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УДК 616.9+616.084
THE CASE OF MULTI-DRUG RESISTANT HIV-1 IN CHILDREN
OF NOVOSIBIRSK REGION
Feruza Odilzhonovna MIRDZHAMALOVA1,2, Yulia Vladimirovna MESHCHERYAKOVA1,
Yevgenia Vladimirovna KAZAEVA1, Ekaterina Borisovna SAVOCHKINA1,2,
Vladislav Viktorovich BOGACHEV2, Pavel Borisovich BARYSHEV2,
Yulia Vladimirovna NIKONOROVA2, Yuri Аndreevich TOPCHIN1,
Naila Yakubovna CHERNOUSOVA1, Valery Nikolevich MIKHEEV2,
Nataliya Matveevna GASHNIKOVA2
1
State Budgetary Health Institution Novosibirsk Regional Center for Prevention
and Control of AIDS and Infectious Diseases
630559, Koltsovo, «Vector», 20
State Research Center of Virology and Biotechnology «Vector»
630559, Koltsovo
2
A comprehensive assessment of cases of multidrug-resistant HIV-1 isolated in children aged 1.5 to 6 years in the
Novosibirsk region in 20102011 has been performed. The genetic diversity of HIV-1, the analysis of mutations
in the genome of the virus, which arise in response to antiretroviral therapy were studied and their prevalence
was evaluated. It was shown that among the studied variants of HIV-1 most mutations responsible for the formation of resistance are due to nucleoside and non-nucleoside reverse transcriptase inhibitors (M184V, Y181C
and K103N). A new recombinant form CRF02_AG / A HIV-1 was revealed in 11 of 12 patients with treatment
failure in history. It was found that the correction scheme based on ART resistance profile of HIV-1 in the majority of cases leads to therapy viral effectiveness and immunosuppression severity reduction. However, adherence to therapy and early detection of the full range of mutations of the virus, the correct assessment of the current profile of resistance and genetic characteristics of HIV-1 are also important factors in the success of ART.
Key words: HIV-1, antiretroviral therapy, children, antiretroviral drug resistance, the Novosibirsk Region.
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Mirdzhamalova F.O. – infectious diseases doctor, e-mail: [email protected]
Meshcheryakova Yu.V. – infectious diseases doctor, е-mail: [email protected]
Kazaeva Ye.V. – infectious diseases doctor, head of department, е-mail: [email protected]
Savochkina E.B. – infectious diseases doctor, е-mail: [email protected]
Bogachev V.V. – junior researcher of department of retroviruses, e-mail: [email protected]
Baryshev P.B. – junior researcher of department of retroviruses, e-mail: [email protected]
Nikonorova Yu.V. – junior researcher of department of retroviruses , e-mail: [email protected]
Topchin Yu.А. – head of department of epidemiology, е-mail: [email protected]
Chernousova N.Ya. – chief medical officer, е-mail: [email protected]
Mikheev V.N. – candidate of medical sciences, deputy director general, e-mail: [email protected]
Gashnikova N.M. – candidate of biological sciences, head of the retroviruses department,
e-mail: [email protected]