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SUBJECT NATURAL SCIENCES TITLE OF LEARNING OBJECT CURRICULAR AXIS STANDARD COMPETENCIES LEARNING OBJECTIVES GRADE 11th LEARNING UNIT WHAT IS EVERYTHING THAT SURROUNDS US MADE OF? Why are amines weak bases? Living environment I relate functional groups with to physical and chemical properties of substances. To interpret some of the physical and chemical properties of amines and their derivatives. To explain the physical and chemical properties of amines. To identify the basicity of an amine according to its molecular structure. To evaluate the applications of some amines in society. SKILLS/ KNOWLEDGE SKILL 1: Identifies the functional amino group and the spatial disposition of atoms. SKILL 2: Recognizes neutralizing chemical reactions between an amine and a strong acid. SKILL 3: Orders amines according to their basicity. SKILL 4: Inquires on amines and their applications. LEARNING FLOW • Introduction • Objectives • Activity 1. Amines and nomenclature • Activity 2. Amines physical properties and reactions • Activity 3. Amine applications • Summary • Homework • Evaluation • Glossary ASSESSMENT The following sequence must be taken into account to answer the GUIDELINE question: - To identify the structure of amines. - To name amines based on the IPUAC nomenclature. - To recognize the physical characteristics of amines. - To recognize the neutralization reaction that amines with a strong base have. - To identify amine applications. Step Introduction Learning Flow Introduction Teaching / Learning Activities Recommended Resources The teacher presents the topic Student material Resource 1. Animation that represents amines that we find in our daily lives. Student material Objectives Activity 1 Introduction The teacher presents the topic To interpret some of the physical and Game chemical properties of amines and their derivatives. To explain the physical and chemical properties of amines. To identify the basicity of an amine according to its molecular structure. To evaluate the applications of some amines in society. Skill 1: Identifies the functional amino group and Student material the spatial disposition of atoms What characterizes amines? These organic compounds have a tetrahedral geometry and are formed by Nitrogen (N). Their general formula is R3N; R can be an H or a hydrocarbon group (Brown, LeMay, Jr., Bursten & Burdge, 2004). An example of these methylamine CH3N: compounds is the Resource 2 Image, example of an amine Figure 1. Molecular structure of methylamine. Figure modified from (Johll, 2008). Did you know that... The element known as Nitrogen (N) was discovered in 1772 by Daniel Rutherford. N is a component of our atmosphere. (“nitrogeno.htm,” n.d.). Developme nt The classification of amines depends on the number of organic substituents attached to N. Resource 3 map, whose objective is to show amines' classification Primary: N is connected to one C and two H (R-NH2). Secondary: N is connected to two C and one H (R2NH). Tertiary: N is connected to three C (R3N). How are these compounds called? Primary Amines They are named by adding the suffix -amine to the name of the organic substituent. Example: H2NCH2CH2CH2CH2NH2 Butane-1,4-diamine If there is an additional functional group, the name will be the carbon number attached to the Nitrogen and the word amine. Student material Figure 2. Structure of a primary amine with a carboxyl group. Retrieved from: (McMurry & Simanek, 2007). Secondary and Tertiary Amines If the amines are symmetrical, they are named by adding the di- or tri- prefix to the alkyl group. Figure 3. Structure of a symmetrical secondary amine. Retrieved from: (McMurry & Simanek, 2007). When they are more complex compounds and are not symmetrical, the longest organic group is chosen as the main group and the other groups are considered to be N-substituents. Resource 4 The student will be able to find images which correspond to examples of the usage of naming conventions for amines. Figure 3. Structure of a non-symmetrical secondary amine. Retrieved from: (McMurry & Simanek, 2007). To better understand... https://www.youtube.com/watch?v=Kpov3GS6tjM https://www.youtube.com/watch?v=CJzuu_k9Nv0 &ebc=ANyPxKqCzOAub9rV_TXcBhD4tqK24cE1 