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Priv.-Doz. Dr. Suat Özbek 01.12.1968, Marl Heidelberg Institute of Zoology Dept. of Molecular Evolution and Genomics Im Neuenheimer Feld 230 69120 Heidelberg Tel.: 06221 545638 Fax: 06221 545678 e-mail: [email protected] CURRICULUM VITAE 1988 – 1995: 1995 – 1995: 1996 – 2000: 2000 - 2004: 2004: Since 11/2004: Study of Biology, TH Darmstadt Diploma Thesis PhD Thesis I. Med. Klinik, Johannes Gutenberg-University Mainz, Germany Advisor: Prof. Dr. Stefan Rose-John „Structure/Function analysis of the human IL-6 Receptor“ Postdoctoral position at the Biozentrum, University of Basel, Switzerland, Prof. Dr. Jürgen Engel “Structure/Function analysis of assembly domains in ECM proteins” Habilitation in Biochemistry, University of Basel Group leader at the University of Heidelberg, Institute of Zoology, Dept. of Molecular Evolution and Genomics Molecular Evolution of signaling and ECM proteins FIELDS OF INTEREST Biochemistry and molecular evolution of ECM and signaling molecules in the model organism Hydra. PUBLICATIONS (10 most important publications): Ozbek S, Engel J, Stetefeld J. Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3). EMBO J. 2002 Nov 15;21(22):5960-8. Ozbek S, Pertz O, Schwager M, Lustig A, Holstein T, Engel J. Structure/function relationships in the minicollagen of Hydra nematocysts. J. Biol. Chem. 2002 Dec 20;277(51):49200-4. Mann HH, Ozbek S, Engel J, Paulsson M, Wagener R. Interactions between COMP and matrilins:Implications for matrix assembly and the pathogenesis of chondrodysplasias. J. Biol. Chem., 2004 Jun 11;279(24):25294-8. Pokidysheva E, Milbradt AG, Meier S, Renner C, Haussinger D, Bachinger HP, Moroder L, Grzesiek S, Holstein TW, Ozbek S, Engel J. The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall. J. Biol. Chem., 2004 Jul 16;279(29):30395-401. Marz P, Probst A, Lang S, Schwager M, Rose-John S, Otten U, Ozbek S. Ataxin-10, the SCA10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. J. Biol. Chem., 2004 August 20;279(34): 35542–550. Ozbek S, Pokidysheva E, Schwager M, Schulthess T, Tariq N, Barth D, Milbradt AG, Moroder L, Engel J and Holstein TW. The glycoprotein NOWA and minicollagens are part of a disulfidelinked polymer that forms the cnidarian nematocyst wall. J. Biol. Chem., 2004 December 10;279(50): 52016–52023. Nüchter, T., Benoit, M., Engel, U., Ozbek S and Holstein, T.W. Nanosecond kinetics of nematocyst discharge. Current Biology, 2006 May 9;16(9):R316-8. Marz P, Stetefeld J, Bendfeldt K, Nitsch C, Reinstein J, Shoeman RL, DimitriadesSchmutz B, Schwager M, Leiser D, Ozcan S, Otten U and Ozbek S. Ataxin-10 interacts with O-linked beta -N-acetylglucosamine transferase in the brain. J Biol Chem. 2006 Jul 21;281(29):20263-70. Meier S ,Jensen PR, David CN, Chapman J, Holstein TW, Grzesiek S and Ozbek S. Continuous molecular evolution of protein domain structures by single amino acid changes. Current Biology 2007 Jan 23;(17) 173-178. Meier S. and Ozbek S. A biological cosmos of parallel universes: Does protein structural plasticity facilitate evolution? Bioessays, 2007 Nov;29(11):1095-104.