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CURRICULUM VITAE
Göran K. Hansson
October, 2014
Education:
Medical school, Gothenburg University; Med.kand. (Bachelor of Medicine) 1972;
Läkarexamen (M.D.) 1977; Ph.D. 1980 in histology, Gothenburg University.
Positions/Appointments:
Docent, Histology, Gothenburg University 1981
NIH-Fogarty Postdoctoral Research Fellow, University of Washington, Seattle, 1981-82
Internship and residency, Sahlgrenska University Hospital, Gothenburg, 1983-89
Senior Scientist in Cardiovascular Cell Biology, Medical Research Council 1990-94
Professor of Cell Biology, Gothenburg University, 1994-95
Professor of Cardiovascular Research, Karolinska Institutet, 1995Visiting Professor, Harvard Medical School, 2008
Distinguished Professor, Karolinska Institutet, 2010Awards, Honours, Named Lectures etc (selected)
Erik K. Fernström Prize for Medical Research, 1992
Visiting Professor, Università Catolica del Sacro Cuore, Rome 1996
Elected to the Nobel Assembly at Karolinska Institute, 1997
Lars Werkö Prize for Heart Research, 1998
Russell Ross Memorial Lecture, International Atherosclerosis Society, 2000
Pfizer Visiting Professor, Univ of Texas at Houston, 2001
Nikkilä Lecture, Scand Soc Atherosclerosis Research, 2002
Eijkman Medal, Utrecht University 2003
Vulnerable Plaque Lifetime Achievement Award, AEHA, Chicago 2003
Leducq Visiting Professor, Harvard Medical School, Boston 2005
Kennedy Visiting Professor, Imperial College, London 2005
David Geffen School of Medicine Visiting Professor, UCLA 2006
Anitschkow Prize, European Atherosclerosis Society 2007
Hugh Sinclair Lecture, British Atherosclerosis Society 2007
George Lyman Duff Memorial Lecture, American Heart Association 2007
Elected to the Royal Swedish Academy of Sciences 2007
Elected to Academia Europæa 2007
William Harvey Medal, European Society of Cardiology, Munich 2008
Outstanding Achievement Award, Intl Atherosclerosis Society, Boston 2009
Distinguished Service Award, American Heart Association, Orlando 2009
Federa Prize, Federation of Biomedical Scientific Societies, Leiden, The Netherlands 2011
Middlesex Memorial Lecture, University College London 2012
Honorary Professor, Shandong University, China 2014
Anthony Cerami Prize in Translational Medicine, Feinstein Institute, New York 2014
Commissions of trust (selected)
Nobel Committee for physiology or medicine, member 1998-; Chair 2004-06; Secretary of the
Nobel Assembly and Nobel Committee, 2009-; Director of the Medical Nobel Institute, 2010;
Member, Board of Directors of the Nobel Foundation, 2009-; Vice Chair 2010-.
Louis-Jeantet Foundation, Geneva, Member, Science Committee 2000-; Chair 2009-.
Scientific advisory boards: Heart Research Institute, Sydney 1994; Wihuri Research Institute,
Helsinki, 1995-; Gladstone Foundation for Cardiovascular Research, San Francisco 2001;
Division of Medical Sciences, Oxford University, 2002; Medical University of Vienna, 2007;
Scientific advisor, Academy of Finland, 2002-06; Center for Medical Inflammation Research
(CEMIR), NTNU, Trondheim 2009-.
KI commissions of trust:
Director, graduate school, faculty of medicine, Gothenburg Univ 1991-4; Member, board of
graduate school, Karolinska Institute 1996-98; Member, board for research, Karolinska
Institute 1999-2005; Member, board of Karolinska Hospital, 2003; Search committee for new
president of KI 2004, Search committee for deans 2005; Steering committee, Center for
Molecular Medicine, Karolinska Hosp, 2002-.
Scientific conferences: Chair, Gordon Conference on Atherosclerosis, 1999; Vice chair, Intl
Symposium on Atherosclerosis, Stockholm 2000; Chair, Days of Molecular Medicine (w/
Nature Med and Salk Inst) 2005; Chair, J Int Med symposium on inflammation and
atherosclerosis, 2007; Chair, Wenner-Gren Symposium on Inflammation, 2010; Organizer,
Nobel Week Dialogue Symposium on the Genetic Revolution and Society, 2012.
Scientific journals: European Editor, Arteriosclerosis, Thrombosis, and Vascular Biology,
2000-7; Consulting Editor, Journal of Clinical Investigation, 2002-10; Editorial Boards:
Circulation, 2000-; Annals of Medicine 2001-; J Atherosclerosis Thrombosis, 2003-, Journal
of Internal Medicine 2006-, European Heart Journal 2009-12; Rambam Medical Journal
2008-, Circulation Research 2009-10; European Journal of Immunology 2013-.
Scientific supervision:
23 graduate students awarded PhD degrees (* indicates GKH main supervisor): Lena Jonasson*
(PhD 1987), Sten Stemme* (1992), Yong-jian Geng* (1994), Anders Svenningson (1996), Zhongqun Yan* (1998), Giuseppina Caligiuri* (1999), Xinghua Zhou* (2000), Dirk Wuttge (2001),
Anna-Karin Robertson* (2004), Emmanuel Tupin (2004), Andreas Gidlöf* (2005), Kristina
Edfeldt (2005), Anne-Louise Hemdahl* (2005), Yuri Sheikine* (2006), Dexiu Bu (2006),
Charlotta Hjerpe (2007), Ariane Sultan (2007), Peder Olofsson* (2008), Andreas Hermansson*
(2010), Olga Ovchinnikova* (2010), Daniel Johansson* (2012); Daniela Strodthoff* (2014),
Yajuan Wang (2014). Currently supervising 5 PhD students (2 as main supervisor).
Supervised 18 postdoctoral fellows: Paul S. Seifert (1987-9, currently staff scientist at Gore, Inc.,
Phoenix, Ariz., USA) Tasuku Yokota (1994-6, senior consultant Osaka Christian Hospital, Japan),
Tatsuro Shimokama (1996-7, senior consultant Tsukuba University Hospital, Japan), Antonino
Nicoletti (1996-8, professor Institut des Cordeliers, Université de Paris VI, France), Guro Valen
(1996-9, professor physiology Oslo University), Gabrielle Paulsson Berne (assoc prof KI), Allan
Sirsjö (1997-2000, professor cell biology Örebro University), Wolfgang Erl (1997-9, senior
scientist Ludwig-Maximilians-Universität Munich, Germany), Rima Elhage (2000-02, scientist
Pasteur Inst Lille, France), Jacek Jawien (2003-4, consultant clin pharmacology Jagellonian Univ,
Krakow), Anders Gabrielsen (2003-5, consultant/clinical researcher cardiology, Karolinska Hosp),
Magnus Bäck (2004-6, consultant/clinical researcher cardiology, Karolinska Hosp), Roland
Klingenberg (2007-8, resident cardiology Univ Hospital Zürich), John Andersson (2009-10, Asst
prof KI), Norbert Gerdes (2007-11, Asst prof, Ludwig-Maximilians Univ München); Daniel
Ketelhuth (2006-10, asst prof KI); Robert Badeau (2009-12, Univ Helsinki); Anna Lundberg
(medical advisor Novartis). Currently supervising 4 postdoctoral fellows: Maria Rosen-Klement
(from Stockholm Univ); Olga Ovchinnikova (from KI), John Pirault (from INSERM, Hôpital de la
Pitié Paris), Reiner Mailer (from Univ Hannover).
