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CURRICULUM VITAE
Name:
Marco Ciotti
Date and place of birth:
30 November, 1963
Roccagorga (LT), Italy
Citizenship:
Italian
Marital Status:
Married, 2 children.
Address:
(home)
(offfice)
Via Castro dei Volsci, 10
00179 Rome, Italy
Tel.: + 39 067801828
Cell phone:+39 338-3715759
University Hospital Tor Vergata
Clinical Microbiology and Virology
Viale Oxford 81, 00133 Rome, Italy
Tel.: +39 0620902088; +39 0620902070
E-mail:[email protected] or
[email protected]
Professional history:
March, 1999 to present
Virologist, Laboratory of molecular virology
University Hospital Tor Vergata
Rome, Italy
25 August,1997-27 February,1999
Visiting Associate
Heritable Disorders Branch
Section on Genetic Disorders of Drug Metabolism
National Institue of Child Health and
Human Development
National Institutes of Health
Bethesda,Maryland,U.S.A.
8 August,1992-7 August,1997
Visiting Fellow
Heritable Disorders Branch
Section on Genetic Disorders of Drug Metabolism
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National Institute of Child Health
And Human Development
National Institutes of Health
Bethesda,Maryland,U.S.A.
Fellow, Oncology School 1989-1992
Department of Experimental Medicine
and Biochemical Science
University of Rome Tor Vergata
Rome, Italy
Fellow, Laboratory of Microbiology
1986-1989
Department of Experimental Medicine
and Biochemical Science
University of Rome Tor Vergata
Rome, Italy
Other positions:
Medical officer
Italian Army
Education:
High School Degree
1982
Liceo Classico
“Dante Alighieri”, Italy
Medicine Degree
1989
University of Rome
“La Sapienza”, Italy
Italian Board
1989
University of Rome
“La Sapienza”, Italy
Oncology Degree
1994
University of Rome
Tor Vergata, Italy
Microbiology and Virology Degree
2001
University of Rome
Tor Vergata, Italy
Scientific Societies:
2
Member of the Pediatrics Italian Society
Member of the American Society for Biochemistry
and Molecular Biology
Member of the European Society
Microbiology and Infectious Deseases
of Clinical
Awards:
Award of Bruno Maria Zaini Foundation for:
“Critical contribution to the understanting of the
molecular basis of Crigler-Najjar disease and
bilirubin metabolism”
Foreign languages:
English ; Spanish
Invited Lectures:
Workshop on Crigler-Najjar disease
Riccione, Italy,1996.
Workshop on Crigler-Najjar disease
Rockefeller University, New York, NY,1996.
UGT1 locus mutations:
pharmacologic and metabolic implications.
University of Rome “La Sapienza”, Italy,1997.
Role of the glucuronidation
in the detoxification of exogenous and
endogenous substances.
University of Rome Tor Vergata, Italy,1998.
Phisical state and expression of HPV in SIL and
Cervical cancer. Meeting on genital infections
and human papilloma viruses (HPV). NIH (ISS),
Rome, Italy,2003.
Phisical state and expression of HPV in SIL and
Cervical cancer. Italian Society of Microbiology,
Rome,Italy,2003
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Role of HPV testing in the managementof
minor cervical lesions. 8th World Congress for
infectious and immunological diseases in
obstetrics and gynecology,Venice,Italy,2003.
Clinical applications of drug-resistance tests
Workshop Clinical Immunology, Saint John
Hospital, Rome, Italy,2004
Clinical role of the HPV test. Department of
Gynecology and Obstetrics. Rome, 27/28
May, 2004 and 14/15 October, 2004.
Expression of p16INK4a as prognostic marker of
cervical cancer. Milan,Italian Society of
Microbiology, 26/29 September, 2004.
Detection and expression of E6 and E7
oncogenes in non-small lung cancer. Italian
Society of Medical Virology, Rome, 16/18 May,
2005.
HPV typing: Comparison between sequencing
and Linear array HPV genotyping assay.
Italian Society of Microbiology , Naples, 16-19
October, 2005.
Biology of HPV infection. San Gallicano
Hospital, 20, October, 2005, Rome.
Markers of tumor progression in HPV related
lesions. Workshop HPV infections: from
diagnosis to prevention. National Institute of
Health (ISS), Rome, 9 –10 November, 2005.
Virological molecular diagnosis. Hep-B free
meeting. 7 December, 2005. University of
Rome Tor Vergata.
Monitoring HIV1 infection.
Italian Society of Clinical Microbiology
(AMCLI) 2006, 19-22 September, 2006. Turin.
Markers of tumor progression in cervical lesions
HPV related. Creta, Greece, 12 October, 2006.
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Performance evaluation of the Abbott PCR RealTime
Assay for HCV and HBV: the prospective of a
Virology laboratory. 3° National Virology Congress,
Turkey-Uludag, 9-13 December, 2007.
Referee for peer-review journals

Proceedings of the American Thoracic Society
Teaching activity
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

School of Clinical Microbiology and Virology : Molecular biology and techniques of
molecular virological diagnosis (2002 to date)
School for Technicians of Biomedical Laboratory : Microbiology and Virology (2006 to date).
