Download TBL Module: Blood and Lymphoid Tissue

TBL Module: Blood and Lymphoid Tissue
Learning Objectives
• Describe the microscopic appearance of erythrocytes, their principal function, the
importance of erythrocyte cell-surface antigens, and how different kinds of anemia affect
erythrocyte size and shape.
• Describe the microscopic appearance of the different white blood cells, their relative
proportions, how they function, and the unique cellular features that characterize each
type, e.g., specific granules.
• Describe the microscopic appearance of platelets and be able to explain their role in
thrombus formation.
• List the developmental stages of erythrocytes, granulocytes, and platelets, and be able to
describe the morphological changes that occur during development.
• Explain the distinction between humoral and cell-mediated immune responses and
describe how the different lymphocyte subclasses interact with antigen to elicit these
responses.
• Explain how MHC molecules are involved in lymphocyte activation and be able to
describe the functions of macrophages and other antigen-presenting cells.
• Describe the histological organization of lymphatic nodules, lymph nodes, spleen, and
thymus, their respective roles in the immune response, and be able to distinguish these
lymphoid tissues in the microscope.
• Describe lymphocyte recirculation and know which lymphoid tissues have afferent
lymphatic vessels.
Advance Assignment
Prior to coming to class, you must read the following:
1. Chapters 10 and 14 in Ross and Pawlina, 7th ed.
2. The class notes for “Peripheral Blood and Myeloid Tissue” and “The Immune System”.
Be prepared to take a 10-question, multiple-choice Readiness Assurance Test (RAT) based
on the material in the class notes. However, be sure also to read the book chapters to enhance
your general understanding of the material and to provide a source of relevant diagrams, tables,
and micrographs, which you should consult when studying the class notes.