KpeFTYNQWY50tBTAGxVvkUYLagYTRKKfum9 BvVRh5iT9evURPOR97KnMkYfiKdSbvQ Learning Activity 1 Resource 5 Video that corresponds to feedback on amine nomenclature 1. Identify which of the following compounds corresponds to an amine. A Learning Activity 1 B C The learning activity is of a structural and semistructural kind, where the student must identify the amines, name the compounds and classify them. D E 2. Indicate compounds. A the names of the following B C 3. Classify the following amines as primary, secondary or tertiary. A Trimethylamine tert-Butylamine. C Answer key 1 B and D 2 A 2-Aminobutanoic Acid B Triethylamine C Ethylamine 3 A Tertiary B Primary C Secondary Activity 2 The teacher presents the topic Skill 2: Recognizes neutralizing chemical reactions between an amine and a strong acid. Skill 3: Orders amines according to their basicity. Figure 4. Properties of amines. Resource 6 Image that permits the student to identify some characteristic properties that amines have Can amines form hydrogen bonds? Developme nt Primary and secondary amines can form intermolecular hydrogen bonds; however, these bonds are weaker than those that alcohols form, since the electronegativity of N is lower than that of O. What about their boiling point? Their boiling point is high compared to nonpolar compounds with the same molecular weight; however, the boiling point is lower than that of alcohols and carboxylic acids, because the hydrogen bonds that they form are weaker. In addition, the boiling point of a primary amine is higher than that of a tertiary amine. (Fernández, 2014; Morrison & coaut., 1998). Are they soluble? Amines with less than 5 carbon atoms are generally soluble in water; however, they are less soluble than alcohols. (McMurry, 2012). Why are amines weak bases? Amines have an N atom with a pair of unshared electrons that has the capacity to be a receptor of electrons. As a result, they behave as bases (Brown et al., 2004). Amines are much stronger bases than alcohols, ethers and even water. Additionally, aromatic amines are less basic than aliphatic amines, since the pair of unshared electrons is engaged in ring resonance and less prone to capture protons (McMurry & Simanek, 2007). Let's see some examples: Figure 5. Basicity of some amines. Table modified from (McMurry & Simanek, 2007) Remember that... pKb is the dissociation force of basic molecules ; the lower the pKb value, the more basic the compound. Can amines form salts? Amines are capable of forming salts from a neutralization reaction, that is to say, amine reacts with a strong acid such as HCl or a nitrous acid. For example, if we mix methylamine with HCI in a laboratory, we will obtain a salt called chloride methylammonium. (GuateQuímica, n.d.): Resource 7 Table that shows some examples of amines in respect to pKb indicating how basic it is Primary amines react with nitrous acids and produce diazonium salts. On the other hand, secondary amines form nitrosamines, when they react with a nitrous acid. (Rivera & Teijón, 2006). Let's see how benzene diazonium chloride is synthesized. https://www.youtube.com/watch?v=zA2Q-J-RlX0 Learning Activity 2 1. Number the following compounds from the most basic to least the least basic. Student material Compound (CH3CH2)2NH (CH3)3N CH3NH2 CH3CH2NH2 Basicity Resource 8 Video that shows how to prepare salt in a laboratory (CH3CH2)3N ANSWER KEY Compound (CH3CH2)2NH (CH3)3N CH3NH2 CH3CH2NH2 Basicity 4 5 3 2 6 (CH3CH2)3N 1 22. Match the concepts on the left column to the content on the right based on their relevance. Learning Activity 2 1 Primary amine + strong acid = 2 Amine 3 CH3NH2 + HCl [CH3NH3]+Cl4 Secondary amine + strong acid = ANSWER KEY 1 Primary amine + strong acid = 2 Amine 3 CH3NH2 + HCl [CH3NH3]+Cl4 Secondary amine + strong acid= A Weak base B Diazonium salt C Nitrosamine D Neutralization reaction B Diazonium salt A Weak base D Neutralization reaction C Nitrosamine The learning activity is of a structured type, where the student should complete the table, also there is a game where they must match information from one column with information from another. Activity 3 Introduction Skill 4. Inquire on amines and their applications. The teacher presents the topic Which amines are used as