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Prospective Course Schedule and Weekly Reading Assignments Zoo/Bot 3333 Genetics, Fall 2012 Week of Topic Chapter Reading Assignment Aug 20 Introduction to Course; The Gene; Historical Perspectives on the Nature of Inheritance Hartwell, 1-2 Thompson, 1,2 Aug 27 Principles of Transmission Genetics: Mendel's Experiments Hartwell, 2-3 Thompson, 4 Sept 3 Human Pedigree Analysis; Probability and Risk Assessment; Meiosis; Chromosome Theory of Inheritance; Basic chromosome structure Hartwell, 3-4 Thompson, 4-5, 7 Sept 10 Sex linked Traits; Binomial Expansion and Chi Square analysis; (Exam #1 9/14, Fri) Hartwell, 3-5 Thompson, 6-7; (8-9)* Sept 17 Dominance relationships, polygenic traits; epistasis and environmental interactions; Linkage and Mapping Hartwell, 3-5 Thompson, 10-12 Sept 24 Three-point Test Cross; Tetrad Analysis; Mitotic Recombination; Gene Mapping Techniques in Humans; Recombination at the Molecular Level Hartwell, 5-6*; 10*; 11* Thompson, 10-12, 14, 15 Oct 1 Mutation and Phenotype; Chromosome Structure and Karyotype Analysis; Sex Chromosomes and Dosage Compensation Hartwell, 7; 13*; 4; 16* Thompson, 16, 19-20 Oct 10 Aberrations in Chomosome Structure and Number; Chromosome Aberrations and Cancer; Departures from Diploidy in Plants; Hartwell, 13; 19* Thompson, 16, 19-20 Oct 15 Introduction to Bacterial Genetics; Gene transfer and Hartwell, 15 Genetic Mapping in Bacteria; (Exam #2 10/17, Wed) Thompson, 13 Oct 22 Bacteriophage Genetics; Biochemical Nature of Gene; Hartwell, 6-7 DNA Molecular Structure Thompson, 13, 3 Oct 29 DNA Replication and Recombination Nov 5 Applications of Bacterial Enzymes and Genomes; Recombinant DNA Technology; DNA and RNA genomes (Exam #3 11/9, Fri) Hartwell, 6 Thompson, 3, 17, 20 Hartwell, 9, 10*-12*; 20* Thompson, 19-20 Nov 12 Synthesis of Classical and Molecular Techniques in the Analysis of Gene Function; Biochemistry of Protein Structure; The Cistron Hartwell, 6-7 Thompson, 17, 20 Nov 19 Cracking the Code; Evolution of the Genetic Code; Extranuclear Genomes; Eukaryotic Genome Organization. Hartwell, 8; 16* Thompson, 17-18 Transcription and Translation in Prokaryotes and Eukaryotes; (Exam #4 11/30, Fri) Hartwell 15-16 Thompson, 17-18 Nov 26 Dec 5 Chromatin Structure; Regulation of Gene Expression Hartwell, 18; 19* in Response to Development and Environment; Population Genetics; Genetic variation and the Hardy- Thompson, 18, 21 Weinberg Equilibrium FINAL EXAM: Monday, 10 December, 8:00 AM to 10:00 AM * I chose the Hartwell textbook for this course because it is comprehensive, and will serve as a suitable reference text for other courses commonly taken in the Zoology major curriculum. It is integrative, and emphasizes how both classical and molecular genetic approaches can be applied for therapeutic and economic benefit. It also discusses some of the potential societal dangers of the misapplication of genetic technology. It does not, however, follow a historical narrative. In contrast, my lectures for this course will discuss advances in genetics in a rough chronological order- my goal here is to provide an appreciation of how conceptual and technological breakthroughs progressively advance our understanding of the world around us. Our understanding of inheritance and the mechanisms of biological information storage and retrieval is a remarkable human achievement, and I think it makes for an interesting story. Our focus will be primarily on material covered in Chapters 1-18. The reading assignments given here will cover the topics discussed in class. Ideally, these reading assignments should be completed before the classroom discussion, i.e., I would like you to "read ahead" of material presented in lecture. As you might imagine in a 900 page textbook, covering in detail the entire text would optimally require a two semester course. The asterisks represent chapters where we will not discuss all the material included in the text. Please NOTE: The pace, but not the subject order, may vary from this tentative schedule; see the detailed course outline on the genetics web page, which gives specific page assignments for topics discussed in asterisked chapters in the Hartwell text. Prior to every exam, the specific material to be covered on that examination will be announced in class and posted on D2L.