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COURSE SYLLABUS Academic year: 2013/2014 Description of Subject of Education - Teaching Program Name of course: PATHOPHYSIOLOGY Head of the Department: Witold Pilecki dr hab. prof. nadzw. Faculty: Field of study: Level of study: Medical Medicine Master’s-level, Uniform (single degree) Form of study: Year of study: Full-time II Type of course: Lecturer’s language: Compulsory English Department conducting the subject Department of Pathophysiology Semester: 3 and 4 Winter semester (hrs) L C S 10 30 Summer semester (hrs) L C S 10 30 Total number of hours per year: 80 Goals of the course: G1 – The aim is to present and elucidate in the clear and comprehensive manner the structural and functional pathomechanisms underlying the most common disorders and diseases affecting the individual systems and organs of the human body. Matrix of the education effects for the subject in reference to methods of verification of the effects intended and to forms of the course (K – knowledge; S – skills) No. of education effect Description of education effect Verification methods of Forms of the course ** achieving the intended education effects* Student knows and understands oral response, credit test L, C K1 the pathophysiological background of the most common and crucial diseases and disorders. K2 K3 S1 Student knows how to combine the various symptoms to make up a diagnosis of the disease. oral response, credit test L, C Student knows how to predict the complications of the diseases. oral response, credit test L, C Student is able to recognize and give an interpretation of the essential abnormalities of the discussion C electrocardiographic (ECG) recordings, blood smear, gasometry, spirometry and levels of hormons. * presentation, response, discussion, essay, colloquium, examination (oral, written, test) ** L- lecture; S- seminar; C- class; EL- e-learning Balance of ECTS points Activities at the university Student’s own work Total student’s workload ECTS of the course (per year) 80 (40+40) hours 42 (15 + 27) hours 122 (55+67) hours 6.0 DETAILED PROGRAM OF THE COURSE Winter semester – Lectures (Tutor: M. Sobieszczańska) 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Pathophysiological background of electrocardiography Modern and experimental electrocardiographic techniques (e.g. BSPM, MCG, SATRO). Pathomechanisms and risk factors of atherosclerosis; essentials of cardiovascular disease prevention. Ischemic heart disease – pathogenesis, clinical forms, diagnostics. Genetically determined heart diseases. Structures and functioning of the gastrointestinal system. Peptic ulcer disease (PUD) – etiology, signs, complications. Jaundice – pathomechanisms and differential diagnosis. Bronchial asthma – etiology, clinical presentation. Chronic obstructive pulmonary disease (COPD) – etiology, clinical presentation. Winter semester – Seminars (M. Sobieszczańska, M. Poręba, A. Biełous, P. Kolęda, M. Tabin) Principles of normal ECG analysis Practicing the normal ECGs interpretation and description Pathomechanisms and classification of cardiac rhythm disturbances Reading the ECGs presenting cardiac arrhythmias Pathomechanisms and classification of heart blocks Reading the ECGs presenting heart blocks Acute coronary syndromes and myocardial infarction – pathogenesis and diagnostics Reading the ECGs presenting various forms of myocardial ischemia and infarct Heart failure – right and left ventricular; pathomechanisms, clinical signs Arterial hypertension – causes, symptoms and signs, consequences Valvular heart disease – pathogenesis, influence over hemodynamics ECG findings in various clinical states (hypertrophy, electrolytes imbalance, artificial pacemaker) Credit Test #1 (Cardiology) Oesophageal achalasia, GERD (gastroesophageal reflux disease) Inflammatory bowel disease (IBD) – pathogenesis, clinical presentation Hepatitis – etiology, clinical presentation Cholelithiasis and cholecystitis – etiology, clinical presentation Pancreatitis, acute and chronic – etiology, clinical presentation Acute and chronic respiratory insufficiency – etiology, clinical presentation Obstructive lung diseases Restrictve lung diseases Spirometry examination, parameters, interpretation Emphysema, pneumothorax, atelectasis, pulmonary oedema Pulmonary embolism – etiology, clinical