Download Course Title Molecular Biology Number of Lectures 18 (36 h

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Molecular Biology
18 (36 h)
6 (12 h)
English
Associate Professor Yevgeny Nikolaichik, PhD in
Molecular Biology
http://www.bio.bsu.by/molbiol/nikolaichik_english.html
To give basic understanding of universal principles of
molecular biological processes in prokaryotic and
eukaryotic cells
Biochemistry, genetics, microbiology
Genome organisation in major groups of organisms.
DNA replication. Replicative and reparative synthesis
of DNA. The mechanism and catalysis of DNA
polymerisation reaction. Initiation of replication in euand prokaryotes. Topological problems of DNA
replication. Reparation of DNA damage. DNA
recombination and transposition. Transcription.
Structures of RNA polymerases and their promoters.
Transcription factors.
RNA processing. Modification of transcript ends.
Splicing of introns of various types. Translation.
mRNA, tRNA and rRNA structures and functions.
Genetic
code
and
its
properties.
tRNA
aminoacylation. Involvement of translation factors in
three stages of translation. Protein folding and
degradation. Molecular chaperones, ATP-dependent
proteases and 26S proteosome of eukaryotes.
Protein transport (secretion and intracellular sorting).
Sensory processes and intracellular regulation
Lectures, essays and seminars
1. Alberts B. Molecular Biology of the Cell, Fifth
Edition New York, 2008.
2. Lewin B. Genes VIII. Prentice Hall, 2004.
3. Watson J. D. Molecular Biology of the Gene, Fifth
Edition. CSH Laboratory Press, 2004.
4. Lodish H. Molecular Cell Biology (5th Edition) New
York, 2004.
Oral examination
Fifth-year undergraduate students