medicines? There is a class of amines derived from plants called alkaloids. The complexity of these compounds is very varied. Many of these alkaloids are pharmacological agents (McMurry & Resource 9 Animation that shows examples of the most common amines, used by many human beings Simanek, 2007). Figure 6. Examples of some alkaloids used in medicine. Retrieved from (McMurry & Simanek, 2007). Papaver somniferum: Since the seventeenth century, the crude fruit extract of this plant has been used to relieve pain. This extract was called opium. Developme nt Morphine: It was the first isolated opium alkaloid. Morphine is used to relieve pain, because this drug is able to block the transmission of pain signals and also changes its reception in the brain. Codeine: methyl ether of morphine used as an Resource 10 analgesic. Map infographic, Atropa belladonna: The common name of this which allows plant is nightshade. students to interact with the Atropine: It is an antispasmodic used to treat molecular colitis. structures, see curious facts on Rauwolfa serpentina: It is a semi-tropical plant; compounds and the root is used as a medicine. applications Reserpine: tranquilizer and anti-hypertensive medication. Did you know that... Heroin is a morphine-like compound; it is synthesized by morphine's diacetylation (McMurry & Simanek, 2007). Heroin is one of the most dangerous drugs that exist today. https://www.youtube.com/watch?v=KxGL2bZyDb k What is the role of amines in industry? In addition to the medical importance of amines, they are also used to manufacture textile fibers, dyes, fertilizers and resins (Ballester et al., 2011). Resource 11 It is a video where an organic chemistry teacher/researc her explains morphine and heroin Figure 6. Examples of amines used in industry. N-Ethylmethylamine: It is used to produce resins and rubber (RC, 2012). Mauveine: It is also called aniline purple, it was the first dye sintered by the British chemist William Perkin. Mauveine is used to dye silk and other textiles. It is also used for applications in medicine and biology; for example, to stain cells (Claramunt et al., 2015). 1,6-hexanediamine: It is used to produce nylon 6,6. This is produced through the condensation reaction of 1,6-hexanediamine and 1,6hexanedioic acid, also called adipic acid. It is used for the production of socks, parachute Resource 12 Map infographic fabrics, linen, sewing thread, etc. (Ballester et al., that will allow 2011). the student to interact with the molecular Learning Activity 3 structures of compounds and Answer the following questions: their applications 1. What types of amines are used as medicines? 2. What applications do amines have? Discuss and consult with a classmate. 3. Consult other applications that amines have (different from those seen in this section) and provide some examples. Discuss your findings with your classmates. Learning activity 3 is not structured, the students will have to discuss in class. Abstract Learning Activity 3 The teacher presents the topic Amines are organic compounds that Student material contain Nitrogen (N), and its general Animation formula is R3N. Amines are classified as primary, secondary and tertiary, taking into account Homework Evaluation The teacher presents the topic the number of N's substituents. Amines are polar compounds; if they are amines with less than 5 carbon atoms they are typically water soluble, since they are capable of forming intermolecular hydrogen bonds. They have a lower boiling point than that of alcohols. They behave as weak bases, because N has a pair of unshared electrons. Aromatic amines are usually less basic than aliphatic amines. When an amine reacts with a strong acid (neutralization reaction) it is capable of forming salts. They have a great variety of applications, including medicine, dyes, resins, etc. 1. In pairs, look for a molecular structure of an amine, different from the ones seen in this section. 2. Draw the molecular structure on a letter-sized sheet of paper, but without writing your name. 3. These drawings will be exchanged in class, and each pair will have another team's molecular structure. 4. Students should name the structure and look for information on its properties and applications. 