Bibliometry (Google Scholar, Oct. 2014): 307 publications including original papers and
reviews in peer-reviewed journals. Cited 41,334 times; h-index 89.
Patents: Interferon treatment of restenosis, 1990; Atherosclerosis vaccine, 2000;
Peptide-based immunization therapy for treatment of atherosclerosis, 2003; Abrogation of Tcell response to LDL as a treatment of atherosclerosis, 2009.
SCIENTIFIC PUBLICATIONS
Göran K. Hansson, October 2014
1.
Bondjers G, Brattsand R, Hansson GK, Björkerud S: Cholesterol transfer and
content in regions with defined endothelial integrity from rabbits with moderate
hypercholesterolemia. Nutr Metab 20:452-460, 1976.
2.
Bondjers G, Hansson GK, Werkö L: Immunpatologiska mekanismer vid
ateroskleros. Läkartidn. 73:2815-2817, 1976.
3.
Bondjers G, Hansson GK, Brattsand R, Björkerud S: The effect of moderate
hypercholesterolemia on the blood-artery cholesterol transfer barrier. Adv Exp
Med Biol 82:237-239, 1977.
4.
Bylock A, Björkerud S, Brattsand R, Hansson GK, Hansson H-A, Bondjers G:
Endothelial structure in rabbits with moderate hypercholesterolemia - a scanning
electron microscopic study.
Acta path microbiol Scand 85A:671-682, 1977.
5.
Bondjers G, Brattsand R, Bylock A, Hansson GK, Björkerud S: Endothelial
integrity and atherogenesis in rabbits with moderate hypercholesterolemia.
Artery 3:395-408, 1977.
6.
Bondjers G, Björkerud S, Brattsand R, Bylock A, Hansson GK: Endothelial
injury in normocholesterolemic and hypercholesterolemic rabbits. In:
International Conference on Atherosclerosis; L A Carlson et al, eds. Raven
Press, New York 1978, pp 567-577.
7.
Hansson GK, Bondjers G, Nilsson L-Å: Plasma protein accumulation in injured
endothelial cells. Immunofluorescent localization of IgG and fibrinogen in the
rabbit aortic endothelium. Exp Mol Pathol 30:12-26, 1979.
8.
Hansson GK, Bylock A, Bondjers G: Endothelial injury and atherosclerosis in
relation to the immune and inflammatory systems. In: Immunity and
Atherosclerosis. F Pratesi, ed. Academic Press, New York 1980, pp. 69-77.
9.
Hansson GK, Bondjers G, Bylock A, Hjalmarsson L: Ultrastructural studies of
the localization of IgG in the aortic endothelium and subendothelial intima of
atherosclerotic and non-atherosclerotic rabbits. Exp Mol Pathol 33:302-315,
1980.
10.
Hansson GK, Bondjers G: Endothelial proliferation and atherogenesis in rabbits
with moderate hypercholesterolemia. Artery 7:316-329, 1980.
11.
Hansson GK: Endothelial injury and monocyte adhesion in atherogenesis.
Experimental studies in the rabbit. Thesis, Gothenburg University. Gotab,
Gothenburg 1980.
12.
Hansson GK, Björnheden T, Bylock A, Bondjers G: Fc-receptor mediated
binding of monocytes to areas with endothelial injury in the rabbit aorta. Exp
Mol Pathol 34:264-280, 1981.
13.
Björkerud S, Bondjers G, Bylock A, Hansson GK: Studies of arterial endothelial
integrity with the dye exclusion test - a review. In: Structure and Function of
the Circulation, CJ Schwartz et al., eds. Vol. 3, pp 211-238, Plenum Press, New
York 1981.
14.
Björntorp P, Hansson GK, Jonasson L, Pettersson P,Sypniewska G: Isolation
and characterization of endothelial cells from the epididymal fat pad of the rat.
J Lipid Res 24:105-112, 1983.
15.
Björnheden T, Bylock A, Hansson GK, Bondjers G: A system for long-term
perfusion rabbit aorta in vitro. Arteriosclerosis 3:366-382, 1983.
16.
Hansson GK, Schwartz SM: Endothelial dysfunction without cell loss. In:
Biochemical Interactions at the Endothelium. A Cryer, ed. Elsevier, Amsterdam
1983, pp 343-361.
17.
Hansson GK, Schwartz SM: Evidence for cell death in the vascular endothelium
in vivo and in vitro. Am J Pathol 112:278- 286, 1983.
18.
Kjellström T, Ahlman H, Dahlström A, Hansson GK, Risberg B: The uptake of
5-hydroxytryptamine in endothelial cells cultured from the pulmonary artery
in rats - a cytochemical study. Acta Physiol Scand 120:243-250, 1984.
19.
Hansson GK, Starkebaum GA, Benditt EP, Schwartz SM: Fc- mediated binding
of IgG to cytoskeletal intermediate filaments in vascular endothelial cells. Proc
Natl Acad Sci USA 81:3103-3107, 1984.
20.
Hansson GK, Holm J, Kral JG: Accumulation of IgG and complement factor C3
in human arterial endothelium. Acta path microbiol Scand 92A:429-435, 1984.
21.
Jonasson L, Hansson GK, Bondjers G, Bengtsson G, Olivecrona T:
Immunohistochemical localization of lipoprotein lipase in human adipose tissue.
Atherosclerosis 51:313-326, 1984.
22.
Jonasson L, Holm J, Skalli O, Gabbiani G, Hansson GK: Expression of class II
transplantation antigens on vascular
smooth muscle cells in human
atherosclerosis. J Clin Invest 76:125-131, 1985.
23.
Rozell B, Stenman G, Hansson H-A, Dahl D, Hansson GK, Mark J: Intermediate
filaments asnd microfilaments in cultured human pleomorphic adenomas. An
immunohistochemical study. Acta path microbiol immunol Scand 93A:335-343,
1985.
24.
Hansson GK, Chao S, Schwartz SM, Reidy MA: Aortic endothelial cell death
and replication in normal and lipopolysaccharide-treated rats. Am J Pathol
121:123-127, 1985.
25.
Hansson GK: The binding of immunoglobulins to cytoskeletal intermediate
filaments (letter to the editor). J Immunol Methods 82:185, 1985.
26.
Hansson GK: Solid-phase preparation of vimentin-type intermediate filaments
for immunoassays. J Immmunol Methods 85:401-407, 1985.
27.
Jonasson L, Holm J, Skalli O, Bondjers G, Hansson GK: Regional
accumulations of T cells, macrophages, and smooth muscle cells in the human
atherosclerotic plaque. Arteriosclerosis 6:131-138, 1986.
28.
Hansson GK, Jonasson L, Holm J, Claesson-Welsh L: Class II MHC antigen
expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR,
HLA-DQ and the invariant chain.
Clin Exp Immunol 64:261-268, 1986.
29.
Risberg B, Eriksson E, Björk S, Hansson GK: Immunohistochemical
localization of plasminogen activators in human saphenous veins. Thromb Res
37:301-308, 1986.
30.
Hansson GK, Bondjers G: Endothelial dysfunction and injury in atherosclerosis.
Acta Med Scand Suppl 715:11-17, 1987.
31.