presentation, outcome Credit Test #2 (Alimentary and Respiratory systems) Summer semester – Lectures (Tutor: M. Sobieszczańska) 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Organization of the endocrine system, neuro-humoral regulation, negative feedback loop. Endocrine organs – structure and functioning. Hormones – classification, structure, secretion and molecular functioning. Pituitary gland – structure, hormones, regulation axis, hypofunction, hyperfunction. Pathophysiology of the adrenal medulla, stress hormones, pheochromocytoma. Metabolic syndrome, obesity – definition, epidemiology, clinical relevance. Diabetes mellitus type 2 as civilization pandemia; definition of cardiodiabetology. Menopause – pathophysiology, signs, management. Biochemical disorders in kidney insufficiency. Genetic background of the blood coagulation disorders. Summer semester – Seminars (M. Sobieszczańska, M. Poręba, A. Biełous, P. Kolęda, M. Tabin) Growth hormone – pathophysiology, dysfunctions: dwarfism, gigantism and acromegaly Posterior pituitary hormones (ADH and oxytocin) abnormalities Hyperthyroidism, Graves’ disease – etiology, pathomechanism, symptoms and signs Hypothyroidism – congenital, acquired; etiopathogenesis, clinical presentation Calcium-phosphates metabolism; hormonal regulation, rickets Hypoparathyroidism – causes, clinical signs: hypocalcemia, tetany Hyperparathyroidism: primary and secondary – causes; hypercalcemia – consequences Adrenocortical hormones (glucocorticoids, mineralocorticoids, sex hormones) – pathophysiology Hypercortisolism – Cushing’s syndrome, Cushing’s disease, cushingdoidal syndrome Hyperaldosteronism – Conn’s syndrome: arterial hypertension, hypopotasemia Adrenocortical insufficiency – Addison’s disease: etiopathogenesis, clinical presentation Diabetes mellitus – epidemiology, etiology, pathomechanisms, clinical classification Diabetes mellitus type 1 – clinical presentation, acute and chronic complications, treatment Diabetes mellitus type 2 – clinical presentation, acute and chronic complications, pathophysiology of accelerated atherosclerosis, management (diet, drugs and physical activity) Hormone secreting pancreatic tumors (insulinoma, glucagonoma, somatostatinoma) Credit Test # 3 (Endocrinology) Kidneys structures and functions – review Urinalysis – normal and pathological components; polyuria, oliguria, anuria; proteinuria, bacteriuria Acute renal failure – causes, pathomechanisms, clinical presentations, lab tests Chronic renal failure – causes, pathomechanisms, clinical presentations, lab tests Nephrotic syndrome – causes , clinical presentation, complications Glomerulonephritis – etiology, classification, manifestations, diagnostics, complications Pyelonephritis – etiology, clinical presentation, diagnostics, complications Renal stones – etiology, clinical presentation, diagnostics, complications Acid-base equilibrium pathophysiology (renal, lung and blood components), gasometric tests analysis Acidosis – respiratory / metabolic: causes, signs, compensatory mechanisms Alkalosis – respiratory / metabolic: causes, signs, compensatory mechanisms Normal blood composition, blood count, main blood functions. Thrombophilia (hypercoagulability, prothrombotic state) – predisposing factors, consequences Pathological bleeding – vascular abnormalities, platelets disorders, coagulation disorders Platelets disorders: thrombocytopenia, thrombocytosis, thrombocytopathia Blood coagulations factors pathology: inherited and acquired Hemophilia A and B – etiopathogenesis, clinical course, outcome, replacement therapy Anemias – etiopathogenesis, classification, clinical signs, laboratory diagnostics Leukemias – acute and chronic: etiopathogenesis, classification, signs, diagnostics, prognosis Credit Test # 4 (Nephrology & Hematology) Teaching aids: Laptop, multimedia projector, 12-lead ECG apparatus Terms for successful completion of course: Passing four credit exams (tests) and final examination (test). Name and address of the unit leading the course; contact (tel./email): Zakład Elektrokardiologii i Prewencji Chorób Sercowo Naczyniowych Katedry Patofizjologii Tel./fax: 71 784 12 47 E-mail: [email protected] Person responsible (Examiner) : Dr hab. Małgorzata Sobieszczańska, prof. nadzw. The Unit Head’s signature: .………....…..……….. Date: 20.09.2013 Dean’s signature: ……….………..……