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Biochimica et Biophysica Acta
CONTENTS
Molecular and Cell Biology of Lipids
Abstracted indexed in: BIOSIS - Chemical Abstracts - Current Contents Life Sciences - EMBASE - EMBiology - Index Chemicus MEDLINE® - Science Citation Index Sociedad Iberoamericana de Información Científica (SIIC) Data Bases. Also covered in the abstract and citation database Scopus®. Full text available
on ScienceDirect ®
Special Issue: New Frontiers in Sphingolipid Biology
Guest Editors: J. Holthuis and Y. Igarashi
Preface
New frontiers in sphingolipid biology
J. Holthuis and Y. Igarashi
645
738
745
759
766
773
783
BBA
Biochimica et Biophysica Acta
Molecular and
Cell Biology of
Lipids
Special Issue
New Frontiers in
Sphingolipid Biology
793
799
Guest Editors
J. Holthuis
Y. Igarashi
811
1841/5
Sphingolipid homeostasis in the web of metabolic
routes
A. Aguilera-Romero, C. Gehin and H. Riezman
647
Sphingolipids and lifespan regulation
X. Huang, B.R. Withers and R.C. Dickson
657
Sphingolipids as modulators of membrane proteins
A.M. Ernst and B. Brügger
665
Ceramide synthases as potential targets for
therapeutic intervention in human diseases
J.-W. Park , W.-J. Park and A.H. Futerman
671
New insight into the structure, reaction
mechanism, and biological functions of
neutral ceramidase
M. Ito, N. Okino and M. Tani
682
The role of sphingomyelin and sphingomyelin
synthases in cell death, proliferation and
migration—from cell and animal models to
human disorders
M. Taniguchi and T. Okazaki
692
Co-evolution of sphingomyelin and the ceramide
transport protein CERT
K. Hanada
704
Imaging local sphingomyelin-rich domains in the
plasma membrane using specific probes and
advanced microscopy
M. Abe and T. Kobayashi
720
Sphingolipid regulation of ezrin, radixin, and
moesin proteins family: Implications for cell
dynamics
M. Adada, D. Canals, Y.A. Hannun and L.M. Obeid 727
Visualizing S1P-directed cellular egress by
intravital imaging
C.C. Giannouli, P. Chandris and R.L. Proia
Second generation S1P pathway modulators:
Research strategies and clinical developments
M. Bigaud, D. Guerini, A. Billich, F. Bassilana and
V. Brinkmann
Molecular and physiological functions of
sphingosine 1-phosphate transporters
T. Nishi, N. Kobayashi, Y. Hisano, A. Kawahara
and A. Yamaguchi
Sphingosine 1-phosphate is a key metabolite
linking sphingolipids to glycerophospholipids
A. Kihara
Sphingolipids in colon cancer
M. García-Barros, N. Coant, J.-P. Truman,
A.J. Snider and Y.A. Hannun
Autophagy paradox and ceramide
W. Jiang and B. Ogretmen
Pathological roles of ceramide and its metabolites in
metabolic syndrome and Alzheimer’s disease
K. Yuyama, S. Mitsutake and Y. Igarashi
Sphingolipids and lysosomal pathologies
H. Schulze and K. Sandhoff
Gaucher disease and Fabry disease: New markers
and insights in pathophysiology for two
distinct glycosphingolipidoses
M.J. Ferraz, W.W. Kallemeijn, M. Mirzaian,
D. Herrera Moro, A. Marques, P. Wisse, R.G. Boot,
L.I. Willems, H.S. Overkleeft and J.M. Aerts
Vol. 1841 (2014) 645 – 826
Special issue papers
ISSN 1388-1981
Volume 1841, Issue 5, May 2014
www.elsevier.com/locate/bbalip
Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta
BBA
BBA
Volume 1841, Issue 5, May 2014
ELSEVIER
Available online at www.sciencedirect.com
Founded in 1947 by H.G.K. Westenbrink
Managing Editor, 1947-1964
Honorary Executive Editor
E.C. Slater (UK)
Biochimica et Biophysica Acta
BBA
EDITOR-IN-CHIEF:
Uli Brandt (Nijmegen, Netherlands)
Molecular and Cell Biology of Lipids
Executive Editors:
Suzanne Jackowski (Memphis, TN, USA)
Rudolf Zechner (Graz, Austria)
Aims and Scope
The BBA Molecular and Cell Biology of Lipids section publishes papers on original research dealing with novel aspects of molecular genetics
related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and
function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or
functional insight in the area of lipids.
Regular papers and reviews are considered for publication.
BBA – Publication schedule for 2014
BBA is published according to a volume-numbering scheme that embraces all sections of the journal.
Full subscription: 10 volumes
BIOENERGETICS
BIOMEMBRANES
GENERAL
GENE
REGULATORY SUBJECTS
MECHANISMS
1 volume:
1 volume:
1 volume:
1837
(12 issues)
1838
(12 issues)
1839
(12 issues)
1 volume:
1840
(12 issues)
MOLECULAR
AND CELL
BIOLOGY
OF LIPIDS
MOLECULAR
BASIS
OF
DISEASE
MOLECULAR
CELL
RESEARCH
PROTEINS
AND
PROTEOMICS
1 volume:
1 volume:
1 volume:
1 volume:
1841
(12 issues)
1842
(12 issues)
1843
(12 issues)
1844
(12 issues)
REVIEWS
ON
CANCER
2 volumes:
1845 –1846
(4 issues)
Submission
It is a condition of publication that all manuscripts must be written in clear and grammatical English and be submitted to the Biochimica et
Biophysica Acta – Molecular and Cell Biology of Lipids Web site at http://ees.elsevier.com/bbalip. Minimal exceptions will be allowed. If you are
unable to provide an electronic version of your paper, please contact the Editorial Office prior to submission (e-mail: [email protected]).
Reviews on timely topics are considered for publication. Prospective authors of reviews should send a presubmission enquiry with key references
to the Editorial Office. Color figures in reviews are published free of charge.
For detailed instructions on the preparation of electronic artwork, please visit http://www.elsevier.com/artworkinstructions.
Language (Usage and Editing services). Please write your text in good English (American or British usage is accepted, but not a mixture of
these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to
conform to correct scientific English may wish to use the English Language Editing service available from Elsevier’s WebShop http://webshop.
elsevier.com/languageediting/ or visit our customer support site http://support.elsevier.com for more information.
Contact details for questions arising after acceptance of an article, especially those relating to proofs, are provided after registration of an article
for publication.
For a full and complete Guide for Authors, please
go to: http://www.elsevier.com/locate/bbalip
Color figures
Color figures are published free online, and published in printed issues at the author’s expense.
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image(s) and improve them to a professional standard. Please visit the website to find out more.
BBA has no page charges. The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail.
The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and
a disclaimer outlining the terms and conditions of use.
Available online at www.sciencedirect.com