Hansson GK, Holm J, Jonasson L: Interactions between leukocytes, endothelial
cells and smooth muscle cells in atherogenesis. In: Fourth Münster International
Arteriosclerosis Symposium: Recent Advances in Arteriosclerosis Research.
WH Hauss, RW Wissler, J Grünwald, eds. Rheinisch-Westfälische Akademie
der Wissenschaften, vol. 76 pp. 157-164, 1987.
32.
Hansson GK, Lagerstedt E, Bengtsson A, Heideman M: IgG binding to
cytoskeletal intermediate filaments activates the complement cascade. Exp Cell
Res 170:338-350, 1987.
33.
Jonasson L, Bondjers G, Hansson GK: Lipoprotein lipase in atherosclerosis: its
presence in smooth muscle cells and absence from macrophages. J Lipid Res
28:437-445, 1987.
34.
Hansson GK: Pathogenetic mechanisms of arteritis in Kawasaki disease - a
critical analysis. Progr Clin Biol Res 250:383-394, 1987.
35.
Bengtsson A, Hansson GK, Heideman M: In vivo determination of modulated
migration of radiolabeled leukocytes. Arch Surg 122:909-912, 1987.
36.
Jonasson L, Holm J, Hansson GK: Smooth muscle cells express Ia antigens
during arterial response to injury. Lab Invest 58:310-315, 1988.
37.
Jonasson L, Holm J, Hansson GK: Cyclosporin A inhibits smooth muscle
proliferation in the vascular response to injury. Proc Natl Acad Sci USA
85:2303-2306, 1988.
38.
Rubin K, Tingström A, Hansson GK, Larsson E, Rönnstrand L, Terracio L,
Heldin C-H, Fellström B, Klareskog L: Induction of PDGF receptors may
regulate cell proliferation in vascular diseases. Lancet 1988 (i):1353-1356.
39.
Andersson R, Hansson GK, Söderström T, Jonsson R, Bengtsson B-Å,
Nordborg E. HLA-DR expression in the vascular lesion and circulating T
lymphocytes of patients with giant cell arteritis. Clin Exp Immunol 73:82-87,
1988.
40.
Hansson GK, Jonasson L, Lojsthed B, Stemme S, Kocher O, Gabbiani G:
Localization of T lymphocytes and macrophages in fibrous and complicated
human atherosclerotic plaques. Atherosclerosis 72:135-141, 1988.
41.
Fager G, Hansson GK, Ottosson P, Dahllöf B, Bondjers G: Human arterial
smooth muscle cells in culture. Effects of platelet-derived growth factor and
heparin on growth in vitro. Exp Cell Res 176:319-335, 1988.
42.
Hansson GK, Jonasson L, Holm J, Clowes MM, Clowes AW: -interferon
regulates vascular smooth muscle proliferation and Ia expression in vivo and in
vitro. Circ Res, 63:712-719, 1988.
43.
Hansson GK, Holm J, Jonasson L, Stemme S: The immune system modulates
cellular growth and differentiation in the vessel wall. In: Atherosclerosis VIII,
Proc 8th Intl Symp Atherosclerosis, Rome 1988, G Crepaldi, AM Gotto, E
Manzato, G Baggio, eds. Pp. 571-574. Excerpta Medica, Amsterdam 1989.
44.
Fager G, Hansson GK, Gown AM, Larson DM, Skalli O, Bondjers G: Human
arterial smooth muscle cells in culture: Inverse relationship between
proliferation and expression of contractile proteins. In Vitro Cell Dev Biol
25:511-520, 1989.
45.
Seifert PS, Hugo F, Hansson GK, Bhakdi S. Prelesional complement activation
in experimental atherosclerosis. Lab Invest 60:747-754, 1989.
46.
Seifert PS, Hansson GK. Decay-accelerating factor is expressed on vascular
smooth muscle cells in human atherosclerotic lesions. J Clin Invest 84:597-604,
1989.
47.
Hansson GK, Holm J, Jonasson L. Detection of activated T lymphocytes in the
human atherosclerotic plaque. Am J Pathol 135:169-175, 1989.
48.
Hansson GK, Jonasson L, Seifert PS, Stemme S. Immune mechanisms in
atherosclerosis (Invited review). Arteriosclerosis 9:567-578, 1989.
49.
Stemme S, Jonasson L, Holm J, Hansson GK. Immunologic control of vascular
cell growth in arterial response to injury and atherosclerosis. Transpl. Proc.
21:3697-3699, 1989.
50.
Hansson GK, Hellstrand M, Rymo L, Rubbia L, Gabbiani G. Interferoninhibits both proliferation and expression of differentiation-specific -smooth
muscle actin in arterial smooth muscle cells. J Exp Med 170:1595-1608, 1989.
51.
Seifert PS, Hansson GK. Complement receptors and regulatory proteins in
human atherosclerotic lesions. Arteriosclerosis 9:802-811, 1989.
52.
Hansson GK, Holm J, Jonasson L, Seifert PS, Stemme S. Immunologic control
of vascular cell growth and differentiation. J Cardiovasc Pharmacol 14 (suppl
6):S82-S84, 1989.
53.
Stemme S, Fager G, Hansson GK: MHC class II antigen expression in human
vascular smooth muscle cells is induced by interferon-gamma and modulated by
tumor necrosis factor and lymphotoxin. Immunology 69:243-249, 1990.
54.
Holm J, Hansson GK. Cellular and immunologic features of carotid artery
disease in man and experimental animals. Eur J Vasc Surg 4:49-55, 1990.
55.
Jonasson L, Hansson GK, Bondjers G, Noe L, Etienne J. Interferon-gamma
inhibits lipoprotein lipase in human monocyte-derived macrophages. Biochim
Biophys Acta 1053:43-48, 1990.
56.
Andersson K, Blomstrand C, Frizell M, Hansson GK, Rönnbäck L, Wall M.
Likvorcytologi - en värdefull diagnostisk metod vid olika neurologiska
frågeställningar. Läkartidn. 87:1761-1764, 1990.
57.
Hansson GK, Stemme S, Seifert PS, Holm J. Immune-vascular interactions:
Pathogenetic mechanisms that may lead to new therapeutic approaches. In:
Applied Cardiovascular Biology 1989; P Zilla, R Fasol, A Callow, eds. Karger,
Basel 1990.
58.
Hansson GK, Seifert PS, Högh-Kristiansen I, Westin J. Paroxysmal nokturnal
hemoglobinuri - en molekyldefekt på cellytan. Läkartidn. 87:3179-3182, 1990.
59.
Hansson GK, Stemme S. Lymphokines may regulate cellular growth and
differentiation in the atherosclerotic plaque. In: Growth Factors in Health and
Disease. B Westermark, C Betsholtz and B Hökfeldt, eds. Nordisk Insulin
Symposium No. 4, pp. 109-116. Elsevier, Amsterdam, 1990.
60.
Hansson GK. Aspetti immuni e infiammatori dell'aterosclerosi. G Ital Cardiol
20:1059-1061, 1990.
61.
Bondjers G, Hansson GK, Olsson G, Pettersson K. Smoking, catecholamines,
and their effects on endothelial integrity. Adv Exp Med Biol 273:51-59, 1991.
62.
Libby P, Hansson GK. Involvement of the immune system in human
atherogenesis: Current knowledge and unanswered questions. Lab Invest 64:515, 1991.
63.
Thyberg J, Hansson GK. Cyclosporine A inhibits induction of DNA synthesis
by PDGF and other peptide mitogens in cultured rat aortic smooth muscle cells
and dermal fibroblasts. Growth Factors 4:209-219, 1991.