School of Oncology : Viral Oncogenesis (2007)
Books and Chapters of Books




Co-author of the Chapter: HPV and low-grade cervical lesions. In: Cervicovaginal pathology.
From laboratory to clinic, pp. 109-114. Masson Edition, 2002.
Co-author “Clinical Microbiology” textbook (Favalli C e Brunello O) EMSI, Rome,2006.
Co-author “Priciples of Clinical Immunology” textbook (Favalli C e Perricone R) EMSI,
Rome,2007.
Co-author “Medical Microbiology” textbook (Fadda G, Favalli C, Palu’ G) EMSI,
Rome,2007.
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Publications:
1. Ciotti,M., Yeatman, M.T., Sokol, R.J., and I.S. Owens. Altered coding for a
strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a CriglerNajjar type I patient. J. Biol. Chem. 270(7):3284-3291,1995.
2. Silvestri, I., Albonici, L., Ciotti, M., Lombardi, M.P., Sinibaldi, P., Manzari, V.,
Orlando, P., Carretta, F., Strazzollo, G., and P., Grippo. Antimitotic and antiviral activities
of Kelletinin A in the HTLV-I infected MT2 cells. Experentia 51(11):1076-1080,1995.
3. Ciotti, M., and I.S. Owens. Evidence for overlapping active sites for 17Ethynylestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase. Biochemistry 35(31):10119-10124,1996.
4. Ciotti, M., Obaray, R., Martin, M.G., and I.S. Owens. Genetic defects at the UGT 1 locus
associated with Crigler-Najjar type I disease, including a prenatal diagnosis.
Am.J.Med.Genetics 68:173-178,1997.
5. Ciotti, M., Marrone, A., Potter, C., and I.S. Owens. Genetic polymorphism in the human
UGT1A6 (planar phenol) UDP-glucuronosyltransferase: Pharmacological implications.
Pharmacogenetics 7(6):485-495,1997.
6. Ciotti, M., Chen, F., Rubaltelli, F.F., and I.S. Owens. Coding defect and a
TATA Box mutation at the bilirubin UDP-glucuronosyltransferase gene cause
Crigler-Najjar type I disease. BBA-Molecular Basis of Disease 1407(1):
40-50,1998.
7. Ciotti, M., Cho, J.W., George, J., and I.S Owens. Required buried -helical
structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable
phenylalanine. Biochemistry 37(31):11018-11025,1998.
8. Ciotti, M., Werlin, S.L., and I.S. Owens. Delayed response to phenobarbital
Treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in
the bilirubin UDP-glucuronosyltransferase gene. J. Pediatr. Gastroenterol. Nutr. 28(2):210213,1999.
9. Ciotti, M., Basu, N., Brangi, M., and I.S. Owens. Glucuronidation of 7-Ethyl-10Hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the
UGT1 locus. Biochem. Biophys. Res. Commun. 260(1):199-202,1999.
10. Ciotti, M., Lakshmi, V. M., Basu, N., Davis, B.B., Owens, I.S., and T.V Zenser,..
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Glucuronidation of benzidine and its metabolites by cDNA-expressed human
UDP-glucuronosyltransferases and pH stability of glucuronides. Carcinogenesis
20(10):1963-1969,1999.
11. Brangi, M., Litman, T., Ciotti, M., Nishiyama, K., Kohlhagen, G., Takimoto, C., Robeyl, R.,
Pommier, Y., Fojol, T., Bates, S.E.. Camptothecin resistance: Role of the ATP-binding
cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for
glucuronidation in MXR-expressing cells. Cancer Res 59(23):5938-5946, 1999.
12. Giuliani, L., Magnanti, M., Gandini, O., Gazzaniga, P., Santiemma, V., Ciotti, M.,
Saccani, G., Frati, L., Aglianò, A.M.. Follicle-stimulating hormone testosterone and hypoxia
differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat and
peritubalar myoid cells. J. Steroid Biochem. Mol. Biol. 74:149-155,2000.
13. Giuliani, L., Gazzaniga, P., Caporuscio, F., Ciotti, M., Frati, L., and Aglianò,
A.M.. Can down-regulation of UDP-glucuronosyltransferases in human bladder tissue
impact the risk of chemical carcinogenesis? Int. J. Cancer 91(1):141-143,2001.
14. Fontana, C., Ciotti, M., Favaro, M., Pistoia, E.S., Pietroiusti, A., Galante, A.,
Favalli, C.. Diagnosi molecolare di Helicobacter Pylori a confronto con tecniche tradizionali.
Bollettino di Microbiologia e Indagini di Laboratorio news 7(2):5-19,2001.
15. Medici, M.A., Sciortino, M.T., Perri, D., Amici, C., Avitabile, E., Ciotti, M.,
Balestrieri, E., De Smaele, E., Franzoso, G., and Mastino, A.. Protection by herpes simplex
virus Glycoprotein D against Fas-mediated Apoptosis: ROLE OF NUCLEAR
FACTORκB.J Biol Chem 278(38):36059-36067,2003.
16. Ciotti, M., Basu, N.K., Hwang, M.S., Kole, L., Mitra, P.S., Cho, J.W., and Owens, I.S.
Differential and special properties of the major human UGT1-encoded gastrointestinal
UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem
, 279(2):1429-1441,2004.
