Download better life. - barostim therapy

Consider the
journey towards a
better life.
If you suffer from heart failure,
your symptoms, medications and
hospital stays can make your life
very difficult.
BAROSTIM THERAPY™
improves cardiovascular function
and reduces symptoms, helping
you to get your life back.
Considering the therapy
BAROSTIM NEO™ I CONSIDERING THE THERAPY
What causes heart failure?
Heart failure can be caused by a heart attack, high blood
pressure, an imbalance in your nervous system, or other
conditions that progressively weaken the heart.
Left
Atrium
Left
Atria
Aorta
Left
Ventricle
Aorta
Left
Ventricle
Normal Heart:
Systolic Heart Failure:
The heart squeezes,
pumping blood out
to the body
The heart becomes enlarged and cannot
squeeze strongly. This means it cannot
pump enough blood around the body.
IMBALANCE MEANS GREATER RISK
Your body is controlled by two systems that lead your heart’s reaction to
different situations. The sympathetic system is responsible for the “fight or flight”
reaction, which is triggered when you face stressful situations. On the contrary,
the parasympathetic system is responsible for “rest and digest” activities, and
generally helps your heart and body calm down.
In heart failure, these two parts of the nervous system are imbalanced. Meaning,
there is too much sympathetic activity and not enough parasympathetic activity
in your body, putting your heart under a lot of stress and your overall health at
serious risk.
BAROSTIM NEO™ I CONSIDERING THE THERAPY
Heart failure: when your
heart needs your help
HOW DOES YOUR HEART WORK?
Your heart is the engine that provides fuel to your whole
body. It works in two phases:
• Diastole: Your heart relaxes and fills with blood.
• Systole: It contracts and pumps out blood throughout your body:
Diastole
(Filling)
Systole
(Pumping)
KEEPING HEART FAILURE UNDER CONTROL IS VITAL
If you’ve been diagnosed with heart failure, it means that your heart can’t pump
enough blood to meet your body’s needs. This condition is generally associated
with a sense of fatigue and weakness, shortness of breath, swollen legs and
ankles, and often a need to sleep with the head elevated.
As you are probably already experiencing, the symptoms of heart failure can have
a serious impact on your quality of life. They can limit your ability to perform daily
activities and put your whole life at risk. Understandably, multiple medications
and hospital stays can also make living more difficult.
Since heart failure tends to get even worse with time,
keeping your condition under control is vital.
Are you taking control of heart failure before
it controls you?
BAROSTIM NEO™ I CONSIDERING THE THERAPY
A small device that helps
your nervous system
find balance
BAROSTIM NEO™ has been created for
people like you, who have been diagnosed
with heart failure. It is a minimally-invasive
implant that works together with your body,
by sending signals that communicate with
your brain. These messages activate a
natural process that brings your nervous
system back into balance. Multiple
studies have shown BAROSTIM NEO’s
effectiveness in rebalancing your nervous
system. By doing this, physical activity
levels increase by 32%, and hospitalizations
related to heart failure decrease by 84%.1
With BAROSTIM THERAPY™, you can
regain the confidence that you will not be
spending your life in the hospital. 1, 2, 3
BAROSTIM THERAPY BALANCES SYMPATHETIC AND
PARASYMPATHETIC ACTIVITY
SYMPATHETIC
ACTIVITY
PARASYMPATHETIC
ACTIVITY
BAROSTIM THERAPY
BAROSTIM NEO™ I CONSIDERING THE THERAPY
Rest assured with
well-documented safety
The vast majority of people treated with BAROSTIM NEO™
did not have any short-term or long-term complications
that were related to the procedure. Most side effects that
may occur are minor and can be easily treated. During
clinical studies, there were no unexpected issues and none
that were related to the actual BAROSTIM NEO device.1, 2, 3
“ We went for this option because it was the
easiest surgically and had a better success
rate. I found it risk-free.”
Marwan Nader,
gardener and recipient of BAROSTIM THERAPY™
“ I hardly had any convalescence because
I felt much better. Now, I find myself living
a wonderful new life.”
Paolo Verna,
painter and recipient of BAROSTIM THERAPY™
A personalized therapy that has been used
in over 1,000 people
BAROSTIM THERAPY can be adjusted to your body’s unique needs and will
not hinder your lifestyle. In fact, studies show that overall quality of life improves
significantly with BAROSTIM THERAPY. And because the device functions
automatically, there is no additional daily action needed from you once it is
inserted. So you can have the peace of mind that you’ll be able to live a safer,
higher quality of life.1, 2, 3, *
BAROSTIM NEO™ I CONSIDERING THE THERAPY
The mission of our life is to
improve yours.
Our vision is to advance health for people everywhere,
giving each patient a fuller life. CVRx® pioneers unique
therapies that harness and harmonize the body’s natural
systems, benefiting society and making CVRx® a universal
role model in healthcare.
MESSAGE FROM THE FOUNDER OF
BAROSTIM THERAPY™ AND CVRx®, INC
Robert Kieval
Founder,
Chief Development
Officer
“When talking about BAROSTIM THERAPY, I’m often asked, ”What
problems or concerns keep you up at night?” To me, there’s only
one: “Can we make BAROSTIM THERAPY available to all those who
need it, in time to help them?” For the past 15 years, my colleagues
and I have worked tirelessly to develop a therapy that is above
all safe, but can also help people cope with, recover from, and
further avoid, the devastating consequences of their illnesses. We
want people to feel confident that they are being protected with
our product, but not limited in terms of daily lifestyle.
My most rewarding experiences have been getting to speak
to people who have benefited from BAROSTIM THERAPY. I’m
delighted to hear their personal stories on how their health and
lives have been improved. And I’m reminded that we need to
continue working until we establish BAROSTIM THERAPY as the
standard of care for people worldwide.”
Ask your doctor for more information on how to best prepare for the
BAROSTIM NEO® placement procedure. Gain control over heart failure with
BAROSTIM THERAPY. Help your heart help itself.
BAROSTIM NEO™ is CE Marked and approved for sale for heart failure patients in
Europe. It is also CE Marked and approved for sale for hypertension patients in Europe.
For more information, please visit www.barostimtherapy.com. CVRx, BAROSTIM NEO,
Baroreflex Activation Therapy and BAROSTIM THERAPY are all trademarks of CVRx, Inc.
© 2016 CVRx, Inc. All rights reserved.
1. Zile MR et al. Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients
with and without cardiac resynchronization therapy. Eur J Heart Fail. 2015 Oct;17(10):1066-74.
2. Wustmann K et al. Hypertension 2009, 54:530-536
3. Gronda E, et al. Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function and cardiac haemodynamics in heart
failure: a proof of concept study. European Journal of Heart Failure 2014.
* Main results from the HTN patient survey . CVRx Data on file. Survey that was administered to 33 patients who had had BAROSTIM THERAPY™
for longer than 6 months, and who had declared that they remembered what their life was like before receiving it.
950248-001 Rev B
BAROSTIM NEO™ I CONSIDERING THE THERAPY