64.
Hansson GK, Seifert PS, Olsson G, Bondjers G. Early infiltration of monocytes
and T lymphocytes in atherosclerotic lesions of cholesterol-fed rabbits.
Arterioscl Thromb 11:745-750, 1991.
65.
Hansson GK, Holm J. InterferonCirculation 84:1266-1272, 1991.
66.
Hedin U, Holm J, Hansson GK. Induction of tenascin in rat arterial injury:
relationship to altered smooth muscle cell phenotype. Am J Pathol 139:649656, 1991.
67.
Bäck H, Nilsson G, Hansson GK, Rödjer S, Tarkowski A. M-component with
reactivity against actin associated with thrombocytopenic purpura. Am J Med
91:429-433, 1991.
68.
Hansson GK, Holm J, Holm S, Fotev Z, Fingerle J, Hedrich H. T lymphocytes
inhibit the vascular response to injury. Proc Natl Acad Sci USA 88:1053010534, 1991.
69.
Strawn WB, Bondjers G, Kaplan JR, Manuck SB, Schwenke D, Hansson GK,
Shively CA, Clarkson TB. Endothelial dysfunction in response to psychosocial
stress in monkeys. Circ Res 68:1270-1279, 1991.
70.
Bondjers G, Glukhova M, Hansson GK, Postnov YV, Reidy MA, Schwartz SM.
Hypertension and atherosclerosis - cause and effect, or two effects with one
unknown cause? Circulation 84 (suppl VI):VI-2 - VI-16, 1991.
71.
Hansson GK, Stemme S. The role of T lymphocyte activation in arteriosclerosis
and vascular inflammation. Abh. Rheinisch-Westfälische Akad. der
Wissenschaften, 76:31-35, 1991.
72.
Stemme S, Rymo L, Hansson GK. Polyclonal origin of T lymphocytes in human
atherosclerotic plaques. Lab Invest 65:654-660, 1991.
73.
Hansson GK. Immune mechanisms in plaque formation. Atherosclerosis
Reviews 23:169-176, 1991.
74.
Hansson GK, Andersson M, Jarl H, Stemme S. Flow cytometric analysis of
reticulocytes using an RNA-binding fluorochrome. Scand J Clin Lab Invest
52:35-41, 1992.
inhibits arterial stenosis after injury.
75.
Geng Y-j, Hansson GK. Interferon- inhibits scavenger receptor expression and
foam cell formation in human monocyte-derived macrophages. J Clin Invest
89:1322-1330, 1992.
76.
Stemme S, Holm J, Hansson GK: T lymphocytes in human atherosclerotic
plaques are memory cells expressing CD45R0 and the integrin VLA-1.
Arterioscl Thromb 12:206-211, 1992.
77.
Hansson GK, Stemme S, Geng Y-j, Holm J: Can immunocompetent cells and
their cytokines play a role in atherogenesis? Nouv Rev Fr Hematol 34:S43-S46,
1992.
78.
Stemme S, Patarroyo M, Hansson GK: Adhesion of activated T lymphocytes to
vascular smooth muscle cells and dermal fibroblasts is mediated by 1- and 2integrin receptors. Scand J Immunol 36:233-242, 1992.
79.
Geng Y-j, Hansson GK, Holme E. Interferon- and tumor necrosis factor
synergize to induce nitric oxide production and inhibit mitochondrial respiration
in vascular smooth muscle cells. Circ Res 71:1268-1276, 1992.
80.
Hansson GK. Role of immune responses in atherogenesis. Editorial. Nutr Metab
Cardiovasc Dis 2:49-51, 1992.
81.
Hansson GK. Immune and inflammatory mechanisms in the development of
atherosclerosis. Br Heart J 69:S38-S41, 1992.
82.
Tarkowski A, Trollmo C, Seifert PS, Hansson GK. Expression of decayaccelerating factor on synovial lining cells in inflammatory and degenerative
arthritides. Rheumatol Int 12:201-205, 1992.
83.
Hansson GK: Immunological markers of atherosclerosis.
Editorial commentary, The Lancet 341:278, 1993.
84.
Schaufelberger C, Stemme S, Andersson R, Hansson GK. T lymphocytes in
giant cell arteritic lesions are polyclonal cells expressing
type antigen
receptors and integrin receptors. Clin.Exp.Immunol. 91:421-428, 1993.
85.
Hansson GK: Lymphocyte adhesion and cellular immune reactions in chronic
rejection and graft arteriosclerosis. Transpl Proc 25:2050-2051, 1993.
86.
Svenningsson A, Hansson GK, Andersen O, Andersson R, Patarroyo M,
Stemme S. Adhesion molecule expression on cerebrospinal fluid T
lymphocytes. Evidence for common recruitment mechanisms in multiple
sclerosis, aseptic meningitis, and normal controls. Ann Neurol 34:155-161,
1993.
87.
Johansson SR, Emanuelsson H, Holm J, Hansson GK: Restenos efter
angioplastik - klinik och cellbiologi. Läkartidn 90:3310-3317, 1993. H KOPIE
88.
Hansson GK: Immunological factors in atherosclerosis. In: Vascular
Medicine, Proc. 16th World Congress of the Intl. Union of Angiology, H.
Boccalon, ed., pp. 131-136. Excerpta Medica, Amsterdam 1993.
89.
Geng YJ, Kodama T, Hansson GK: Differential expression of scavenger
receptor isoforms during monocyte-macrophage differentiation.
Arterioscler. Thromb. 14:798-806, 1994.
90.
Stemme S, Hansson GK: Immune mechanisms in atherosclerosis.
Coronary Artery Disease 5:216-222, 1994.
91.
Guss SB, Hansson GK: Coronary artery restenosis: Rationale for a trial of
gamma-interferon. Primary Cardiology 20:35-38, 1994.
92.
Stemme S, Hansson GK: Immune mechanisms in atherogenesis.
Ann Med 26:141-146, 1994. CMM FÖR KOP
93.
Hansson GK: Immunological control mechanisms in plaque formation. In:
Arteriosclerosis - New Insights into Pathogenetic Mechanisms and Prevention;
Just H, Hort W, Zeiher AM, eds.
Basic Research in Cardiology, vol. 89 suppl. 1, 1994, pp. 41-46.
94.
Hansson GK, Geng YJ, Holm J, Stemme S: Immune mechanisms in the
pathogenesis of atherosclerosis. In: Atherosclerosis, Inflammation, and
Thrombosis, GG Neri Serneri, GF Gensini, R Abbate, D Prisco, eds. Pp 163168. Scientific Press, Florence 1994.
95.
Bremell T, Lange S, Holmdahl R, Rydén C, Hansson GK, Tarkowski A:
Immunopathological features of rat Staphylococcus aureus arthritis.
Infect. Immun. 62:2334-2344, 1994.
96.
Geng YJ, Almqvist M, Hansson GK: cDNA cloning and expression of
inducible nitric oxide synthase from rat smooth muscle cells. Biochim.
Biophys. Acta 1218:421-424, 1994.
97.
Hansson GK, Geng YJ, Holm J, Hårdhammar P, Wennmalm Å, Jennische E:
Arterial smooth muscle cells express nitric oxide synthase in response to
endothelial injury. J.Exp.Med. 180:733-738, 1994.
98.