17. Ciotti, M.,Sesti, F., Paba, P., Benedetto, A., Patrizi, L., Criscuolo, A., Piccione, E., Branca,
M., Syrjänen K., Favalli, C. Human papillomavirus (HPV) testing in the management of
women with abnormal pap smear. Experience from colposcopy referral clinic. Eur J
Gynaecol Oncol 25(5):577-584,2004.
18.
Basu, N.K., Kubota, S., Meselhy, M.R., Ciotti, M., Chowdhury, B., Hartori, M., and
Owens, I.S.. Gastrointestinally-distributed UDP-glucuronosyltransferase1A10 which
metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon
pphosphorylation. J Biol Chem, 279(27):28320-28329,2004.
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19. Splendiani, G., Cipriani, S., Condò, S., Paba, P., Ciotti, M., Favalli, C., Vega, A.,
Dominijanni, S., and Casciani, C.U.. Polyoma virus BK and renal dysfunction in a
transplanted population. Transplant Proc, 36(3):713-715,2004.
20. Branca, M., Ciotti, M., Santini, D., Di Bonito, L., Giorgi, C., Benedetto, A.,
Paba, P., Favalli, C., Costa, S., Agarossi, A., Alderisio, M., and Syrjänen, K.
p16INK4a expression is related to grade of CIN and high-risk human papillomavirus but
does not predict virus clearence after conization or disease outcome. Int J Gynecol
Pathol, 23(4):354-365, 2004.
21. Branca, M, Ciotti, M, Santini, D, Di Bonito, L, Benedetto, A, Giorni, C, Paba,
P, Favalli, C, Costa, S, Agarossi, A, Alderisio, M, and Syrjanen, K. Activation
of the ERK/MAP kinase patway in cervical intraepithelial neoplasia is related
to grade of the lesion but not to high-risk human papillomavirus, virus
clearence, or prognosis in cervical cancer. Am J Clin Pathol, 122:902-911,2004.
22. Branca, M.., Costa, S., Mariani, L., Sesti, F., Agarossi, A., Di Carlo, A., Galati,
M., Benedetto, A., Ciotti, M., Giorgi, C., Criscuolo, A., Valieri, M., Favalli,
C., Paba, P., Santini, D., Piccione, E., Alderisio, M., De Nuzzo, M., Di Bonito,
L., and Syrjanen,K.. Assessment of risk factors and Human Papillomavirus
(HPV) related pathogenic mechanisms of CIN in HIV-positive and HIVnegative women .Study Design and Baseline Data of the HPV-PathogenISS
Study. European Journal of Gynaecological Oncology , 25(6):689-698,2004.
23. Giuliani, L., Ciotti, M., Stoppacciaro, A., Pasquini, A., Silvestri, I., De Matteis,
A.,Frati, L., and Aglianò, A.M..UDP-glucuronosyltransferases 1A expression in
human urinary bladder and colon cancer by immunohistochemistry. Oncol
Rep., 13(2):185-191,2005.
24. Branca, M, Giorgi, C, Santini, D, Di Bonito, L, Ciotti, M, Costa, S, Benedetto, A,
Casolati, EA, Favalli, C, Paba, P, Di Bonito, P, Mariani, L, Syrjanen, S,
Bonifacio, D, Accardi, L, Zanconati, F, Syrjanen,K. Survivin as a marker of
cervical intraepithelial neoplasia and high-risk human papillomavirus and a
predictor of virus clearance and prognosis in cervical cancer.
Am J Clin Pathol, 124(1):1-9,2005.
25. Branca, M, Giorgi, C, Santini, D, Di Bonito, L, Ciotti, M, Benedetto, A, Paba, P, Costa, S, ,
Bonifacio, D, Di Bonito, P, Accardi, L, Favalli, C, Syrjanen,K. Aberrant expression of
VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high-risk HPV,
but does not predict virus clearence after treatment of CIN or prognosis of cervical cancer. J
Clin Pathol, 59:40-47, 2006.
26. Ciotti, M, Paba, P, Bonifacio, D, Di Bonito, L, Benedetto, A, Favalli, C. Single or
multiple HPV types in cervical cancer and associated metastases. Oncol Rep, 15(1):143-148,
2006.
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27. Branca, M, Ciotti, M, Giorgi, C, Santini, D, Di Bonito, L, Costa, S, , Benedetto, A,
Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Syrjanen, S, Favalli, C, Syrjanen, K. Matrix
metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIPM-2) are prognostic factors in
cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV)
or virus persistence after treatment of CIN. Anticancer Res 26:1543-1556, 2006.
28. Branca, M, Giorgi, C, Ciotti, M, Santini, D, Di Bonito, L, Costa, S, , Benedetto, A,
Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Syrjanen, S, Favalli, C, Syrjanen,
K. Relationship of up-regulation of 67 –kd laminin receptor to grade of cervical
intraepithelial neoplasia and to high-risk HPV types and prognosis in cervical cancer. Acta
Cytol ,50 (1):6-15,2006.
29. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A,
Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Favalli, C, Syrjanen,
K. Down-regulated nucleoside diphosphate NDP kinase nm23-H1 expression is unrelated to
high-risk human papillomavirus but associated with progression of CIN and unfavourable
prognosis in cervical cancer. J Clin Pathol, 59:1044-1051, 2006.
