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The Neuro Capsule September 2006 The Posttraumatic Stress Disorder (PTSD)… Posttraumatic Stress Disorder (PTSD) Stress, it’s life… Distress, it’s sickness… Eustress, it’s happiness… and we live it… A distress involves many repetitive events. We are then speaking of « chronic stress». September 2006, Volume 2 Posttraumatic Stress Disorder (PTSD) Definition The PTSD taked place following a particularly traumatizing event, at the mental, psychoemotive or physical level. For the person, the indescriptable or unimaginable nature of the event, the intensity or the assiduous repetition leaves an indelible mark, at that time, we are speaking of PTSD. September 2006, Volume 2 Some statistics… The last statistics show that the PTSD is a worlwide reality and its incidence increases according to the event to the psycho-socio-environmental event… In 2004, the following figures show the importance of this syndrome at a worldwide level, for the countries of North America, Australia, some Western Europe countries and, some countries of a particular interest for NeuroAXIS Inc. US Census Bureau, 2004 September 2006, Volume 2 NORTH AMERICA AND AUSTRALIA COUNTRIES In 2004, prevalence (M of people) of PTSD 6 5 4 3 2 1 0 USA Canada Mexico Australia US Census Bureau, 2004 September 2006, Volume 2 WESTERN EUROPE COUNTRIES In 2004, prevalence (M of people) of PTSD 1 600 1 400 1 200 1 000 800 600 400 200 0 France Spain United Kingdom Italy Germany Netherlands Belgium Sweden Denmark US Census Bureau, 2004 September 2006, Volume 2 PARTICULAR CASES’ COUNTRIES FOR NEUROAXIS In 2004, prevalence (M of people) of PTSD 1 600 1 400 1 200 1 000 800 600 400 200 0 Switzerland EGYPT Romania US Census Bureau, 2004 September 2006, Volume 2 Posttraumatic Stress Disorder (PTSD) The criterions related to its diagnosis: The exposed person was overcome by fear, powerlessness or horror at the time of the event. The registered perceptions and sensations are expressed at the mental (images, thoughts) or the sensorial level (sight, noise, touch, smell). The profound and persistent need to avoid or to forget from the associated stimuli to the traumatism is omnipresent: (thoughts, feelings, conversation, geographical place, crowd). September 2006, Volume 2 Posttraumatic Stress Disorder (PTSD) The criterions related to its diagnosis: The symptoms related to an increase of the stimulus (hyper vigilance, irritability, lack of concentration, anger, sleep disorders) persist since more than a month. The PTSD can create a significative clinical distress or a deterioration of the social and occupational behavior. September 2006, Volume 2 Our results… The acute and chronic stress After studying the impacts of varied acute and chronic stress, we are able to figure out some comments: The acute stress is normaly well assimilated by the organism at the neuro-psycho-physiological level and leaves the place to an other life’s experience… The chronic stress induces some indelible at the sensorial, emotive and mental level and it will stay engraved in the memory for a long time… Our motto « I remember of… » is applicable. September 2006, Volume 2 Our results… The chronic stress The chronic stress induces some metabolic changes,measurable quantitatively at the clinical level. Indeed, our « SymPath Test » allows to distinguish between the anxious states from the depressive states. Following a diagnostic, a neurobio-psycho-social approach is now available through to a customized coaching within our Neuro Éduc program . The chronic stress as such PTSD can therefore be understood, managed and take in charge by the sick person through an integrated approach based on optimization of its neurophysiology. September 2006, Volume 2 SymPath and its clinical values Clinical Values in 890 Subjects Human Serum DBH Enzyme Activity Population 18 % Clinical Values* 30 DEPRESSIVE STATES** 67 % 30-70 15 % 70 ANXIOUS DISORDERS ** Activity LOW NORMAL HIGH * Results are expressed in nmoles of octopamine formed/mL of serum/min (IU). ** More advanced clinical Investigation is needed. September 2006, Volume 2 Posttraumatic Stress Disorder The pharmacological and neurobio-psychobehavioral approach in relation with the results of our SymPath Test …for… Anxious Disorders Depressive States Integrated and suggested therapeutical approaches for the attending physician Integrated and suggested therapeutical approaches for the attending physician Pharmacological therapy Benzodiazepines Selective inhibitors of serotonin reuptake Behavioral therapy : Neuro Éduc Pharmacological therapy Selective inhibitors of noradrenaline re-uptake Antidepressors IMAO Antipsychotics Behavioral therapy : Neuro Éduc September 2006, Volume 2 Our conclusions The PTSD is treated by a pharmacological approach prescribed by the physician and by a neurobio-psycho-social approach based on the optimization of the neurophysiology of the person integrating a verbal, non-verbal and cognitive approach. The PTSD induces some physio-pathological behaviors related to the neurochemistry of emotions. September 2006, Volume 2