Geng YJ, Wu Q, Hansson GK: Protein kinase C activation inhibits cytokineinduced nitric oxide synthase in vascular smooth muscle cells. Biochim.
Biophys. Acta 1223:125-132, 1994.
99.
Grunewald J, Andersson R, Rydberg L, Gigliotti D, Schaufelberger C, Hansson
GK, Wigzell H: CD4+ and CD8+ T cell expansions using selected TCR V and
J gene segments at the onset of giant cell arteritis. Arthritis Rheum 37:12211227, 1994.
100.
Geng YJ, Petersson A-S, Wennmalm Å, Hansson GK: Cytokine-induced
expression of nitric oxide synthase results in nitrosylation of heme and nonheme
iron proteios in vascular smooth muscle cells.
Exp Cell Res 214:418-428, 1994.
101.
Hansson GK: Immune and inflammatory mechanisms in the pathogenesis of
atherosclerosis. J. Atheroscler. Thromb. 1 suppl 1:86-89, 1994. .
102.
Hansson GK: Cytokines regulate proliferation and cytoskeletal organization of
vascular smooth muscle cells. Path. Res. Pract. 190:891-894, 1994.
103.
Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK:
T lymphocytes from human atherosclerotic plaques recognize oxidized LDL.
Proc. Natl Acad. Sci USA 92:3893-3997, 1995.
104.
Geng, Y-j, Hansson GK. High endothelial cells of postcapillary venules
express the scavenger receptor in human peripheral lymph nodes. Scand J
Immunol 42:289-296, 1995.
105.
Yan Z-q, Hansson GK, Skoogh B-E, Lötvall JO. Induction of nitric oxide
synthase in a model of allergic occupational asthma. Allergy 50:760-764,
1995.
106.
Geng Y-j, Hansson GK. Cytokine-induced expression of nitric oxide synthase
in vascular smooth muscle cells is inhibited by phorbol esters. Nitric oxide,
Proc 3rd Intl Symp, 1995.
107.
Geng YJ, Holm J, Nygren S, Bruzelius M, Stemme S, Hansson GK:
Expression of macrophage scavenger receptor in atheroma. Relationship to
immune activation and the T-cell cytokine interferon- . Arteriosclerosis,
Thrombosis, and Vascular Biology 15:1995-1202, 1995.
108.
Hansson GK, Libby P: The role of the lymphocyte. In: "Atherosclerosis and
Coronary Heart Disease", eds. V Fuster, R Ross and E Topol. Pp. 557-568.
Raven Press, New York, 1995.
109.
Dufva M, Svenningsson A, Hansson GK. Differential regulation of
macrophage scavenger receptor isoforms: mRNA quantification using the
polymerase chain reaction. J Lipid Res. 36:2282-2290, 1995.
110.
Svenningsson A, Andersen O, Hansson GK, Stemme S: Reduced frequency
of memory CD8+ T lymphocytes in cerebrospinal fluid and blood of patients
with multiple sclerosis. Autoimmunity 21:231-239, 1995.
111.
Yokota T, Hansson GK: Immunological mechanisms in atherosclerosis. J of
Int Med 238:479-489, 1995
112.
Geng Y.J., Wu Q, Muszynski M, Hansson GK, Libby P: Apoptosis of vascular
smooth muscle cells induced by in vitro stimulation with interferon- , tumor
necrosis factor- and interleukin-1 . Arterioscl Thromb Vasc Biol 16:19-27,
1996.
113.
Geng, YJ, Hellstrand, K, Wennmalm, Å, Hansson GK. Apoptotic death of
human leukemic cells induced by vascular cells expressing nitric oxide
synthase in response to interferon and tumor necrosis factor- . Cancer Res
56:866-874, 1996.
114.
Hansson GK: Immune responses in atherosclerosis. In: Immune Functions of
the Vessel Wall, G K Hansson and P Libby, editors, Pp. 143-158. Harwood
Academic Publishers, Amsterdam 1996.
115.
Hansson GK, Libby P (Editors): Immune Functions of the Vessel Wall.
Harwood Academic Publishers, Amsterdam 1996.
116.
Hansson GK: Immune-Vascular interactions in atherosclerosis and transplant
arteriosclerosis. In: Transplant Vascular Sclerosis, CG Orosz, editor. Ch. 7,
pp. 71-82. R G Landes/Springer, Austin, 1996.
117.
Yan Z-q, Yokota T, Zhang W, Hansson GK: Expression of inducible nitric
oxide synthase inhibits platelet adhesion and restores blood flow in the injured
artery. Circ Res 79:38-44, 1996.
118.
Zhou, X., Stemme, S., Hansson, GK: Evidence for a local immune response in
atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein E-deficient
mice. Am J Pathol 149:359-366, 1996.
119.
Akyürek ML, Fellström BC, Yan, Z-q, Hansson GK, Funa, K, Larsson E:
Inducible and endothelial nitric oxide synthase expression during development
of transplant arteriosclerosis in rat aortic grafts. Am J Pathol 149:1981-1990,
1996.
120.
Akyürek ML, Hansson GK, Larsson E, Fellström BC: Nitric oxide generation
by nitric oxide synthase isoforms in transplanted vessels. Transplant Proc
29:2565-2566, 1997.
121.
Hansson GK, Stemme V, Yokota T: Cytokines and the cardiovascular system.
In: Cytokines in Health and Disease, 2nd ed., pp 507-518. Eds. DG Remick
and JS Friedland; Marcel Dekker, Inc., New York 1997.
122.
Hansson GK: Cell-mediated immunity in atherosclerosis. Current Opinion
Lipidol 8:301-311, 1997.
123.
Hansson GK: Receptorer för invandring i kärlvägg. Läkartidningen 94 (10):
852-854, 1997.
124.
Sirsjö A, Hansson GK: Proinflammatory cytokines and the regulation of
connective tissue. In: Connective Tissue Biology. Integration and
Reductionism, eds R Reed and K Rubin. Wenner-Gren International Series.
Pp171-178.Portland Press, London 1997.
125.
Caligiuri G, Hansson GK: Più del grasso, potè l'antigene. Ricerca Roche 7:4850, 1997.
126.
Libby P, Hansson GK, Pober, JS: Atherogenesis and inflammation. In:
Molecular Basis of Heart Disease, S Chien, J Breslow, J Leiden, R Rosenberg,
C Seidman, editors. Ch 16, pp 349-366. W B Saunders, Philadelphia, 1998.
127.
Yan Z-q, Hansson GK: Overexpression of inducible NO synthase by
neointimal smooth muscle cells. Circ Res 82:21-29, 1998.
128.
Yokota T, Ehlin-Henriksson B, Hansson GK: Scavenger receptors mediate
adhesion of activated B lymphocytes. Exp Cell Res 239:16-22, 1998.
129.
Zhou X, Paulsson G, Stemme S, Hansson GK: Hypercholesterolemia is
associated with a Th1/Th2 switch of the autoimmune response in
atherosclerotic ApoE-knockout mice. J Clin Invest 101:1717-1725, 1998.
130.
Hulthe J, Wikstrand J, Lidell A, Wendelhag I, Hansson GK, Wiklund O:
Antibody titers against oxidized LDL are not elevated in patients with familial
hypercholesterolemia. Arterioscler Thromb Vasc Biol 18:1203-1211, 1998.
131.
Hansson GK: Atherosclerosis: cell biology and lipoproteins. Curr Opin
Lipidology 9:73-75, 1998.