30. Ciotti, M, Giuliani, L, Ambrogi, V, Ronci, C, Benedetto, A, Mineo, CT, Syrjanen, K, Favalli,
C. Detection and expression of human papillomavirus oncogenes in non-small cell lung
cancer. Oncol Rep , 16(1):183-189, 2006.
31. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A,
Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Syrjanen, S, Favalli, C,
Syrjanen, K. Down-regulation of E-cadherin is closely associated with progression of
cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus
(HPV) or disease outcome in cervical cancer. Eur J Gynaecol Oncol., 27(3):215-223,
2006.
32. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A,
Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu M, Syrjanen S,
Favalli, C, Syrjanen, K. Upregulation of nuclear factor-kB (NF-kB) is related to the grade of
cervical intraepithelial neoplasia, but is not an indipendent predictor of high-risk human
papillomavirus or disease outcome in cervical cancer. Diagn Cytopathol, 34(8):555-563, 2006.
33. Natoli, S, Ciotti, M, Paba, P, Testore, GP, Palmieri, G, Orlandi, A, Sabato, AF,
Leonardis, F. A novel mutation of varicella-zoster virus associated to fatal
hepatitis. J Clin Virol, 37:72-74, 2006.
34. Rezza, G, Valdarchi, C, Puzelli, S, Ciotti, M, Farchi, F, Fabiani, C, Calzoletti, L,
Donatelli, I, Perno, CF.Respiratory viruses and influenza-like
illness: a survey in the area of Rome, winter 2004-2005. Eur Surveill,
11 (10), 2006.
35. Ciotti, M, Coletti, A, Giuliani, L, Cappiello, G, Syrjanen, K, Favalli, C.
The p53 codon 72 arg/arg homozygous women in Central Italy are at
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increased risk for HPV infections. Anticancer Res, 26:3745-3748, 2006.
36. Giuliani, L, Coletti, A, Syrjanen, K, Favalli, C, and Ciotti, M. Comparision of
DNA sequencing and Roche linear array in human papillomavirus (HPV)
genotyping. Anticancer Res, 26:3939-3941, 2006.
37. Branca, M, Ciotti, M, Giorgi, C, Santini, D, Di Bonito, L, Costa, S, Benedetto,
A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Syrjanen, S, Favalli, C,
Syrjanen, K. Up-regulation of proliferatine cell nuclear antigen (PCNA) is
closely associated with high-risk human papillomavirus (HPV) and progression
of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome
in cervical cancer. Eur J Obstet Gynecol Reprod Biol , 2006 [Epub ahead of print]
38. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S,
Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L,
Ruutu M, Syrjanen SM, Favalli, C, Syrjanen, K. Over-expression of
Topoisomerase II α is related to the grade of cervical intraepithelial
Neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not
predict prognosis in cervical cancer or HPV clearance after cone treatment.
Int J Gynecol Pathol, 25(4):383-392, 2006.
39. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S,
Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L,
Ruutu, M, Syrjanen, S, Favalli, C, Syrjanen, K. Upregulation of telomerase
(hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not
an independent predictor of high-risk human papilllomavirus, virus persistence, or
disease outcome in cervical cancer. Diagn Cytopathol 34:739-748, 2006.
40. Gentile, G, Picardi, A, Capobianchi, A, Spagnoli, A, Cudillo, L, Dentamaro, T,
Tendas, A, Cupelli, L, Ciotti, M, Volpi, A, Amadori, S, Martino, P, de
Fabritiis, P. A prospective study comparino quantitative cytomegalovirus
(CMV) polymerase chain reaction in plasma and pp65 antigenemia in
Monitoring patients after allogenic stem cell transplantation. BMC Infect Dis,
6:167, 2006.
41. Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’, MG, Branca, M, Costa, S,
Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K, and Giorgi, C. Serum antibody response to
Human papillomavirus (HPV) infections detected by a novel ELISA technique based on
denatured recombinant HPV16 L1, L2, E4, E6 and E7 proteins.Infect Agent Cancer , 1:6,
2006.
42. Orlandi, A, Francescani, A, Angeloni, C, Palmieri, G, Fulvia, G, Ciotti, M,
Criscuolo, A, Sesti, F, Czernobilsky, B, and Spagnoli, L.G. Human papilloma virus
infection of the vulva: comparision between clinical and pathological findings in
relation to genotyping. Acta Obstet Gynecol Scand, 86:1003-10,2007.
10
43. Marchetti, S, Graffeo, R, Siddu, A, Santangelo, R, Ciotti, M, Picardi, A, Favalli, C, Fadda, G,
Cattani, P. BK virus DNA detection by real-time polymerase chain reaction in clinical
specimens. New Microbiologica, 30:119-26,2007.
44. Giuliani, L, Jaxmar, T, Casadio, C, Gariglio, M, Manna, A, D’Antonio, D,Syrjanen, K,
Favalli, C, and Marco Ciotti. Detection of oncogenic viruses (SV40, BKV, JCV, HCMV,
HPV) and p53 codon 72 polymorphism in lung carcinoma. Lung Cancer, 57:273-281, 2007.
45. Giuliani, L, Favalli, C, Syrjanen, K, and Ciotti, M. Human Papillomavirus Infections
in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature.
