Download Michael A. Henderson

"Chemoprevention: The Anti-Cancer
Effects of Inositol Hexaphosphate“
Presented By: Michael A. Henderson
GK-12 Fellow
Tuskegee University/Notasulga High School
Overview
The Cell and its components
The Cell Theory
Mitosis And Meiosis
What is Cancer
My Current Research
Classroom Implementation
The Cell and its Components
The cell is the basic unit of biology.
Every organism either consists of cells or is a cell
itself
The Cell Theory
M. SCHLEIDEN (1804 - 1881)
All organisms consist of one or more cells.
The cell is the basic unit of structure for all
organisms
All cells arise from preexisting cells
The Cell Cycle
Cell stages
G1: Cell growth
S:DNA synthesis and
replication
G2: Preparation for mitosis
M:Mitosis consists of nuclear
division (Karyokinesis)
Prophase
Metaphase
Anaphase
Telophase
Cytokinesis (cytoplasmic div)
Regulation of the Cell Cycle
Regulation of the cell cycle involves steps
crucial to the cell these include
detecting and repairing genetic damage
provision of various checks to prevent
uncontrolled cell division
What is cancer
•
•
Cancer begins in your cells, which are the
building blocks of your body.
It is characterized as a class of diseases in
which a group of cells display the traits of:
–
–
–
uncontrolled growth (growth and division beyond
the normal limits),
invasion (intrusion on and destruction of
adjacent tissues),
and sometimes metastasis (spread to other
locations in the body via lymph or blood)
What is Cancer
Oncology
A proto-oncogene is a normal
gene that can become an oncogene
due to mutations or increased
expression
Proto-oncogenes code for proteins
that help to regulate cell growth and
differentiation
An oncogene is a protein encoding
gene, which — when deregulated —
participates in the onset and
development of cancer
Risk Factors
Family History-Genetics
Age
Lifestyle
Habits
Diet
Physical Activity
Sexual Activity
Environment
Air pollution
Exposure to UV
Chemical pollution
My Current Research
Chemoprevention
The use of drugs, vitamins, or other agents to delay the
start of cancer, keep it from starting, or stop it from
coming back
Background
A large number of naturally occurring nutritive and nonnutritive constituents present in vegetables, fruits, and grain
products has been shown to inhibit carcinogenesis in
animals
Investigations have shown remarkable consistency in
finding lower risk for a variety of cancers among
populations consuming large amounts of plant foods,
particularly fruits and vegetables
Inositol hexaphosphate
(IP6)
(IP6) is a
polyphosphorylated
carbohydrate found in
high concentrations in
cereals and legumes
Phytic Acid (IP6)
The anticancer properties of IP6 have been
demonstrated in different experimental
models
IP6 has been demonstrated to prevent and
abrogate both primary tumor and metastasis
in vivo.
Remember Diet is Very
Important
Top 10 Cancer Fighting Foods
1.Tomatoes
2.Broccoli Sprouts
3.Berries
4.Soybeans
5.Tea
6.Pumpkin
7.Spinach
8.Garlic
9.Pineapple
10. Apple
Lecture Ideas/Lab Activities
The day of presentation, I plan to bring some platters containing a few of the
fruits that were displayed in the previous slide
A 3-Day lab activity where students will learn to make solutions
Day 1: Calculations (worksheets and hand-outs)
Day 2: Preparing Stock solutions from solids and liquids
Day 3: Dilutions (C1*V1=C2*V2 ) and learn proper use of pipettes
Once students have obtained the skills to make solutions, in the next lab
students (in groups) will run an actual western blot where they make their own
necessary solutions and prepare a gel
Purpose: To emphasize the importance of proteins in cellular processes. Relate back to the role
proteins play in the progression of cancer.
Lastly, students will perform lab Extracting DNA. This is a two-part lesson
Purpose: To develop understanding of DNA by modeling the process of DNA extraction
In the first part, students will explore Internet resources to develop their knowledge of DNA.
In the second part, the class will do an experiment that demonstrates DNA extraction.
Acknowledgements
Thank You GK-12
Questions