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Fundamentos Biomoleculares de la Prescripción del Ejercicio MSc. Cristian Contador C. Director Carrera Kinesiología Universidad San Sebastián – Santiago [email protected] Obesidad Abdominal Estado Pro Trombótico Dislipidemia Aterogénica CARDIOMETABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio C. Holm. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochemical Society Transactions (2003) Volume 31, part 6 Alon Eliakim, Dan Nemet, Frank Zaldivar, Robert G. McMurray,Floyd L. Culler, Pietro Galassetti, and Dan M. Cooper. Reduced exercise-associated response of the GH-IGF-I axis and catecholamines in obese children and adolescents. J Appl Physiol 100: 1630–1637, 2006. BENTE KIENS. Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance. Physiol Rev 86: 205–243, 2006 BENTE KIENS. Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance. Physiol Rev 86: 205–243, 2006 Rebecca J. Tunstall, Kate A. Mehan, Glenn D. Wadley, Gregory R. Collier, Arend Bonen, Mark Hargreaves, And David Cameron-smith. Exercise training increases lipid metabolism gene expression in human skeletal muscle. Ajpendocrinol Metab • VOL 283 • JULY 2002 Mitochondrial long chain fatty acid oxidation,fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise. Graham P. Holloway1, Veronic Bezaire, George J. F. Heigenhauser, Narendra N. Tandon, Jan F. C. Glatz, Joost J. F. P. Luiken, Arend Bonen and Lawrence L. Spriet. J Physiol 571.1 (2006) pp 201– 210. Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio Fujii N, Jessen N and Goodyear L. AMP-activated Protein Kinase and the Regulation of Glucose Transport.. Am J Physiol Endocrinol Metab 291: E867 – E877. 2006 AS160 phosphorylation is associated with activation of 221- but not 223-AMPK trimeric complex in skeletal muscle during exercise in humans. Jonas T. Treebak, Jesper B. Birk, Adam J. Rose, Bente Kiens, Erik A. Richter, and Jørgen F. P. Wojtaszewski. Am J Physiol Endocrinol Metab 292: E715–E722, 2007. Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. Giorgos N. Kraniou, David Cameron-Smith, and Mark Hargreaves. J Appl Physiol 101: 934–937, 2006. Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio Efectos Vasculares • Diversos estudios señalan que la actividad física regular: – Disminuye los factores de riesgo – Impide el desarrollo de ateroesclerosis – Ayuda al tratamiento de la enfermedad coronaria Efectos del Ejercicio Ejercicio e Hipertensión • Al evaluar la dilatación dependiente de endotelio (EDD). • Estudios in vivo demostraron un incremento del EDD en – – – – Arterias Arteriolas (ME) Arteriolas coronarias Estos cambios se deben a una modificación genética de la eNOS – La inactividad física disminuye la EDD y la expresión génica Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. M. Harold Laughlin, Sean C. Newcomer, and Shawn B. Bender. J Appl Physiol 104: 588–600, 2008. Aerobic exercise attenuates inducible TNF production in humans. Richard P. Sloan,Peter A. Shapiro Ronald E. DeMeersman,Paula S. McKinley, Kevin J. Tracey, Iordan Slavov,Yixin Fang, and Pamela D. Flood. J Appl Physiol 103: 1007–1011, 2007. Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Magkos, Faidon, David C. Wright, Bruce W. Patterson, B. Selma. Mohammed, and Bettina Mittendorfer. Am J Physiol Endocrinol Metab 290: E355–E362, 2006. Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Magkos, Faidon, David C. Wright, Bruce W. Patterson, B. Selma. Mohammed, and Bettina Mittendorfer. Am J Physiol Endocrinol Metab 290: E355–E362, 2006. ¿Qué Efectos tiene el envejecimiento? Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Mark D. Ross, Eva Malone, and Geraint Florida-James. Oxidative Medicine and Cellular Longevity. Volume 2016 Aerobic exercise training reduces plasma endothelin-1 concentration in older women. Maeda, Seiji, Takumi Tanabe, Takashi Miyauchi, Takeshi Otsuki, Jun Sugawara, Motoyuki Iemitsu, Shinya Kuno, Ryuichi Ajisaka, Iwao Yamaguchi, and Mitsuo Matsuda. J Appl Physiol 95: 336–341, 2003. Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio Dislipidemia Aterogénica Obesidad Abdominal Estado Pro Trombótico CARDIO METABÓLICO Insulinoresistencia y/o Intolerancia a la glucosa Hipertensión Arterial Estado pro inflamatorio The anti-inflammatory effect of exercise Petersen, Anne Marie W., and Bente Klarlund Pedersen. J Appl Physiol 98: 1154–1162, 2005.
