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Tidalvolumeisnormalbreathing.MAXinspirtionfollowedbyMAXexpiration;the exhaledvolumeisthevitalcapacityandthegas(ofthemaximallyinspiredbreath) thatremainsinthelungsiscalledtheresidualvolume.Thevolumeofgas remaininginthelungafteranormal expirationiscalledthefunctional residualcapacity.FRCandRV havetobemeasuredbyheliumdilution techniquesorbodyplethysmography, notaspirometer. AverageTidalVolume=500ml, Totalvent=7500ml(RRof15) Anatomicaldead-space=150ml Alveolargas=~3000ml, Alveolarventilation=5250ml/min Pulmonarycapilaryblood=70ml Pulmonarybloodflow=5000ml/min Alveolarventilationiswhatreallymatters-isthevolumeoffresh(non-deadspace)gasthat enterstherespiratoryzone(areaofgasexchange)perminute.Itcanbedeterminedbythe CO2outputofthebodydividedbythefractionalconcentrationofCO2intheexpiredgas (alveolargasequation).TheconcentrationofCO2(andit'spartialpressure)inalveolargasis inverselyrelatedtothealveolarventilation-thisisimportantbecauseifalveolarventilation HALVES,thenpaCO2doubles.Innormalbodies,thepCO2ofarterialbloodandinthe alveoliareprettymuchidentical. Va-Ventilationofalveoli Vco2=rateofCO2production Pco2=partialpressureofCO2 K=constantof863mmHg Thisisthevolumeoftheconductingairways.Normalvalueisaround150ml,butincreaseswith largerbreathsbecauseofthetractionexertedonthebronchibythesurroundinglung parenchyma.DSalsodependsonthesizeandpostureofthepatient-usually2mg/kgin uprightposition.FOWLER'SMETHODestimatesdeadspacevolumeusingavalveboxanda continuousnitrogenanalyseratthelips.-followingasinglebreathof100%O2,nitrogenwill risesasthedeadspacegasisincreasinglywashedoutbyalveolargas,finallyauniformconc isseenontheanalyseras'pure'alveolargascomesout. DSgivesinformationonhowmuchoftotalventilationthatreachesbothventilatedandperfused alveoliandthusallowsgasexchangebetweenalveoliandpulmonaryblood. RealisingthatCO2retentioncanbeaneffectnotonlyoflowtotalventilationbutalsoof increaseddeadspaceisIMPORTANT. Moreover,deadspacewillgiveinsightintothematchingofventilationandperfusion. ExpiredCO2comesfromalveolargas,notanatomicaldeadspace.Therefore,Bohr's methodcancalculatephysiologicaldeadspace.ITISTHEVOLUMEOFGASTHATDOES NOTELIMINATECO2.YouhavetocomparearterialandexpiredCO2tocalculatethe mismatch.ThisisimportantwhenconsideringPE'sandmanyotherlungdiseases. VD=Physiologicaldeadspace VT=Tidalvolume PaCO2=ArterialCO2 PeCO2=ExpiredCO2 Thiswasidentifiedwhentheycalculatedwhereradiationofinhaledxenonwas detectedbycounterslinedupagainsttheposteriorchestwall.Lowerportions ofthelungshadmorexenondetectedinthem. Thetopofthelungswereleastwellventilated.Thisisallduetogravitywhenstandingup. Whensupine-apexandbaseoflungarethesame,butthePOSTERIORlobesarebetterventilated. Whenlateral-thedependentareaisbetterventilated. Intrapleuralpressureishigheratthebasesofthelungs(lessnegative) -andexpandsbetteroninspiration,thereforeventilationisbetter....(largeoversimplification!) ThisconceptisextremelyimportantinsicklungsandparticularlyinICU-whichiswhysome practitionerselecttoPRONEpeopletochangethe dependentareaofthelung,improveventilationin thehealthierportionsoflungandimprove oxygenation. West'sPhysiology+http://www.ncbi.nlm.nih.gov/pubmed/16682925 ProfessorWesthasawonderfulrepositoryofonlinevideotutorialsonrespiratoryphysiology -http://meded.ucsd.edu/ifp/jwest/resp_phys/