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Is Parkinson's disease (PD) a single disease entity? PD is in most cases a sporadic disorder caused by the preferential, progressive loss of the neuromelanin-containing dopaminergic neurons in the substantia nigra pars compacta and associated with Lewy bodi... Olga Corti et al. Physiol Rev 2011;91:1161-1218 ©2011 by American Physiological Society