Anticancer Res, 27(40):2697-704,2007.
46. Marchetti, S, Graffeo, R, Siddu, A, Santangelo, R, Ciotti, M, Picardi, A, Favalli, C, Fadda, G,
Cattani, P. BK virus DNA detection by real-time polymerase chain reaction in clinical
specimens. New Microbiologica, 30:119-26,2007.
47. Mazibrada, J, Ritta’, M, Mondini, M, De Andrea, M, Azzimonti, B, Borgogna, C, Ciotti, M,
Orlandi, A, Surico, N, Chiusa, L, Landolfo, S, Gariglio, M. Interaction between inflammation
and angiogenesis during different stages of cervical carcinogenesis. Gynecol Oncol 2007
[Epub ahead of print].
48. Benedetto, A, Giuliani, L, Paba, P, Favalli, C, and Ciotti, M.Evaluation of viral and cellular
factors to assess the risk of oncogenesis by human papillomavirus.
Res Adv Virol, 2, 2007 (Invited review).
49. Gravina, P, Ciotti, M, Masini, S, Valentini, A, Marcuccilli, F, Crocetta, N, Federici, G, Perno,
CF, and Bernardini, S. Impact of storage conditions on genetic analysis or viral load
determination in clinical specimens. Clin Chem Lab Med 2008. (In press)
11
Abstracts
1.
Ciotti, M., Ritter, J:K., Yeatman, M.T., Kaiser, C., and I.S Owens. Bilirubin UDPglucuronosyltransferase specific mutations in the UGT1 gene complex. The FASEB
Journal 7(7):A1022,1993.
2.
Owens, I.S., Ritter, J.K., Chen, F., Ciotti, M. and M.T. Yeatman. Organization and
alteration at the human UGT1 locus encoding multiple Phenol UGT isozymes.
Glucuronidation Workshop-Pitlochry 22, 1993.
3.
Ciotti, M., Huang, T., and I. S. Owens. Characterization of two micro-regions
in the human major bilirubin UDP-glucuronosyltransferase isozyme. The FASEB Journal
8(7):A1062, 1994.
4. Owens , I.S., Ciotti ,M., and Huang, T. Structure-function relationship as defined by the
characterization of the two conserved micro-regions in the human major bilirubin UDPglucuronosyltransferase isozyme. 10th International Symposium on Microsomes and
Drug Oxidation 8, 1994.
5. Ciotti, M., Obaray, R., Martin, M. G., and I.S., Owens. Identification of a two-base
mutation in the bilirubin UDP-glucuronosyltransferase at the UGT1 gene complex locus
in two unrelated Crigler Najjar type I patients. The FASEB Journal 9(6): A63, 1995.
6. Rubaltelli, D., Ciotti, M., Rubaltelli, F.F., and I.S., Owens. Two differente missense
mutations at the UGT1 gene complex locus that generate pH-sensitive activity of the
major bilirubin UDP-glucuronosyltransferase in Crigler Najjar type II patients. . The
FASEB Journal 9 (6):A64, 1995.
7. Ciotti, M, Chen, F., Ritter J.K., and I.S., Owens. Genetic-basis of impaired detoxification
of bilirubin. The Second International Symposium on Fertility Regulation, Beijing,
China, 1995.
8. Ciotti, M, Marrone, A., and I.S., Owens. Genetic polymorphism in HLUG-P1 gene.
XIth International Symposium on Microsomes and Drug Oxidation L 100, 1996.
9. Ciotti, M, Rubaltelli, F.F., and I.S., Owens. Two missense mutations in the major bilirubin
UDP-glucuronosyltransferase at the UGT1 gene complex locus that cause Crigler Najjar type II
syndrome. International Perinatology Collegium 19, 1996.
10. Ciotti, M. and I.S. Owens. Comparison of bilirubin and 17Ethynylstradiol
glucuronidation by HUG-Br1 and some of its mutants. The FASEB Journal 10 (6):A2212,
1996.
11. Cho, J.W., Huang T., Gholami, N., Potter C., Ciotti, M., and I.S., Owens. Extension of
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the human UGT1 gene complex locus and characterization of some encoded isoforms.
VIIth Glucuronidation Workshop on Glucuronidation, Iowa City, Iowa, 1996.
12. Ciotti, M., and I.S., Owens. Genetic polymorphism in Crigler-Najjar type I and II
Syndrome and its relationship to hyperbilirubinemia. International Workshop, Riccione,
Italy, 1996.
13. Ciotti, M., Rubaltelli, D., Rubaltelli, F.F., and I.S., Owens. Two different mutations in
the TATA box element of the UGT1A gene are responsible for its reduced expression.
Conference on treatment of Crigler Najjar syndrome. Rockefeller University, New York, N.Y.,
1996.
14. Askari, F.K., Turcotte, J.K., Bromberg, J. G., Dickinson, C.J., Ciotti, M., and W. M.,
McDonnel. Infra-hepatic auxiliary liver transplantation with preservation of the entire
native liver in the treatment of Crigler Najjar syndrome type I. Gastroenterology 9:A 1216,
1997.