132.
Nicoletti A, Kaveri S, Caligiuri G, Bariéty J, Hansson GK: Immunoglobulin
treatment reduces atherosclerosis in apoE knockout mice. J Clin Invest 102:
910-918, 1998.
133.
Hammar N, Linnersjö A, Hansson GK, Björkander J, Hammarström L:
Ischaemic heart disease in primary immunodeficiency. Lancet 352:1786, 1998.
134.
Hansson GK, Jörnvall H, Lindahl SGE: Kväveoxid som signalmolekyl i hjärtkärlsystemet. Läkartidningen 95 (43):4703-4708, 1998.
135.
Yan Z-q, Sirsjö A, Bochaton-Piallat M-L, Gabbiani G, Hansson GK:
Augmented expression of inducible NO synthase in vascular smooth muscle
cells during aging is associated with enhanced NF- B activation. Arterioscler
Thromb Vasc Biol. 19:2854-2862, 1999.
136.
Hunter GC, Henderson AM, Westerband A, Kobayashi H, Suzuki, F., Yan Zq, Sirsjö A, Putnam CW, Hansson GK: The contribution of inducible nitric
oxide and cytomegalovirus to the stability of complex carotid plaque. J Vasc
Surg 30:36-49, 1999.
137.
Yan, Z-q, Hansson GK: Cytokines in Cardiovascular Diseases. In:
Comprehensive Vascular Biology and Pathology - An Encyclopedic
Reference. Ed. A. Bikfalvi. Springer Verlag, Berlin & Heidelberg, 1999.
138.
Nicoletti A, Caligiuri G, Thörnberg I, Kodama T, Stemme S, Hansson GK:
The macrophage scavenger receptor type A directs modified proteins to
antigen presentation. Eur J Immunol 29:512-521, 1999.
139.
Frostegård J, Ulfgren A-K, Nyberg P, Hedin U, Swedenborg J, Andersson U,
Hansson GK: Cytokine expression in advanced human atherosclerotic plaques:
Dominance of proinflammatory (Th1) and macrophage-stimulating cytokines.
Atherosclerosis 145:33-43, 1999.
140.
Erl W, Hansson GK, de Martin R, Draude G, Weber KSC, Weber C: Nuclear
factor- B regulates induction of apoptosis and Inhibitor of apoptosis protein-1
expression in vascular smooth muscle cells. Circ Res 84:668-677, 1999.
141.
Caligiuri G, Nicoletti A, Zhou X, Törnberg I, Hansson GK: Effects of sex and
age on atherosclerosis and immunity in apoE-deficient mice. Atherosclerosis
145:301-308, 1999.
142.
Neuville P, Yan Z-q, Gidlöf A, Pepper MS, Hansson GK, Gabbiani G, Sirsjö
A: Retinoic acid regulates arterial smooth muscle cell proliferation and
phenotypic features in vivo and in vitro through a RAR -dependent signalling
pathway. Arterioscl Thromb Vasc Biol 19:1430-1436. 1999.
143.
Caligiuri G, Lévy B, Pernow J, Thorén P, Hansson GK: Myocardial infarction
mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc
Natl Acad Sci USA 96:6920-6924, 1999.
144.
Forséni M, Hansson GK, Bagger-Sjöbäck D, Hultcrantz M: Infiltration of
immunocompetent cells in the middle ear during acute otitis media. Am J
Otology 20:152-157, 1999.
145.
Hansson GK: T cells, specific immunity and atherosclerosis. Immunol News
6:33-35, 1999.
146.
Valen G, Erl W, Eriksson P, Wuttge D, Paulsson G, Hansson GK: Hydrogen
peroxide induces mRNA for tumor necrosis factor- by human endothelial
cells. Free Radic Res 31:503-512, 1999.
147.
Zhou X, Hansson GK: Detection of B cells and proinflammatory cytokines in
atherosclerotic plaques of hypercholesterolemic apoE knockout mice.
Scand J Immunol 50:25-30, 1999.
148.
Forséni M, Hansson GK, Bagger-Sjöbäck D, Hultcrantz, M: An
immunohistochemical study of inducible nitric oxide synthase in the rat
middle ear, with reference to tympanosclerosis. Acta Otolaryngol 119:577582, 1999.
149.
Jiang J, Thorén P, Caligiuri G, Hansson GK, Pernow J: Enhanced
phenylephrine-induced phasic activity in the atherosclerotic mouse aorta via
increased opening of KCa channels: Relation to KV channels and nitric oxide.
Brit J Pharmacol, 128:637-646, 1999.
150.
Svenningsson A, Petersson A-S, Andersen O, Hansson GK: Nitric oxide
metabolites in CSF of patients with MS is related to clinical disease course.
Neurology 53:1880-1882, 1999.
151.
Hansson GK: Inflammation and Immune Response in Atherosclerosis. Current
Atherosclerosis Reports. 1:150-155, 1999.
152.
Hansson GK, Zhou X, Törnquist E, Paulsson G, Caligiuri G: Immune
mechanisms in atherosclerosis. In: XXI Congress Eur Soc Cardiol, F NavarroLópez, ed. Pp. 215-221. Monduzzi, Bologna 1999.
153.
Nicoletti A, Caligiuri G, Paulsson G, Hansson GK. Functionality of specific
immunity in atherosclerosis. Am Heart J. 1999;138:S438-43.
154.
Paulsson G, Zhou X, Törnquist E, Hansson GK: Oligoclonal T cell expansions
in atherosclerotic lesions of apoE-deficient mice. Arterioscl Thromb Vasc Biol
20:10-17, 2000.
155.
Stemme V, Swedenborg J, Claesson H-E, Hansson GK: Expression of
cyclooxygenase-2 in human atherosclerotic arteries. Eur J Vasc Surg 20:146152, 2000.
156.
Nicoletti A, Paulsson G, Caligiuri G, Hansson GK: Induction of neonatal
tolerance to oxidized LDL reduces atherosclerosis susceptibility in apoE
knockout mice. Mol Med 6:283-290, 2000.
157.
Valen G, Paulsson G, Bennet AM, Hansson GK, Vaage J: Gene expression of
inflammatory mediators in different chambers of the human heart. Ann Thorac
Surg 70:562-567, 2000.
158.
Erl W, Weber C, Hansson GK: Pyrrolidine dithiocarbamate-induced apoptosis
depends on cell type, density, and the presence of Cu2+ and Zn2+. Am J
Physiol 278:C1116-C1125, 2000.
159.
Valen G, Hansson GK, Dumitrescu A, Vaage J: Unstable angina activates
myocardial heat shock protein 72, endothelial nitric oxide synthase, and
transcription factors NF- B and AP-1. Cardiovasc Res 47:49-56, 2000.
160.
Hansson GK, Zhou X, Törnquist E, Paulsson G: The role of adaptive
immunity in atherosclerosis. Ann. N.Y. Acad. Sci. 902: 53-64, 2000.
161.
Caligiuri G, Paulsson G, Nicoletti A, Maseri A, Hansson GK: Evidence for
antigen-driven T-cell response in unstable angina. Circulation 102:1114-1119,
2000.
162.
Nicoletti A, Caligiuri G, Hansson GK: Immunomodulation of atherosclerosis:
myth and reality. J Intern Med 247:397-405, 2000.
163.
