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A schematic presentation of early stages of mouse and human eye development, and their chronology during embryogenesis. Human eye development is
described in more detail in Table 240-3. The emphasis is on the morphogenesis of the eye cup and lens, and the development of the neuroretina and the
retinal pigment epithelium (RPE). Three major stages are emphasized: the optic vesicle stage, the lens placode stage, and the optic cup stage. The first
morphologic manifestation of mammalian eye development is the evagination of the embryonic forebrain to form the optic pit. This evagination becomes a
lateral diverticulation of the forebrain, the optic vesicle. As the optic vesicle approaches the overlying surface ectoderm, it induces the formation of the lens
placode, which later invaginates and pinches off to form the lens vesicle and, eventually, the lens. The cells of the lens vesicle nearest the optic cup
Source: Transcription Factors in Eye Disease and Ocular Development, The Online Metabolic and Molecular Bases of Inherited Disease
differentiate into elongated lens fibers, while the lateral cells, closest to the surface ectoderm, remain as a monolayer. The invagination of the optic vesicle
Citation: Valle
D, Beaudet
AL, Vogelstein
B, Kinzler
Antonarakis
Gibson
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Accessed:
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2017
neuroretina. The iris develops from the peripheral edge of the optic cup, from a cell layer continuous with the neuroretina. The cornea develops from a
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layer of overlying
ectoderm.
In McGraw-Hill
the depictionEducation.
of an E11.5
visibly differentiating cells are illustrated; the majority of the first differentiating cells
one can detect are ganglion cells. In the adult retina, the nucleus of each cell type is situated in one of three nuclear layers; two plexiform layers containing