15. Owens, I.S., Ciotti, M., Chen, F., and F.F., Rubaltelli. A common genetic defect
between the Crigler Najjar type I and II diseases in the transcriptional TATA box
promoter element of the bilirubin UDP-glucuronosyltransferase gene. 7th International
Congress of Inborn Errors Metabolism: O65, 1997.
16. Ciotti, M, Marrone, A., and I.S., Owens. Genetic polymorphism in the human
UGT1A6 gene : Pharmacological implications. The American Journal of Human
Genetics 61(4): A1449, 1997.
17. Ciotti,M., Cho J.W., George J., and I.S., Owens. A required buried -helical structure in
the human bilirubin UGT1A1 contains a non-replaceable phenylalanine.
12th InternationalSymposium on Microsomes and Drug Oxidation S2-1, 1998.
18. Gong, Q., Cho, J.W., George, J., Potter, C., Gholami, N., Ciotti, M., Hwang, M.S., and
I.S.Owens. Completition of the description of the UGT1A locus and the partial
characterization of its metabolic function. IXth International Workshop on
Glucuronidation and the UDP-Glucuronosyltransferases, Brisbane, Australia, 1998.
19. Magnanti, M., Giuliani, L., Gandini, O., Gazzaniga, P., Ciotti, M., Aglianò, A.M.
UDP-glucuronosyltransferase 1 isoform mRNA expression in rat testis. The Endocrine
Society’s 81 Annual Meeting : P2-84, 1999.
20. Fontana, C., Ciotti, M., Pietroiusti, A., Luzzi, I., Capalbo, F., Pistoia, E.S., Marino, D.,
Favalli, C. Diagnosi su feci e diagnosi sierologica di Helicobacter Pylori. 27˚ Congresso
Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:78, 1999.
21. Fontana, F., Ciotti, M., Pietroiusti, A., Giorgetti, G., Pistoia, E.S., Marino, D.,
Favalli, C. Diagnosi di H. Pylori: fattori interferenti. 27˚ Congresso
Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:79, 1999.
13
22. Fontana, C., Ciotti, M., Pistoia, E.S., Capalbo, F., Favalli, C. Helicobacter Heilmannii:
sospetto ruolo nella dispepsia gastrica. . 27˚ Congresso
Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:79, 1999.
23. Basu, N., Ciotti, M., Hsai, N., and I.S. Owens. Detoxification of natural chemicals by a
subset of the human family A UDP-glucuronosyltransferase isozymes. The FASEB Journal
633:A636,1999.
24. Fontana, C., Ciotti, M., Ciotti, L., Favaro, M., Pistoia, E.S., Marino, D., Capalbo, F.,
Favalli, F.. Incerta posizione tassonomica di Helicobacter Heilmannii. 28˚ Congresso
Nazionale della Società Italiana di Microbiologia, Anno 2-N. 2:84, 2000.
25. Perri, D., Sciortino, M.T., Medici, M.A., Avitabile, E., Valveri, V., Ciotti, M.,
Matteucci, C., Amici, C., De Smaele, E., Mastino, A.. HSV-1 inibisce l’apoptosi mediata
da Fas in cellule U937 mediante l’attivazione di NF-KB. 29˚ Congresso Nazionale della
SocietàItaliana di Microbiologia, Anno 3-N.2:66, 2001.
26. Ciotti, M., Paba, P., Benedetto, A., Sesti, F., Criscuolo, A.A., Piccione, E., and Favalli,
C..Correlazione tra citologia cervicale deponente per ASCUS e L-SIL e positività al test
HPV alto rischio. Osservazioni preliminari. 30 Congresso Nazionale della Società
Italiana di Microbiologia, Anno 4-N.1: 87, 2002.
27.
Basu, N.K., Kole, L.A., Ciotti, M., Owens, I.S.. A novel human chemical defense system in
the gastrointestinal tract regulated by PKC mediated phosphorylation and dietary constituents.
The Faseb Journal 16(4): A150.5, 2002.
28. Sesti, F., Criscuolo, A.A., Ciotti, M., Paba, P., Benedetto, A., Favalli, C., Piccione, E..
HPV e alterazioni cellulari cervicali di basso grado. Osservazioni preliminari.
XVII Congresso Nazionale della Società Italiana di Colposcopia e Patologia Cervico
Vaginale, Roma 5-7 Dicembre 2002: 109-114,in Patologia Cervicovaginale: Dal laboratorio
alla Clinica. Edizione Masson.
29. Sesti,F., Ciotti,M., Paba,P., Benedetto,A., Criscuolo,A., Branca,M., Favalli,C.,
and Piccione,E.. Use of HPV typing in management of women with ASCUS/LSIL.
5th International Multidisciplinary Congress Eurogin 2003.
30. Branca,M.,Giorgi,C.,Benedetto,A.,Favalli,C.,Ciotti,M.,Piccione,E.,Sesti,F.,Sbiroli,C.,
Mariani,L.,Vecchione,A.,Costa,S.,Santini,D.,Agarossi,A.,Di Carlo,A.,Di Bonito,L.,
Syrjanen.K.. Assessment of the risk factors,pathogenetic mechanisms and cervical cancer in
HIV-positive and HIV-negative women with implications in screening and management
(HPV-pathogenesis study). 5th International Multidisciplinary Congress Eurogin 2003.
