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Hemodialysis removes blood from the patient’s body (indicated by arrows from patient to artificial kidney) and passes it through an artificial kidney that contains a semipermeable membrane. Inside the artificial kidney, waste products pass into the dialysis fluid and are eliminated from the body. If drug molecules can pass through the pores in the semipermeable membrane, they will also be eliminated from the body. The extraction ratio of the artificial kidney can be computed using the concentration into (Cin) and out of (Cout) the device. Dialysis clearance can be calculated by taking the product of the dialysis extraction ratio and blood flow to the dialysis machine (Q). D = drug; D.F. = dialysis fluid. Source: Chapter 3. Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions, Applied Clinical Pharmacokinetics, 2e Citation: Bauer LA. Applied Clinical Pharmacokinetics, 2e; 2008 Available at: http://mhmedical.com/ Accessed: June 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
