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Study Questions – Chapter 8 1. What is the characteristic that determines gonadal sex of a male? Of a female? 2. What are the primary sex characteristics of a male? What are the secondary sex characteristics of a male? 3. What are the primary sex characteristics of a female? What are the secondary sex characteristics of a female? 4. How is sex different from gender? 5. What is the evidence that homosexuality in men may be genetically determined? 6. What biological process is determined by the presence or absence of the SRY gene? 7. What is the indifferent gonad? 8. What controls the development of the Müllerian ducts? 9. How do we know that the entire Y is not required to determine sex? 10. Why are Klinefelter syndrome males sterile? Why are Turner syndrome females sterile? 11. Why do XY women with CAIS have testicles? Why don’t they have other male sexual characteristics? Why don’t they have a cervix, uterus or fallopian tubes? 12. Why don’t XY women with a mutation in the SRY gene have testicles? Why do they have a cervix, uterus or fallopian tubes? 13. What role does SOX9 play in sex determination? 14. What causes levels of SOX9 to change? 15. If male sex can be determined by the simple step of expressing SRY, why can sex reversal result from mutations in RSPO1 or the androgen receptor? 16. If there were no “gay gene” on Xq28, what else could have caused the Xq28 mapping result? 17. Why might the Parisian model be considered male, and why might she be considered female? 18. Is there evidence of a biological basis for gender? 19. How can age-related penetrance complicate interpretation of heritability studies? 20. Why might the female sex be considered the default sex? Copyright © 2011, Elsevier Inc. All rights reserved. 1