Download midodrine

midodrine
Pronunciation: MY doe drin
Brand: ProAmatine
What is the most important information I should know about midodrine?
• In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact
your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats,
pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
• In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek
emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual
awareness of heartbeats. These may be signs of a slowed heart rate.
• Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least
3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to
skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
• Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be
dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal
products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine
headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
What is midodrine?
• Midodrine is a vasopressor. Midodrine causes constriction (tightening) of the blood vessels which leads to an
increase in blood pressure.
• Midodrine is used to treat low blood pressure.
• Midodrine may also be used for purposes other than those listed here.
What should I discuss with my healthcare provider before taking midodrine?
• Do not take midodrine without first talking to your doctor if you have
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heart or blood vessel problems (other than low blood pressure);
high blood pressure;
kidney problems;
difficulty urinating;
pheochromocytoma; or
over active thyroid.
• Before taking this medication, tell your doctor if you have
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liver problems;
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visual disturbances;
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diabetes; or
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glaucoma.
• You may not be able to take midodrine, or you may require a dosage adjustment or special monitoring during
treatment.
• Midodrine is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn
baby. Do not take midodrine without first talking to your doctor if you are pregnant or could become pregnant during
treatment.
• It is not known whether midodrine passes into breast milk. Do not take midodrine without first talking to your doctor if
you are breast-feeding a baby.
How should I take midodrine?
• Take midodrine exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse,
or pharmacist to explain them to you.
• Take each dose with a full glass of water.
• Midodrine can be taken with or without food.
• Take midodrine at regular intervals as directed by your doctor.
• Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least
3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to
skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
• Your doctor may want you to have regular blood pressure monitoring or other medical evaluations during treatment
with midodrine to monitor progress and side effects.
• Store midodrine at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed dose as soon as you remember then wait the prescribed amount of time before taking another
dose. Generally, doses should not be taken less than 3 hours apart. Follow your doctor's instructions.
double dose of this medication, unless otherwise directed by your doctor.
Do not
take a
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected.
• Symptoms of a midodrine overdose may include increased blood pressure (flushing, headache, pounding heartbeat,
blurred vision), goosebumps, difficulty urination, a feeling of being cold, and loss of consciousness.
What should I avoid while taking midodrine?
• Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least
3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to
skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
• Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be
dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal
products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine
headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
What are the possible side effects of midodrine?
• In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact
your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats,
pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
• In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek
emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual
awareness of heartbeats. These may be signs of a slowed heart rate.
• If you experience any of the following serious side effects, stop taking midodrine and seek emergency medical
attention or contact your doctor immediately:
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an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or
fainting); or
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irregular heartbeats, fluttering feeling in the chest, or chest pain.
• Other, less serious side effects may be more likely to occur. Continue to take midodrine and talk to your doctor if you
experience
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chills or goosebumps;
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itching or tingling of the skin;
increased need to urinate or difficulty with urination;
feeling of pressure or fullness in the head;
dryness of the mouth; or
nervousness or anxiety.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual
or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect midodrine?
• Before taking midodrine, talk to your doctor if you are taking any other medicines especially any of the following:
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an alpha adrenergic blocker such as alfuzosin (Uroxatral), doxazosin (Cardura), guanadrel (Hylorel), prazosin
(Minipress), or terazosin (Hytrin);
flecainide (Tambocor);
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cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);
digoxin (Lanoxin);
metformin (Glucophage);
fludrocortisone (Florinef);
triamterene (Dyrenium, Dyazide, Maxzide);
drugs that stimulate alpha-adrenergic receptors such as pseudoephedrine, phenylephrine, ephedrine, or
dihydroergotamine;
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quinidine (Quinaglute, Quinidex, Quin-Release); or
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procainamide (Procan SR, Procanbid, Pronestyl).
• You may not be able to take midodrine, or you may require a dosage adjustment or special monitoring during
treatment if you are taking any of the medicines listed above.
• Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be
dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal
products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine
headache medicines, heart or blood pressure medicines, irregular heartbeat medicines, or antidepressants without
first talking to your doctor.
• Drugs other than those listed here may also interact with midodrine. Talk to your doctor and pharmacist before taking
any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Where can I get more information?
• Your pharmacist has additional information about midodrine written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines
with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but
no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by
healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are
appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend
therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients
and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of
healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug
or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of
healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking,
check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.03. Revision Date: 12/15/2010.