31. Splendiani, G., Cipriani, S., Condò, S., Paba, P., Ciotti, M., Favalli, C., Vega, A., Muraca,
F., Casciani, C.U.. Epidemiologia del polioma virus BKV in una popolazione di pazienti
trapiantati. XXVII Congresso Nazionale S.I.T.O. 2003.
32. Ciotti, M., Paba, P., Ambrogi, V., Benedetto, A., Mineo, T.C., Favalli, C.. Cancro del
14
Polmone ed infezione da HPV. XXXIII Congresso Nazionale AMCLI, Firenze 14-17
Ottobre, Microbiologia Medica, 18(2): 161, 2003.
33. Ciotti, M., Paba, P., Ambrogi, V., Benedetto, A., Mineo, T.C., Syrjanen, K., Favalli, C..
Rilevazione di multipli genotipi di HPV nel cancro del polmone mediante ibridazione
inversa. 31° Congresso Nazionale SIM, Bollettino SIM, Anno 5 (1): 82, 2003.
34. Paba, P., Ciotti, M., Benedetto, A., Syrjanen, K., Branca, M., Favalli, C.. Stato fisico ed
Espressione di HPV nei carcinomi cervicali. 31° Congresso Nazionale SIM, Bollettino SIM,
Anno 5 (1): 89, 2003.
35.
Sciortino, M.T., Medici, M.A., Perri, D., Valveri, V., Ciotti, M., Camuti, A. P., Grelli, S.,
Mastino, A... Herpes simplex tipo 1 induce l’espressione di geni pro-sopravvivenza NF-KBdipendenti nelle fasi precocissime dell’infezione. 31° Congresso Nazionale SIM, Bollettino
SIM, Anno 5 (1): 48, 2003.
36.
Marchetti, S., Ciotti, M., Graffeo, R., Santangelo, R., Manzara, S., Siddu, A.., Della
Monica, L., Splendiani, G., Cattani, P., Favalli, C., Fadda, G.. Diagnosi molecolare
dell’infezione da polyomavirus umano BKV. 31° Congresso Nazionale SIM, Bollettino
SIM, Anno 5 (1): 39, 2003.
37. Sesti, F., Ciotti, M., Paba, P., Benedetto, A., Altieri, A., Calugi, G., Criscuolo, A., Favalli,
C., Piccione, E.. Role of HPV testing in the management of women with minor cervical
lesions. 8th World Congress for Infectious and Immunological Diseases in Obstetrics and
Gynaecology : 84, Venezia, 8-11 November, 2003.
38. Branca,M., Giorgi, C., Benedetto, A., Favalli, C., Ciotti, M., Piccione, E., Sesti, F., Sbiroli,
C., Mariani. L., Costa, S., Santini, D., Agarossi, A., Di Carlo, A., Di Bonito, L., Syrjanen,
K.. Assessment of risk factors and HPV-related pathogenetic mechanisms of CIN in HIVpositive and HIV-negative women. Implications in screening and patient managment.
21st International Papillomavirus Conference, Mexico City, Mexico, February 20-26,2004:
A125.
39. Ciotti, M., Paba, P., Benedetto, A., Branca, M., Syrjanen, K., Favalli, C.. Expression of
p16INK4a is a prognostic factor in cervical cancer, related to grade of CIN and high-risk human
papillomavirus (HPV) but does not predict virus clearence after cone treatment. XXXIII
Congresso Nazionale AMCLI, Padova, 8-11 Giugno, 2004, Vol. 19 (2): P170.
40.
Ciotti, M., Paba, P., Benedetto, A., Branca, M., Syrjanen, K., Favalli, C..
L’espressione di p16INK4a è un fattore prognostico nel cancro della cervice, correlato
al grado CIN e al papillomavirus ad alto rischio, ma non predice la clearence virale
dopo conizzazione. 32° Congresso SIM, 26-29 Settembre,2004:A13.
41.
Giuliani, L., Ciotti, M., Paba, P., Benedetto, A., Favalli, C.. Presenza di papillomavirus
umano (HPV) in tumori polmonari non a piccole cellule. 2° Congresso Nazionale Società
Italiana di Virologia Medica, 16-18 Maggio,2005:A36.
15
42.
Ciotti, M., Paba, P., Benedetto, A., Bonifacio, D., Di Bonito, L., Favalli, C. HPV types in
cervical carcinoma and associated metastases: can single cancer cells harbor multiple HPV
genotypes? ESGO 14 meeting, 25-29 September, 2005, Instambul.
43.
Coletti, A., Giuliani, L., Cappiello, T., Calugi, G., Ciotti, M., e Favalli, C. Polimorfismo al
codone 72 della p53 e lesioni cervicali associate ad infezioni HPV ad alto rischio. 33°
Congresso SIM, 16-19 Ottobre, 2005: 7.
44.
Giuliani, L., Ciotti, M., Benedetto, A., Favalli, C. Presenza di papillomavirus umano
(HPV) in tumori polmonari non a piccole cellule. Congresso SIM, 16-19 Ottobre, 2005: 70.
45.
Calugi, G., Ciotti, M., Benedetto, A., D’Agostini, C., Grelli, S., Favalli, C. HIV menome
and long term non progressor. Congresso SIM, 16-19 Ottobre, 2005: 5
46.