5. This work will be discussed in class, and each pair will have 5 minutes to present their corresponding molecular structure. 1. Indicate the names of the following compounds: 1 The homework is a group activity, where they will need to consult, analyze the molecular structure, name and find properties and applications. Additionally, students will need to discuss in class. Student material ANSWER KEY: N-Methylethylamine ANSWER KEY: Tricyclohexylamine ANSWER KEY: Butane-1,3-diamine 2. Classify the following amines as primary, secondary or tertiary. 4. (CH3)2CHNH2 ANSWER KEY: primary, N is connected to 1 C. 5. (C2H5)3N ANSWER KEY: tertiary, N is connected to 3 C. 6. (CH3CH2)2NH ANSWER KEY: secondary, N is connected to 2 C. 3. Match the concepts in the left column to the corresponding content in the right column. 7 Hydrogen bonding amines 8 Diazonium salts 9 Class of amines that are less basic 10 Class of amines that cannot form intermolecular hydrogen bonds Product of a reaction between an amine and a strong acid Tertiary amines They are lower than alcohol, because there is higher electronegativity in N than in O Aromatic amines ANSWER KEY 7 Hydrogen bonding amines They are lower than alcohol, because there is higher electronegativity in N than in O 8 Diazonium salts Product of a reaction between an amine and a strong acid 9 Class of amines that Aromatic amines are less basic 10 Class of amines Tertiary amines that cannot form intermolecular hydrogen bonds Glossary Isomers: compounds that have an equal Student material molecular formula, but different spatial distribution of atoms. Enantiomers: also known as optical isomers, they are compounds with the same physical and chemical properties, but they are not superimposable; in other words, they are mirror images. Colitis: Inflammation of the large intestine. Antispasmodic: a medicine to relieve muscle spasms. Antihypertensive: a substance or drug used to reduce high blood pressure. Pesticides: synthetic or natural compounds used for pest control; for example, to destroy certain insects that destroy crops. Opium: a substance that is extracted from the fruit of the Papaver somniferum plant. Aliphatic: a linear-chain or open-chain compound. Bibliography Ballester, J. R., Ballester, M. E., Calatayud, M. L., Sabater, J. V., & Trilles, E. (2011). Química 2o Bachillerato. Nau Llibres. Brown, T. L., LeMay, H. E., Jr., Bursten, B. E., & Burdge, J. R. (2004). Quimica. Pearson Educación. Claramunt Vallespí, M. R., Cornago Ramírez, P., Esteban Santos, S., Farrán Morales, A., Torralba Pérez, M., & Sanz del Castillo, D. (2015). PRINCIPALES COMPUESTOS QUÍMICOS. Editorial UNED. Fernández, G. (2014). Química Orgánica. Germán Fernández. Retrieved from https://books.google.com/books?id=uhXGAgAAQBAJ&pgis=1 GuateQuímica. (n.d.). Propiedades Químicas. Retrieved March 25, 2016, from http://www.guatequimica.com/tutoriales/aminas/Propiedades_Quimicas.htm Johll, M. E. (2008). Química e investigación criminal: Una perspectiva de la ciencia forense. Reverte. McMurry, J. (2012). Quimica Orgánica. Cengage Learning Editores. McMurry, J. E., & Simanek, E. (2007). Fundamentals of Organic Chemistry (6th ed.). Thomson. Morrison, R. T., & coaut., R. N. B. (1998). Química orgánica. Pearson Educación. Nitrogeno.htm. (n.d.). Retrieved March 24, 2016, http://www.quimicaweb.net/tablaperiodica/paginas/nitrogeno.htm from RC, R. (2012). “USOS DE COMPUESTOS QUÍMICOS ORGÁNICOS.” Retrieved April 5, 2016, from http://compuestosorganicos203.blogspot.com.co/ Rivera, J. M. T., & Teijón, J. M. (2006). La Química en problemas. Editorial Tebar. Vocabulary box: Compound: composed of or resulting from the union of separate elements, ingredients or parts. Base: in chemistry, any substance that in water solution is slippery to the touch, tastes bitter, changes the color of indicators (e.g., turns red litmus paper blue), reacts with acids to form salts, and promotes certain chemical reactions (base catalysis). Britannicacom. (2016). Encyclopedia Britannica. Retrieved 13 April, 2016, from http://global.britannica.com Neutralization: to cause to be neither an acid nor a base. Polar: the condition of having positive and negative charges and especially magnetic or electrical poles. English review topic: yes/no and Wh- questions.