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Activated Notch1 signaling promotes tumor cell
proliferation and survival in Hodgkin and anaplastic large
cell lymphoma
by Franziska Jundt, Ioannis Anagnostopoulos, Reinhold Förster, Stephan Mathas,
Harald Stein, and Bernd Dörken
Blood
Volume 99(9):3398-3403
May 1, 2002
©2002 by American Society of Hematology
Lymph node biopsy specimens of cHD and ALCL.(A-D) Paraffin-embedded sections
immunostained for Notch1 and counterstained with hematoxylin.
Franziska Jundt et al. Blood 2002;99:3398-3403
©2002 by American Society of Hematology
High Notch1 and Notch2 expression in cultured HRS and ALCL cells.(A) Upper panel: Western
blot analysis of cell lysate proteins from Hodgkin (lanes 1-5) cell lines, non-Hodgkin (lanes 6-10)
cell lines, mature CD2+ T cells (lane 11), and mature CD19+B cells ...
Franziska Jundt et al. Blood 2002;99:3398-3403
©2002 by American Society of Hematology
Activated Notch1 signaling promotes growth and survival of lymphoma cells.(A) Proliferative
responses of Notch1-expressing lymphoma cells after activation by Jagged1.
Franziska Jundt et al. Blood 2002;99:3398-3403
©2002 by American Society of Hematology