Marchetti, S., Graffeo, R., Siddu, A., Ciotti, M., Santangelo, R., Manzara, S., favalli, C., e
Fadda, G. Determinazione di poilomavirus BK mediante real-time PCR nel sangue di
pazienti trapiantati di midollo. Congresso SIM, 16-19 Ottobre, 2005: 43.
47.
Calugi, G., Ciotti, M., Benedetto, A., D’Agostini, C., Grelli, S., Favalli, C. HIV menome
and long term non progressor. XXII Coferenza Nazionale di Citometria, 4-8 Ottobre,
2005: 28.
48.
Grelli, S., D’Agostini, C., Ombres, D., Calugi, G., Ciotti, M., Montella, F., Vullo, V.,
Favalli, C., Vella, S., Macchi, B., and Mastino, A. Contribution of CD8+ cells to decreased
levels of lymphocyte apoptosis in response to highly active antiretroviral therapy in HIV
patients. . XXII Coferenza Nazionale di Citometria, 4-8 Ottobre, 2005: 32.
49.
Marzano, V, Nuccetelli, M, Ciotti, M, Giuliani, L, Plachino, G, Urbani, A, Favalli, C, and
Federici, G. Proteomic expression patterns in HPV-16 transfected human cell line: P6.
Perspective of metabonomics and proteomics investigations in clinical science, 29-30
March, 2006, Fondazione Santa Lucia, Rome.
50.
Parruti, G, Manna, A, Di Girolamo, A, Ciotti, M, Racciati, D, D’Amico, G, Favalli, C,
Pizzigallo, E, D’Antonio, A. Diagnostic relevance of screening clinical specimens from
patients attending infectious diseases and haematology units for HHV6 DNA: a two-year
experience. 16th European Congress of Clinical Microbiology and Infectious Diseases, Nice
1-4, April 2006, France.
51.
Ciotti, M, Marcuccilli, F, Guenci, T, Perno, CF. Confronto tra due dosaggiin Real-time per
la determinazione quantitativa di HCV-RNA. XXXV Congresso AMCLI, Torino 19-22,
Settembre, 2006: A87.
52.
Lenci, I, Di Paolo, D, Tisone, G, Marcuccilli, F, Ciotti, M, Guerci, T, Perno, CF, Angelico,
M. Covalently closet circular DNA (cccDNA) in post-transplant liver biopsies: a new tool
to assess the need of continous prophylaxis against HBV recurrence. J Hepatol 46:S72,
2007.
16
53.
Giuliani, L, Jaxmar, T, Casadio, C, Gariglio, M, Manna, A, D’Antonio, D,Syrjanen, K,
Favalli, C, and Marco Ciotti. Detection of oncogenic viruses (SV40, BKV, JCV, HCMV,
HPV) and p53 codon 72 polymorphism in lung carcinoma.7th National Congress of the
Italian Society of Virology, Orvieto, 24-26 June, 2007:46.
54.
Giorgi, C, Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’ MG, Branca, M, Costa,S,
Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K. Clinical and epidemiological correlates of
antibody response to denatured recombinant human papillomavirus (HPV16) L and E
antigens as measured by a novel ELISA. 7th National Congress of the Italian Society of
Virology, Orvieto, 24-26 June, 2007:33.
55.
Ciotti, M, Marcuccilli, F, Guenci, T, Belladonna, S, Pulvirenti, FR, Perno, FC. Evaluation
of the new Abbott Realtime HBV assay. Third European Congress of Virology, 1-5
September, 2007:95.
56.
Giorni, C, Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’, MG, Branca, M, Costa, S,
Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K. Clinical and epidemiological correlates of
antibody response to denatured recombinant HPV16L and E antigens. Third European
Congress of Virology, 1-5 September, 2007:95.
57.
Giuliani, L, Casciani, S, Ronci, C, Massarelli, R, Federici, G, Favalli, C, Ciotti, M, and
Dessi’, M. Detection of HPV, BKV, JCV and SV40 in urine of healthy individuals.
Biochimica Clinica 31(5):414, 2007.
58.
Dessi’, M, Giuliani, L, Casciani, S, Ronci, C, Federici, G, Favalli, C, Perno, CF, Ciotti, M.
Ricerca di HPV, BKV, JCV e SV40 nell’urina di individui sani. Italian J Lab Med 3
(Sup):177,2007.
59.
Ciotti, M, Marcuccilli, F, Guenci, T, Belladonna, S, Pulvirenti, FR, Perno, FC. Confronto
tra due dosaggi in Real-time per la determinazione quantitativa di HBV-DNA.
Microbiologia Medica 22(3):236, 2007.
60.
Perno, CF, Marcuccilli, F, Bertoli, A, Ciotti, M, Lenci, I, Di Paolo, D, Angelico, M. HBV,
cccDNA e resistenze. 35º Congresso Nazionale della Societa’ Italiana di Microbiologia,
catania, 30 Sett-3 Ottobre, 2007:17.
61.
Svicher, V, Giuliani, L, Coletti, A, Calugi, G, Perno, CF, Ciotti, M. Prevalence of human
papillomavirus genotypes in a cohort from central Italy. 35º Congresso Nazionale della
Societa’ Italiana di Microbiologia, catania, 30 Sett-3 Ottobre, 2007:45.
62.
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