Sirsjö A, Gidlöf AC, Olsson A, Törmä H, Ares M, Kleinert H, Förstermann U,
Hansson GK: Retinoic acid inhibits nitric oxide synthase-2 expression through
retinoic acid receptor- . Biochem Biophys Res Commun 270:846-851, 2000.
164.
Zhou X, Nicoletti A, Elhage R, Hansson GK: Transfer of CD4+ T cells
aggravates atherosclerosis in immuodeficient apoE knockout mice. Circulation
102:2919-2922, 2000.
165.
Hansson GK: Inflammation, injury and atherosclerosis – The Russell Ross
memorial lecture. In: Atherosclerosis XII, Proc XIIth Intl Symp on
Atherosclerosis, eds S Stemme, AG Olsson, pp 53-66, Elsevier, Amsterdam
2000.
166.
Daugherty A, Hansson GK: Lymphocytes in atherogenesis. In:
Atherosclerosis. Gene Expression, Cell Interactions, and Oxidation. RT Dean,
DT Kelly, editors. Pp 230-2492. Oxford University Press, Oxford 2000.
167.
Caligiuri G, Rottenberg M, Nicoletti A, Wigzell H, Hansson GK: Chlamydia
pneumoniae infection does not induce atherosclerosis and has a minor effect
on cholesterol-induced atherosclerosis in mice. Circulation. 103:2834-2838,
2001.
168.
Zhou X, Caligiuri G, Hamsten A, Lefvert AK, Hansson GK: LDL
immunization induces T-cell-dependent antibody formation and protection
against atherosclerosis. Arterioscl Thromb Vasc Biol 21: 108-114, 2001.
169.
Laurat E, Poirier BV, Tupin E, Caliguri G, Hansson GK, Bariéty J, Nicoletti
A: In vivo downregulation of T 1 helper cell responses reduces atherogenesis
in E-knockout mice. Circulation. 104: 202, 2001.
170.
Wuttge DM, Romert A, Eriksson U, Törmä H, Hansson GK, Sirsjö A:
Induction of CD36 by all-trans retinoic acid: Retinoic acid receptor signaling
in the pathogenesis of atherosclerosis. FASEB J 15:1221-1223, 2001.
171.
Hansson GK, Nilsson J: Pathogenesis of atherosclerosis. In: Cardiology. MH
Crawford, JP DiMarco, eds. Pp 1.1-1.12. Mosby, London 2001.
172.
Bian Z, Yan Z-q, Hansson GK, Thorén P, Normark S: Activation of inducible
nitric oxide synthase/nitric oxide by curli fibers leads to a fall in blood
pressure during systemic Escherichia coli infection in mice. J Infect Dis
183:612-619, 2001.
173.
Hansson GK: The Stabilized Plaque: Will the Dream Come True? Eur Heart J
3:C69-C75, 2001.
174.
Wuttge DM, Eriksson P, Sirsjö A, Hansson GK, Stemme S: Expression of
interleukin-15 in mouse and human atherosclerotic lesions. Am J Pathol
159:417-423, 2001.
175.
Valen G, Yan ZQ, Hansson GK: Nuclear Factor Kappa-B and the Heart. J Am
Coll Cardiol. 38:307-314, 2001.
176.
Hansson GK: Immune mechanisms in atherosclerosis. Arterioscl Thromb Vasc
Biol 21:1876-1890, 2001.
177.
Hansson GK: Cellular immune responses in atherosclerosis. In: Inflammatory
Diseases of Blood Vessels. GS Hoffman, CM Weyand, eds. Pp. 155-173.
Marcel Dekker, New York 2001.
178.
Hansson GK: Regulation of immune mechanisms in atherosclerosis. Ann NY
Acad Sci 947: 157-165, 2001.
179.
Hansson GK, Nicoletti A: Autoimmune Aspects of Atherosclerosis. In:
Atherosclerosis and Autoimmunity. Shoenfeld Y, Harats D, Wick G, eds. Pp
17-25, Elsevier Science B.V, 2001.
180.
Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ: Expression of Toll-like
receptors in human atherosclerotic lesions: A possible pathway for plaque
activation. Circulation 105:1158-1161, 2002.
181.
Caligiuri G, Nicoletti A, Poirier B, Hansson GK: Protective immunity against
atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest
109:745-753, 2002.
182.
Hansson GK: The B cell: A good guy in vascular disease? Arterioscl Thromb
Vasc Biol 22:523-524, 2002.
183.
Yang R, Yan Z-q, Chen F, Hansson GK, Kiesesling R: Hyaluronic acid and
chondroitin sulphate A rapidly promote differentiation of immature DC with
upregulation of costimulatory and antigen-presenting molecules, and
enhancement of NF-kappaB and protein kinase activity. Scand J Immunol
55:2-13, 2002.
184.
Rolph MS, Zimmer S, Bottazzi B, Garlanda C, Mantovani A, Hansson GK:
Production of the long pentraxin PTX3 in advanced atherosclerotic plaques.
Arterioscl Thromb Vasc Biol 22:e10-14, 2002.
185.
Hansson GK, Libby P, Schönbeck U, Yan Z-Q: Innate and adaptive immunity
in the pathogenesis of atherosclerosis. Circ Res 91:281-291, 2002.
186.
Schuster GU, Parini P, Wang L, Alberti S, Steffensen KR, Hansson GK,
Angelin B, Gustafsson JÅ: Accumulation of foam cells in liver X receptordeficient mice. Circulation 106:1147-1153, 2002.
187.
Sirsjö A, Löfving A, Hansson GK, Wågsäter D, Tokuno S, Valen G:
Deficiency of nitric oxide synthase 2 results in increased neointima formation
in a mouse model of vascular injury. J Cardiovasc Pharmacol 41:897-902,
2003.
188.
Caligiuri G, Rudling M, Ollivier V, Jacob M-P, Michel J-B, Hansson GK,
Nicoletti A: Interleukin-10 deficiency increases atherosclerosis, thrombosis,
and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med
9:10-17, 2003.
189.
Elhage R, Jawien J, Rudling M, Ljunggren HG, Takeda K, Akira S, Bayard F,
Hansson GK: Reduced atherosclerosis in interleukin-18 deficient
apolipoprotein E-knockout mice. Cardiovasc Res 59:234,240, 2003.
190.
Erl W, Hristov M, Neureuter M, Yan ZQ, Hansson GK, Weber PC: HMGCoA
reductase inhibitors induce apoptosis in neointima-derived vascular smooth
muscle cells. Atherosclerosis 169:251-258, 2003.
191.
Robertson AKL, Rudling M, Zhou X, Gorelik L, Flavell RA, Hansson GK:
Disruption of TGF- signalling in T cells accelerates atherosclerosis. J Clin
Invest 112:1342-1350, 2003.
192.
Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J,
Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH,
Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ,
Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G,
Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W,
Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr
R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W
Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S,
Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah
PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new
definitions and risk assessment strategies: Part I.
Circulation. 2003; Oct 7;108(14):1664-72.
193.
Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J,
Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH,
Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ,
Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker
CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder
RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R,
Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr,
Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler
H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK,
Willerson JT. From vulnerable plaque to vulnerable patient: a call for new
definitions and risk assessment strategies: Part II.
Circulation. 2003;108(15):1772-8.
194.
Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren HG, Hansson GK,
Paulsson Berne G: CD1d-dependent activation of NKT cells aggravates
atherosclerosis. J Exp Med, 2004;199:417-422.
195.
