionalities including molecular recognition, catalysis, construction of
complex patterns, and even nanomechanical motions. Importantly, these synthetic
constructs can be programmed to perform a wide range of molecular functions in a
controlled manner—this is a powerful feature that cannot be easily realized in other
macromolecules. Furthermore, when combined with other functional materials, they
offer unique capabilities with regards to the creation of molecular machines that can
perform complex functions in the right order at the right time.
To fully realize this potential, my work has focused on the development of novel
methodologies to generate nucleic acid-based multi-functional biopolymers and their
applications. Specifically, I will introduce an innovative in vitro selection strategy
enabling the discovery of functional DNA nanostructures that undergo bindinginduced structure-switching. I will subsequently show that the generated synthetic
allosteric regulators perform useful molecular functions for diagnostics, imaging and
targeted therapy applications. Furthermore, I will demonstrate a unique catalytic RNAs
(ribozymes) that recognize and polymerize the targeted short RNAs by processive
ligation events. Finally, I will describe a novel synthetic method to create hybrid
materials capable of performing complex, multi-step molecular processes by
integrating targeting nucleic acids (aptamers) with other materials (e.g. engineered
polymers) and demonstrate directly their applications in targeted drug delivery.
6 Background :
•
Education
2012
2007
2005
Ph.D. in Materials, University of California, Santa Barbara
M.S. in Materials Science and Engineering, Seoul National University, Korea
B.S. in Materials Science and Engineering, Seoul National University, Korea
•
Work
2016~Present Assistant Professor, Department of Materials Science and Engineering, POSTECH
2014-2016
Research Fellow, Harvard Medical School/Massachusetts General Hospital, Boston
2012-2014
Postdoc, University of California, Santa Barbara
7. Questions :
(☏ 031-299-4115)