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FEASIBILITY AND OUTCOME OF ROBOT ASSISTED SYMPLE PROSTATECTOMY- OUR EARLY EXPERIENCE. Federica Mazzoleni, Deliu-Victor Matei, Sara Melegari, Giacomo Galasso, Giovanni Cordima, Antonio Brescia, Gennaro Musi, Danilo Bottero, Serena Detti, Ottavio de Cobelli Divisione di Urologia, Istituto Europeo di Oncologia Objectives: The aim of this study is to evaluate outcome, feasibility and reproducibility of robot assisted approach for high-volume symptomatic benign prostatic hyperplasia . Patients & Methods: From March 2009 to March 2012 two surgeons, robot experienced, performed a total of 39 consecutive robot assisted simple prostatectomy (RASP) in patient with high volume prostatic hyperplasia. He used the technique previously described by Sotelo. Median prostate volume on preoperative TRUS was 99 ml. 25,7% of patients had indwelling catheter. Mean IPSS was 28. Results: Median operative time was 178 minutes, average hospitalization was 3 days, while average catheterization was 7 days. 25.1% of patients needed discontinuous or continuous catheter irrigation. Median blood loss was 100 cc, none needed blood transfusion. The average postoperative peak flow was 18.9 ml/s (p<0.001), while mean IPS-score was 7 (p<0.001). Discussion: When a surgical solution is chosen for patients with urinary obstructive symptoms, different parameters, first of all prostate volume, are evaluated in order to select the approach allowing the best results. The AUA and EAU guidelines suggest that open surgery should be the therapeutic choice when prostate volume is higher than 80 ml. Incidence rates of open prostatectomy in developed countries are 12% to 40% (in Italy: 29-32%). However, well-recognized advantages as optimal functional results, short operation time, low rate reoperation rates, no TURP syndrome are mainly overshadowed by disadvantages as longer catheterization time, longer catheter irrigation time, higher blood loss requiring higher transfusion rates. These features translate in longer hospital stay and, consequently longer convalescence. For these reasons, stated that TURP is not an optimal choice for large volume obstructive prostates, different minimally invasive approaches were proposed, as laser enucleation (HoLEP), laparoscopic and, recently, robot assisted adenomectomy. As far as costs are concerned, while robot assisted radical prostatectomy was clearly more expensive than the open one, RASP turned out cheaper than the open simple prostatectomy basically due to the higher costs of the hospitalization; TUR costs in large volume prostates patients were not much more convenient. Conclusions: RASP is a feasible and reproducible procedure; its outcome reveals advantages if compared with the open or with other minimally invasive techniques (laser or laparoscopy). As a result, the robot assisted approach seems to be interesting and worth for consideration in cases of high-volume prostate adenomas, too. Extending the indication of this approach, to the simple prostatectomy, requires first that the surgeon have had completed his robotic learning curve and second, as the incidence rate of high-volume symptomatic benign prostatic hyperplasia is low, the opportunity to “see the procedure” becomes fundamental.