Hansson GK: Detrimental and protective effects of adaptive immunity in
atherosclerosis. Proc XIIIth Intl Symp Atherosclerosis, Elsevier, Amsterdam
2004.
196.
Robertson AK, Zhou X, Strandvik B, Hansson GK: Th2 shift in severe
hypercholesterolemia leads to strong IgE responses to an exogenous antigen.
Scand J Immunol 2004; 59:285-293.
197.
Wuttge DM, Zhou X, Sheikine Y, Wågsäter D, Stemme V, Hedin U, Stemme
S, Hansson GK, Sirsjö A: CXCL16/SR-PSOX is an interferon- regulated
chemokine and scavenger receptor expressed in atherosclerotic lesions.
Arterioscl Thromb Vasc Biol 2004; 24:750-755.
198.
Hemdahl AL, Falk E, Thorén P, Hansson GK: Thrombin inhibitor reduces
myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol
2004;287:H872-877.
199.
Zhou X, Hansson GK: Vaccination and atherosclerosis. Curr Atheroscler
Reports 2004;6:158-164.
200.
Libby P, Hansson GK, Pober JS. Inflammation and immunity in
atherogenesis. In: Chien KR, editor. Molecular Basis of Cardiovascular
Disease: A Companion to Braunwald's Heart Disease, 2nd edition.
Philadelphia: Saunders;2004. p. 349-364.
201.
Persson L, Boren J, Robertson AK, Wallenius V, Hansson GK, Pekna M.Lack
of Complement Factor C3, but Not Factor B, Increases Hyperlipidemia and
Atherosclerosis in Apolipoprotein E-/- Low-Density Lipoprotein Receptor-/Mice. Arterioscler Thromb Vasc Biol. 2004, 24:1062-1067.
202.
Zhou X, Hansson GK: Immunomodulation and vaccination for atherosclerosis.
Expert Opin Biol Ther. 2004;4:599-612.
203.
Sheikine Y, Hansson GK: Chemokines and atherosclerosis.
Ann Med. 2004;36:98-118.
204.
Zhou X, Hansson GK: Effect of sex and age on serum biochemical reference
ranges in C57BL/6J mice. Comp Med. 2004;54:176-8.
205.
Hansson GK, Robertson AKL: TGF-beta in atherosclerosis.
Arterioscler Thromb Vasc Biol. 2004;24:e137-8.
206.
Edfeldt K, Bennet AM, Eriksson P, Frostegard J, Wiman B, Hamsten A,
Hansson GK, de Faire U, Yan ZQ: Association of hypo-responsive toll-like
receptor 4 variants with risk of myocardial infarction.
Eur Heart J. 2004;25:1447-53.
207.
Hansson GK: Glimpse of the secret life of the plaque. Atheroscler Thromb
Vasc Biol 2004;24:2203-4 (Editorial).
208.
Hansson GK, Berne GP. Atherosclerosis and the immune system.
Acta Paediatr Suppl. 2004 Dec;93(446):63-9.
209.
Nilsson J, Hansson GK, Shah PK: Immunomodulation of Atherosclerosis.
Implications for Vaccine Development. Arterioscler Thromb Vasc Biol.
2005;25:18-28.
210.
Chen F, Eriksson P, Hansson GK, Herzfeld I, Klein M, Hansson LO, Valen G.
Expression of matrix metalloproteinase 9 and its regulators in the unstable
coronary atherosclerotic plaque.
Int J Mol Med. 2005 Jan;15(1):57-65.
211.
Zhou X, Robertson AK, Rudling M, Parini P, Hansson GK. Lesion
development and response to immunization reveal a complex role for CD4 in
atherosclerosis. Circ Res 2005;96:427-34.
212.
Hansson GK. ATVB In Focus: Immunity and Atherosclerosis. Arterioscler
Thromb Vasc Biol 2005;25:17.
213.
Olofsson PS, Jatta K, Wågsäter D, Gredmark S, Hedin U, Paulsson-Berne G,
Söderberg-Nauclér C, Hansson GK, Sirsjö A. The antiviral cytomegalovirusinducible gene 5/viperin is expressed in atherosclerosis and regulated by
proinflammatory agents. Arterioscler Thromb Vasc Biol 2005; 25:e113-6.
214.
Hansson GK. Inflammation, atherosclerosis, and coronary artery disease.
Mechanisms of Disease. N Engl J Med 2005;352:1685-1695.
215.
Hansson GK, Edfeldt K. Toll to be paid at the gateway to the vessel wall.
Editorial. Arterioscler Thromb Vasc Biol 2005;25:1085-1087.
216.
Lundberg GA, Kellin A, Samnegård A, Lundman P, Tornvall P, Dimmeler S,
Zeiher AM, Hamsten A, Hansson GK, Eriksson P. Severity of coronary artery
stenosis is associated with a polymorphism in the CXCL16/SR-PSOX gene. J
Intern Med 2005;415-22.
217.
Hemdahl AL, Caligiuri G, Hansson GK, Thoren P. Electrocardiographic
characterization of stress-induced myocardial infarction in atherosclerotic
mice. Acta Physiol Scand 2005;184:87-94.
218.
Elhage R, Gourdy P, Jawien J, Brouchet L, Castano C, Fievet C, Hansson GK,
Arnal JF, Bayard F. The Atheroprotective Effect of 17 -Estradiol Depends on
Complex Interactions in Adaptive Immunity. Am J Pathol 2005;167:267-74.
219.
de Graaf KL, Berne GP, Herrmann MM, Hansson GK, Olsson T, Weissert R.
CDR3 sequence preference of TCRBV8S2(+) T cells within the CNS does not
reflect single amino acid dependent avidity expansion. J Neuroimmunol
2005;166:47-54.
220.
Persson L, Boren J, Nicoletti A, Hansson GK, Pekna M. Immunoglobulin
treatment reduces atherosclerosis in apoE-/- LDLR-/- mice via the
complement system. Clin Exp Immunol 2005;142:441-5.
221.
Hallenbeck JM, Hansson GK, Becker KJ. Immunology of ischemic vascular
disease: plaque to attack. Trends Immunol 2005;26:550-6.
222.
Bäck M, Bu DX, Bränström R, Sheikine Y, Yan ZQ, Hansson GK.
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Wang Y, Gabrielsen A, Lawler PR, Paulsson-Berne G, Steinbruchel DA,
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Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J,
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Hansson GK. Epidemiology complements immunology in the heart.
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Tran PK, Agardh HE, Tran-Lundmark K, Ekstrand J, Roy J, Henderson B,
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Robertson AK, Hansson GK. Autoreactive CD4+CD28- T cells and acute
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Gabrielsen A, Lawler PR, Yongzhong W, Steinbruchel D, Blagoja D,
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Yan ZQ, Hansson GK. Innate immunity, macrophage activation, and
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Olofsson PS, Söderström LÅ, Wågsäter D, Sheikine Y, Ocaya P, Lang F,
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Breland UM, Halvorsen B, Hol J, Oie E, Paulsson-Berne G, Yndestad A,
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Hansson GK, Nilsson J: Atherosclerosis as inflammation: a controversial
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Jawien J, Bian Z, Sheikine Y, Olofsson PS, Pang Y, Edholm T, Dou Y,
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Schaufelberger C, Andersson R, Nordborg E, Hansson GK, Nordborg C,
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Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR,
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Olofsson PS, Söderström LÅ, Jern C, Sirsjö A, Ria M, Sundler E, de Faire U,
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